LOCUS       NM_177222               2534 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus dynein axonemal intermediate chain 7 (Dnai7), mRNA.
ACCESSION   NM_177222
VERSION     NM_177222.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2534)
  AUTHORS   Zhang,Y., Chen,Y., Zheng,J., Wang,J., Duan,S., Zhang,W., Yan,X. and
            Zhu,X.
  TITLE     Vertebrate Dynein-f depends on Wdr78 for axonemal localization and
            is essential for ciliary beat
  JOURNAL   J Mol Cell Biol 11 (5), 383-394 (2019)
   PUBMED   30060180
REFERENCE   2  (bases 1 to 2534)
  AUTHORS   Wirschell,M., Yang,C., Yang,P., Fox,L., Yanagisawa,H.A., Kamiya,R.,
            Witman,G.B., Porter,M.E. and Sale,W.S.
  TITLE     IC97 is a novel intermediate chain of I1 dynein that interacts with
            tubulin and regulates interdoublet sliding
  JOURNAL   Mol Biol Cell 20 (13), 3044-3054 (2009)
   PUBMED   19420136
  REMARK    Erratum:[Mol Biol Cell. 2009 Aug;20(15):3617]
REFERENCE   3  (bases 1 to 2534)
  AUTHORS   Liu,Y., Vikis,H.G., Yi,Y., Futamura,M., Wang,Y. and You,M.
  TITLE     Degradation of lung adenoma susceptibility 1, a major candidate
            mouse lung tumor modifier, is required for cell cycle progression
  JOURNAL   Cancer Res 67 (21), 10207-10213 (2007)
   PUBMED   17974961
  REMARK    GeneRIF: The differential degradation of Las1-A/J and Las-B6
            produced from the 2 corresponding alleles, has important
            implications for its intracellular function and may eventually
            explain Las1-A/J in lung tumorigenesis.
REFERENCE   4  (bases 1 to 2534)
  AUTHORS   Galbiati,F., Pettinicchio,A., Dragani,T.A. and Manenti,G.
  TITLE     Allelic effects of mouse Pas1 candidate genes in human lung cancer
            cell lines
  JOURNAL   Cancer Lett 244 (2), 176-181 (2006)
   PUBMED   16458428
REFERENCE   5  (bases 1 to 2534)
  AUTHORS   Nathan,B.M., Hodges,C.A., Supelak,P.J., Burrage,L.C., Nadeau,J.H.
            and Palmert,M.R.
  TITLE     A quantitative trait locus on chromosome 6 regulates the onset of
            puberty in mice
  JOURNAL   Endocrinology 147 (11), 5132-5138 (2006)
   PUBMED   16873534
REFERENCE   6  (bases 1 to 2534)
  AUTHORS   Liu,P., Wang,Y., Vikis,H., Maciag,A., Wang,D., Lu,Y., Liu,Y. and
            You,M.
  TITLE     Candidate lung tumor susceptibility genes identified through
            whole-genome association analyses in inbred mice
  JOURNAL   Nat Genet 38 (8), 888-895 (2006)
   PUBMED   16862160
  REMARK    GeneRIF: Whole-genome association analyis of lung tumor
            susceptibility refined the Pas1 locus to a region of less than 0.5
            Mb containing two strong candidates, Kras2 and Casc1 (also known as
            Las1).
            GeneRIF: Casc1 knockout mouse tumor bioassays showed that
            Casc1-deficient mice were susceptible to chemical induction of lung
            tumors.
REFERENCE   7  (bases 1 to 2534)
  AUTHORS   Manenti,G., Galbiati,F., Gianni-Barrera,R., Pettinicchio,A.,
            Acevedo,A. and Dragani,T.A.
  TITLE     Haplotype sharing suggests that a genomic segment containing six
            genes accounts for the pulmonary adenoma susceptibility 1 (Pas1)
            locus activity in mice
  JOURNAL   Oncogene 23 (25), 4495-4504 (2004)
   PUBMED   15064703
  REMARK    GeneRIF: Las1 is part of the complex multigenic Pas1 locus, with a
            functional role for its intragenic polymorphisms and AA changes in
            lung tumor susceptibility. It may be a tumor suppressor.
REFERENCE   8  (bases 1 to 2534)
  AUTHORS   Zhang,Z., Futamura,M., Vikis,H.G., Wang,M., Li,J., Wang,Y.,
            Guan,K.L. and You,M.
  TITLE     Positional cloning of the major quantitative trait locus underlying
            lung tumor susceptibility in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (22), 12642-12647 (2003)
   PUBMED   14583591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY485608.1, CJ202396.1 and BB374869.1.
            
            On Dec 31, 2009 this sequence version replaced NM_177222.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY485608.1, AY485607.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2462              AY485608.1         1-2462
            2463-2528           CJ202396.1         336-401
            2529-2534           BB374869.1         258-263
FEATURES             Location/Qualifiers
     source          1..2534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.37 cM"
     gene            1..2534
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /note="dynein axonemal intermediate chain 7"
                     /db_xref="GeneID:320662"
                     /db_xref="MGI:MGI:2444480"
     exon            1..164
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2354
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /note="lung adenoma susceptibility 1; cancer
                     susceptibility candidate protein 1; dynein intermediate
                     chain CFAP94, axonemal; lung adenoma susceptibility
                     protein 1; cancer susceptibility candidate gene 1 protein
                     homolog; protein CASC1; cancer susceptibility candidate 1;
                     cilia and flagella associated protein 94"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 7"
                     /protein_id="NP_796196.3"
                     /db_xref="CCDS:CCDS39705.1"
                     /db_xref="GeneID:320662"
                     /db_xref="MGI:MGI:2444480"
                     /translation="MAPKSKKAPSKKKMTKAERLRLMQEEEERRLKEEEEARLKFEKE
                     EQERLEIQRIEREKWSLLEKKDLERRSQELEELALLEGCFPEAEKQKREIRALAQWKH
                     YTECDGSPDPWVAQEMNTFISLWEEEKNQAFEQVMEKSKLVLSLIEKVKLILLETPTY
                     ELDHRTVLQHQGSILRLQELLSLKINVATELLLRQASNLADLDTGNMEKIIKDENVTL
                     YVWANLKKNPRHRSVRFSETQIGFEIPRILATSNVALRLLHTRYDHITPLFPIAVTEQ
                     NQNPVGAEQVNVEESTEKAMTEEKLFTEEKAANEDEQPKAEQERELNLVQEENKYEAI
                     ENTVLQRTSDSEGEDSQTTQLELEMKLLSEAVLAAQLCLVENVVELPEASQAYKVDLC
                     HFSTLGGVYHLDVLELPPQCKPVKGWVLVEILQEGLQRFIYPPDTTEEPDPDVTFPPI
                     EVTLEIHKSVIFFERPRVVRWDNEGKFWRSDGISSVYYNREDRLLTFSMDTLGPVTLI
                     QDAHVNMPYQSWEMSPCGMNKVLLIVKTVFMELQIYIKENLCMLASVKLRGKGLEFHL
                     KGKWMAPIPFILALKEAGLNIFPAVYSHFYVVINNKVPQVELKAYRQMALLSSAFSFG
                     WSKWNMVCNSTRVVIRVREQLSEETEHHTWSLLMFSGDRAQMLKMQEENDKFSEALRE
                     GTEFHSTLYHMMKDFASPVAMERVRHSNCQFIDSVCYMLLSIRVLSYS"
     exon            165..182
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..264
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..356
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..458
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..596
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..743
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..847
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1184
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1266
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1427
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1584
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1799
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1967
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2081
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2534
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /note="hexamer: AATAAA"
     polyA_site      2531
                     /gene="Dnai7"
                     /gene_synonym="A230084G12Rik; Casc1; Cfap94; Las1"
                     /note="major polyA site"
ORIGIN      
        1 gacttgggca gtactcaccg gaagactaca gtgcgattgc gcaggttgtc cttcgcaaaa
       61 cactgggagt tgtgagtggg cgtggcctgt cgtcttgaca accgtgagcg ttcctgctct
      121 gcagagttca cttatcccta agcaaagttc ctgcttctgt catggctccc aaatcaaaaa
      181 aggctcccag taagaaaaag atgaccaaag ccgagcgact gcggctgatg caggaggagg
      241 aggagagacg cctgaaggag gaagaagagg cgcggctgaa atttgaaaaa gaagaacagg
      301 aaaggctaga aatacagcgg attgagagag agaagtggag tctgctggaa aagaaagacc
      361 tagaacgaag aagccaagag cttgaagagc ttgctctgct cgagggttgt tttcctgaag
      421 cagagaaaca gaagcgggaa attcgagctc tggctcagtg gaagcactac acggagtgtg
      481 atgggagccc cgacccttgg gttgcccagg aaatgaacac gttcattagc ctgtgggaag
      541 aggagaagaa ccaggccttt gaacaagtga tggagaaaag caaactggtg ctgtcgttga
      601 ttgaaaaggt gaagttaatt ttactggaaa ctccgacata tgagctggac cacaggactg
      661 tcctgcagca tcaagggtca attctgcgcc tacaagagct gctcagcctg aagatcaacg
      721 tggccacaga actacttctt cgacaagcta gtaacttagc agatctggac actgggaata
      781 tggagaaaat catcaaagat gagaatgtca ccctgtacgt gtgggcaaac ctcaaaaaga
      841 atccaaggca ccggagtgtg aggttctcag agacacaaat tggatttgaa atcccaagga
      901 tcctggccac gagcaatgtt gctcttcggc ttctacacac acgctatgac cacatcacac
      961 ccttgttccc cattgccgtc actgagcaaa atcagaaccc cgtgggagca gagcaagtca
     1021 acgtcgagga aagtacagaa aaggccatga ctgaagaaaa gctctttact gaagaaaaag
     1081 ctgccaacga agatgagcag cccaaggctg aacaggaaag agagctcaac ttggttcaag
     1141 aggagaacaa atatgaagct atagagaaca ctgtcttaca aaggacttcc gactctgaag
     1201 gggaggattc ccaaaccacc caacttgaac tggagatgaa gctgctgagt gaagcagtct
     1261 tagcagcaca gctgtgcctg gtagagaatg tggtggaatt gccagaagcc tcacaagcct
     1321 acaaggtgga cttgtgccat ttctctaccc tgggcggcgt gtaccacctg gatgttctgg
     1381 agctgccccc tcagtgcaag cctgtgaagg gctgggtgct agtggagata ctccaggaag
     1441 gactgcagag gtttatatat cctccagaca ccacagagga acctgatcca gacgtcacct
     1501 tcccacccat agaggtcaca ctggagatcc acaagagcgt catcttcttt gagcgcccta
     1561 gggtcgtcag gtgggacaat gaaggtaaat tctggcggtc agatggcatc agcagtgtct
     1621 attacaaccg agaagacagg ctcctaacct tcagtatgga tactttgggc cctgtgacct
     1681 tgattcagga tgctcacgtg aacatgcctt accagtcctg ggagatgagt ccctgtggca
     1741 tgaacaaagt ccttctaata gtgaagacgg ttttcatgga gctccagata tacatcaagg
     1801 aaaacctctg catgctggct tcagtgaaac tgaggggcaa gggactcgag tttcatctaa
     1861 aaggaaaatg gatggctcct atacccttca ttctggcttt gaaagaggcc gggctgaaca
     1921 tcttccctgc tgtatactcc catttttatg tggtcatcaa caataaggta ccccaggtgg
     1981 agttgaaggc ctatcggcaa atggccctgc tgagctctgc cttctcgttt ggctggagca
     2041 agtggaacat ggtctgcaat tccacaaggg ttgtgattcg ggtgagggaa caactgtcag
     2101 aagaaacaga gcaccatacc tggtcgctcc tcatgttcag tggtgacaga gcgcagatgc
     2161 tcaagatgca ggaagagaac gacaagttct cggaggccct cagggagggc accgagttcc
     2221 actccacctt gtaccacatg atgaaggact tcgcctcccc cgtggcaatg gagagggtca
     2281 ggcattcgaa ctgccagttc atcgactcag tgtgctacat gctgctgtct atccgcgtcc
     2341 tcagctattc ctagctattc ctagccctta cagcgtgtgt aagcatggtg gacccttata
     2401 ccgagaggaa tcaggtatct ttccagtcag ccgctaaagt gatttaagag caccaggcgt
     2461 tccagccaca ctgcacaaag atttgaatgg tctttatttg gatacatctc aataaagtct
     2521 gatgcctctc actc
//
