LOCUS       NM_001355438            3535 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B5
            (Dnajb5), transcript variant 1, mRNA.
ACCESSION   NM_001355438 XM_006538110
VERSION     NM_001355438.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3535)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3535)
  AUTHORS   San Gil,R., Pascovici,D., Venturato,J., Brown-Wright,H., Mehta,P.,
            Madrid San Martin,L., Wu,J., Luan,W., Chui,Y.K., Bademosi,A.T.,
            Swaminathan,S., Naidoo,S., Berning,B.A., Wright,A.L., Keating,S.S.,
            Curtis,M.A., Faull,R.L.M., Lee,J.D., Ngo,S.T., Lee,A., Morsch,M.,
            Chung,R.S., Scotter,E., Lisowski,L., Mirzaei,M. and Walker,A.K.
  TITLE     A transient protein folding response targets aggregation in the
            early phase of TDP-43-mediated neurodegeneration
  JOURNAL   Nat Commun 15 (1), 1508 (2024)
   PUBMED   38374041
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3535)
  AUTHORS   Ago,T., Liu,T., Zhai,P., Chen,W., Li,H., Molkentin,J.D.,
            Vatner,S.F. and Sadoshima,J.
  TITLE     A redox-dependent pathway for regulating class II HDACs and cardiac
            hypertrophy
  JOURNAL   Cell 133 (6), 978-993 (2008)
   PUBMED   18555775
REFERENCE   4  (bases 1 to 3535)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   5  (bases 1 to 3535)
  AUTHORS   Chen,M.S., Roti,J.R. and Laszlo,A.
  TITLE     Hsc40, a new member of the hsp40 family, exhibits similar
            expression profile to that of hsc70 in mammalian cells
  JOURNAL   Gene 238 (2), 333-341 (1999)
   PUBMED   10570961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672276.9.
            
            On Jan 6, 2023 this sequence version replaced NM_001355438.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3952952.1,
                                           SRR7652917.454860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL672276.9         86098-86212
            116-583             AL672276.9         86684-87151
            584-828             AL672276.9         89349-89593
            829-1430            AL672276.9         92734-93335
            1431-3535           AL672276.9         93526-95630
FEATURES             Location/Qualifiers
     source          1..3535
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.93 cM"
     gene            1..3535
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /note="DnaJ heat shock protein family (Hsp40) member B5"
                     /db_xref="GeneID:56323"
                     /db_xref="MGI:MGI:1930018"
     exon            1..115
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /inference="alignment:Splign:2.1.0"
     exon            116..583
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1664
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock protein hsp40-3; dnaJ homolog subfamily B member 5;
                     heat shock protein cognate 40; DnaJ (Hsp40) homolog,
                     subfamily B, member 5"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 5 isoform 1"
                     /protein_id="NP_001342367.1"
                     /db_xref="GeneID:56323"
                     /db_xref="MGI:MGI:1930018"
                     /translation="MFKRTVLSCPPPAAPPLQARGAFRSFPHFWGEDFLASLMFKIQL
                     EPLKLRAWTLNGFVKFRNKEPSTGPVAVMGKDYYKILGIPSGANEDEIKKAYRKMALK
                     YHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRSLYDQYGEEGLKTGGGSSGGSGGSFHY
                     TFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGF
                     NGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTV
                     RTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVL
                     YSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGD
                     LIVEFKVRFPDRLTPQTRQILKQHLPCS"
     exon            584..828
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1430
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..3535
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2824..2829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /note="hexamer: AATAAA"
     polyA_site      2845
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /note="major polyA site"
     regulatory      3505..3510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
                     /note="hexamer: ATTAAA"
     polyA_site      3535
                     /gene="Dnajb5"
                     /gene_synonym="1110058L06Rik; Hsc40; Hsp40-3"
ORIGIN      
        1 gtctgcggcc ggcgggcagg cgactcctgt cccgagtgga ggcggcggag ccggagccgg
       61 gggagggggc agcggctgat agaaggaccg cggcggcgcc cgcagctcct caccggtaca
      121 cacgctgcca ctcaacaact acacactgtc actgccagcc tcactgtcac acagccgaac
      181 aggcgctcac atcattcagc cagacactgc tgcacctgag agcaggtggc cactggatcc
      241 tctctctgca ctctacacct ggggaccggg tccagctccc tgggcacgat acaggccttg
      301 ctgggtcacg gcctctggga atctgaggag gtggcttcca gagctacagc gtcccaagca
      361 ggctccggtg gagcgatcag aggtgagggg cttggctggg catgtttaag cgcacagtgc
      421 tgtcctgccc acccccagca gcacccccac tgcaggctcg aggagctttc cggagcttcc
      481 cacacttctg gggagaagac ttcttagcca gcttgatgtt taaaattcag ctggagccct
      541 taaaacttcg agcgtggacg ctgaatgggt ttgtaaagtt tcggaacaag gagcccagca
      601 ccggtccagt ggctgtgatg ggaaaagatt attacaagat tcttgggatc ccgtctgggg
      661 ccaatgagga tgagatcaag aaggcctatc ggaagatggc cttgaagtac cacccagaca
      721 agaacaaaga gcccaacgcc gaggagaagt ttaaggagat tgctgaggcc tacgatgtgc
      781 tgagtgaccc taagaagcgg agcctgtacg accagtatgg tgaggaaggc ctcaagaccg
      841 gcggtggttc ctcaggtggt tccggtggct cctttcacta cacctttcat ggggaccctc
      901 atgccacctt tgcttccttc tttggtggct ccaacccctt cgatatcttc tttgccagca
      961 gccgctccac tcggcccttc agtggctttg accctgatga catggatgtg gatgaagatg
     1021 aggacccatt tggtgccttt ggccgctttg gcttcaatgg gctgagtagg ggtccaaggc
     1081 gagccccaga gccactgtac ccccggcgca aggtacagga cccccctgtg gtgcacgagc
     1141 tgcgggtgtc cctggaggag atctaccatg gctccaccaa gcggatgaag atcacaaggc
     1201 ggcgccttaa ccctgacggg cgaactgtgc gcaccgagga caaaatcctg cacattgtca
     1261 tcaaacgagg ctggaaagaa ggtaccaaga ttaccttccc caaagagggc gacgccacac
     1321 ctgacaacat cccagccgac attgtcttcg tgctcaaaga caagcctcat gcacacttcc
     1381 gccgagatgg caccaacgtg ctctacagtg ccctcatcag cctcaaggag gcgctgtgtg
     1441 gctgcaccgt gaacattccc accattgatg gccgagtgat ccctttaccc tgcaatgatg
     1501 ttatcaagcc aggcaccgtg aaaagactcc gtggggaggg acttcccttc cccaaggtgc
     1561 ccactcagcg gggagacctc attgttgagt tcaaagttcg attcccagac agattaaccc
     1621 cacagacacg gcagatcctt aagcagcacc tcccctgctc ctaggctctg ccctggccag
     1681 tctggagcct accacagcaa tacccccaca ctcaccccat ctcacgtgga cccggctgga
     1741 tgtccactgg acactggcac ttttctaaaa tgcaaagcca ctgattttca ggagactgtt
     1801 cctgttcccg acccctttcg gagctgggct gctttggggg aatgggaggg cggtggggaa
     1861 gagctagccc agaccagggg tcaattttct gtcacgtgct ttgaatccag ttcccactgc
     1921 agtggctgga gagagacttg agagctactc ggagctatag attccttgtc ctgcctgtaa
     1981 atagcatgcc ctcctccctc tgagccttgc taacactttt cctctccctt ccctttggct
     2041 tcctcctgtt tctggagaaa gaggatagaa aggacaccgc ttcccacccc accccgggtg
     2101 ggtctgtagt gtccgaggcc actgcacaag tgtccgtgca cacgaagcat ttgccaaaat
     2161 ggtctctgtc tctccgggag acaagaaagg acaggagata ggaagggaag gcccgttacc
     2221 tgtgaacaag gctgttcttt gagcacgaga cacttttcat ttggggcagg gaagtgagcc
     2281 aacactcagg agcctcccca acagctgccc tgcctgcacc gcacagagtt ggaggatctg
     2341 tccccctcag ctgctctggg gagtgttcaa gggtggagag aagaaaaatg gggctgaacc
     2401 atcccagcta agaggtgggg caggacccat ttcccagcca gcatcaggaa ggaaaagggc
     2461 tttggggtca ggtggcagct gttccccacc aagagattca ggatcacagg tttcccccca
     2521 tatctctgaa ctcagggcct agccacccca aacttccaag ccccactttt gtgatatgtg
     2581 aagctgcttc tttcttactt ggaggctgtg ttggaagcgt ccagcccctc tctgcctgtg
     2641 tgacccccac cccaccccac cccactccca cagttgtata gaagtcgaat agtgaaggag
     2701 ctgggagaaa actgcttcag ctggtcttgg ggtggggttc ttaggttttc tcactttgac
     2761 aagcccctga atgtttttat agtagttttt tgtatttttt tgtaatgaca gtattatgaa
     2821 aaaaataaag tattttaaaa atatagcctc tgcgcagaag cagtaaccct ggtgcaggca
     2881 ggaacacaga gccactgtca gcctccttcc agggtcctgg gcaccccagg aaagccggtc
     2941 aaccttagca tatgctgagg ctcaactctt cttcctataa gctctgacct cttggaattc
     3001 cagaacatat accccaaacg acaacgctag aagccacagc ccagctgcct atgaaaaaga
     3061 caccctcgat tgtgagaaag agggcccagc cccttcagaa gctgtcaaca cgagagctaa
     3121 cacacttgtc taaatgttct ctttgaatta gagacactgt tccttgcagg acgtggaggg
     3181 ctttctcact gatgagaata ggcacactcc caaaaataga gcctggctac caagtgcgct
     3241 ggagacggct cagcagttaa gagcactgac tgctcttaca gagaagccaa gttcagttcc
     3301 caggacacat caggcggctc acaactgctc acggggatct aacaagtcca gcctcgtcag
     3361 gaacctgcac tcatgcacac acacttataa ataataaaaa aaaatgaatt tttttaaagt
     3421 ttgggcacaa agaagataga tagaataaag atagatagat acaggtgaaa ggtcctggct
     3481 ggggacctgg gctccatgat ggacattaaa cacagttcct gctccttgaa ccata
//
