LOCUS       NM_025926               4839 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B4
            (Dnajb4), transcript variant 2, mRNA.
ACCESSION   NM_025926
VERSION     NM_025926.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Inoue,M., Noguchi,S., Inoue,Y.U., Iida,A., Ogawa,M., Bengoechea,R.,
            Pittman,S.K., Hayashi,S., Watanabe,K., Hosoi,Y., Sano,T., Takao,M.,
            Oya,Y., Takahashi,Y., Miyajima,H., Weihl,C.C., Inoue,T. and
            Nishino,I.
  TITLE     Distinctive chaperonopathy in skeletal muscle associated with the
            dominant variant in DNAJB4
  JOURNAL   Acta Neuropathol 145 (2), 235-255 (2023)
   PUBMED   36512060
  REMARK    GeneRIF: Distinctive chaperonopathy in skeletal muscle associated
            with the dominant variant in DNAJB4.
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Weihl,C.C., Topf,A., Bengoechea,R., Duff,J., Charlton,R.,
            Garcia,S.K., Dominguez-Gonzalez,C., Alsaman,A., Hernandez-Lain,A.,
            Franco,L.V., Sanchez,M.E.P., Beecroft,S.J., Goullee,H., Daw,J.,
            Bhadra,A., True,H., Inoue,M., Findlay,A.R., Laing,N., Olive,M.,
            Ravenscroft,G. and Straub,V.
  TITLE     Loss of function variants in DNAJB4 cause a myopathy with early
            respiratory failure
  JOURNAL   Acta Neuropathol 145 (1), 127-143 (2023)
   PUBMED   36264506
  REMARK    GeneRIF: Loss of function variants in DNAJB4 cause a myopathy with
            early respiratory failure.
REFERENCE   3  (bases 1 to 4839)
  AUTHORS   Luo,W.J., Yu,S.L., Chang,C.C., Chien,M.H., Chang,Y.L., Liao,K.M.,
            Lin,P.C., Chung,K.P., Chuang,Y.H., Chen,J.J.W., Yang,P.C. and
            Su,K.Y.
  TITLE     HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12
            heterodimerization in macrophages
  JOURNAL   Elife 11, e76094 (2022)
   PUBMED   35983991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4839)
  AUTHORS   Hsu,M.C., Luo,W.J., Guo,B.C., Chen,C.H., Hu,P.A., Tsai,Y.H.,
            Su,K.Y. and Lee,T.S.
  TITLE     Genetic Deletion of HLJ1 Does Not Affect Blood Coagulation in Mice
  JOURNAL   Int J Mol Sci 23 (4), 2064 (2022)
   PUBMED   35216179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4839)
  AUTHORS   Chen,C.H., Chang,W.H., Su,K.Y., Ku,W.H., Chang,G.C., Hong,Q.S.,
            Hsiao,Y.J., Chen,H.C., Chen,H.Y., Wu,R., Yang,P.C., Chen,J.J. and
            Yu,S.L.
  TITLE     HLJ1 is an endogenous Src inhibitor suppressing cancer progression
            through dual mechanisms
  JOURNAL   Oncogene 35 (43), 5674-5685 (2016)
   PUBMED   27065329
REFERENCE   6  (bases 1 to 4839)
  AUTHORS   Katoh,M.
  TITLE     Functional proteomics, human genetics and cancer biology of GIPC
            family members
  JOURNAL   Exp Mol Med 45 (6), e26 (2013)
   PUBMED   23743496
  REMARK    Review article
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123075.5 and BC017161.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_025926.6.
            
            On Sep 30, 2017 this sequence version replaced NM_025926.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017161.1, AK136240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC123075.5         145312-145353
            43-2329             BC017161.1         1-2287
            2330-4839           AC123075.5         155068-157577
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.03 cM"
     gene            1..4839
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="DnaJ heat shock protein family (Hsp40) member B4"
                     /db_xref="GeneID:67035"
                     /db_xref="MGI:MGI:1914285"
     exon            1..469
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1272
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /note="isoform 1 is encoded by transcript variant 2; dnaJ
                     homolog subfamily B member 4; DnaJ (Hsp40) homolog,
                     subfamily B, member 4"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 4 isoform 1"
                     /protein_id="NP_080202.1"
                     /db_xref="CCDS:CCDS17915.1"
                     /db_xref="GeneID:67035"
                     /db_xref="MGI:MGI:1914285"
                     /translation="MGKDYYHILGIDKGATDEDVKKAYRKQALKFHPDKNKSPQAEEK
                     FKEVAEAYEVLSDPKKREIYDQFGEEGLKGGAGGTDGQGGTFRYTFHGDPHATFAAFF
                     GGSNPFEIFFGRRMGGGRDSEEMEIDGDPFSAFGFSMNGYPRDRNSVGPSRLKQDPPI
                     IHELKVSLEEIYSGCTKRMKISRKRLNPDGRSYRSEDKILTIEIKKGWKEGTKITFPR
                     EGDETPNSIPADIVFVIKDKEHPKFKRDGSNIVYTAKISLREALCGCSLNVPTMDGRN
                     LPMSVTDIVKPGMRRRVIGYGLPFPKNPDQRGDLLIEFDVSFPDVISAASKEILRKHL
                     PAS"
     exon            470..1038
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..4839
                     /gene="Dnajb4"
                     /gene_synonym="1700029A20Rik; 2010306G19Rik;
                     5730460G06Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacacgta gttgaagtgg gagggtctag ctgaggccgt ctccgtgcgg tgtctattta
       61 tctgtaagtg agctgccggg gaggaattaa atagagacgc tgcctgctgc ctctggacag
      121 ctgagccgag ttgctgattt gctttaactt gtaagatacc cagcttgctt tattttctca
      181 ggatcattgt gttgctaagc ctggggacgc tgttttcttt tacaaaggga aatctaagtt
      241 catttcaagg cattcgaaat ggggaaagac tattatcaca ttttgggaat tgacaaagga
      301 gctacagatg aagatgttaa aaaggcttac cgaaagcaag ccctcaaatt tcacccggac
      361 aagaacaaat ctcctcaagc agaggaaaaa tttaaagagg tcgcagaagc gtatgaagta
      421 ctgagtgatc ctaaaaagag agaaatatat gatcagtttg gcgaagaagg cttgaaggga
      481 ggcgctggag gtactgatgg acaaggaggt accttcaggt acactttcca cggagatcct
      541 catgccacat ttgcagcctt tttcggaggt tccaaccctt ttgaaatctt ctttgggaga
      601 cggatgggtg gaggtcgaga ttctgaagaa atggaaatag atggagatcc ctttagtgcc
      661 tttggattca gcatgaatgg atatccaaga gacaggaatt ctgtgggacc ctcccgtctc
      721 aaacaagacc ctcccattat tcatgaactt aaagtatcgc ttgaagaaat atatagtggc
      781 tgcaccaaac ggatgaagat ttctcgaaaa agattaaatc ctgacggaag gagttacaga
      841 tctgaggaca aaattctcac cattgagatc aaaaaagggt ggaaagaagg caccaaaatc
      901 acttttccga gggaaggcga tgaaacacca aatagtatcc cagcagacat tgtttttgtt
      961 attaaagaca aagaacatcc caagtttaaa agagacggat caaatatagt ttatactgct
     1021 aaaattagtt tacgggaggc attgtgtggc tgctcactta atgtgccaac aatggacgga
     1081 agaaacctac ctatgtcagt cactgatatt gtgaaacctg ggatgaggag aagagttatt
     1141 ggatatgggc tgccatttcc aaaaaaccct gaccagcgtg gcgacctact gatagaattt
     1201 gatgtgtcct tcccagacgt catatctgca gcatccaaag agatcctgag gaagcatctc
     1261 cctgcctcct aggatgagaa gaaccttgct atccatagtt tgataagaca ctgaaaatat
     1321 aaaagtaccg gcagttgact gctgtgaatt ctgtgtaaag atgtgtaaac tcttctgagg
     1381 gctcattaaa ctgcatgaat agacacagtt caaataggca acgtgggttt ttacagtagg
     1441 gatgaaaagt cattcactgt atttcatttc tcccaaatca gaaattttta gtatttcatt
     1501 tacaagtaaa agttggtttt gtggtctatg gatatacttc tagtaaatac tagattatcc
     1561 aagtactgtg tgcatgtgcg tgtgtgtgtg tgtgtgtgtg tgtacgcgcg cgtgtgtgtc
     1621 tgtgtgtgct cgtgtctgtg tgtgtatctt taaatgatca gtgtgatagg ctcctttaat
     1681 aaaaattaaa attcttaagt gtatatgtaa tatgtggaga ataaaagcca aagtcataca
     1741 gaaatgcagt ctaggtgaca ttcagagatg ctgtgttggg ctggtaccag aatgcattga
     1801 tgtgtgtgct ttaccgttgt gacttctcaa tattctgcag cgtttcttaa gagcatggtt
     1861 gtaatgttcg taaagcagac ctcatcataa gaagaaaatg aatgacattt tctctcctgt
     1921 ggaagtccca atagccagag ctcctgatat tttagaaaca gatggttttt aagtggccac
     1981 atgtaatttt atgcagttga ctatatatct taaacttaat aagctcattt tgtggttcat
     2041 tagtttaagg tatttgttta ctaacatgtt tttagagaaa atactgttac ttggcattaa
     2101 ttgtccattt acagtgttct gttaagttcc tcatgctatg caccttacat aatttcccta
     2161 aagaacagtc atctatcact gtggtgttaa accgcaatct ggatataaca aacaccatca
     2221 ctgcttgtgg gtaatgtgct gtcatcatat aaatattcta ccttttcatg tatatagatt
     2281 gcatttctta ggtgttttaa tttttaaaat atatttacat tctaaaaaat tactgtcttc
     2341 tgttttatat ctatcaaaag tgatgttatg aaaaattttt tgtaaaacag ttttcagaat
     2401 gatatatatc tatacataaa tatatatggt atactgagtc ctatagtctt tttaatagaa
     2461 tgtgaagtta tttagaaatt ctgtataaaa ttatagtaag cgtatacctt gtggctttat
     2521 tgaaatagaa ttctcataag ataaaattca cactaacctc cctcattttt ttggtactgt
     2581 tgactgacgt cagagctgcg tgcacactaa gtgcctccca ccgtggagct gtgcccagcc
     2641 tccccctctc tctctctttc tttgtggtgt agttttgaat ttcgtgtatc cacagacctg
     2701 tgcagtcacc atgaacagct tctgtgcccc ctctcccctc agcccctgga gcactgatct
     2761 gcttttcaag atggattcta ttgtagaata gaatcggtcg gcatgcggct cctttatttg
     2821 ctgtcgttca cccagcacag cactgttctc aaggtccagt ctggcctcat tatcagtaac
     2881 ttcatccttt gtgtggcaga tcatgtactt gggtagaatc ccatttggtc agcttacctc
     2941 ttctttggtg ttttgggcat ctgggttcta tctactcagt atgaataatg atgctatgag
     3001 catttgtaaa caaatttctg tgtggataga ctgactgcat tctctgaggt acatagttga
     3061 gagtggaatg gttaggaaaa gctacatcca ttagttgcaa atagaaaatg ttaaaaatgc
     3121 cagagagttg aggtaatcgc accatctcct tgaacatcat ggaaattcac acagatataa
     3181 agagctaaag tcttggagtg atggttgtag ttcatattcg aaaccacata cccacagtat
     3241 tcaacttttg agttgtttga ggggggcagg gtgtgtgtgt gtttgtgtct gcttgtttgg
     3301 aggtagggtc ttactatgta gctctggctg gtatgttgct ccatgtgact caagttcacg
     3361 ataaatttat gggaattttt ctccctgcct catagtggct ggaatgaatg gcatgtgcca
     3421 ttcacaccac acaggctttg aaccaacaat tattattgca gtcttattga gtaaacattt
     3481 tctctgagcc aaaataaagg gtttataaac acaaataatc tttcagttag ttcctttagt
     3541 aataattatt ctaacaatca atcaatcaat caatcaatct gtactactct tagggctgag
     3601 ggtagggttc ggtgacagta gtagaataaa tgtacaaaat atataaattt agaggaaaca
     3661 tgcttccgag tgtagtaagt gcccattgtt ttgttaaata ttgaattaat actgacagta
     3721 aaatgttaaa aattttcaga tttaaactat gagagtactt ttgacttcta agatgttcct
     3781 tttaggggct ggaaagaggg ctcagaggca cttgcctctc gtgagtggac ctgggttcag
     3841 ttcccaggac acacttggag gctcccagcc gtctgaaact ccagttccaa ggacacctct
     3901 ttggtctcca tgggcaccag gcatgcatgt ggtgcaccta catacatgca gacaaacaca
     3961 gcatcctttt tttttaaaat tcttttaaag tgtttaattt actagtcctt gcatagctca
     4021 aatgattttg cagcataatg agtccagtaa agcttcttat taaagatgtt tgttaaaaga
     4081 acacatatcc acgggtctta tggctttcca gggcaggtgt tgtatttggt agctctgtag
     4141 ctgaggaaca gttttcttag gacggttcta agcgagacgc actgttccat cacatctgcc
     4201 ctccctgcca cgtggtgctt cgtaacccat ggccttgaaa gcattgggct ctgacatcca
     4261 cattagcttg tctctctggc tattagtcgg tcttggaggc aaggggttga acaagcctct
     4321 tgtttattct taggaaactg tcattggaat gtttgtgatt ggatgaaatg aaattagtgc
     4381 aagtgattgg actcagtcaa tggccttgat gaaacactcc tctcacattt caggaattac
     4441 ctgctcagtc ttggggagtc aaggccaaca tggctttcat tcaataatag ataatgtagt
     4501 atggctgact atcttcacaa tctctctctc tgtatgtgtg tgtgtaggtg aacacgtgtg
     4561 tttaagcaaa tgtcttaaca cgaactaata ttaagatagg aaagagtaat ttatgctgtt
     4621 tataacaatg acaaatacac aaaatttaga ttcttggctt acaatattta tatttaaatt
     4681 atttatattt aatactgaag ttttgtaaaa ttgattcagg gaacaagact agaaagttac
     4741 tttgcctggg tttctaacgc cctttaacct tttttgaaac tcttttcttc tagttttttc
     4801 taaaaattaa atttgtcttt tgacaatacc ataaatgaa
//
