LOCUS       NM_018808               3019 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member B1
            (Dnajb1), transcript variant 1, mRNA.
ACCESSION   NM_018808
VERSION     NM_018808.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3019)
  AUTHORS   Zhu,L., Duan,W., Yang,B. and Wang,L.
  TITLE     Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse
            hepatic I/R injury in an age-independent manner
  JOURNAL   Int J Med Sci 20 (12), 1562-1569 (2023)
   PUBMED   37859693
  REMARK    GeneRIF: Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in
            mouse hepatic I/R injury in an age-independent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3019)
  AUTHORS   Kastenhuber,E.R., Lalazar,G., Houlihan,S.L., Tschaharganeh,D.F.,
            Baslan,T., Chen,C.C., Requena,D., Tian,S., Bosbach,B.,
            Wilkinson,J.E., Simon,S.M. and Lowe,S.W.
  TITLE     DNAJB1-PRKACA fusion kinase interacts with beta-catenin and the
            liver regenerative response to drive fibrolamellar hepatocellular
            carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), 13076-13084 (2017)
   PUBMED   29162699
  REMARK    GeneRIF: Study validates the DNAJB1-PRKACA fusion kinase as an
            oncogenic driver and candidate drug target for fibrolamellar
            hepatocellular carcinoma in mouse model in which tumorigenesis was
            significantly enhanced by genetic activation of beta-catenin.
REFERENCE   3  (bases 1 to 3019)
  AUTHORS   Engelholm,L.H., Riaz,A., Serra,D., Dagnaes-Hansen,F.,
            Johansen,J.V., Santoni-Rugiu,E., Hansen,S.H., Niola,F. and
            Frodin,M.
  TITLE     CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the
            Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling
            Fibrolamellar Hepatocellular Carcinoma
  JOURNAL   Gastroenterology 153 (6), 1662-1673 (2017)
   PUBMED   28923495
  REMARK    GeneRIF: Generation of the Dnajb1-Prkaca fusion gene in wild-type
            mice to be sufficient to initiate formation of tumors that have
            many features of human fibrolamellar hepatocellular carcinonma.
REFERENCE   4  (bases 1 to 3019)
  AUTHORS   Park,S.K., Hong,J.Y., Arslan,F., Kanneganti,V., Patel,B.,
            Tietsort,A., Tank,E.M.H., Li,X., Barmada,S.J. and Liebman,S.W.
  TITLE     Overexpression of the essential Sis1 chaperone reduces TDP-43
            effects on toxicity and proteolysis
  JOURNAL   PLoS Genet 13 (5), e1006805 (2017)
   PUBMED   28531192
  REMARK    GeneRIF: Overexpression of DNAJB1 relieves TDP-43 mediated toxicity
            in primary rodent cortical neurons.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3019)
  AUTHORS   Krzemien-Ojak,L., Goral,A., Joachimiak,E., Filipek,A. and
            Fabczak,H.
  TITLE     Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein
            Hsp90
  JOURNAL   J Cell Biochem 118 (2), 420-429 (2017)
   PUBMED   27496612
REFERENCE   6  (bases 1 to 3019)
  AUTHORS   Yamagishi,N., Ishihara,K., Saito,Y. and Hatayama,T.
  TITLE     Hsp105 but not Hsp70 family proteins suppress the aggregation of
            heat-denatured protein in the presence of ADP
  JOURNAL   FEBS Lett 555 (2), 390-396 (2003)
   PUBMED   14644449
REFERENCE   7  (bases 1 to 3019)
  AUTHORS   Wang,G., Zhang,J., Moskophidis,D. and Mivechi,N.F.
  TITLE     Targeted disruption of the heat shock transcription factor (hsf)-2
            gene results in increased embryonic lethality, neuronal defects,
            and reduced spermatogenesis
  JOURNAL   Genesis 36 (1), 48-61 (2003)
   PUBMED   12748967
REFERENCE   8  (bases 1 to 3019)
  AUTHORS   Tanaka,S., Kitagawa,K., Ohtsuki,T., Yagita,Y., Takasawa,K., Hori,M.
            and Matsumoto,M.
  TITLE     Synergistic induction of HSP40 and HSC70 in the mouse hippocampal
            neurons after cerebral ischemia and ischemic tolerance in gerbil
            hippocampus
  JOURNAL   J Neurosci Res 67 (1), 37-47 (2002)
   PUBMED   11754079
REFERENCE   9  (bases 1 to 3019)
  AUTHORS   Hata,M. and Ohtsuka,K.
  TITLE     Cloning and expression of murine Hsp40 gene: differences in
            initiation sites between heat-induced and constitutive transcripts
  JOURNAL   DNA Seq 11 (3-4), 213-223 (2000)
   PUBMED   11092732
REFERENCE   10 (bases 1 to 3019)
  AUTHORS   Chen,M.S., Roti,J.R. and Laszlo,A.
  TITLE     Hsc40, a new member of the hsp40 family, exhibits similar
            expression profile to that of hsc70 in mammalian cells
  JOURNAL   Gene 238 (2), 333-341 (1999)
   PUBMED   10570961
  REMARK    GeneRIF: This is a paper that uses purification techiques to find
            the following: Hsc40, a new member of the hsp40 family, exhibits
            similar expression profile to that of hsc70 in mammalian cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY251864.1, AK146657.1,
            AC151992.3, AA794374.1, BY658568.1 and BY476619.1.
            
            On Apr 28, 2015 this sequence version replaced NM_018808.2.
            
            Summary: This gene encodes a member of the DnaJ or Hsp40 (heat
            shock protein 40 kD) family of proteins. The encoded protein is a
            molecular chaperone that stimulates the ATPase activity of Hsp70
            heat-shock proteins in order to promote protein folding and prevent
            misfolded protein aggregation. The encoded protein may also inhibit
            apoptosis. Peritoneal macrophages derived from homozygous knockout
            mice for this gene exhibit impaired heat tolerance. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146657.1, AK167718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY251864.1         2-57
            57-2263             AK146657.1         1-2207
            2264-2372           AC151992.3         35346-35454         c
            2373-2756           AA794374.1         1-384
            2757-3011           BY658568.1         172-426
            3012-3019           BY476619.1         480-487
FEATURES             Location/Qualifiers
     source          1..3019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.22 cM"
     gene            1..3019
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
                     /note="DnaJ heat shock protein family (Hsp40) member B1"
                     /db_xref="GeneID:81489"
                     /db_xref="MGI:MGI:1931874"
     exon            1..368
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..949
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..3014
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2241..2246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
                     /note="hexamer: ATTAAA"
     polyA_site      2264
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
                     /note="major polyA site"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
                     /note="hexamer: AATAAA"
     polyA_site      3014
                     /gene="Dnajb1"
                     /gene_synonym="0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1"
ORIGIN      
        1 gggccgcagc gattggccgg tgtcgtgcgg cgcatcggga ggggcggaag gttctggagg
       61 gctggcggga tctggaagct tccgccggac gggtatatag agtccgggac ggggcagcag
      121 cggagccgga ggcggcgaca gctgggcggc ggtggccatg ggcaaggact actatcagac
      181 gctgggcctg gcccgcggcg cgtccgacga cgagatcaag cgagcctacc gccgccaggc
      241 gctgcgctac cacccggaca agaacaagga gcccggcgct gaggagaagt tcaaggagat
      301 cgccgaggcc tacgacgtgc tcagcgaccc gcgcaagcgc gagattttcg accgctatgg
      361 agaggaaggc ctgaagggtg gtagccccag tggaggaagc agtggtggtg ctaatggtac
      421 ctctttcagc tacacattcc acggagaccc ccatgccatg tttgctgagt tcttcggtgg
      481 cagaaacccc tttgatacct tttttgggca gcgcaacggg gaagaaggca tggacattga
      541 tgacacattc tctagctttc caatgggtat gggtggcttc accaacatga actttggacg
      601 ttcccgccct tctcaagagc ccacccggaa gaagcaagat cctccagtca cccatgacct
      661 tcgggtctcc cttgaagaga tctacagcgg ctgtaccaag aagatgaaaa tctcccacaa
      721 gcggctgaac cctgatggaa agagcattcg aaatgaagat aagatcctga ccatcgaagt
      781 gaagaggggc tggaaagaag ggaccaaaat cacctttccc aaggaagggg accagacctc
      841 gaacaacatt ccagcagaca tcgtctttgt tttaaaggac aagccacaca atatcttcaa
      901 gagagatggt tctgatgtca tctatccagc caggattagc cttcgggagg ctctctgtgg
      961 ttgcactgtg aatgtcccta ctctggacgg caggaccatc cctgttgtat tcaaagatgt
     1021 catcaggcct ggtatgcggc ggaaagtccc tggagaaggc ctccctctcc ccaaaacacc
     1081 tgagaaacgt ggagaccttg ttatcgagtt tgaagtgatc ttcccggaaa ggattcccgt
     1141 ctcatccaga accatcctgg agcaggttct tcccatatag ccacctgcac tcctcaagga
     1201 ctgagccagg ggctttcaga gctgcagatc tccagaccgt tccactggtt gcatactgcg
     1261 ggagggccca gggagggctt ttgctctgcc gaatgttttc cacagaatat attacaatct
     1321 ttcaaagtcg cgcactagac tacagtggtt tttcgagcga taggcaggcg gtgggaacag
     1381 cagccctcct ggaatggacc caccctctgc accccagctc ctgcccaagg gtgtgaggca
     1441 ggcctgcaac tggactcttg ccctctgttg tccttagtct ggctgtcatg tgacagtggt
     1501 ccgccatctc agttgccaga ccctgtgcac tagtcagtct ccactgtgtg ggaggttctt
     1561 gttttatctg tatttgtccc atgccttgtt cctcctcccc agaagagtcc tgtcttgtct
     1621 tggccatctc aaattgagac caattcccta ggactgccag gccagcatca caagcaatac
     1681 ctggttgcag gaccacaggg ccagcctcct tccaggttct ggggcctggc cagccaggag
     1741 atcccctgga cctctggctc cattgacatc agatggctgg cttacagtca cagtacttgc
     1801 tggtccagag gtagaccttg gccacacctg gcacttctca gaggcacagg tgattttgtg
     1861 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtaat ggactctgaa
     1921 ctctagaagg atacaatcct tttggatttt gcacagtcct agatctaatc ccttttgata
     1981 aaagggtctt tgcttctgat gaaaggagca ctgtggaacg tatgtaaata tgtttttata
     2041 attccattgg aagctggtgt gcactcagac gaaagcagtc cctgtcaact actgtccagg
     2101 gctgtgatgg gatcagacct gggcgtgaaa gtatctgttc tttggagcta gcctggtgtt
     2161 ctgaccattc aactcattgt aagttgccac taccaacaca agaccaaagt gtgtgacttg
     2221 tcattatgca gtgtgacagc attaaagact gatgctaaac ctcaggggag cagtccttcg
     2281 actctgtttg agggctttgc tggggggagg agcggcatgg ttactgttct cattctcaaa
     2341 agaaagctct gtttcccttc ctgggacaca ttggtttccc gttcaggacc ccagcatcac
     2401 tgtggtgacg gttggggtag gagcccgccc tgagtgcctt ttctaccttg caagctcctg
     2461 gccacatctg gggacctagt aaccaccagg gctgaggatt acagtgccat ctgcctgaat
     2521 tcccccttcc aacttggtag ggtaggctag gctagcctag agctaggatg cacctgccca
     2581 gagttggctg ctctggggag aaacccactt cctttcccca cttgataggg gtgtctgaga
     2641 acttctttga agaggtaggt tgattataga gcaatgtgtt ggttttgtct ctgtgttctg
     2701 gtggttctgg ttgtggagcc cagggttttt cttctccagc tgactacagc taccagccat
     2761 gctgcagtct gctcaacagt aaaacctgtc taagaaattg taacatagaa agataatccc
     2821 agagccagat gtgacctctg taaactcaac actgggaagg ctaagcccag aagtagttgg
     2881 aaatctgtct aagctatggt agagtattga tccagcctat gtaagtctac ctaagagctg
     2941 ctttccctta ccaccaaagg caactctgga atgtttgttg ttgtttaata aaatagttcc
     3001 tctagtctcc ctaaaaaaa
//
