LOCUS       NM_011847               1645 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B6
            (Dnajb6), transcript variant 3, mRNA.
ACCESSION   NM_011847
VERSION     NM_011847.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1645)
  AUTHORS   Ding,Y., Lang,D., Yan,J., Bu,H., Li,H., Jiao,K., Yang,J., Ni,H.,
            Morotti,S., Le,T., Clark,K.J., Port,J., Ekker,S.C., Cao,H.,
            Zhang,Y., Wang,J., Grandi,E., Li,Z., Shi,Y., Li,Y., Glukhov,A.V.
            and Xu,X.
  TITLE     A phenotype-based forward genetic screen identifies Dnajb6 as a
            sick sinus syndrome gene
  JOURNAL   Elife 11, e77327 (2022)
   PUBMED   36255053
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1645)
  AUTHORS   Qian,F.Y., Guo,Y.D., Zu,J., Zhang,J.H., Zheng,Y.M., Abdoulaye,I.A.,
            Pan,Z.H., Xie,C.M., Gao,H.C. and Zhang,Z.J.
  TITLE     A novel recessive mutation affecting DNAJB6a causes myofibrillar
            myopathy
  JOURNAL   Acta Neuropathol Commun 9 (1), 23 (2021)
   PUBMED   33557929
  REMARK    GeneRIF: A novel recessive mutation affecting DNAJB6a causes
            myofibrillar myopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1645)
  AUTHORS   Ji,Q., Pan,C., Wang,J., Yang,Z., Li,C., Yang,C., Zhang,W., Wang,M.,
            Dong,M., Sun,Z. and Nie,S.
  TITLE     Long non-coding RNA Hsp4 alleviates lipopolysaccharide-induced
            apoptosis of lung epithelial cells via miRNA-466m-3p/DNAjb6 axis
  JOURNAL   Exp Mol Pathol 117, 104547 (2020)
   PUBMED   32976821
  REMARK    GeneRIF: Long non-coding RNA Hsp4 alleviates
            lipopolysaccharide-induced apoptosis of lung epithelial cells via
            miRNA-466m-3p/DNAjb6 axis.
REFERENCE   4  (bases 1 to 1645)
  AUTHORS   Bengoechea,R., Findlay,A.R., Bhadra,A.K., Shao,H., Stein,K.C.,
            Pittman,S.K., Daw,J.A., Gestwicki,J.E., True,H.L. and Weihl,C.C.
  TITLE     Inhibition of DNAJ-HSP70 interaction improves strength in muscular
            dystrophy
  JOURNAL   J Clin Invest 130 (8), 4470-4485 (2020)
   PUBMED   32427588
  REMARK    GeneRIF: Inhibition of DNAJ-HSP70 interaction improves strength in
            muscular dystrophy.
REFERENCE   5  (bases 1 to 1645)
  AUTHORS   Watson,E.D., Hughes,M., Simmons,D.G., Natale,D.R., Sutherland,A.E.
            and Cross,J.C.
  TITLE     Cell-cell adhesion defects in Mrj mutant trophoblast cells are
            associated with failure to pattern the chorion during early
            placental development
  JOURNAL   Dev Dyn 240 (11), 2505-2519 (2011)
   PUBMED   21972064
  REMARK    GeneRIF: Mrj(-/-) chorions at embryonic day 8.5 have expanded
            Rhox4b expression domains and do not form normal layers of gene
            expression suggesting that chorion patterning requires Mrj.
REFERENCE   6  (bases 1 to 1645)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   7  (bases 1 to 1645)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   8  (bases 1 to 1645)
  AUTHORS   Scott,I.C., Anson-Cartwright,L., Riley,P., Reda,D. and Cross,J.C.
  TITLE     The HAND1 basic helix-loop-helix transcription factor regulates
            trophoblast differentiation via multiple mechanisms
  JOURNAL   Mol Cell Biol 20 (2), 530-541 (2000)
   PUBMED   10611232
REFERENCE   9  (bases 1 to 1645)
  AUTHORS   Hunter,P.J., Swanson,B.J., Haendel,M.A., Lyons,G.E. and Cross,J.C.
  TITLE     Mrj encodes a DnaJ-related co-chaperone that is essential for
            murine placental development
  JOURNAL   Development 126 (6), 1247-1258 (1999)
   PUBMED   10021343
REFERENCE   10 (bases 1 to 1645)
  AUTHORS   Baker,R.K., Haendel,M.A., Swanson,B.J., Shambaugh,J.C.,
            Micales,B.K. and Lyons,G.E.
  TITLE     In vitro preselection of gene-trapped embryonic stem cell clones
            for characterizing novel developmentally regulated genes in the
            mouse
  JOURNAL   Dev Biol 185 (2), 201-214 (1997)
   PUBMED   9187083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ079100.1 and AK134387.1.
            
            On May 15, 2008 this sequence version replaced NM_011847.3.
            
            Transcript Variant: This variant (3) differs in the 3' coding
            region and 3' UTR when compared to variant 1. Variant 3 encodes
            isoform c, which has a shorter, distinct C-terminus when compared
            to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134387.1, AK152626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                CJ079100.1         1-42
            43-1645             AK134387.1         2-1604
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.27 cM"
     gene            1..1645
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /note="DnaJ heat shock protein family (Hsp40) member B6"
                     /db_xref="GeneID:23950"
                     /db_xref="MGI:MGI:1344381"
     exon            1..219
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     exon            220..310
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..974
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /note="isoform c is encoded by transcript variant 3; dnaJ
                     homolog subfamily B member 6; heat shock protein J2;
                     mammalian relative of DnaJ; DnaJ (Hsp40) homolog,
                     subfamily B, member 6"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 6 isoform c"
                     /protein_id="NP_035977.2"
                     /db_xref="CCDS:CCDS39043.1"
                     /db_xref="GeneID:23950"
                     /db_xref="MGI:MGI:1344381"
                     /translation="MVDYYEVLGVQRHASPEDIKKAYRKQALKWHPDKNPENKEEAER
                     KFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGGIHFDSPFEFGFTFRNPDDVFR
                     EFFGGRDPFSFDFFEDPFDDFFGNRRGPRGNRSRGAGSFFSTFSGFPSFGSGFPAFDT
                     GFTPFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKIVNGKKITTKRIVENGQERVE
                     VEEDGQLKSLTINGKEHLLRLDNK"
     exon            311..420
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     exon            421..483
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     exon            484..594
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     exon            595..726
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     exon            727..868
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1645
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1601..1606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="Dnajb6"
                     /gene_synonym="HSJ-2; mDj4; Mrj"
                     /note="major polyA site"
ORIGIN      
        1 ggaggctgct gcgcacgtta gcttcagggc cgggcggaag tcgacgtcgc cgggccgcgc
       61 cgccaccgcg tgacgcactt cctgtttgtt gttggagaaa agaagagaaa ggaaagcgcg
      121 aggagacgcc gccgccgcca ccgccaccag cgcagctgtg ccacagccgc gaggagaccg
      181 gccgcctgac ttccctcctc gctggccgcc gtgtcctcgg atttattcca acagtcagtt
      241 aaaacatggt ggattactat gaagtgctgg gcgtgcagag acatgcctca cctgaggaca
      301 ttaaaaaggc gtatcgaaaa caggcactta aatggcaccc ggacaaaaat cctgaaaata
      361 aagaagaagc agagcggaag ttcaaacaag tagctgaggc atatgaagtg ttatcggatg
      421 ctaaaaagcg ggacatctac gacaaatatg gcaaagaagg attaaatggt ggtggaggag
      481 gaggtggaat tcattttgac agtccatttg agtttggctt cacattccgg aacccagatg
      541 atgtcttcag ggaatttttt ggtggaaggg acccattttc atttgacttc tttgaagacc
      601 catttgatga cttttttgga aaccgaaggg gtccccgagg aaatagaagc cgaggtgccg
      661 gctcattttt ctctaccttc agtggatttc cttcttttgg aagtggattt cctgcttttg
      721 atacaggctt cactccattt gggtcactag gtcatggggg tctcacttca ttttcttcaa
      781 cgtcatttgg cggcagtgga atgggcaact tcaaatcaat atcaacttca actaagatag
      841 ttaatggcaa aaaaatcacg acaaagagga ttgtggagaa cggtcaagaa agagtagaag
      901 ttgaagaaga tgggcagtta aagtccttga caataaatgg taaggagcac ctgctacgct
      961 tggataacaa gtaactcaac gcacgcattt aacagaaatg ttaaaccata acaagcacca
     1021 tttgaggaat aacaggaact ttttttttga agatttgaaa cgaactcgac tttctgtata
     1081 actgtaccta aactaaagta tttataaaaa agctcattgg agcctccatc tatcagattt
     1141 ttgagtttgt tgttgggacc acaaaatagg accttatttt ctatttcttt tgtccttaaa
     1201 attgttgtaa tctctgtatg cactttgctt taaaccaatc gtaatctgag gtgagccctg
     1261 tgacttttga gtagtgctag gaagagactg tctgtaacac cagcatggat ctgcttccca
     1321 ttgtggtgaa ttgtgagtga gtagtgtcag cctgctgtgg acttaacatt gccagatgaa
     1381 tctacagaaa tacttcaatt ttattttcag tatttagtga tgaaagctat tactgcatca
     1441 atggtaatac atttctggtt tagtgtacac taaggatgtt ttctagttgt gcatggatgt
     1501 cggcaacctc gtcagtttga ctattgttta aatatgtaat gttaagctta ggtttaaaaa
     1561 agctggtaat ttgggttttt gtcatttgct taaaaaaaaa aataaatgcg aatgtgtttg
     1621 gtgcattctt tcatgagtgg ggtct
//
