LOCUS       NM_025384                671 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C15
            (Dnajc15), mRNA.
ACCESSION   NM_025384
VERSION     NM_025384.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 671)
  AUTHORS   Wu,M.H., Valenca-Pereira,F., Cendali,F., Giddings,E.L.,
            Pham-Danis,C., Yarnell,M.C., Novak,A.J., Brunetti,T.M.,
            Thompson,S.B., Henao-Mejia,J., Flavell,R.A., D'Alessandro,A.,
            Kohler,M.E. and Rincon,M.
  TITLE     Deleting the mitochondrial respiration negative regulator MCJ
            enhances the efficacy of CD8+ T cell adoptive therapies in
            pre-clinical studies
  JOURNAL   Nat Commun 15 (1), 4444 (2024)
   PUBMED   38789421
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 671)
  AUTHORS   Santamans,A.M., Cicuendez,B., Mora,A., Villalba-Orero,M.,
            Rajlic,S., Crespo,M., Vo,P., Jerome,M., Macias,A., Lopez,J.A.,
            Leiva,M., Rocha,S.F., Leon,M., Rodriguez,E., Leiva,L., Pintor
            Chocano,A., Garcia Lunar,I., Garcia-Alvarez,A.,
            Hernansanz-Agustin,P., Peinado,V.I., Barbera,J.A., Ibanez,B.,
            Vazquez,J., Spinelli,J.B., Daiber,A., Oliver,E. and Sabio,G.
  TITLE     MCJ: A mitochondrial target for cardiac intervention in pulmonary
            hypertension
  JOURNAL   Sci Adv 10 (3), eadk6524 (2024)
   PUBMED   38241373
REFERENCE   4  (bases 1 to 671)
  AUTHORS   Pena-Cearra,A., Pascual-Itoiz,M.A., Lavin,J.L., Fuertes,M.,
            Martin-Ruiz,I., Castelo,J., Palacios,A., Barriales,D.,
            Fullaondo,A., Aransay,A.M., Rodriguez,H., Anguita,J. and Abecia,L.
  TITLE     Mitochondrial complex I dysfunction alters the balance of soluble
            and membrane-bound TNF during chronic experimental colitis
  JOURNAL   Sci Rep 12 (1), 9977 (2022)
   PUBMED   35705557
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 671)
  AUTHORS   Goikoetxea-Usandizaga,N., Serrano-Macia,M., Delgado,T.C., Simon,J.,
            Fernandez Ramos,D., Barriales,D., Cornide,M.E., Jimenez,M.,
            Perez-Redondo,M., Lachiondo-Ortega,S., Rodriguez-Agudo,R.,
            Bizkarguenaga,M., Zalamea,J.D., Pasco,S.T., Caballero-Diaz,D.,
            Alfano,B., Bravo,M., Gonzalez-Recio,I., Mercado-Gomez,M.,
            Gil-Pitarch,C., Mabe,J., Gracia-Sancho,J., Abecia,L., Lorenzo,O.,
            Martin-Sanz,P., Abrescia,N.G.A., Sabio,G., Rincon,M., Anguita,J.,
            Minambres,E., Martin,C., Berenguer,M., Fabregat,I., Casado,M.,
            Peralta,C., Varela-Rey,M. and Martinez-Chantar,M.L.
  TITLE     Mitochondrial bioenergetics boost macrophage activation, promoting
            liver regeneration in metabolically compromised animals
  JOURNAL   Hepatology 75 (3), 550-566 (2022)
   PUBMED   34510498
  REMARK    Erratum:[Hepatology. 2022 Aug;76(2):532. doi: 10.1002/hep.32505..
            PMID: 35451511]
REFERENCE   6  (bases 1 to 671)
  AUTHORS   Hatle,K.M., Gummadidala,P., Navasa,N., Bernardo,E., Dodge,J.,
            Silverstrim,B., Fortner,K., Burg,E., Suratt,B.T., Hammer,J.,
            Radermacher,M., Taatjes,D.J., Thornton,T., Anguita,J. and Rincon,M.
  TITLE     MCJ/DnaJC15, an endogenous mitochondrial repressor of the
            respiratory chain that controls metabolic alterations
  JOURNAL   Mol Cell Biol 33 (11), 2302-2314 (2013)
   PUBMED   23530063
  REMARK    GeneRIF: DNAJC15 localizes at the mitochondrial inner membrane,
            where it interacts preferentially with complex I of the electron
            transfer chain.DnaJC15 functions as a negative regulator of
            mitochondrial membrane potential and ATP production.
REFERENCE   7  (bases 1 to 671)
  AUTHORS   Elsen,G.E., Hodge,R.D., Bedogni,F., Daza,R.A., Nelson,B.R.,
            Shiba,N., Reiner,S.L. and Hevner,R.F.
  TITLE     The protomap is propagated to cortical plate neurons through an
            Eomes-dependent intermediate map
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 4081-4086 (2013)
   PUBMED   23431145
REFERENCE   8  (bases 1 to 671)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   9  (bases 1 to 671)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   10 (bases 1 to 671)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC027509.1.
            
            On Jun 19, 2003 this sequence version replaced NM_025384.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027509.1, BY707836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 41.04 cM"
     gene            1..671
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /note="DnaJ heat shock protein family (Hsp40) member C15"
                     /db_xref="GeneID:66148"
                     /db_xref="MGI:MGI:1913398"
     exon            1..120
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..468
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /note="DnaJ (Hsp40) homolog, subfamily D, member 1; DnaJ
                     (Hsp40) homolog, subfamily C, member 15"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 15"
                     /protein_id="NP_079660.1"
                     /db_xref="CCDS:CCDS27292.1"
                     /db_xref="GeneID:66148"
                     /db_xref="MGI:MGI:1913398"
                     /translation="MATGGGVTSREGLRYAEYLPPSAQRSDADIDHTAGRRLLAVGLG
                     VAAVAFAGRYAFQIWKPLEQVITATARKISSPSFSSYYKGGFEQKMSKREASLILGVS
                     PSAGKAKIRTAHKRIMILNHPDKGGSPYLASKINEAKDLLEASSKAN"
     exon            121..172
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            173..246
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            247..323
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            324..394
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /inference="alignment:Splign:2.1.0"
     exon            395..648
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      597..602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /note="hexamer: AATAAA"
     polyA_site      619
                     /gene="Dnajc15"
                     /gene_synonym="1110003P16Rik; Dnajd1; MCJ"
                     /note="major polyA site"
ORIGIN      
        1 tcggagtcct gcagtgccat ggctaccggt ggcggcgtga cctccagaga ggggctgcgc
       61 tacgccgaat acctgcctcc ttctgcccaa aggtcggacg ccgacatcga ccacacagcg
      121 gggagaaggt tgctagctgt aggactaggt gttgcagctg ttgcatttgc aggtcgctat
      181 gcatttcaga tctggaaacc tctagaacaa gtaatcacgg caacagcaag gaagatttcc
      241 tctccaagct tttcatccta ctataaagga ggattcgagc agaaaatgag taagcgagag
      301 gctagtctta ttttaggtgt aagcccatct gctggcaagg ccaagattag aacagcacac
      361 aagagaatta tgattttaaa ccatccagac aaaggtggat ctccttactt agcatccaaa
      421 ataaatgaag caaaagattt gctcgaagca tccagcaaag ctaactgatg ctaaaggact
      481 gtacataccg agggaaaatg gaacaaacgc acagctgtaa aagtccttca gaagaatgtg
      541 gcacgtggtc gtgttccata ctgacccagt ctgttttctg tcattaagtg tgcagcaata
      601 aaagcctggc agccttgcag ccttggtctg gcagggactt catccgtcaa aaaaaaaaaa
      661 aaaaaaaaaa a
//
