LOCUS       NM_019964                989 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B8
            (Dnajb8), mRNA.
ACCESSION   NM_019964 XM_981913
VERSION     NM_019964.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 989)
  AUTHORS   Tenney,A.P., Di Gioia,S.A., Webb,B.D., Chan,W.M., de Boer,E.,
            Garnai,S.J., Barry,B.J., Ray,T., Kosicki,M., Robson,C.D., Zhang,Z.,
            Collins,T.E., Gelber,A., Pratt,B.M., Fujiwara,Y., Varshney,A.,
            Lek,M., Warburton,P.E., Van Ryzin,C., Lehky,T.J., Zalewski,C.,
            King,K.A., Brewer,C.C., Thurm,A., Snow,J., Facio,F.M., Narisu,N.,
            Bonnycastle,L.L., Swift,A., Chines,P.S., Bell,J.L., Mohan,S.,
            Whitman,M.C., Staffieri,S.E., Elder,J.E., Demer,J.L., Torres,A.,
            Rachid,E., Al-Haddad,C., Boustany,R.M., Mackey,D.A., Brady,A.F.,
            Fenollar-Cortes,M., Fradin,M., Kleefstra,T., Padberg,G.W.,
            Raskin,S., Sato,M.T., Orkin,S.H., Parker,S.C.J., Hadlock,T.A.,
            Vissers,L.E.L.M., van Bokhoven,H., Jabs,E.W., Collins,F.S.,
            Pennacchio,L.A., Manoli,I. and Engle,E.C.
  TITLE     Noncoding variants alter GATA2 expression in rhombomere 4 motor
            neurons and cause dominant hereditary congenital facial paresis
  JOURNAL   Nat Genet 55 (7), 1149-1163 (2023)
   PUBMED   37386251
REFERENCE   2  (bases 1 to 989)
  AUTHORS   Wang,F., Kong,S., Hu,X., Li,X., Xu,B., Yue,Q., Fu,K., Ye,L. and
            Bai,S.
  TITLE     Dnajb8, a target gene of SOX30, is dispensable for male fertility
            in mice
  JOURNAL   PeerJ 8, e10582 (2020)
   PUBMED   33391882
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 989)
  AUTHORS   Yamashita,M., Hirohashi,Y., Torigoe,T., Kusumoto,H., Murai,A.,
            Imagawa,T. and Sato,N.
  TITLE     Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in
            the Tumor Initiation and Resistance to Docetaxel but Is Dispensable
            for Stress Response
  JOURNAL   PLoS One 11 (1), e0146501 (2016)
   PUBMED   26751205
  REMARK    GeneRIF: Dnajb8 has a role in tumor initiation, side population
            ratio and sphere formation but it is dispensable for stress
            responses
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 989)
  AUTHORS   Nishizawa,S., Hirohashi,Y., Torigoe,T., Takahashi,A., Tamura,Y.,
            Mori,T., Kanaseki,T., Kamiguchi,K., Asanuma,H., Morita,R.,
            Sokolovskaya,A., Matsuzaki,J., Yamada,R., Fujii,R., Kampinga,H.H.,
            Kondo,T., Hasegawa,T., Hara,I. and Sato,N.
  TITLE     HSP DNAJB8 controls tumor-initiating ability in renal cancer
            stem-like cells
  JOURNAL   Cancer Res 72 (11), 2844-2854 (2012)
   PUBMED   22552285
  REMARK    GeneRIF: findings suggest that DNAJB8 plays a role in Cancer
            stem-like cell (CSC) maintenance and that it offers a candidate for
            CSC-targeting immunotherapy in renal cell carcinoma
REFERENCE   5  (bases 1 to 989)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
REFERENCE   6  (bases 1 to 989)
  AUTHORS   Khandekar,M., Suzuki,N., Lewton,J., Yamamoto,M. and Engel,J.D.
  TITLE     Multiple, distant Gata2 enhancers specify temporally and
            tissue-specific patterning in the developing urogenital system
  JOURNAL   Mol Cell Biol 24 (23), 10263-10276 (2004)
   PUBMED   15542836
REFERENCE   7  (bases 1 to 989)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB028856.1.
            
            On May 4, 2006 this sequence version replaced XM_981913.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB028856.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="CD-1"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.25 cM"
     gene            1..989
                     /gene="Dnajb8"
                     /gene_synonym="1700016F14Rik; 1700031F10Rik; mDj6"
                     /note="DnaJ heat shock protein family (Hsp40) member B8"
                     /db_xref="GeneID:56691"
                     /db_xref="MGI:MGI:1922801"
     exon            1..989
                     /gene="Dnajb8"
                     /gene_synonym="1700016F14Rik; 1700031F10Rik; mDj6"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..900
                     /gene="Dnajb8"
                     /gene_synonym="1700016F14Rik; 1700031F10Rik; mDj6"
                     /note="DnaJ homolog 6; DnaJ (Hsp40) homolog, subfamily B,
                     member 8"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 8"
                     /protein_id="NP_064348.1"
                     /db_xref="CCDS:CCDS20334.1"
                     /db_xref="GeneID:56691"
                     /db_xref="MGI:MGI:1922801"
                     /translation="MANYYEVLGVQSSASPEDIKKAYRKLALRWHPDKNPDNKEEAEK
                     KFKQVSEAYEVLSDSKKRSVYDRAGCDRWRAGGGANVPHSSPFGAGYPFRNPEDIFRE
                     FFGGLDPFSFEFWDTPFSGRGRPHGLHRVFPSGFGEFPAFMEALSSFNTLGHGGGSRS
                     TFSSASFGGSGSSGFKSVMSSTEMVNGRKVTTKRIIENGQERVEVEEDGQLRSVTVNG
                     KEKLMRVDK"
ORIGIN      
        1 ccgcttcggc ctggcccaga gcggcactgt ccctaccccc aagcccctct cagtggaggc
       61 tccacctgtc cctgagaacg gggaggatgg aaagctaaac tctcaccacc cagagtcaga
      121 agattccagc aagtccccca cccaaaggag gaccccagcc actcacctca gccctcctca
      181 gtcctccatc tcatccagtc ccccactgcc cttaccatgg ccaactacta tgaagtgctg
      241 ggtgtacaat caagcgcctc ccctgaggac atcaagaagg cctatcgaaa gctggctttg
      301 cgttggcacc ctgacaagaa ccccgacaac aaagaagaag ctgagaagaa gtttaagcag
      361 gtttccgaag cctacgaagt cttgtcagac tctaagaagc gttctgtgta cgaccgggca
      421 ggctgtgaca gatggagagc aggtggcggt gccaatgtcc cccatagcag tcccttcggt
      481 gctggctatc ccttccgaaa tcctgaggat attttccgcg agttctttgg gggactggac
      541 cctttttcct ttgaattctg ggacactccg ttcagcggcc gaggccggcc ccatggttta
      601 cacagagtct tcccttcggg ctttggtgag ttcccagcct tcatggaagc cttgtcatct
      661 ttcaatactc tgggccatgg tgggggcagc cgctccacct tttcatctgc ttcgtttggt
      721 ggctctggca gctcagggtt caagtcagtg atgtcatcga ctgagatggt gaacggccgt
      781 aaggtgacca ccaagcgaat cattgagaac ggccaagagc gggtggaggt ggaagaagat
      841 ggacagctcc ggtcagtaac tgtcaatggc aaggagaagc tcatgagggt ggacaagtga
      901 cagccaccta acccatccct gggccagcct agggggccac aaggggacat agtagtcgca
      961 acctaactgg ttaataaatg tgccaagtg
//
