LOCUS       NM_009584               2053 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C2
            (Dnajc2), transcript variant 1, mRNA.
ACCESSION   NM_009584 NM_009583
VERSION     NM_009584.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Helary,L., Castille,J., Passet,B., Vaiman,A., Beauvallet,C.,
            Jaffrezic,F., Charles,M., Tamzini,M., Baraige,F., Letheule,M.,
            Laubier,J., Moazami-Goudarzi,K., Vilotte,J.L., Blanquet,V. and
            Duchesne,A.
  TITLE     DNAJC2 is required for mouse early embryonic development
  JOURNAL   Biochem Biophys Res Commun 516 (1), 258-263 (2019)
   PUBMED   31230751
  REMARK    GeneRIF: Invalidation of DNAJC2 leads to early post-implantation
            lethality of mouse embryos.  Dnajc2 is expressed throughout early
            mouse embryogenesis.  Maternal Dnajc2 mRNAs allow early
            preimplantation mouse embryonic development.
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Barilari,M., Bonfils,G., Treins,C., Koka,V., De Villeneuve,D.,
            Fabrega,S. and Pende,M.
  TITLE     ZRF1 is a novel S6 kinase substrate that drives the senescence
            programme
  JOURNAL   EMBO J 36 (6), 736-750 (2017)
   PUBMED   28242756
  REMARK    GeneRIF: These findings reveal a mechanism by which nutrient
            sensing pathways impact on cell senescence through the activation
            of mTORC1-S6 kinases and the phosphorylation of ZRF1.
REFERENCE   5  (bases 1 to 2053)
  AUTHORS   Kaymak,A. and Richly,H.
  TITLE     Zrf1 controls mesoderm lineage genes and cardiomyocyte
            differentiation
  JOURNAL   Cell Cycle 15 (23), 3306-3317 (2016)
   PUBMED   27754813
  REMARK    GeneRIF: Zrf1 is identified as a novel regulator of the mesodermal
            lineage that might facilitate spatiotemporal expression of genes.
REFERENCE   6  (bases 1 to 2053)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   7  (bases 1 to 2053)
  AUTHORS   Royaux,I., Minner,F., Goffinet,A.M. and de Rouvroit,C.L.
  TITLE     A DnaJ-like gene, Hsj2, maps to mouse chromosome 5, at
            approximately 24 cM from the centromere
  JOURNAL   Genomics 53 (3), 415 (1998)
   PUBMED   9799614
REFERENCE   8  (bases 1 to 2053)
  AUTHORS   Shoji,W., Inoue,T., Yamamoto,T. and Obinata,M.
  TITLE     MIDA1, a protein associated with Id, regulates cell growth
  JOURNAL   J Biol Chem 270 (42), 24818-24825 (1995)
   PUBMED   7559602
REFERENCE   9  (bases 1 to 2053)
  AUTHORS   Hughes,R., Chan,F.Y., White,R.A. and Zon,L.I.
  TITLE     Cloning and chromosomal localization of a mouse cDNA with homology
            to the Saccharomyces cerevisiae gene zuotin
  JOURNAL   Genomics 29 (2), 546-550 (1995)
   PUBMED   8666407
REFERENCE   10 (bases 1 to 2053)
  AUTHORS   Bar,I., Lambert De Rouvroit,C., Royaux,I., Krizman,D.B.,
            Dernoncourt,C., Ruelle,D., Beckers,M.C. and Goffinet,A.M.
  TITLE     A YAC contig containing the reeler locus with preliminary
            characterization of candidate gene fragments
  JOURNAL   Genomics 26 (3), 543-549 (1995)
   PUBMED   7607678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125313.2.
            
            On Mar 7, 2023 this sequence version replaced NM_009584.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131964.1, U53208.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC125313.2         70771-70967
            198-388             AC125313.2         72719-72909
            389-464             AC125313.2         74560-74635
            465-563             AC125313.2         79141-79239
            564-705             AC125313.2         80881-81022
            706-786             AC125313.2         82098-82178
            787-852             AC125313.2         85406-85471
            853-944             AC125313.2         87219-87310
            945-1066            AC125313.2         87398-87519
            1067-1216           AC125313.2         89251-89400
            1217-1305           AC125313.2         92127-92215
            1306-1375           AC125313.2         92441-92510
            1376-1560           AC125313.2         94231-94415
            1561-1661           AC125313.2         95230-95330
            1662-1769           AC125313.2         95483-95590
            1770-1924           AC125313.2         98037-98191
            1925-2053           AC125313.2         98547-98675
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.97 cM"
     gene            1..2053
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /note="DnaJ heat shock protein family (Hsp40) member C2"
                     /db_xref="GeneID:22791"
                     /db_xref="MGI:MGI:99470"
     exon            1..197
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..388
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..464
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..563
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..705
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..786
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..852
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..944
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1066
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1216
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1305
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1375
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1560
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1661
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1769
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1924
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2053
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /note="hexamer: AATAAA"
     polyA_site      2053
                     /gene="Dnajc2"
                     /gene_synonym="MIDA1; Zrf1; Zrf2"
                     /note="major polyA site"
ORIGIN      
        1 actggtcgtc tccatgcgcc ggctccgggg cgtaaagcct aggcgcgagg ctcagaccac
       61 aggtagtgcg gacgcggagg gccctgcctg ccggccgtga gccgcggcgt ccgcgggacc
      121 agccccaacc agcatgctgc tcctgccgag cgccgcggag ggccagggca ccgccatcac
      181 ccacgctctg acctccgcct cttcagtctg tcaagttgaa cctgtgggaa gatggtttga
      241 agcttttgtt aagaggagaa acagaaatgc ttctacatct tttcaggaac tggaagataa
      301 gaaagagttg tcagaggaat cagaagatga agagttacag ttagaagaat tccccatgct
      361 gaaaacactt gatcccaaag attggaagaa tcaagatcat tatgcggttc ttggacttgg
      421 ccacgtcaga tacacagcta cacagagaca gatcaaagca gctcataaag caatggtctt
      481 gaaacatcat ccagacaaac ggaaagcggc tggggaaccc atcaaagaag gagacaatga
      541 ctacttcact tgcataacta aagcttatga aatgttgtct gatccagtga aaaggcgggc
      601 atttaacagt gtagatccta cttttgacaa ctcagttcct tctaaaagtg aagctaagga
      661 caattttttt caagtgtttt ctccagtgtt tgaaaggaat tcaagatggt caaataaaaa
      721 aaatgttccc aagcttggtg atatgaactc ctcgtttgaa gatgtagatg cgttttactc
      781 tttctggtat aattttgatt cttggagaga attttcttat ttagatgaag aagaaaaaga
      841 aaaagcagaa tgccgtgatg agaggaagtg gattgaaaag cagaacagag ccacgagggc
      901 acaaaggaaa aaggaagaga tgaacagaat aagaacatta gttgataatg cttacagttg
      961 tgacccaagg ataaaaaaat ttaaggaaga agaaaaggcc aagaaagaag cagaaaagaa
     1021 agcaaaagca gaggccaggc ggaaggagca ggaagccaaa gaaaagcaaa gacaagctga
     1081 attagaagct gttcggttgg ctaaggagaa agaagaggaa gaagttagac agcaagcatt
     1141 gttggccaag aaggaaaaag atatccagaa gaaagccatt aaaaaggaaa ggcagaaact
     1201 tcggaactcg tgcaagagct ggaatcactt ctcggacaat gaggcagacc gtgttaaaat
     1261 gatggaagag gtggaaaaac tctgtgatcg gcttgaacta gcaagcttgc agggcttgaa
     1321 tgaaatcctg gcttcatcta cgagagaagt aggaaaagct gcacttgaaa aacagataga
     1381 agaagtgaat gagcagatga ggagagagaa ggaggaagct gatgctcgga tgcggcaagc
     1441 atccaagaat gcagagaagt caactggtgg aagtgggagt ggcagtaaaa attggtcaga
     1501 agatgatctg caattattaa ttaaagctgt caatctcttc cctgctggaa caaactcaag
     1561 atgggaagtc attgctaatt atatgaacat acattcttct tctggcgtca aaagaactgc
     1621 caaagatgtt attagcaagg ctaaaagcct ccaaaaactt gaccctcatc aaaaagatga
     1681 cattaacaaa aaggcttttg ataagtttaa aaaagaacat ggagtggcct ctcaggctga
     1741 cagtgcagca ccatcagaac ggtttgaagg tccctgcata gattccaccc cttggacaac
     1801 agaagaacag aaacttttag aacaggcttt gaaaacatac ccagtaaata ctcctgaacg
     1861 atgggaaaag atagccgaag ctgttcctgg caggacgaag aaggactgca tgaggcgata
     1921 caaggaactt gtggagatgg tgaaagccaa gaaagctgct caggagcaag tgctgaatgc
     1981 aagcagagcc aggaaataat gcaggcaatc ctggttgtgt gtgcactttt ataataaaac
     2041 tgaaaatact gta
//
