LOCUS       NM_001159883            3067 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B2
            (Dnajb2), transcript variant 3, mRNA.
ACCESSION   NM_001159883
VERSION     NM_001159883.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Pemberton,S., Madiona,K., Pieri,L., Kabani,M., Bousset,L. and
            Melki,R.
  TITLE     Hsc70 protein interaction with soluble and fibrillar
            alpha-synuclein
  JOURNAL   J Biol Chem 286 (40), 34690-34699 (2011)
   PUBMED   21832061
  REMARK    GeneRIF: Hsc70, Hdj1 and Hdj2 interact with soluble and fibrillar
            alpha-synuclein
REFERENCE   3  (bases 1 to 3067)
  AUTHORS   Claeys,K.G., Sozanska,M., Martin,J.J., Lacene,E., Vignaud,L.,
            Stockholm,D., Laforet,P., Eymard,B., Kichler,A., Scherman,D.,
            Voit,T. and Israeli,D.
  TITLE     DNAJB2 expression in normal and diseased human and mouse skeletal
            muscle
  JOURNAL   Am J Pathol 176 (6), 2901-2910 (2010)
   PUBMED   20395441
  REMARK    GeneRIF: Data show that DNAJB2 is expressed in skeletal muscle at
            the neuromuscular junction of normal fibers, in the cytoplasm and
            membrane of regenerating fibers, and in protein aggregates and
            vacuoles in protein aggregate myopathies.
REFERENCE   4  (bases 1 to 3067)
  AUTHORS   Borrell-Pages,M., Canals,J.M., Cordelieres,F.P., Parker,J.A.,
            Pineda,J.R., Grange,G., Bryson,E.A., Guillermier,M., Hirsch,E.,
            Hantraye,P., Cheetham,M.E., Neri,C., Alberch,J., Brouillet,E.,
            Saudou,F. and Humbert,S.
  TITLE     Cystamine and cysteamine increase brain levels of BDNF in
            Huntington disease via HSJ1b and transglutaminase
  JOURNAL   J Clin Invest 116 (5), 1410-1424 (2006)
   PUBMED   16604191
  REMARK    GeneRIF: Cystamine and cysteamine increase brain levels of BDNF in
            Huntington disease via HSJ1b and transglutaminase
REFERENCE   5  (bases 1 to 3067)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3067)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY073498.1, AK171494.1 and BF467509.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156083.1, AK171494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BY073498.1         4-58
            56-3049             AK171494.1         2-2995
            3050-3067           BF467509.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.64 cM"
     gene            1..3067
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /note="DnaJ heat shock protein family (Hsp40) member B2"
                     /db_xref="GeneID:56812"
                     /db_xref="MGI:MGI:1928739"
     exon            1..167
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     exon            168..264
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1174
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /note="isoform 3 is encoded by transcript variant 3; dnaJ
                     homolog subfamily B member 10; dnaJ homolog subfamily B
                     member 2; heat shock protein, DNAJ-like 1; DnaJ (Hsp40)
                     homolog, subfamily B, member 10; DnaJ (Hsp40) homolog,
                     subfamily B, member 2"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 2 isoform 3"
                     /protein_id="NP_001153355.1"
                     /db_xref="CCDS:CCDS78622.1"
                     /db_xref="GeneID:56812"
                     /db_xref="MGI:MGI:1928739"
                     /translation="MASYYEILDVPRSASPDDIKKAYRKKALQWHPDKNPDNKEFAEK
                     KFKEVAEAYEVLSDKHKREIYDRYGREGLTGAGSGPSRSETGGAGPGFTFTFRSPEEV
                     FREFFGSGDPFSELFDDLGVFSELQNQGPRLTGPFFTFSSSFPANSDFSSSSFSFSPG
                     AGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVSINGVPDDLALGLEL
                     SRREQQPSVAPGLGVMQVRPTSLSRPPDHDLSEDEDLQLAMAYSLSEMEAAGQKPAGG
                     RGAQQRQHGQPKAQHRDLDVGGTHKSVRGEAAKLSPSSEEKASRCHIL"
     exon            265..374
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     exon            375..428
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     exon            429..551
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     exon            552..644
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     exon            645..747
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     exon            748..818
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     exon            819..3053
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3033..3038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /note="hexamer: AATAAA"
     polyA_site      3053
                     /gene="Dnajb2"
                     /gene_synonym="2700059H22Rik; Dnajb10; Hsj1; mDj8"
                     /note="major polyA site"
ORIGIN      
        1 gtgaccggcc gagccggccc tctgagtctc tagtagtttc cagggcgctg acgcatgctt
       61 gcgcacacaa cccagcctgg cgtgtcgtac gcagtggccg cgagccgggc agcgggtgct
      121 aggcggttcc cctgcggggg gcaggggcgg gactcccggc agaggagcct ggaggaggga
      181 cgtctgacgc tgagttgcca tggcatccta ctacgagatt ctagacgtac cgcggagtgc
      241 gtcccctgat gacatcaaga aggcgtaccg aaagaaggct ctgcagtggc acccagacaa
      301 gaacccggat aataaagaat ttgctgaaaa aaaatttaag gaggtggcag aggcctatga
      361 agtactatct gacaagcaca aacgggagat ctatgaccgc tatggccggg aagggctgac
      421 cggggcagga agtggtcctt ctcgatcgga aactggtggt gcggggcctg gcttcacatt
      481 caccttccgt agccccgagg aagtcttccg ggagttcttc gggagcggag accctttttc
      541 agagctcttt gatgacttgg gtgtcttctc ggagcttcag aaccagggtc cccgactcac
      601 gggccctttc ttcactttct cttcttcctt tcctgccaac tccgatttct cctcctcatc
      661 tttctccttc agcccggggg ctggtgcttt ccgctccgtt tctacgtcca ccacctttgt
      721 ccaaggccgc cgcatcacca cacgcagaat catggagaac gggcaggagc gggtagaagt
      781 ggaagaggat ggacaactga agtcagtgtc aatcaatggt gtcccagatg acctggcact
      841 aggcttggag ctgagccgtc gtgagcagca accttcagtt gcccctgggc tgggggtcat
      901 gcaggtccgg ccgacctctc tctctcgtcc ccctgaccat gatctttctg aggatgagga
      961 cctgcagctc gccatggctt acagcctgtc agagatggag gcggctgggc agaagccagc
     1021 aggtgggcgg ggggcacagc aacgacagca tgggcagccc aaggcccagc accgagacct
     1081 tgacgtgggg ggcacccata agagtgtgag gggcgaggca gctaaactca gcccgtcctc
     1141 agaggagaag gcctctcgct gccacattct ctgagaacca ggcagagcct ggactaattc
     1201 agatcccgac ttggagtcca gctcactgtc aggagtgcag aatagtgtgg cccaagccgc
     1261 aggattccaa actctgtccc tccacatgtt tccctcccag gtccaccgtt ctgtagcatg
     1321 ggcagggatc tgttgtactc tgtccagggc tgataggtcc ctgggtaaag cccaggattt
     1381 ggggggaggg ggtggcatca gtgcctgtgg agctcagagg cactggttgg atcagacact
     1441 gctgaaggac actagtgggt ttggggtggg ccttttgtgc ccaagtcttt ttctgccatt
     1501 tatgttgctg atgctgtcaa gaaaggagga cttggcctgg catgctctga acttgagttg
     1561 gcaactttct cccagggcac agcgcaggcc gagcgagcga gcggagcctc tgctgtcctt
     1621 ggccagctgc agccctcctg gtttctgtgt agaactaagc tctcacccac ccaccttctc
     1681 gctcctcctc tggtgctgct gtcctcccct ccgctctctg caacgcccac ccttcggccg
     1741 caacgcttgc tttcattgct gcttggctag gtctcccttc tccttttctt tgaagcccag
     1801 gaagatgctg gggccagtgg gtccataaga tcttctgggg aggctagcta ggtggggtgg
     1861 aagcctctca gccctccaga gtctcaacca gagtcaactc ctcttccctt cttgctgcct
     1921 cagcctgccc tggccacagg actaggcaga ggtgaggctg gctatccttg gagaggtggg
     1981 atagggccag ggtgacccag agggaggcct aggtggggag tgtatttgtg ctacctgcaa
     2041 aggagagctt aggggccggc cacagggctg acctaggagt gcatgctcag ctccatcctc
     2101 catctgcttg cagctgaccc tctctcctgt cacccacccc tgctctctcc ccagatgtgt
     2161 tctgagctgg atatcctgga tacagagttg ctgcagttcc aacaggacag cgccctcccc
     2221 agtgtgctag gagggaacac tacattcctc tccctcattt atgctgagtg tagagctggg
     2281 ggttggggtg gtgggtggag actgagtggg aagcacctat agtcttagcc tctgaactct
     2341 catccatggg ttcttagcgc tgtcttttgc ggactacaag tcccagaatg caatgcaccc
     2401 tggacttggc tcttgtaaca cttattccag gggaagagct gctcagttac aaagctgagt
     2461 tacttgggat atgtagttcc aaccccggcc agtcagtcac tctctgaatg gggagatctt
     2521 gtttttcatt ttgtccctgg caggggaggt gagaattgta gatgaccaga actttagttc
     2581 ctatggcact tcttgctaga ctcgggttga agtgagcaga ttcctgtagc atctgagaga
     2641 gtttgttttc ccttgggcaa cctggggggt ccgaggagta agctaatggg gcagtgggct
     2701 gtgtaggtag ggcacggtct tggatggatg cgggctggca gaacctgcgt gggaaaggag
     2761 gctgccttgg ctggagtgtg tatggcaagg actggcatgc agagggagcg ttggacatat
     2821 tgcttgaatg gctttctttg acctctgacc ttgctgccca ttctttctta tcatcaattc
     2881 atcctccatg agccacctgt cctcctgcct ggggagccca aagccgcatg gggattggtg
     2941 gagcaggcta tggccggcct ctgttaacac tgagcctttg agacccatca aagcaagatg
     3001 agctgagctc agactgaggg gaaacggagg caaataaagc tgagttttga gaaaaaaaaa
     3061 aaaaaaa
//
