LOCUS       NM_001271584            4378 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C5
            (Dnajc5), transcript variant 2, mRNA.
ACCESSION   NM_001271584
VERSION     NM_001271584.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4378)
  AUTHORS   Wang,N., Zhu,B., Allnutt,M.A., Grijalva,R.M., Zhao,H. and
            Chandra,S.S.
  TITLE     Decoding transcriptomic signatures of cysteine string protein
            alpha-mediated synapse maintenance
  JOURNAL   Proc Natl Acad Sci U S A 121 (24), e2320064121 (2024)
   PUBMED   38833477
REFERENCE   2  (bases 1 to 4378)
  AUTHORS   Dash,S., Lamb,M.C., Lange,J.J., McKinney,M.C., Tsuchiya,D., Guo,F.,
            Zhao,X., Corbin,T.J., Kirkman,M., Delventhal,K., Moore,E.L.,
            McKinney,S., Shiang,R. and Trainor,P.A.
  TITLE     rRNA transcription is integral to phase separation and maintenance
            of nucleolar structure
  JOURNAL   PLoS Genet 19 (8), e1010854 (2023)
   PUBMED   37639467
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4378)
  AUTHORS   Naseri,N.N., Ergel,B., Kharel,P., Na,Y., Huang,Q., Huang,R.,
            Dolzhanskaya,N., Burre,J., Velinov,M.T. and Sharma,M.
  TITLE     Aggregation of mutant cysteine string protein-alpha via Fe-S
            cluster binding is mitigated by iron chelators
  JOURNAL   Nat Struct Mol Biol 27 (2), 192-201 (2020)
   PUBMED   32042150
  REMARK    GeneRIF: Point mutations in cysteine string protein-alpha (CSP
            alpha) cause dominantly inherited adult-onset neuronal ceroid
            lipofuscinosis (ANCL). Normally palmitoylated cysteine string
            region of cysteine string protein alpha loses palmitoylation in
            ANCL mutants.
REFERENCE   4  (bases 1 to 4378)
  AUTHORS   Nieto-Gonzalez,J.L., Gomez-Sanchez,L., Mavillard,F.,
            Linares-Clemente,P., Rivero,M.C., Valenzuela-Villatoro,M.,
            Munoz-Bravo,J.L., Pardal,R. and Fernandez-Chacon,R.
  TITLE     Loss of postnatal quiescence of neural stem cells through mTOR
            activation upon genetic removal of cysteine string protein-alpha
  JOURNAL   Proc Natl Acad Sci U S A 116 (16), 8000-8009 (2019)
   PUBMED   30926666
  REMARK    GeneRIF: Studied role of the synaptic co-chaperone cysteine string
            protein-alpha in postnatal quiescence of mouse hippocampal radial
            glia-like (RGL) neural stem cells through mechanistic target of
            rapamycin kinase (mTOR) activation.
REFERENCE   5  (bases 1 to 4378)
  AUTHORS   Deng,J., Koutras,C., Donnelier,J., Alshehri,M., Fotouhi,M.,
            Girard,M., Casha,S., McPherson,P.S., Robbins,S.M. and Braun,J.E.A.
  TITLE     Neurons Export Extracellular Vesicles Enriched in Cysteine String
            Protein and Misfolded Protein Cargo
  JOURNAL   Sci Rep 7 (1), 956 (2017)
   PUBMED   28424476
  REMARK    GeneRIF: Results indicate that by assisting local
            lysosome/proteasome processes, CSPalpha-mediated removal of toxic
            proteins via extracellular vesicles plays a central role in
            synaptic proteostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4378)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   7  (bases 1 to 4378)
  AUTHORS   Lambert,J., Bergeron,D., Kozak,C.A. and Rassart,E.
  TITLE     Identification of a common site of provirus integration in
            radiation leukemia virus-induced T-cell lymphomas in mice
  JOURNAL   Virology 264 (1), 181-186 (1999)
   PUBMED   10544143
REFERENCE   8  (bases 1 to 4378)
  AUTHORS   Lyu,M.S., Rhee,S.G., Chae,H.Z., Lee,T.H., Adamson,M.C., Kang,S.W.,
            Jin,D.Y., Jeang,K.T. and Kozak,C.A.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
REFERENCE   9  (bases 1 to 4378)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 4378)
  AUTHORS   Chin,H., Lyu,M.S., Kwon,O.J. and Kozak,C.A.
  TITLE     Genetic mapping of the gene encoding cysteine string protein
  JOURNAL   Mamm Genome 8 (6), 456-457 (1997)
   PUBMED   9257949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY333630.1, BY101584.1, AK029006.1 and AK035288.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            and contains another compared to variant 1. Variants 1, 2, and 3
            all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.49849.1, BC012268.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BY333630.1         1-66
            67-420              BY101584.1         2-355
            421-3199            AK029006.1         306-3084
            3200-4378           AK035288.1         562-1740
FEATURES             Location/Qualifiers
     source          1..4378
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.63 cM"
     gene            1..4378
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /note="DnaJ heat shock protein family (Hsp40) member C5"
                     /db_xref="GeneID:13002"
                     /db_xref="MGI:MGI:892995"
     exon            1..213
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            214..266
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            267..384
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..874
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /note="cysteine string protein; DnaJ (Hsp40) homolog,
                     subfamily C, member 5"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 5"
                     /protein_id="NP_001258513.1"
                     /db_xref="CCDS:CCDS17215.1"
                     /db_xref="GeneID:13002"
                     /db_xref="MGI:MGI:892995"
                     /translation="MADQRQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHP
                     DKNPDNPEAADKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLS
                     SWWAKALFVVCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVSPEDLEAQLQ
                     SDEREATDTPIVIQPASATETTQLTADSHPSYHTDGFN"
     exon            385..598
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            599..770
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            771..4378
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacacacg tctttttccg ggggcgcgcg tgccagtgag tgagcgtgcg cgttcttgct
       61 gccgccagtg ttgcttccgc cgtcctctgc cgctgctacg gctgtcgccg cccgggatcc
      121 tcaggccgag cagtaggccg gccggctgcc caccactgcc ccgggacgga aagcggagcc
      181 gcggaaccgg tggaccggcg ggcgtgccga caggagatga tttctccgaa ttcattaagt
      241 gcatcttcgg aaaaataatg caaaagacta acctaacatg gccgaccaga ggcagcgctc
      301 actctctact tccggggaat cattatacca tgttcttgga ctggacaaga atgcaacctc
      361 agatgacatt aaaaagtcct atcggaagct ggccctgaag tatcaccctg acaagaaccc
      421 tgataaccca gaggctgcag acaagtttaa ggagattaac aacgcacacg ccatcctgac
      481 agacgccacg aaaagaaaca tttatgacaa gtatggctcg ctggggctct atgtggcgga
      541 gcagtttggg gaggagaacg tcaacaccta cttcgtactc tccagctggt gggccaaggc
      601 gctgtttgtt gtttgtggcc tcctcacctg ctgctactgc tgctgctgtt tgtgctgttg
      661 ctttaactgc tgctgtggga aatgcaagcc caaggcacct gagggtgagg agacagaatt
      721 ctacgtatcc cctgaagact tggaggcaca gctgcagtct gatgaaaggg aggctacaga
      781 cacaccgatc gtcatacagc cagcatctgc cacagagacc acccagctga cagctgactc
      841 ccaccccagc tatcacaccg acgggttcaa ctaaattcag gagaggctgt gattagagga
      901 tgaatcagca tctggccact gcaaccttag aatcatgaac tgtagtcact gagatgggaa
      961 ggcagccgtc aacctgacct gctctggctg gtcagggcca ctcccacctc ctctaagtcc
     1021 acccatctgt caatccttga tacatgaagt gcgtagcatg cagtatttaa agcagtgtag
     1081 ctacggtctt cttctgtttt atcctttttt taatagcatg tatgggttat gttcaatgtc
     1141 tgtgttgtgg acgtgctgca gctgggctga attaactgga tggtagtgct tattttgggt
     1201 tttcagccaa gcgggtccag tgaaggttca gctgtctcct tgtgcttaca ggagtcaggt
     1261 aagcacctgg agctacatct ccttgttggc ctctgtgtcc tgtgatatgg tctagtccat
     1321 ggctctgatc tcatcctcaa ggctgcagac agggctctga tatcacctgc aaaggaggga
     1381 actgggcccc gtcttccagg caccaccagc atcagtcgtt tgcacggtgt tcgtgttggg
     1441 aagctttcat agggtctctg catcatctca ctcggcctcg tgacagtttt cctgttagat
     1501 ctgctatgga gagtgcaggt atgccccttc tgaaagtggg agcacactct gtgtaatgtc
     1561 actatcttgg gtctcctggc cttgtggact gaaatcctat cattggaggc atgtctcttg
     1621 ctggtgtgtg ggaaatcatt tgtctctgtt ctgcaccttt ccaggtcaaa agctggattg
     1681 acggggccac agcctccttc cctcattcct gggtcatctt ccacattcct tcaagccaac
     1741 cttttaatct tttttggact tttaagaacc acaaatggca gcacctgcca cttagtcata
     1801 gtcagaaagt ctcttgagtc cagttgtggg tggcatgcaa ctgcttatgc agagtctgag
     1861 tgcccaggct ccagaacctc ctccctgtgc ttgccagtgc cccaccccct gcttgccttc
     1921 gcttccacct gtcactatca atgcctctgg cagctggagt gttgggttcc tggagcaggt
     1981 ggctggaccc tggtgctcct ggctcagaag ggttggcttc tagggaagct atggtagtag
     2041 tcactcaacc tgggaggcca gctcccggcc acaggattcc tttgtgaacc tctctccagt
     2101 cagtattcca gtcttggttc tagggtacca tggtgggtgg agttgaaaaa tgtggttacc
     2161 agtgatatgg agccatccta cccttttaca gttagctaga tagttgtacc agacttcaat
     2221 gagccaggtt cctccagaac cttcccgttg gctgctgctg cccatctgca tttccagaac
     2281 agatgaagaa ggagaaggct catgtggtgg ctctgtggcc cagacaaacc atcatgtgtt
     2341 tctgaagccc accccgccca cctcctggcc ccagctcacc agggccttca ggaccagatc
     2401 aggttgtcag gaagttacaa gaagaggcag cactgtgagg acaaacatgg cagtgatcaa
     2461 gggaacccat ccaggtcctg ggagacactg atgccaagtt cccagttgac cctacaacag
     2521 aactacatga gccaagatcc tcccatggat ttgttagttt cgttctttaa aggattttag
     2581 ggatatccac taacatagtc agttaaaagt aatttgtaaa catcagacct gtgtctagat
     2641 gtagtgggat acgcctataa tcccagcact agggaggctg aggtaggagg accttgagtt
     2701 gtagaccagt ctgggcttac acagtaagac cctaactcaa ataaaacaac ctaaaagaag
     2761 aatgagaaat ctattaattg gcccatattt gggacaaagg aaaaagaagt cactggtcaa
     2821 cctggggtgc tgggcctctt ttcctacagt gaccaggaac caggtccaga cttgtagatg
     2881 atcagttgca gtctggtagc acacccctcc tgcatgtagc tctgtggccc tttccctcac
     2941 atcctaacga gctagatcct gaactgggac ttgtggtgct gtcaggatga gaacatggaa
     3001 gttttgaacc tagtgtcttt tggaattcgt aaagctaaat aaatgatgtt gaacttgaaa
     3061 ccctccatat gtagatcagt ttcaaagtga taatagtgat tgccacggcc agtaagtacc
     3121 ctgacctgtc cctgtgcaga ctcccttgca gggttttact atgttgatct aaggtctcct
     3181 tgatttcatt tgtcctaagc taagaactgg tgagtctcag gatcagtctg actgttcttg
     3241 tccaaatata aatattaaat agagaaacac acacactccc ctaactccta tactggcagg
     3301 cagtgtagat ggtgctgtgc tgtgttgccc agagagtgct ggaatctgtg catgcaagct
     3361 catcctgtgc agtggagacc acttctgacc tacagaaagt agtcgggaga gaccctgggg
     3421 gacccgtcta ccaaggctgc tggagtgtag gtttctgttt gtgcccagtg atgtctttcc
     3481 ttgtcttcct tttgactgta ttttaagatt actttagatg attctgtgca atgtttatga
     3541 cctttcctac ccttctaatg ttcagttaac acagccagta cccaatgggg aaaaaccagg
     3601 ctgggtgatg gtggcagatg ccttatgtcc cagcacttgg gaagcagagg caggcggctc
     3661 acggagcctg ttctacagaa ctagttccag gacagccagg actacacaca aagaaatcct
     3721 gtcttaagaa gaaaaaaaaa acaaagcaaa acaaaacaaa acaaaagaaa aaagccagtg
     3781 cttactgtgg ttaggcaact ttttcccaag ttacttgctg gatttgttcc tgaatcataa
     3841 agccagtctc ttcagatgtc aagatttaat atcagtcagt acccgttgtc ctgctgatcc
     3901 atggtgtctg ttacaggtga gccttgttaa aggaggtgcc agtgctgcag ctggtagact
     3961 ccagagagag tgacataatc attcaagctg cccctgaggg tgtgggtgct gtagtacaga
     4021 gaacctgtgg gccgtgagca tcctactttg gctttcagtg caccttttat tgaggaacag
     4081 ttgtgaacag tgtaaaccgt gactgatctt attctttttc cagtattttg agctgtgaac
     4141 ccatgtgtcc cagcactggc ttgttccttt ttagtttgat tgaattatcc tcctatggaa
     4201 gtggcaaaat ctatgtcttt actgtcctta caagcacagt gtgtgttacc acatactgtg
     4261 agtgtgggtt gtggtgtgtg tcagtgtgtg tacatatgtg tatatgtata tatcacacag
     4321 caggcctgtc atgcctctgt ttggtggcaa agcaacaagt acaataaaag tcagctcc
//
