LOCUS       NM_026332                686 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C19
            (Dnajc19), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_026332
VERSION     NM_026332.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 686)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 686)
  AUTHORS   Richter-Dennerlein,R., Korwitz,A., Haag,M., Tatsuta,T.,
            Dargazanli,S., Baker,M., Decker,T., Lamkemeyer,T., Rugarli,E.I. and
            Langer,T.
  TITLE     DNAJC19, a mitochondrial cochaperone associated with
            cardiomyopathy, forms a complex with prohibitins to regulate
            cardiolipin remodeling
  JOURNAL   Cell Metab 20 (1), 158-171 (2014)
   PUBMED   24856930
REFERENCE   4  (bases 1 to 686)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   5  (bases 1 to 686)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA469052.1, AK007866.1 and AC068294.26.
            
            On Nov 26, 2013 this sequence version replaced NM_026332.3.
            
            Transcript Variant: This variant (1) uses an alternate 3' terminal
            exon which results in a frameshift compared to variant 2. The
            resulting protein (isoform 1) has a distinct C-terminus and is
            shorter than isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007866.1, BY707873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CA469052.1         38-70
            34-165              AK007866.1         2-133
            166-166             AC068294.26        91635-91635         c
            167-686             AK007866.1         135-654
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 16.43 cM"
     gene            1..686
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /note="DnaJ heat shock protein family (Hsp40) member C19"
                     /db_xref="GeneID:67713"
                     /db_xref="MGI:MGI:1914963"
     exon            1..169
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..517
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial import inner membrane translocase subunit
                     TIM14; DnaJ (Hsp40) homolog, subfamily C, member 19"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit TIM14 isoform 1"
                     /protein_id="NP_080608.3"
                     /db_xref="CCDS:CCDS38412.1"
                     /db_xref="GeneID:67713"
                     /db_xref="MGI:MGI:1914963"
                     /translation="MASTVVAVGLTIAAAGFAGRYVLQAMKHVEPQVKQVFQSLPKSA
                     FGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGGSPYIAAK
                     INEAKDLLEGQAKK"
     exon            170..221
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /inference="alignment:Splign:2.1.0"
     exon            222..295
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /inference="alignment:Splign:2.1.0"
     exon            296..375
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /inference="alignment:Splign:2.1.0"
     exon            376..446
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /inference="alignment:Splign:2.1.0"
     exon            447..686
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      621
                     /gene="Dnajc19"
                     /gene_synonym="1810055D05Rik; Tim14"
                     /note="major polyA site"
ORIGIN      
        1 actttgtgcg acagttccga cgcactttac ggcgccgctg ccgtgttgcg cggcgctagt
       61 ggaagtggcg gcatcgctgg ctcggccctg tcgttctcca cagctgtacc gtggcggtgg
      121 gctcgcgctg ggatgagcgc gcggtgccga gccgcggagt ggagtcatgg ccagcacagt
      181 ggtagcagtc gggttgacca ttgctgctgc aggatttgca ggccgttatg ttttacaagc
      241 catgaagcat gtggagcctc aagtaaaaca agtttttcag agcctaccaa aatctgcatt
      301 cggtggtggg tactacagag gtggatttga acccaaaatg acaaaacggg aagcagcatt
      361 aatattaggt gtaagcccta ctgccaataa agggaagatc agggatgctc atcgccggat
      421 tatgctatta aatcacccag acaagggagg atctccttat atagcagcca aaatcaatga
      481 agctaaagac ttactagaag gacaagctaa aaaataaagt aatctgatga attttaagtc
      541 cattagtcta cttatgagca tgttttgtaa taaaaatgcc tcagagctat aacccatgaa
      601 aattgcttgg caaaagctaa atcagtgtct tggtatattt tgttcaaact taaggatttc
      661 aagaattatg attacacaca ttagac
//
