LOCUS       NM_030046               2119 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C21
            (Dnajc21), mRNA.
ACCESSION   NM_030046 XM_127961 XM_906184 XM_976356 XM_976393 XM_976430
VERSION     NM_030046.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102101.7.
            
            On Feb 25, 2022 this sequence version replaced NM_030046.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR15390195.445820.1,
                                           SRR13422589.326693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC102101.7         52702-53019
            319-412             AC102101.7         59304-59397
            413-536             AC102101.7         60938-61061
            537-659             AC102101.7         61286-61408
            660-964             AC102101.7         61860-62164
            965-1116            AC102101.7         63178-63329
            1117-1204           AC102101.7         68427-68514
            1205-1363           AC102101.7         70920-71078
            1364-1406           AC102101.7         71687-71729
            1407-1579           AC102101.7         73536-73708
            1580-1655           AC102101.7         75513-75588
            1656-2119           AC102101.7         76058-76521
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.35 cM"
     gene            1..2119
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /note="DnaJ heat shock protein family (Hsp40) member C21"
                     /db_xref="GeneID:78244"
                     /db_xref="MGI:MGI:1925371"
     exon            1..318
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1817
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /note="DnaJ (Hsp40) homolog, subfamily C, member 21"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 21"
                     /protein_id="NP_084322.2"
                     /db_xref="CCDS:CCDS49581.1"
                     /db_xref="GeneID:78244"
                     /db_xref="MGI:MGI:1925371"
                     /translation="MKCHYEALGVRRDASEEELKKAYRKLALRWHPDKNLDNAAEAAE
                     QFKLIQAAYDVLSDPQERAWYDNHREALLKGGLDGEYQDDSLDLLHYFTVTCYSGYGD
                     DERGFYAVYRVVFELIAKEELECMSEGDVEDFPTFGDSQSDYDTVVHPFYAHWQSFCT
                     QKNFSWKEEYDTRQASNRWEKRAMEKENKKIRDRARKEKNELVRQLVAFIRKRDKRVQ
                     AHRKLVEEQNAEKARKAEEMRRQQKLKQAKLAEQYREQSWMTMANLEKELQEMEARYE
                     KEFGDGSDENEVEDQEPRNGLDGKDSEEAEEAELYQDLYCPACDKSFKTEKAMKNHEK
                     SKKHREMVALLKQQLEEEEEQFSGVQMDENVLNANSEEEMEDTPKQKLSKKQKKKKQK
                     SAQNFDDNFNENGTEEGGKIAPEKTKSNEDNAKELENRPQENTCITETTEACEDPKSE
                     AKSVPKSKGKKTKDVKKSVKAPAEAQPVSDVLISCATCHSEFPSRNKLFDHLKATGHA
                     RAPSATASLNSVTRNKKEKRRSR"
     exon            319..412
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..536
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            537..659
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            660..964
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1116
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1204
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1363
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1406
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1579
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1655
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..2119
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2099..2104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2119
                     /gene="Dnajc21"
                     /gene_synonym="4930461P20Rik; 9930116P15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccccctccg cgcgcccgcg tgccgcagcc cgcgtcgtcc accgccgcgc gcctccgcca
       61 ccccgcgccg ctgccgccgc cgccgccggg ctcgctggct ggcgggctgc tggcgccggg
      121 ctcccgccgg aggagaggac agccagcgcc gccgctgcgg cttctgcccg ggcccgggcg
      181 tcggccccgc cccgggcccc ggcccggtgt ccagccccgc catgaagtgt cactacgagg
      241 cgctgggggt gcggcgcgac gccagcgagg aggagctcaa gaaggcctat cggaagctgg
      301 ccctgaggtg gcacccggat aaaaatctgg acaatgccgc agaagcagct gagcagttta
      361 aattaatcca agctgcatat gacgtcttaa gtgaccctca ggaaagagcg tggtacgata
      421 accaccgaga ggccttactt aaaggagggc tcgatgggga atatcaagat gacagcttag
      481 atctgcttca ttatttcacg gttacctgtt attctggtta tggggacgat gaaagggggt
      541 tctatgcagt gtatcgtgtt gtctttgagc tgattgcaaa agaagaactg gagtgtatgt
      601 cagagggaga tgttgaggat tttccaacct tcggcgactc ccagagcgac tatgacacgg
      661 tggtccaccc tttctacgct cactggcaga gtttctgcac acaaaagaat ttttcctgga
      721 aggaagagta tgatacccgg caagcctcga accgctggga aaaacgagcc atggaaaaag
      781 aaaacaaaaa aattcgagac agagcaagga aagagaaaaa tgaactggtg cgccagctgg
      841 tagccttcat tcgtaaacga gataagagag tgcaggccca tcggaagctt gtggaggagc
      901 agaacgcaga gaaggcgagg aaggcagagg agatgaggag gcagcagaag ctgaagcaag
      961 ccaagctggc agagcagtac agagagcaga gctggatgac catggccaat ttggagaagg
     1021 agctccagga gatggaagca aggtacgaga aggagtttgg agatggatca gatgaaaacg
     1081 aagtggagga tcaggagccc agaaacggat tggatggcaa ggacagcgag gaggctgagg
     1141 aggctgagct ttaccaggac ctttactgcc cagcttgtga caaatccttc aagacagaaa
     1201 aggccatgaa gaatcacgag aagtcaaaga aacatcggga aatggttgcc ttgttaaaac
     1261 agcagttgga ggaggaggaa gaacagtttt caggagttca aatggatgaa aatgtattga
     1321 atgccaattc tgaggaggaa atggaagata caccaaagca gaagctttct aaaaaacaga
     1381 agaaaaagaa acagaaatca gcacagaatt ttgatgacaa tttcaatgaa aatggaactg
     1441 aagaaggagg aaagattgct ccagaaaaga ctaagtcaaa tgaagacaat gccaaagaat
     1501 tagaaaatag gccccaagaa aatacctgta ttacagagac cacagaagcc tgtgaggatc
     1561 caaaaagcga agctaaaagt gttcctaaat ccaaaggaaa gaaaaccaaa gatgtgaaaa
     1621 aatctgtcaa agcacctgct gaagcacagc cagtgagtga tgtcctcatc agctgtgcga
     1681 cttgccacag tgaatttcca tcccggaata aactgtttga tcatctaaag gctactggtc
     1741 atgcaagagc accttcagcc acagcatctt taaacagtgt aactaggaac aagaaagaga
     1801 agcgtagaag tagataggaa ttctgttaac tctttttttt ttttaactgt ctctagatct
     1861 ggaaccaaaa actgaactga cataatctag agttaaaatt tcagtgatct gcaattcatt
     1921 gcattgtgga agattatttt tatcttataa agacattttt gtttaatata tatttttaaa
     1981 catttcacta gtgattgaat tctactttgc catctgaatt cacttgaatg tttcatgaca
     2041 ggtaaatatt ataaatgtgt atctggattt ctcatgtgaa cagaaatgta cagggaaaat
     2101 taaattattt tgacacata
//
