LOCUS       NM_172864               3082 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus dynein axonemal intermediate chain 3 (Dnai3), mRNA.
ACCESSION   NM_172864 XM_916188
VERSION     NM_172864.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3082)
  AUTHORS   Zhao,K., Wang,D., Zhao,X., Wang,C., Gao,Y., Liu,K., Wang,F., Wu,X.,
            Wang,X., Sun,L., Zang,J. and Mei,Y.
  TITLE     WDR63 inhibits Arp2/3-dependent actin polymerization and mediates
            the function of p53 in suppressing metastasis
  JOURNAL   EMBO Rep 21 (4), e49269 (2020)
   PUBMED   32128961
  REMARK    GeneRIF: WDR63 inhibits Arp2/3-dependent actin polymerization and
            mediates the function of p53 in suppressing metastasis.
REFERENCE   2  (bases 1 to 3082)
  AUTHORS   Zhang,Y., Chen,Y., Zheng,J., Wang,J., Duan,S., Zhang,W., Yan,X. and
            Zhu,X.
  TITLE     Vertebrate Dynein-f depends on Wdr78 for axonemal localization and
            is essential for ciliary beat
  JOURNAL   J Mol Cell Biol 11 (5), 383-394 (2019)
   PUBMED   30060180
REFERENCE   3  (bases 1 to 3082)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   4  (bases 1 to 3082)
  AUTHORS   Young,S.A., Miyata,H., Satouh,Y., Kato,H., Nozawa,K., Isotani,A.,
            Aitken,R.J., Baker,M.A. and Ikawa,M.
  TITLE     CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines
            Identified Ccdc63 as Essential for Spermiogenesis
  JOURNAL   Int J Mol Sci 16 (10), 24732-24750 (2015)
   PUBMED   26501274
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3082)
  AUTHORS   Diao,S., Yang,D.M., Dong,R., Wang,L.P., Wang,J.S., Du,J., Wang,S.L.
            and Fan,Z.
  TITLE     Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced
            osteogenic differentiation potentials of stem cells from apical
            papilla
  JOURNAL   J Endod 41 (2), 205-211 (2015)
   PUBMED   25498833
REFERENCE   6  (bases 1 to 3082)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   7  (bases 1 to 3082)
  AUTHORS   Takeda,S., Yonekawa,Y., Tanaka,Y., Okada,Y., Nonaka,S. and
            Hirokawa,N.
  TITLE     Left-right asymmetry and kinesin superfamily protein KIF3A: new
            insights in determination of laterality and mesoderm induction by
            kif3A-/- mice analysis
  JOURNAL   J Cell Biol 145 (4), 825-836 (1999)
   PUBMED   10330409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029903.1 and BX631982.1.
            
            On Sep 4, 2008 this sequence version replaced NM_172864.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029903.1, BC158119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-424               AK029903.1         2-425
            425-3081            AK029903.1         427-3083
            3082-3082           BX631982.1         4-4                 c
FEATURES             Location/Qualifiers
     source          1..3082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.03 cM"
     gene            1..3082
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /note="dynein axonemal intermediate chain 3"
                     /db_xref="GeneID:242253"
                     /db_xref="MGI:MGI:3045269"
     exon            1..124
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            125..211
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2910
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /note="WD repeat domain 63; WD repeat-containing protein
                     63; dynein intermediate chain 3, axonemal"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 3"
                     /protein_id="NP_766452.2"
                     /db_xref="CCDS:CCDS17899.2"
                     /db_xref="GeneID:242253"
                     /db_xref="MGI:MGI:3045269"
                     /translation="MAPKPPKSPKGQKKGKKNMKQQLLVPEEEEPMNMESMGHPEIYP
                     LVLTTKTQEIFNCRVDEDMTDEQTYKLIKKEDILADLQNRAAVSDFHPVKKIVREYPG
                     EELLLVYDKDFKYGLNFYLIGTEDGKENFLKPPEVPEEQEEPKEHVQEDVYVYNPPVS
                     KPWVSLGSEKEIEEESVQESGKRVTYMISRKRSEFGAPVTFSDQNASSVKDAYIECTS
                     YPEKNYTLSQVEKDVGLQVIAEVKDTSTQTKWAFPKNATTQYYPREFSEEEKSLIGKS
                     KSLVDFFNNVSTSVEVALQQNEIMNTFIDDWKNLAEEESTFGDKTDTHLKEYQSFTDL
                     HNTMEKMITCVSWHPTIFGLIVVSVAVRLSYEERVQNSGRLLLQPSLLLFWSFSDPIH
                     PQLMLESPDDIFCFEFCPSDPNIIAGGCINGQIVLWDITAHADRIENIKTGGHRSKKT
                     SLKPMFLLEPDSNKESMYIRHCAVSSIENGHRKVITDIHWLPDSFEINRMGSVFENRS
                     GINCQLVTCSADCTICFWDIRPQKPAVTAAAAASAATTATNNANSQQSPVEKKKEENI
                     DIPFDVPSTFLHLDLSWKPLSRLKLSKGDTSLDHCPTKLSLGEDPFLCKIQGTSSIHI
                     ILRDKMLSQIKMVKTSEINPYQNLEAGIANILKPIEDFCTKFFVGTEEGEVIYTDWKM
                     ERDSDTGRLMAKKPVSLYTVHDGAVHTIQRSPFFNDIVLTVGGWNVAIWKEEVMTGPL
                     LQTCCGPKRYTAGHWSLTRPGVFYIGREDGNVDIWDLLEKTHEPAQSQNICITMITYI
                     KPWTFSSKQQFIAVADYYGTLHILEIPWTLSHPSLNEVSSVNYYFEREVRHLEYVQQR
                     KEIREQEKIDMALELVKKKAKIYQKTKEQMEAELKLEYESYLDLEKSVLFALGLSKVS
                     EKKSYLDSH"
     exon            212..250
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            251..432
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            433..537
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            538..687
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            688..887
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1004
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1195
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1320
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1410
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1497
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1626
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1700
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1902
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1990
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2151
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2215
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2346
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2551
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2643
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2766
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..3082
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /note="hexamer: ATTAAA"
     polyA_site      3082
                     /gene="Dnai3"
                     /gene_synonym="4931433A13Rik; IC140; Ida7; Wdr63"
                     /note="major polyA site"
ORIGIN      
        1 ggaaatttga ggtttatttt cctgagcaag aagagtcaga cagactccca cctcctactc
       61 tcgaaggagc gtttctcccg ggaactgcca agaagctgcc ttcttttccc tttagtgatt
      121 ccagcctaca tcagagccat ggcacccaag ccaccgaaga gccccaaggg ccagaaaaag
      181 ggcaaaaaga atatgaagca acagttactt gttcctgagg aagaggagcc catgaacatg
      241 gagagcatgg gccatccaga aatttatcca ctagtattaa ctaccaagac ccaggaaata
      301 ttcaactgtc gagtagatga agatatgaca gacgaacaaa cgtataagct tatcaaaaag
      361 gaagatatct tggcagactt gcaaaaccga gccgcagtat ctgacttcca cccagtcaaa
      421 aaaattgtcc gggagtaccc aggggaggaa cttctcctcg tttatgacaa agacttcaag
      481 tatggactta acttttacct cattggaaca gaggacggca aggagaactt tttaaagcca
      541 ccagaagtgc cagaggaaca agaagagccc aaggagcacg tccaagaaga cgtgtacgtc
      601 tacaatcctc ccgtctccaa gccatgggtg tcgctgggca gcgagaaaga aattgaggaa
      661 gaatctgtcc aggaatcagg aaagcgggtg acctacatga tttctagaaa acggagtgaa
      721 tttggtgcac cagtgacttt cagtgaccag aatgcctcta gcgtaaaaga tgcctacatt
      781 gagtgtacgt cttacccaga gaaaaattac accctctcac aagttgagaa agatgtcggc
      841 ttgcaagtca ttgctgaagt caaggacaca agcacgcaga caaaatgggc ttttcctaaa
      901 aatgctacca ctcagtatta tccaagagaa ttctcagaag aggaaaaaag cctcatcgga
      961 aaatcaaaat ctttggtcga ctttttcaac aatgtgtcca caagcgttga agtagccctg
     1021 cagcagaatg agatcatgaa cacgtttatc gacgactgga agaacctcgc agaggaggag
     1081 agcacctttg gggacaagac tgacacccat ctgaaggagt accagtcctt tacagacctt
     1141 cacaacacca tggagaaaat gattacctgt gtctcttggc acccgaccat cttcgggctc
     1201 atagtcgtgt ctgtggccgt gcgcctctcc tatgaagaga gagtccagaa ttccggcaga
     1261 ctgctgctgc agccgtcact gctcctcttc tggagcttct ccgaccccat ccaccctcag
     1321 ttgatgctgg agagcccgga tgacatcttc tgcttcgagt tctgtccaag tgaccccaat
     1381 atcatcgccg gaggctgcat taacggacag atcgtcttgt gggatatcac ggcacacgcg
     1441 gaccgcatag agaacatcaa gacgggcggc cacagaagta aaaagacctc tctcaagccc
     1501 atgtttctcc ttgaaccaga cagcaataaa gaatcgatgt acatcagaca ctgtgcagtg
     1561 tcttccattg aaaatggcca taggaaagta atcacggata tacactggct gcccgactca
     1621 ttcgagatta acaggatggg atccgtcttt gagaaccgaa gtggaataaa ttgtcagctc
     1681 gtcacatgct cagcagactg cacgatttgt ttttgggata tccggcccca aaaacctgca
     1741 gtcacagctg cagctgcagc ctcagcagca accacagcca ccaacaacgc aaactcccag
     1801 caatcaccgg tagagaagaa gaaagaagaa aacattgaca ttccctttga tgtgccctcg
     1861 actttcttgc acctagatct ctcctggaaa cccctgtcta gattaaaact gtctaagggt
     1921 gatacaagtt tagaccactg tccaaccaag ctgagcctgg gcgaagaccc ttttctttgc
     1981 aaaatacaag gtacgtcgtc cattcatatt attctgagag acaagatgtt aagtcagatc
     2041 aagatggtga agacgtcaga aattaacccc taccaaaacc tggaagcagg gatagccaat
     2101 atcctcaagc cgatagagga cttctgcacg aagttcttcg tgggaacaga ggaaggtgag
     2161 gtgatataca cagactggaa aatggagagg gactctgaca ccggacgact tatggccaag
     2221 aaacctgtga gcctctacac cgtccacgat ggggctgtcc acaccatcca gaggtcgcct
     2281 ttcttcaatg acatcgtcct cactgttggg ggatggaatg tggctatctg gaaggaggag
     2341 gtcatgacgg gaccgctcct tcaaacgtgc tgcggaccga aaaggtacac ggcaggacac
     2401 tggtccctga cgaggcctgg agtgttctac atcggccgag aggacggaaa tgtcgatatc
     2461 tgggacctcc tggagaaaac tcacgagcca gcccagtccc agaatatctg catcaccatg
     2521 atcacctaca tcaaaccctg gaccttctcc tctaagcagc agtttatagc cgtagctgac
     2581 tattacggaa cactgcacat cctagaaatc ccttggacct taagtcaccc ttccttgaat
     2641 gaggtatcga gtgtgaacta ctactttgag agagaagtca gacacctgga atacgtccag
     2701 cagcgcaaag aaatccgtga gcaagaaaag atagatatgg ccctggaact ggtgaagaag
     2761 aaagcgaaaa tctatcaaaa gacaaaagag caaatggagg ccgagctgaa gttggaatac
     2821 gagagctatc tggatcttga gaagtctgtc ctcttcgccc tcggcctcag caaagtctca
     2881 gagaagaagt cctacttgga ttcacattag caaagactct cgaagacagc tcctggggga
     2941 ccccgctggc cttccctctc tttactgagt gtgcgtttta ttttatgtaa ggtaagatag
     3001 caagctgatc atatataggt ttattcgtaa atgctgactt ttatgtaact ggcattaaaa
     3061 caattaaatc ctatcaaatc ta
//
