LOCUS       NM_008929               5163 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C3
            (Dnajc3), mRNA.
ACCESSION   NM_008929
VERSION     NM_008929.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5163)
  AUTHORS   Welters,A., Nortmann,O., Wormeyer,L., Freiberg,C., Eberhard,D.,
            Bachmann,N., Bergmann,C., Mayatepek,E., Meissner,T. and Kummer,S.
  TITLE     Congenital Hyperinsulinism in Humans and Insulin Secretory
            Dysfunction in Mice Caused by Biallelic DNAJC3 Variants
  JOURNAL   Int J Mol Sci 25 (2), 1270 (2024)
   PUBMED   38279270
  REMARK    GeneRIF: Congenital Hyperinsulinism in Humans and Insulin Secretory
            Dysfunction in Mice Caused by Biallelic DNAJC3 Variants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5163)
  AUTHORS   Li,S., Liu,J., Guo,J., Xu,Y., Zhou,Z., Li,Z. and Cai,H.
  TITLE     Progranulin inhibits fibrosis by interacting with and up-regulating
            DNAJC3 during mouse skin wound healing
  JOURNAL   Cell Signal 109, 110770 (2023)
   PUBMED   37329998
  REMARK    GeneRIF: Progranulin inhibits fibrosis by interacting with and
            up-regulating DNAJC3 during mouse skin wound healing.
REFERENCE   3  (bases 1 to 5163)
  AUTHORS   McLaughlin,T., Wang,J., Jia,L., Wu,F., Wang,Y., Wang,J.J., Mu,X.
            and Zhang,S.X.
  TITLE     Neuronal p58IPK Protects Retinal Ganglion Cells Independently of
            Macrophage/Microglia Activation in Ocular Hypertension
  JOURNAL   Cells 12 (12), 1558 (2023)
   PUBMED   37371028
  REMARK    GeneRIF: Neuronal p58[IPK] Protects Retinal Ganglion Cells
            Independently of Macrophage/Microglia Activation in Ocular
            Hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5163)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5163)
  AUTHORS   McLaughlin,T., Dhimal,N., Li,J., Wang,J.J. and Zhang,S.X.
  TITLE     p58IPK Is an Endogenous Neuroprotectant for Retinal Ganglion Cells
  JOURNAL   Front Aging Neurosci 10, 267 (2018)
   PUBMED   30245625
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5163)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 5163)
  AUTHORS   Yan,W., Frank,C.L., Korth,M.J., Sopher,B.L., Novoa,I., Ron,D. and
            Katze,M.G.
  TITLE     Control of PERK eIF2alpha kinase activity by the endoplasmic
            reticulum stress-induced molecular chaperone P58IPK
  JOURNAL   Proc Natl Acad Sci U S A 99 (25), 15920-15925 (2002)
   PUBMED   12446838
  REMARK    GeneRIF: The stress of unfolded proteins in the ER activates
            P58(IPK) transcription through an ER stress-response element in its
            promoter. P58(IPK) interacts with & inhibits PERK, which protects
            cells during the ER-stress response by reducing protein synthesis.
REFERENCE   8  (bases 1 to 5163)
  AUTHORS   Yoder,J.A. and Litman,G.W.
  TITLE     The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define
            two regions of conserved synteny between linkage group 7 and human
            chromosome 11q13
  JOURNAL   Gene 261 (2), 235-242 (2000)
   PUBMED   11167010
  REMARK    Erratum:[Gene 2001 May 16;269(1-2):227]
REFERENCE   9  (bases 1 to 5163)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   10 (bases 1 to 5163)
  AUTHORS   Korth,M.J., Lyons,C.N., Wambach,M. and Katze,M.G.
  TITLE     Cloning, expression, and cellular localization of the oncogenic
            58-kDa inhibitor of the RNA-activated human and mouse protein
            kinase
  JOURNAL   Gene 170 (2), 181-188 (1996)
   PUBMED   8666242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154377.4.
            
            On Sep 13, 2022 this sequence version replaced NM_008929.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148270.1, SRR10223969.15891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AC154377.4         45127-45338         c
            213-323             AC154377.4         30078-30188         c
            324-448             AC154377.4         25305-25429         c
            449-523             AC154377.4         22437-22511         c
            524-676             AC154377.4         15156-15308         c
            677-858             AC154377.4         13016-13197         c
            859-978             AC154377.4         12495-12614         c
            979-1084            AC154377.4         10829-10934         c
            1085-1205           AC154377.4         10484-10604         c
            1206-1338           AC154377.4         8033-8165           c
            1339-1487           AC154377.4         6439-6587           c
            1488-5163           AC154377.4         1595-5270           c
FEATURES             Location/Qualifiers
     source          1..5163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 62.6 cM"
     gene            1..5163
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /note="DnaJ heat shock protein family (Hsp40) member C3"
                     /db_xref="GeneID:100037258"
                     /db_xref="MGI:MGI:107373"
     exon            1..212
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            213..323
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            324..448
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            449..523
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            524..676
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            677..858
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            859..978
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1084
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1205
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1338
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1487
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..5163
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /note="hexamer: ATTAAA"
     polyA_site      1663
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /note="major polyA site"
     regulatory      5137..5142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
                     /note="hexamer: AATAAA"
     polyA_site      5162
                     /gene="Dnajc3"
                     /gene_synonym="Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri"
ORIGIN      
        1 agccgccgct gaggcccgag cgctgaccga gcgagcgagc gagtggacgg ggcgcttcgc
       61 tgcgggctgt tggccgcgcg ggctgctggg ccgcgcacct tcctgctctt cggctcaggc
      121 gcccttggac atggtggccc ccggctcggt gggcagccgg ctgggcgcgg tgttcccgtt
      181 cctgctggtc ctggtggacc tgcagtacga aggcgctgag tgtggagtaa atgcggatgt
      241 ggagaagcat cttgaattgg ggaagaaatt actcgcagcc ggacagctag ccgacgcctt
      301 atcacagttt cacgctgcag ttgatggtga ccccgataac tatatcgcat actataggag
      361 agctaccgtc ttcttagcca tgggaaaatc caaagcagcg ctgcccgacc tcaccaaagt
      421 gattgcgctg aagatggact ttactgccgc aagactacag agaggtcacc tactgctcaa
      481 acaagggaag cttgacgaag cagaagacga tttcaagaaa gtgctcaaat ctaaccccag
      541 tgagcaggag gagaaggaag ccgagtctca gcttgtaaaa gctgacgaga tgcagcggct
      601 gcgctcccaa gcgctcgacg cctttgacgg tgccgattac actgctgcta taaccttcct
      661 tgataagatt ttagaggttt gtgtttggga tgcagaactg cgtgaactgc gagcagaatg
      721 cttcataaag gaaggagagc ccaggaaagc catcagcgac ttaaaggctg cttcaaagct
      781 gaagagtgac aacacagagg ccttttacaa aatcagcaca ctctactacc agctaggaga
      841 ccatgagctg tctctcagtg aagttcgtga atgtctgaaa cttgaccagg atcacaagcg
      901 gtgttttgca cactataagc aagtgaagaa acttaacaag ctgattgagt cagctgaaga
      961 gctgatccga gatggcagat acacagatgc aaccagcaaa tatgaatcag tcatgaaaac
     1021 agagcccagt gttgctgagt acacagtgcg ctcgaaggag aggatctgcc actgcttctc
     1081 taaggatgag aagcccgtgg aagccattag gatatgttct gaagttttac agatggagcc
     1141 cgacaatgtg aatgctctga aagaccgagc cgaggcctac ttaatagagg aaatgtacga
     1201 tgaagccatt caggattatg aagctgctca ggagcacaat gaaaatgacc agcagattcg
     1261 ggaaggctta gagaaagccc agcggttact gaagcagtca cagaaacgag attattataa
     1321 aatcttggga gtaaaaagaa atgccaaaaa acaagaaatc attaaagcat accgaaagtt
     1381 agcactgcag tggcatccag ataatttcca gaatgaagaa gaaaagaaaa aagcagagaa
     1441 aaagttcatt gacatagcag ctgctaaaga agtcctctca gacccagaaa tgagaaagaa
     1501 gtttgatgat ggagaagatc ctcttgatgc agagagtcaa caaggaggtg gtggcaaccc
     1561 cttccacaga agttggaact catggcaagg gtttaacccc ttcagctcag gcggaccgtt
     1621 cagatttaag ttccacttca attaaaccag ctattttact gctcctcttc tttattatta
     1681 tttttaacat taaaaacaaa ttttgtttgg gattctaatg gaaacaaaat ggaacaaatc
     1741 ttttagtttg tccatgacca aagagttgtt ttaaagaaaa aaagctgagc ttattgtaga
     1801 cttaaggttg atgggcctgt caaggtggga agcaaggagc taaccgtatt tctgacgaag
     1861 cagcctatac taatttgtga cttctgggag aagtggtctg agatacttat cctgtggagg
     1921 tgttcagaaa agcgttaaat agacattgat aaccctggag cagacagatt ctatgcaggc
     1981 tgtgtattaa ccgtgaggag gagctgtgat ctttggtgga ttgtgtctca gtattcttaa
     2041 aggagtgtgg acagctgagc ttcatttttg gaggaacagt tatgcttaga ctttggtcag
     2101 tccattcact tgcaagtatt tctgtaccag tgtcctcagc tctcactgca ggaggggaga
     2161 ccgtcttcca ggaaacttac cagcaggtgg taggctgtat gtccaggtat agactggaag
     2221 tatttttgtt gttgttttat atctatagga gaataccaat ttcacttgaa tttaattgtt
     2281 aaactaaaca gagtaagtta aagtatatga aagcggctct gtggttctct agacaacact
     2341 gttgaaagtc agtttgaaat gctttttaag aaagtgaagt tccaagttgt ttggtcgaaa
     2401 ttccctgtca caaaattggt tagaagtgga aagttgctct gtcaacatgg gcagagcatt
     2461 atggttgcct ctcgcaagca gtgcgctgag gcagctgtct ctgttgtttt ccttgctggg
     2521 ttttggactg gctgttccct ggctgtttct tctgtgagaa gaaagtagag gcttgcaaat
     2581 cgattcaact ctggctgtgt accttctatc attcacttaa taagatggca cttcctcctg
     2641 agacattccc gtccctctta ctttaaagca gatacttaag aaatgtacta gtcagtattt
     2701 gtatactgta taatttttgc cttaaaaatc tgttgctaaa caagaatatt gaatacttat
     2761 ggaactactg atgctgtgtt gaaaacttag aagaattact ctggtaagaa ttattgcctc
     2821 tattctagaa aaaaaaattt taaacattgt gagatatttt aagcataaag gtctaatata
     2881 ttgcttttat gaaattaaac attttagtta attgtgggaa ggaagcatga atgtagcagc
     2941 caagcacaaa tcattttgtt aacctatagt catatcaact tgagcagata tagaaaaaga
     3001 ttttgttaac tgcaagaaca tgaattacat aagttgagtt gggcaaaaca ttttaagtgc
     3061 tttttgcctc tacttaggag cctttttctt accaaaacac ttaacaatgc atttcaaaat
     3121 acctttcagc tttcattttg cttcagtgtc tcacagttca aggcaggcaa gaaaactcac
     3181 agcttttatc ctagctgtag agacaggcag aggcaggtgg attcctaaga gtttgagcca
     3241 gcttggttta catagtgagt tccgtgccag ggcctccacc aaaatattaa atcagttcaa
     3301 gccagtgtga aacattgaat gaaaaataaa agaacatttt tgtgtgtttt tcagatctta
     3361 gtaatcttat gttaactact tacctgacgt tgtctttcag tctgactcac tccttttgtg
     3421 atgtcactga cagttgtgaa ctggagtgac ggcacctctg ctttgcacag cccagtgttc
     3481 accagcagaa caaaggaggc atctcggtgc ttacactccc acttagagcg atgtcagctg
     3541 cccgtagtgt gggttgaagg tgggctgcat ggacacaggt cccagatcta gctacctcct
     3601 aacttgcttc ccagaagggt tttctttttc tctttttttc cccttcctac ttgtaacaac
     3661 ccaaagtaac tgaggattag gctttgtcat tgcaaatttt ggtgccaaag gcatatgccg
     3721 tggcaggagg ttagtgaggt aaccctcctg tgctcattag tgaggtaggg gtgtccagcc
     3781 tgccccaggc gagtcacagc gtcagaacag tagtttctgc tacctgcctg acattgcaag
     3841 gcaggcactg tggaaccaca ttactgaaaa agcattctct gcctttgtct ttccctctgt
     3901 ttgcagagcc acttccacat tccaatttct ctgtttagga actgcaggta acctgtgtag
     3961 taattctggg aaaaatatga ccaaaggtca ctttggctga actccgttct gtccatagac
     4021 gtcccctcct ctgtggtgag cttcctaagt acagtgtcac tgggctgtgt ccagtgctcg
     4081 tcgctctgga agaaggaaag gcacctgctg tggggccacg gggccactcc ttttatttct
     4141 cagctctaaa actttactct ttcttactgt gaatagaaga aaacctgaaa aacatctcag
     4201 tggtttatta atgtgaattg gatgtaacgt cttaagttaa aaatgtagtg agtgttaaaa
     4261 gtctgttttt aaatagcagt atgcagattt gtcactggag ttctgataat gaatggaatt
     4321 aaaattcttt tttttttaac ataagcaggc atggtggctc aggcctgtaa tcccagaatg
     4381 tggggctgca atagcatgtc actgtgactt taggccccat ttcaaaaata ccaaacttaa
     4441 acacatcccc aaaacgagtg tgagagagga ttacagataa ctaagtaaaa aatgtcagtg
     4501 gtcaccgtta tctattcctg ggtcagaagc tggcatgtgc catgaaggcg gcaagctgta
     4561 ctaggtaact gtgactccgc aggccctgtg ggtgccgacc tgccttacag atacgtcctg
     4621 ggtaagtggg gggccaagat ggtttgcttg actgtactgg actttgctgt aggaggaggg
     4681 agggaaatgg taatcgctaa gagctcatct tttccagatc gtatcatttc tcttctatta
     4741 gtggcagagt tgattctgta atttcaaatg atgttcaaag gggaggtatt tttttttaaa
     4801 cagatgatct catttgctga atgatttaag agtaaaattt agccactgcg tggctttgtg
     4861 tatagtaaca acaggtttta ttgcactatc tatggttgaa atacctgtgc aaagaaatgc
     4921 agggcacagg ggaggtaaaa attcaagatg tttgatacgt taaattatta ctcttaagtt
     4981 tatatttgtt ttaaatggga cacatcttac ttaatccatc tcaatttagt gttttaataa
     5041 aaaaagaact aaaattattt caacttgggc ttacatgtgt caatatgggc aatatgaata
     5101 tgggcaatat ttttatgccc gtgtattttc acatttaata aaaatattta tggtcatatc
     5161 cac
//
