LOCUS       NM_024181               4054 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C10
            (Dnajc10), mRNA.
ACCESSION   NM_024181 XM_913405
VERSION     NM_024181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4054)
  AUTHORS   Li,M., Wu,X., Chen,M., Hao,S., Yu,Y., Li,X., Zhao,E., Xu,M., Yu,Z.,
            Wang,Z., Xu,N., Jin,C. and Yin,Y.
  TITLE     DNAJC10 maintains survival and self-renewal of leukemia stem cells
            through PERK branch of the unfolded protein response
  JOURNAL   Haematologica 109 (3), 751-764 (2024)
   PUBMED   37496439
  REMARK    GeneRIF: DNAJC10 maintains survival and self-renewal of leukemia
            stem cells through PERK branch of the unfolded protein response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4054)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4054)
  AUTHORS   Jeong,H., Hong,E.H., Ahn,J.H., Cho,J., Jeong,J.H., Kim,C.W.,
            Yoon,B.I., Koo,J.H., Park,Y.Y., Yang,Y.M., Iwawaki,T.,
            Vallance,B.A., Chang,S.Y. and Ko,H.J.
  TITLE     ERdj5 protects goblet cells from endoplasmic reticulum
            stress-mediated apoptosis under inflammatory conditions
  JOURNAL   Exp Mol Med 55 (2), 401-412 (2023)
   PUBMED   36759578
  REMARK    GeneRIF: ERdj5 protects goblet cells from endoplasmic reticulum
            stress-mediated apoptosis under inflammatory conditions.
REFERENCE   4  (bases 1 to 4054)
  AUTHORS   Hong,D.G., Song,G.Y., Eom,C.B., Ahn,J.H., Kim,S.M., Shim,A.,
            Han,Y.H., Roh,Y.S., Han,C.Y., Bae,E.J., Ko,H.J. and Yang,Y.M.
  TITLE     Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic
            liver disease via suppressing Nrf2
  JOURNAL   Free Radic Biol Med 184, 42-52 (2022)
   PUBMED   35390453
  REMARK    GeneRIF: Loss of ERdj5 exacerbates oxidative stress in mice with
            alcoholic liver disease via suppressing Nrf2.
REFERENCE   5  (bases 1 to 4054)
  AUTHORS   Aguila,M., Bellingham,J., Athanasiou,D., Bevilacqua,D., Duran,Y.,
            Maswood,R., Parfitt,D.A., Iwawaki,T., Spyrou,G., Smith,A.J.,
            Ali,R.R. and Cheetham,M.E.
  TITLE     AAV-mediated ERdj5 overexpression protects against P23H rhodopsin
            toxicity
  JOURNAL   Hum Mol Genet 29 (8), 1310-1318 (2020)
   PUBMED   32196553
  REMARK    GeneRIF: AAV-mediated ERdj5 overexpression protects against P23H
            rhodopsin toxicity.
REFERENCE   6  (bases 1 to 4054)
  AUTHORS   Ushioda,R., Hoseki,J., Araki,K., Jansen,G., Thomas,D.Y. and
            Nagata,K.
  TITLE     ERdj5 is required as a disulfide reductase for degradation of
            misfolded proteins in the ER
  JOURNAL   Science 321 (5888), 569-572 (2008)
   PUBMED   18653895
  REMARK    GeneRIF: study found that an endoplasmic reticulum (ER) protein
            ERdj5 had a reductase activity, cleaved the disulfide bonds of
            misfolded proteins & accelerated ER-associated degradation through
            its physical and functional associations with EDEM & BiP
REFERENCE   7  (bases 1 to 4054)
  AUTHORS   Zhang,Y., Maksakova,I.A., Gagnier,L., van de Lagemaat,L.N. and
            Mager,D.L.
  TITLE     Genome-wide assessments reveal extremely high levels of
            polymorphism of two active families of mouse endogenous retroviral
            elements
  JOURNAL   PLoS Genet 4 (2), e1000007 (2008)
   PUBMED   18454193
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4054)
  AUTHORS   Hosoda,A., Kimata,Y., Tsuru,A. and Kohno,K.
  TITLE     JPDI, a novel endoplasmic reticulum-resident protein containing
            both a BiP-interacting J-domain and thioredoxin-like motifs
  JOURNAL   J Biol Chem 278 (4), 2669-2676 (2003)
   PUBMED   12446677
  REMARK    GeneRIF: JPDI may have roles in folding of some proteins in the ER,
            chaperoning by BiP and formation of proper disulfide bonds
REFERENCE   9  (bases 1 to 4054)
  AUTHORS   Cunnea,P.M., Miranda-Vizuete,A., Bertoli,G., Simmen,T.,
            Damdimopoulos,A.E., Hermann,S., Leinonen,S., Huikko,M.P.,
            Gustafsson,J.A., Sitia,R. and Spyrou,G.
  TITLE     ERdj5, an endoplasmic reticulum (ER)-resident protein containing
            DnaJ and thioredoxin domains, is expressed in secretory cells or
            following ER stress
  JOURNAL   J Biol Chem 278 (2), 1059-1066 (2003)
   PUBMED   12411443
REFERENCE   10 (bases 1 to 4054)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016269.1, AK004617.1, CN460590.1 and AW546442.1.
            
            On Dec 16, 2006 this sequence version replaced NM_024181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128945.1, SRR1660815.242753.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-988               AK016269.1         1-988
            989-3228            AK004617.1         744-2983
            3229-3444           CN460590.1         143-358
            3445-4054           AW546442.1         1-610               c
FEATURES             Location/Qualifiers
     source          1..4054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 48.05 cM"
     gene            1..4054
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /note="DnaJ heat shock protein family (Hsp40) member C10"
                     /db_xref="GeneID:66861"
                     /db_xref="MGI:MGI:1914111"
     exon            1..340
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            341..691
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..2869
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /note="ER-resident protein ERdj5; dnaJ homolog subfamily C
                     member 10; j domain-containing PDI-like protein;
                     endoplasmic reticulum DnaJ-PDI fusion protein 1; j
                     domain-containing protein disulfide isomerase-like
                     protein; endoplasmic reticulum DNA J domain-containing
                     protein 5; DnaJ (Hsp40) homolog, subfamily C, member 10"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 10 precursor"
                     /protein_id="NP_077143.2"
                     /db_xref="CCDS:CCDS38159.1"
                     /db_xref="GeneID:66861"
                     /db_xref="MGI:MGI:1914111"
                     /translation="MGVWLNKDDFIRDLKRISLCLLILYVVVVVGTDQNFYSLLGVSK
                     TASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEK
                     GLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSH
                     CHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNG
                     DRSKESLVAFAMQHVRSTVTELSTGNFVNAIETAFAAGVGWLITFCSKGEDCLTSQTR
                     LRLSGMLDGLVNVGWVDCDAQDSLCKSLDTTASTTAYFPPGATLNDREKSSVLFLNSL
                     DAKEIYMEIIHNLPDFELLSANQLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLK
                     NEHIQVGRFDCSSAPGICSDLYVFQPCLAVFKGQGTKEYEIHHGKKILYDILAFAKES
                     VNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDC
                     TIHEGLCNMYNIQAYPTTVVFNQSSIHEYEGHHSAEQILEFIEDLRNPSVVSLTPSTF
                     NELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCT
                     QENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNE
                     KVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGI
                     KAYPSVKLYQYERAKKSIWEEQINSRDAKTIAALIYGKLETLQSQVKRNKDEL"
     exon            692..854
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            855..905
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            906..988
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1120
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1214
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1292
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1336
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1474
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1564
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1678
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1793
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1921
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2038
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2140
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2296
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2430
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2484
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2632
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2752
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2857
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..4054
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4020..4025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /note="hexamer: AATAAA"
     polyA_site      4046
                     /gene="Dnajc10"
                     /gene_synonym="1200006L06Rik; D2Ertd706e; ERdj5; JPDI"
                     /note="major polyA site"
ORIGIN      
        1 ttcacaccct tccttccgcc agcggttgac tacggccgca agatgcctgt gggccgcgct
       61 gcgggatgct tccctatctc tggctaggag cgggacccgc agccaccgcc gcagccacac
      121 agaaggccac gtcagcctcg gcggtcccac ccgtccctcc ctgctggcca cccgtcggcc
      181 ttcgcccacg cctttcccac aatgccccgc gccaggcccc gccccgccgg cgcgacggga
      241 gcggcagaat tgctgctgcg cgcgttcgca ggcagcgtcc ggtcctgccg ggtccggagc
      301 tcggcgacct gaggatgggg cagtagctga ggacgccgag gttaacattt ctgagctgtg
      361 ttcccgagat gcttgattga cccttgaagt tatgtggaca gagattctca cgtgtgtcta
      421 ttttaaccac cggacccagc attgtatctt aatgttcaca taagtcagaa ctttcataag
      481 aaagagaatg ggagtctggt taaacaaaga tgactttatc agagacttga agaggatcag
      541 tctctgtctt ctgatactgt acgtggtcgt tgtggtgggc acagatcaga atttttacag
      601 tttacttgga gtgtcgaaaa ctgcaagcag tagagaaata agacaagcct ttaagaaatt
      661 agcactgaag ttacatcctg ataaaaaccc gaataaccca aatgcacatg gtgatttttt
      721 aaaaataaat agagcatatg aagtactcaa agatgaagat ctacggaaaa agtatgacaa
      781 atatggagaa aagggacttg aagataatca aggaggccag tatgagagct ggagctacta
      841 ccgttacgat ttcggtattt acgatgatga tcctgaaatc ataacattag aaagaagaga
      901 atttgatgct gctgtcaact ctggagaact gtggtttgta aacttttact ccccaggatg
      961 ttcgcattgc catgatttag cccccacttg gagagaattt gctaaagaag tggatgggtt
     1021 gcttcgaatc ggagctgtca actgtggtga tgatcggatg ctctgccgaa tgaaaggagt
     1081 taacagctac cccagcctct tcatctttag gtctggaatg gctgcagtga agtacaatgg
     1141 agatcggtca aaggagagct tagtggcctt cgccatgcag cacgtcagga gcacagtgac
     1201 agagctgtca acaggaaatt ttgttaatgc catagaaact gcttttgctg ctggtgttgg
     1261 ctggctgatc acattctgct ctaaaggaga agattgtttg acatcacaga cccgactcag
     1321 gcttagtggc atgttggacg gccttgttaa cgtgggatgg gtggactgtg acgcccagga
     1381 cagcctctgc aagagcctgg ataccacagc cagcaccacg gcttatttcc ctcctggagc
     1441 cactttgaat gacagggaaa aatccagtgt gttgtttctt aattcattgg atgctaagga
     1501 aatatacatg gaaatcatac ataatcttcc agactttgaa ctgctttcag caaatcaact
     1561 agaggatcgt ttggcacatc atcgctggct tgtatttttt cattttggaa aaaatgaaaa
     1621 cgcaaatgat cctgagttga aaaaactgaa aactctactt aaaaatgagc atattcaagt
     1681 tggaaggttt gattgctctt ctgcaccggg catctgctct gatctttatg tcttccagcc
     1741 ctgcctagca gtgtttaaag gacaaggaac caaagaatat gaaattcatc atggaaagaa
     1801 gattctatac gatatacttg cttttgccaa agaaagtgtt aattctcatg ttaccacact
     1861 tggacctcag aacttccctg caagtgacaa ggaaccatgg cttgttgact tctttgcccc
     1921 ttggtgtccg ccatgtcgtg cgcttttgcc agagttacgg aaagcatcaa cactgctcta
     1981 cggtcaactc aaagttggta ccttagactg tacaattcat gaaggactct gcaacatgta
     2041 taacatccaa gcttatccaa cgacagtggt attcaatcag tccagtattc atgagtatga
     2101 aggacatcac tctgcggaac agatcttgga gttcatagag gatctcagaa acccttcagt
     2161 ggtctctctt acacccagca ctttcaatga gctggttaaa cagagaaagc atgatgaagt
     2221 ctggatggtc gatttctatt ctccatggtg tcatccctgt caggtcttga tgccagaatg
     2281 gaaacgcatg gcccggacgt taactggact gatcaatgta ggcagtgtgg actgccaaca
     2341 gtatcattct ttttgtactc aagaaaatgt tcaaagatac cccgagataa gattttatcc
     2401 ccaaaagtca agtaaagcct atcagtatca tagttacaat ggctggaata gggatgcgta
     2461 ttccctgaga agctggggtc ttggattttt gccccaagca tccatagatt taacacctca
     2521 gactttcaat gaaaaagttc tacaagggaa aactcactgg gtggttgatt tctatgctcc
     2581 ttggtgtgga ccttgccaga attttgctcc tgagtttgaa ctcttggcta ggatgatcaa
     2641 aggaaaagtg agagccggga aagtggactg tcaggcttac ccccagacgt gccagaaagc
     2701 cggcatcaaa gcctacccca gtgtcaaact gtaccagtac gagagagcaa agaaaagtat
     2761 ttgggaagag caaataaatt ccagagatgc aaaaactatt gctgccttaa tttatggaaa
     2821 attggaaacg ctccaaagcc aagtaaaaag aaataaggat gagctttgat ggtgttgaag
     2881 aaaaagcatg taaggaaaag aatctggaga acggcatcaa aagatccctt tcccaagtga
     2941 cgatgctcct gaggaagcag atgcacgtga cctgggcctc gcagttgcct gtgtacacag
     3001 agctcctgtg cggcactgtg ggctgcacat gcttcctgga gagccaggca gcgccatctg
     3061 agactgcagt ccacatatgg ttctgtgttg tgtctttgtt gttgttgtta atccttttag
     3121 aaatacacac atcagtctta gctcagggcc atatagaaat actccacagg ccaagtccag
     3181 cccagggact agtttgctga ccccagaact gatgtttgga cacctggccc tgcacgtggc
     3241 tctgttacct tcagactgta caaagtagac ttgggttttc acttgtaaat ttctgatgcg
     3301 cttgaaaaga actgacttgc ttttcagtca cctcttctaa ttctgtctat gaccatatat
     3361 tttattttga ctattttcac cacataggaa aataaaaatt acccattttt cctactatgt
     3421 actactgtat agacagaggc tttcttgtaa gagttgaaga gttcttaatt tatcacaaca
     3481 gtaagtgtaa aaatcctgta agctgctgtc ccaggaacaa ggtaagaaga agtatttaca
     3541 gcagttgatg ggctgtgtgg ctgtcacagg tctaagcctg tgtttagtat gtacaccttc
     3601 atttatttgc tttcataaat gttcctactg atggttttgt tggttttgtt tcacgtgtct
     3661 tcctgatatt gacatatttc ccttctgggt tctctgtttt gatcactcat gttgattatt
     3721 ttttcccctg tagccgtggt ttttccttct gtccaatatt cactattcca ataggaacag
     3781 taattttaga tttattttaa ttggctcatg atgatgctgt ttttcaatta ttgtcttttt
     3841 cagtaaagtt tccataacaa ctgaagtact ttttactaaa atcaagcaca caatggactc
     3901 ttcccatttc tcagttgttt agactcagag ggtcacaggt ccctgctgca actccaaaaa
     3961 cagagtgacc tctagttcag ttctctcccg gtgtgtgggg tggtcagagg atgccagtga
     4021 ataaagtcaa attatttttt ctaaaattct tttg
//
