LOCUS       NM_001135112            2549 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member A3
            (Dnaja3), transcript variant 2, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001135112
VERSION     NM_001135112.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Sayson,S.L., Fan,J.N., Ku,C.L., Lo,J.F. and Chou,S.H.
  TITLE     DNAJA3 regulates B cell development and immune function
  JOURNAL   Biomed J 47 (2), 100628 (2024)
   PUBMED   37487907
  REMARK    GeneRIF: DNAJA3 regulates B cell development and immune function.
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Winkler,R., Magdefrau,A.S., Piskor,E.M., Kleemann,M., Beyer,M.,
            Linke,K., Hansen,L., Schaffer,A.M., Hoffmann,M.E., Poepsel,S.,
            Heyd,F., Beli,P., Moroy,T., Mahboobi,S., Kramer,O.H. and Kosan,C.
  TITLE     Targeting the MYC interaction network in B-cell lymphoma via
            histone deacetylase 6 inhibition
  JOURNAL   Oncogene 41 (40), 4560-4572 (2022)
   PUBMED   36068335
  REMARK    GeneRIF: Targeting the MYC interaction network in B-cell lymphoma
            via histone deacetylase 6 inhibition.
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Salazar-Petres,E., Pereira-Carvalho,D., Lopez-Tello,J. and
            Sferruzzi-Perri,A.N.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Sheng,X., Liu,C., Yan,G., Li,G., Liu,J., Yang,Y., Li,S., Li,Z.,
            Zhou,J., Zhen,X., Zhang,Y., Diao,Z., Hu,Y., Fu,C., Yao,B., Li,C.,
            Cao,Y., Lu,B., Yang,Z., Qin,Y., Sun,H. and Ding,L.
  TITLE     The mitochondrial protease LONP1 maintains oocyte development and
            survival by suppressing nuclear translocation of AIFM1 in mammals
  JOURNAL   EBioMedicine 75, 103790 (2022)
   PUBMED   34974310
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Maletzko,A., Key,J., Wittig,I., Gispert,S., Koepf,G.,
            Canet-Pons,J., Torres-Odio,S., West,A.P. and Auburger,G.
  TITLE     Increased presence of nuclear DNAJA3 and upregulation of cytosolic
            STAT1 and of nucleic acid sensors trigger innate immunity in the
            ClpP-null mouse
  JOURNAL   Neurogenetics 22 (4), 297-312 (2021)
   PUBMED   34345994
  REMARK    GeneRIF: Increased presence of nuclear DNAJA3 and upregulation of
            cytosolic STAT1 and of nucleic acid sensors trigger innate immunity
            in the ClpP-null mouse.
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Lo,J.F., Hayashi,M., Woo-Kim,S., Tian,B., Huang,J.F., Fearns,C.,
            Takayama,S., Zapata,J.M., Yang,Y. and Lee,J.D.
  TITLE     Tid1, a cochaperone of the heat shock 70 protein and the mammalian
            counterpart of the Drosophila tumor suppressor l(2)tid, is critical
            for early embryonic development and cell survival
  JOURNAL   Mol Cell Biol 24 (6), 2226-2236 (2004)
   PUBMED   14993262
  REMARK    GeneRIF: Tid1 is critical for early mammalian development, most
            likely for its function in sustaining embryonic-cell survival,
            which requires its association with Hsp70.
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Syken,J., Macian,F., Agarwal,S., Rao,A. and Munger,K.
  TITLE     TID1, a mammalian homologue of the drosophila tumor suppressor
            lethal(2) tumorous imaginal discs, regulates activation-induced
            cell death in Th2 cells
  JOURNAL   Oncogene 22 (30), 4636-4641 (2003)
   PUBMED   12879007
  REMARK    GeneRIF: Tid-1S in Th2 cells following activation has a role in
            induction of apoptosis resistance during the activation of Th2
            cells
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   Trentin,G.A., Yin,X., Tahir,S., Lhotak,S., Farhang-Fallah,J., Li,Y.
            and Rozakis-Adcock,M.
  TITLE     A mouse homologue of the Drosophila tumor suppressor l(2)tid gene
            defines a novel Ras GTPase-activating protein (RasGAP)-binding
            protein
  JOURNAL   J Biol Chem 276 (16), 13087-13095 (2001)
   PUBMED   11116152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ148764.1, AK167511.1 and BP757709.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 3'
            region, as compared to variant 1. The resulting isoform (2) has a
            shorter and different C-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027240.1, AK167511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CJ148764.1         2-40
            40-2458             AK167511.1         2-2420
            2459-2549           BP757709.1         1-91                c
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.46 cM"
     gene            1..2549
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /note="DnaJ heat shock protein family (Hsp40) member A3"
                     /db_xref="GeneID:83945"
                     /db_xref="MGI:MGI:1933786"
     exon            1..275
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1426
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /note="isoform 2 is encoded by transcript variant 2; dnaJ
                     homolog subfamily A member 3, mitochondrial; mTid-1; dnaJ
                     protein Tid-1; tumorous imaginal discs protein Tid56
                     homolog; DnaJ (Hsp40) homolog, subfamily A, member 3"
                     /codon_start=1
                     /product="dnaJ homolog subfamily A member 3, mitochondrial
                     isoform 2"
                     /protein_id="NP_001128584.1"
                     /db_xref="CCDS:CCDS49748.1"
                     /db_xref="GeneID:83945"
                     /db_xref="MGI:MGI:1933786"
                     /translation="MAAWCSPRWLRVAVGTPRLPAAAGRGVQQPQGGVVATSLCRKLC
                     VSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTTSFHTSASLAKDDYYQILGVPR
                     NASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSA
                     GFDPGTSSSGQGYWRGGPSVDPEELFRKIFGEFSSSPFGDFQNVFDQPQEYIMELTFN
                     QAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCR
                     RCGGRGSIITNPCVVCRGAGQAKQKKRVTIPVPAGVEDGQTVRMPVGKREIFVTFRVQ
                     KSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGKG
                     IPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGKRS
                     TGN"
     exon            276..409
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            410..493
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            494..694
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            695..847
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            848..995
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1060
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1189
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1305
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1403
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..2531
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /note="hexamer: AATAAG"
     polyA_site      2531
                     /gene="Dnaja3"
                     /gene_synonym="1200003J13Rik; 1810053A11Rik; Tid-1; Tid1l"
                     /note="major polyA site"
ORIGIN      
        1 ggaagacgcg accggcgagg cgggccagtg acggtctgcg caggcgcagt gtccccgggc
       61 caaaatggct gcgtggtgtt ccccacgctg gttgagggtg gcagtgggga ctccccggct
      121 gccggctgca gcggggagag gggtccagca gccccagggg ggcgtagtgg caacatccct
      181 gtgtcgcaag ctgtgcgtct ctgccttcgg gctttccatg ggcgctcacg gcccccgggc
      241 gctgctgaca ttgagacccg gtgtccgcct cacaggaaca aaaagtttcc cttttgtttg
      301 taccacctct ttccacacaa gtgcttcttt ggccaaagat gattattacc agatcctggg
      361 agtgccccga aatgccagcc agaaagatat caagaaagcc tattatcagc ttgccaagaa
      421 atatcatcca gacacaaata aggatgatcc caaagccaag gagaagtttt cccagctggc
      481 agaagcttat gaggtgttga gcgatgaagt gaagaggaag cagtatgacg cttacggctc
      541 tgctggcttt gaccctggca ccagcagctc tgggcagggc tactggagag gaggtccctc
      601 tgttgacccc gaggagttgt tcaggaagat ctttggggag ttctcatctt ctccttttgg
      661 tgatttccag aatgtgtttg atcagcctca ggaatacatc atggaattga cattcaatca
      721 agctgccaag ggtgtcaaca aagagttcac tgtgaacatt atggatacct gtgagcgctg
      781 tgacggcaag gggaacgagc ctggaaccaa agtgcagcat tgccattact gtggcggctc
      841 gggcatggaa actatcaata cagggccttt tgtgatgcgt tccacatgtc ggagatgtgg
      901 tggccggggc tccatcatca caaatccctg tgtggtctgc aggggagcag gacaagccaa
      961 gcagaagaag cgcgtgacaa ttcctgtgcc tgcaggagtt gaagatggtc agactgtaag
     1021 gatgccagtg ggaaaacgag aaatttttgt cacattcagg gtgcagaaaa gccctgtgtt
     1081 ccggagggac ggtgcagaca tccactcgga cctctttatt tcaatagctc aagctattct
     1141 tgggggcaca gccaaagccc agggcctgta tgagacaatc aatgtgacga tccctgcagg
     1201 gattcagaca gaccagaaga ttcgtttgac tggaaaaggc atcccccgga ttaatagcta
     1261 tggctatggt gaccactaca ttcacatcaa gatcagagtt ccaaagaggc tgagcagtag
     1321 gcagcagaac ctgatcctga gctatgccga ggatgagact gacgtggagg ggacggttaa
     1381 tggagtcacc cacacaagca ctggaaagcg gtcaactgga aactaaatgg agcagcagct
     1441 cctctctgtg gccagggcat cagacacagg aggatcccag aacggcagca ctgagcccct
     1501 gctcccagat ccctctgaac cgccgagcaa cagcaaaact atgtgacaac acttctccgc
     1561 ataaaggtta tggtgcccta ggcagtgaca tatggcctca ggctggacac cgagacaggt
     1621 ggaaataccc tgtccattgg tagatgtctt gcttcttctg gttcaggcag ggaaaacact
     1681 tggactcttc ttgcagcact aaaactaacc tggaatcgca tgtagtagag ctgaaagaat
     1741 taaagacccg gcttacagct tcagatgaag ctttaagctg cagtgttgtg aagtgattaa
     1801 ttccctttct accaaccccg tgggagttct acagtacggc tgtcctgaca cggctcttgt
     1861 ctaggaccag ggcggcacat cccaccagcg ccatcttcct ggacagagtg agctgtcagt
     1921 cactccccag gttttttttg tttttggggt tttttttttt ttgtaccaag tagctagaaa
     1981 gtgggaccta gggccctggg aggacaccta gcaacagcag gttccatttc acctcagatg
     2041 gcagcttgcc tggcagtgga cttagagtgt tctagtctga tgtatgtggg gtttcctgcc
     2101 ctgttggacc aaagtttcca tggtcctatg ggatagcctt cagcctctgg agacccagag
     2161 cttgcctgcc agggcttggt tctccatttc cactgctgac atttgatttc cagtgtattt
     2221 aaattactcc gtggtaaatt tcattgtctt ttcctgtgta aatgttaaat gacaatacca
     2281 tcggtgaagg ccctccacag tggacagagc aacttccttt ccagcctctg ctggtagcat
     2341 gctgcagctt ctgtgttaaa ggtcctctgg agctcgtgta agacaggaag aacactttct
     2401 ctgtagtttc tttcttttca tttataattt acaaaagtaa agcatttatt agtgtctgat
     2461 ttaagaatgt aaagtgattc tgtatcaatg taaataagat gatctactac aaaagatatt
     2521 taaaatcaaa aaaaaaaaaa aaaaaaaaa
//
