LOCUS       NM_001190804            2004 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B11
            (Dnajb11), transcript variant 2, mRNA.
ACCESSION   NM_001190804
VERSION     NM_001190804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2004)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2004)
  AUTHORS   Ghosh Roy,S., Li,Z., Guo,Z., Long,K.T., Rehrl,S., Tian,X., Dong,K.
            and Besse,W.
  TITLE     Dnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage
            but not Unfolded Protein Response in Mice
  JOURNAL   J Am Soc Nephrol 34 (9), 1521-1534 (2023)
   PUBMED   37332102
REFERENCE   3  (bases 1 to 2004)
  AUTHORS   Genereux,J.C., Qu,S., Zhou,M., Ryno,L.M., Wang,S., Shoulders,M.D.,
            Kaufman,R.J., Lasmezas,C.I., Kelly,J.W. and Wiseman,R.L.
  TITLE     Unfolded protein response-induced ERdj3 secretion links ER stress
            to extracellular proteostasis
  JOURNAL   EMBO J 34 (1), 4-19 (2015)
   PUBMED   25361606
REFERENCE   4  (bases 1 to 2004)
  AUTHORS   Marcinowski,M., Holler,M., Feige,M.J., Baerend,D., Lamb,D.C. and
            Buchner,J.
  TITLE     Substrate discrimination of the chaperone BiP by autonomous and
            cochaperone-regulated conformational transitions
  JOURNAL   Nat Struct Mol Biol 18 (2), 150-158 (2011)
   PUBMED   21217698
REFERENCE   5  (bases 1 to 2004)
  AUTHORS   Wong,Y.H., Lu,A.C., Wang,Y.C., Cheng,H.C., Chang,C., Chen,P.H.,
            Yu,J.Y. and Fann,M.J.
  TITLE     Protogenin defines a transition stage during embryonic neurogenesis
            and prevents precocious neuronal differentiation
  JOURNAL   J Neurosci 30 (12), 4428-4439 (2010)
   PUBMED   20335479
REFERENCE   6  (bases 1 to 2004)
  AUTHORS   Shen,Y. and Hendershot,L.M.
  TITLE     ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue,
            serves as a cofactor for BiP's interactions with unfolded
            substrates
  JOURNAL   Mol Biol Cell 16 (1), 40-50 (2005)
   PUBMED   15525676
REFERENCE   7  (bases 1 to 2004)
  AUTHORS   Meunier,L., Usherwood,Y.K., Chung,K.T. and Hendershot,L.M.
  TITLE     A subset of chaperones and folding enzymes form multiprotein
            complexes in endoplasmic reticulum to bind nascent proteins
  JOURNAL   Mol Biol Cell 13 (12), 4456-4469 (2002)
   PUBMED   12475965
REFERENCE   8  (bases 1 to 2004)
  AUTHORS   Lau,P.P., Villanueva,H., Kobayashi,K., Nakamuta,M., Chang,B.H. and
            Chan,L.
  TITLE     A DnaJ protein, apobec-1-binding protein-2, modulates
            apolipoprotein B mRNA editing
  JOURNAL   J Biol Chem 276 (49), 46445-46452 (2001)
   PUBMED   11584023
REFERENCE   9  (bases 1 to 2004)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   10 (bases 1 to 2004)
  AUTHORS   Yu,M., Haslam,R.H. and Haslam,D.B.
  TITLE     HEDJ, an Hsp40 co-chaperone localized to the endoplasmic reticulum
            of human cells
  JOURNAL   J Biol Chem 275 (32), 24984-24992 (2000)
   PUBMED   10827079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270762.1, AK050500.1, BY617271.1 and BY640220.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.158312.1,
                                           SRR1660813.177137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY270762.1         2-42
            42-1907             AK050500.1         1-1866
            1908-1999           BY617271.1         335-426
            2000-2004           BY640220.1         419-423
FEATURES             Location/Qualifiers
     source          1..2004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.71 cM"
     gene            1..2004
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /note="DnaJ heat shock protein family (Hsp40) member B11"
                     /db_xref="GeneID:67838"
                     /db_xref="MGI:MGI:1915088"
     exon            1..265
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1274
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /note="dnaJ homolog subfamily B member 11; APOBEC1-binding
                     protein 2; ER-associated dnaJ protein 3; ER-associated
                     Hsp40 co-chaperone; ER-resident protein ERdj3; endoplasmic
                     reticulum DNA J domain-containing protein 3; DnaJ (Hsp40)
                     homolog, subfamily B, member 11"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 11 precursor"
                     /protein_id="NP_001177733.1"
                     /db_xref="CCDS:CCDS28070.1"
                     /db_xref="GeneID:67838"
                     /db_xref="MGI:MGI:1915088"
                     /translation="MAPQNLSTFCLLLLYLIGTVIAGRDFYKILGVPRSASIKDIKKA
                     YRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSH
                     GDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVA
                     RQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRD
                     GMEYPFIGEGEPHVDGEPGDLRFRIKVVKHRIFERRGDDLYTNVTVSLVEALVGFEMD
                     ITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEE
                     AKEGIKQLLKQGPVQKVYNGLQGY"
     exon            266..422
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            423..520
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            521..653
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            654..796
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            797..879
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            880..937
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1049
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1209
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..2004
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /note="hexamer: AATAAA"
     polyA_site      1908
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /note="major polyA site"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
                     /note="hexamer: AATAAA"
     polyA_site      2000
                     /gene="Dnajb11"
                     /gene_synonym="1810031F23Rik; ABBP-2; Dj9; ERdj3; ERj3p"
ORIGIN      
        1 ggcggcgatt ggcccacgcc tggctgctcg ccggctctgg ggctcccgga aggtggcagc
       61 tgaggaaggg gcgcgctacc tgtctccgcg gccgggcaag agagagaccc cggcgtgagg
      121 cggcctccct gggccggaag ggctggtcag ccgacgcagc ggcaccggag gctgagaggg
      181 taggaccagg ggacgccatg gccccgcaga acctgagcac cttctgcctg ttgctgctgt
      241 acctcatcgg gactgtgatc gccgggcgag atttctataa gatcttgggg gtgcctcgaa
      301 gtgcctccat aaaggacatt aaaaaggcct acaggaaact ggccctgcag ctccaccctg
      361 accggaaccc tgatgacccc caagcccagg agaaattcca ggatctaggt gctgcttatg
      421 aggttctgtc agatagtgaa aaacgaaaac agtacgatac ttacggtgaa gaaggcttga
      481 aagatggcca tcagagctct catggggaca ttttttcaca cttctttgga gactttggct
      541 tcatgtttgg aggaacccct cgtcagcagg acaggaatat tccaagagga agtgatatca
      601 tcgtagatct agaagtcact ctggaagaag tgtacgcagg aaattttgtg gaagtagtta
      661 gaaacaagcc tgtggccagg caggctcctg gcaaacggaa atgcaactgt cggcaagaga
      721 tgagaaccac acagctggga ccgggacgct tccaaatgac ccaggaagtg gtttgtgacg
      781 agtgccctaa tgtcaaatta gtgaatgaag aacgaacact agaagtggaa atagagcctg
      841 gggtgcgaga tggcatggag taccccttta ttggagaagg tgagccgcat gtggatgggg
      901 aacccggaga cttacggttc cgaatcaaag ttgtcaagca ccggatattt gagaggagag
      961 gggatgacct gtacacaaat gtgaccgtct cactggttga ggctctggtt ggctttgaga
     1021 tggacataac tcacctggat ggtcacaagg tccatatttc ccgggacaag atcaccaggc
     1081 caggagccaa gctgtggaag aaaggggaag ggctgcccaa ctttgataac aataacatca
     1141 agggctcttt gataatcact tttgatgtgg actttccaaa agaacagctg acagaggaag
     1201 caaaagaagg tatcaagcag cttctcaaac aaggccccgt gcagaaggtg tacaacgggc
     1261 tgcagggcta ttaggagcga agagaactgg actttgaaag aggtggatca gcgatattta
     1321 ttatctgcag tgggtttttg tgtgtgtgtt tcattatttt caatatgcaa gtttggctta
     1381 gtcctttttt ccctgatgac cgtcctgaca agaactagag gtttgaggct ctgtctattg
     1441 cattcagaca acaatggcca gcagaaggtt acctaatacc tccccctctg gggatttaac
     1501 gtctggtgct gcccgaggtt caaggagtaa cgtctcagag gatgcccgag caaaggaaac
     1561 cagatgaggg ttagagacaa ttgttagcta tttcaaaatg ccaactggag aagtctgttt
     1621 ttaaatacat cttgttgtta tttttttttt cttgactcct gtttcttttt cctgtgagcc
     1681 gatgggaagt cttcccatca ggcaggatgg ccacacagca tgcagaggaa cgatgagagc
     1741 ccggctccca ggccccacta aacacatggt gtctatagca acgagctcga agaaaccgag
     1801 tagactagag actgagctac atgaattaaa gttacacaaa gacctcactg tctttgagag
     1861 aacatatttt cccgttttct ttggtaataa taaaatctga tatgggtatt ttactgttta
     1921 gaaggtactt ttctgtatct gtccaaggta gccttatgag ctaagatggc agctttagag
     1981 aataaatatt agaagcagaa ttgc
//
