LOCUS       NM_019794               2936 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member A2
            (Dnaja2), mRNA.
ACCESSION   NM_019794
VERSION     NM_019794.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2936)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2936)
  AUTHORS   Huang,Y., Lu,C., Wang,H., Gu,L., Fu,Y.X. and Li,G.M.
  TITLE     DNAJA2 deficiency activates cGAS-STING pathway via the induction of
            aberrant mitosis and chromosome instability
  JOURNAL   Nat Commun 14 (1), 5246 (2023)
   PUBMED   37640708
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2936)
  AUTHORS   Rosales-Hernandez,A., Beck,K.E., Zhao,X., Braun,A.P. and Braun,J.E.
  TITLE     RDJ2 (DNAJA2) chaperones neural G protein signaling pathways
  JOURNAL   Cell Stress Chaperones 14 (1), 71-82 (2009)
   PUBMED   18595009
  REMARK    GeneRIF: Rdj2 modulates G protein signaling and further suggest
            that chaperoning G proteins is an emerging theme of the J protein
            network.
REFERENCE   4  (bases 1 to 2936)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   5  (bases 1 to 2936)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122409.4 and AC130533.2.
            
            On Feb 7, 2019 this sequence version replaced NM_019794.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028853.1, AK077672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC122409.4         156153-156344
            193-252             AC122409.4         157538-157597
            253-476             AC130533.2         158-381
            477-557             AC130533.2         4606-4686
            558-691             AC130533.2         4871-5004
            692-888             AC130533.2         6859-7055
            889-1033            AC130533.2         13116-13260
            1034-1161           AC130533.2         13391-13518
            1162-2936           AC130533.2         14161-15935
FEATURES             Location/Qualifiers
     source          1..2936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.61 cM"
     gene            1..2936
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /note="DnaJ heat shock protein family (Hsp40) member A2"
                     /db_xref="GeneID:56445"
                     /db_xref="MGI:MGI:1931882"
     exon            1..192
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1353
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /note="DNA J protein; DnaJ (Hsp40) homolog, subfamily A,
                     member 2"
                     /codon_start=1
                     /product="dnaJ homolog subfamily A member 2"
                     /protein_id="NP_062768.1"
                     /db_xref="CCDS:CCDS22500.1"
                     /db_xref="GeneID:56445"
                     /db_xref="MGI:MGI:1931882"
                     /translation="MANVADTKLYDILGVPPGASENELKKAYRKLAKEYHPDKNPNAG
                     DKFKEISFAYEVLSNPEKRELYDRYGEQGLREGSGGGGGMDDIFSHIFGGGLFGFMGN
                     QSRSRNGRRRGEDMMHPLKVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCS
                     ACRGRGVRIMIRQLAPGMVQQMQSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILE
                     VHVDKGMKHGQRITFTGEADQAPGVEPGDIVLLLQEKEHEVFQRDGNDLHMTYKIGLV
                     EALCGFQFTFKHLDARQIVVKYPPGKVIEPGCVRVVRGEGMPQYRNPFEKGDLYIKFD
                     VQFPENNWINPDKLSELEDLLPSRPEVPNVIGETEEVELQEFDSTRGSGGGQRREAYN
                     DSSDEESSSHHGPGVQCAHQ"
     exon            193..252
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     exon            253..476
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     exon            477..557
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     exon            558..691
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     exon            692..888
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1033
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1161
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..2936
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1919..1924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /note="hexamer: AATAAA"
     polyA_site      1940
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /note="major polyA site"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /note="hexamer: ATTAAA"
     polyA_site      2306
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
     regulatory      2917..2922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
                     /note="hexamer: AATAAA"
     polyA_site      2936
                     /gene="Dnaja2"
                     /gene_synonym="1500017M13Rik; 2010206B19Rik; DNAJ; Dnaj3;
                     DNJ3; HIRIP4; mDj3; PRO3015"
ORIGIN      
        1 agccccgcct gcctccccgc gccgtctcct cggcctgcgc cgccgccgct cgtggtccgg
       61 gtcgcgctcc ttccgctccg ccgcctgctt gcgagtgctg cccggcaggc cgccatggcg
      121 aacgtggccg acacgaagct gtacgacatc ctgggcgtcc ctcccggcgc tagcgagaac
      181 gagctgaaga aggcataccg aaagttagcc aaagaatacc accctgataa gaatccaaat
      241 gctggagaca aatttaaaga aataagtttt gcatatgaag tattgtcaaa tccagagaag
      301 cgagagctgt atgacagata tggagaacaa ggcctacggg aaggcagcgg cggaggcggt
      361 ggcatggatg atatcttctc acatattttt ggtggaggat tgtttggctt tatgggcaat
      421 cagagtagaa gtcgaaatgg cagaagaaga ggcgaggaca tgatgcatcc actaaaagta
      481 tctttagaag acctgtacaa tggcaagaca accaaactac aacttagcaa gaatgtgctc
      541 tgtagtgcat gcagtggcca aggtgggaag tctggagctg ttcagaaatg cagcgcttgt
      601 cggggtcgag gtgtgcgcat tatgatcaga cagctggctc caggaatggt gcagcagatg
      661 cagtccgtgt gctccgactg taatggagaa ggggaggtca tcaatgaaaa agaccgctgt
      721 aaaaaatgtg aagggaagaa ggtaatcaaa gaagtcaaga ttctggaagt ccatgtagac
      781 aaaggcatga aacatggaca gaggattacg ttcactgggg aagcagacca ggctccagga
      841 gtggaacctg gagatattgt tcttttgcta caggaaaaag aacatgaggt gttccagaga
      901 gatgggaatg atttgcatat gacatataag ataggacttg ttgaagcttt atgtggattt
      961 cagttcacat ttaaacatct tgatgctcgt cagattgtgg tgaaataccc ccctggcaaa
     1021 gtaattgaac caggatgtgt tcgtgttgtt cgaggtgaag gaatgccaca gtatcgtaat
     1081 ccctttgaaa agggtgatct ctacataaag tttgatgtac agtttcctga gaataactgg
     1141 atcaacccag acaaactttc tgaattagaa gatctcctgc catctagacc agaagttcct
     1201 aatgttattg gagagacaga agaagtggag cttcaggaat ttgatagcac tcgaggctct
     1261 ggcggtggtc agagacgtga agcctataat gatagctctg atgaagaaag tagcagccat
     1321 catggacctg gagtgcagtg tgcccatcag taaactgcag gccactgcac aggtgggttt
     1381 tctttccaca tttgccggat ttgccagctg ctggagtacc tgataagtcc agatggactg
     1441 atggacatct gttgatctat gtgtaacttc taaaattggt atcgtatcca cagagtgtat
     1501 aatttaaact aaccacagag ctttacatct tcatttcgac tgttctgtag cagagtaaag
     1561 cacttgaaat aagactccct ttcacatgtg ggttataagt ttcagtcctg gtatctgctt
     1621 gatttttatc agttttgtgt agactttatg tttcatattt taaactcaaa tccagcattg
     1681 taaagtttgt acaatttgtc ctgaagcttt gtgtttggct gcacctgcat aagctgctac
     1741 aaatagaata aagaattcat agcctgtatc tatcatttag atgcatggaa aaatgggctt
     1801 tgcacacaat gggtttgaag ctgactggga acaatggaaa aaaattacat tagccatggt
     1861 tgtaaagttt tttggctttt ttttaaaacc attttgtgaa aggtttctga aacttgataa
     1921 taaaaagcag ttggtgtaaa ttattctgtg tcacattttt agaaagaaca tattttgaac
     1981 tgtaaaagta tccttacact gaggagtgaa tctttaaaca gcctctaaaa acccatcagc
     2041 ctgaggcttt tgccttgggt acctgcccat tttatagtta aataacacta atgttggttg
     2101 aaacaggctt tattcacttc agttgatgct ctgtagcatc aaaaacatcc aagttaccca
     2161 actcctagat tacctgcata tcgggacaaa cccaggcctc atcctcttgc accccatttt
     2221 ttaaaaataa ggtaataggt cagtagttaa accatgttta catagacctg ttaaaatgct
     2281 gttttaatta aatgttatga aaagttgctc tgtctcatta agttgaatat ctgagtttgg
     2341 gtgagcgtgg actgtttggt tttctgtgta gaaaactaag attcttaggt tagcagaggt
     2401 tctcatgcag agtggccgag ccagcagtgc ctgtgggttc agtttgatcc atgctctgat
     2461 gagcgcctca cttggattac agctgtcctg atgggatgat gaaagggtgt gtgtccatcc
     2521 tctgatgatg actttgtcac tccttgggtg tttttaaaac atttcccttt gaggtccaag
     2581 tcataccagg tacacatctt ttacatttgt caaaggaaca acaggacaaa aatggaaatt
     2641 cagatttttc aatgtatcat accatctctg agcctaatag cactagagta catttctaga
     2701 gctattagaa cttggatgta aaatgtctca aaactaatca agacctgtga gggttaaatt
     2761 actgccctat ccactctacc tccattgtac aaaaaaatat tttgcaacaa gcctgggcaa
     2821 gattcaacca cataatagtt ttgtatttga ggtaacttcc ccacaacact ttaagcctaa
     2881 gcaatgcagt gataatataa actttgtagc ctttccaata aaggtttata aaacca
//
