LOCUS       NM_001034878            2883 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus dynein axonemal intermediate chain 2 (Dnai2), mRNA.
ACCESSION   NM_001034878
VERSION     NM_001034878.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2883)
  AUTHORS   Serra,C.F.H., Liu,H., Qian,J., Mori,M., Lu,J. and Cardoso,W.V.
  TITLE     Prominin 1 and Notch regulate ciliary length and dynamics in
            multiciliated cells of the airway epithelium
  JOURNAL   iScience 25 (8), 104751 (2022)
   PUBMED   35942101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2883)
  AUTHORS   Rojas,T., Cheng,W., Gao,Z., Liu,X., Wang,Y., Malla,A.P., Chin,A.C.,
            Romer,L.H., Snyder,S.H. and Fu,C.
  TITLE     Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover
            via interactions with dynein intermediate chain 2
  JOURNAL   Proc Natl Acad Sci U S A 116 (8), 3278-3287 (2019)
   PUBMED   30718399
REFERENCE   3  (bases 1 to 2883)
  AUTHORS   Yang,Z., Xu,B., Hu,X., Yao,X., Tang,Y., Qian,C., Wang,S., Chen,H.,
            Bai,X. and Wu,J.
  TITLE     Dynein axonemal intermediate chain 2 plays a role in gametogenesis
            by activation of Stat3
  JOURNAL   J Cell Mol Med 23 (1), 417-425 (2019)
   PUBMED   30387321
  REMARK    GeneRIF: Dnaic2 plays a role in oogenesis and spermatogenesis by
            activation of Stat3.
REFERENCE   4  (bases 1 to 2883)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2883)
  AUTHORS   Shorter,S.L., Albaghdadi,A.J. and Kan,F.W.
  TITLE     Alterations in oviductal cilia morphology and reduced expression of
            axonemal dynein in diabetic NOD mice
  JOURNAL   Tissue Cell 48 (6), 588-595 (2016)
   PUBMED   27823762
  REMARK    GeneRIF: Results obtained with Western blot analysis revealed that
            the expression of DNAI2 protein was significantly less in oviducts
            of dNOD mice as compared to that of cNOD mice corroborating the
            results obtained with immunohistochemistry
REFERENCE   6  (bases 1 to 2883)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   7  (bases 1 to 2883)
  AUTHORS   Matsuo,M., Shimada,A., Koshida,S., Saga,Y. and Takeda,H.
  TITLE     The establishment of rotational polarity in the airway and
            ependymal cilia: analysis with a novel cilium motility mutant mouse
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 304 (11), L736-L745 (2013)
   PUBMED   23525783
REFERENCE   8  (bases 1 to 2883)
  AUTHORS   Omran,H., Kobayashi,D., Olbrich,H., Tsukahara,T., Loges,N.T.,
            Hagiwara,H., Zhang,Q., Leblond,G., O'Toole,E., Hara,C., Mizuno,H.,
            Kawano,H., Fliegauf,M., Yagi,T., Koshida,S., Miyawaki,A.,
            Zentgraf,H., Seithe,H., Reinhardt,R., Watanabe,Y., Kamiya,R.,
            Mitchell,D.R. and Takeda,H.
  TITLE     Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal
            dyneins
  JOURNAL   Nature 456 (7222), 611-616 (2008)
   PUBMED   19052621
REFERENCE   9  (bases 1 to 2883)
  AUTHORS   Yang,Z. and Wu,J.
  TITLE     Mouse dynein axonemal intermediate chain 2: cloning and expression
  JOURNAL   DNA Cell Biol 27 (9), 479-488 (2008)
   PUBMED   18547164
  REMARK    GeneRIF: These data suggest that Dnaic2 plays a role in ovarian
            follicular development.
REFERENCE   10 (bases 1 to 2883)
  AUTHORS   Geremek,M. and Witt,M.
  TITLE     Primary ciliary dyskinesia: genes, candidate genes and chromosomal
            regions
  JOURNAL   J Appl Genet 45 (3), 347-361 (2004)
   PUBMED   15306728
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB867928.1, AK138639.1, BM950889.1, AK081229.1, CJ049712.1,
            AL663079.9 and BE946605.1.
            
            On Jul 6, 2018 this sequence version replaced NM_001034878.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.60716.1,
                                           SRR10662774.2750597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               BB867928.1         9-365
            358-690             AK138639.1         292-624
            691-1241            BM950889.1         2-552
            1242-1871           AK081229.1         553-1182
            1872-2115           CJ049712.1         172-415
            2116-2719           AL663079.9         76305-76908
            2720-2883           BE946605.1         1-164               c
FEATURES             Location/Qualifiers
     source          1..2883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.19 cM"
     gene            1..2883
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /note="dynein axonemal intermediate chain 2"
                     /db_xref="GeneID:432611"
                     /db_xref="MGI:MGI:2685574"
     exon            1..357
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            358..560
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..2249
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /note="dynein, axonemal, intermediate polypeptide 2;
                     dynein intermediate chain 2, axonemal"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 2"
                     /protein_id="NP_001030050.2"
                     /db_xref="CCDS:CCDS36366.1"
                     /db_xref="GeneID:432611"
                     /db_xref="MGI:MGI:2685574"
                     /translation="MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVER
                     NPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEK
                     DENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQE
                     IKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSP
                     LVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKT
                     GTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFM
                     VGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWS
                     EDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKV
                     CDDPLFCLRVQDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREK
                     ILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAE
                     ALKKKPKPRKKSSVKVEAEEEVEENVGEEEEAGGIIGIDAVEDMSEEAGEEQEDVPT"
     exon            561..722
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            723..844
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            845..987
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1101
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1241
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1364
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1588
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1724
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1871
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2099
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2867
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /note="hexamer: ATTAAA"
     polyA_site      2864
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /note="major polyA site"
ORIGIN      
        1 agccgtttaa gctgcgctgg agctgggact ggtcttgggc gcttctcctg ggctgtgtgg
       61 caggaggtga gccaggataa ggggcgggcg tcctagagga cgtccaagcc cgaaagaaga
      121 cctggcaaaa agagggaaaa gctctcgagg gtaataatca ccaacagtgc aagaaatctc
      181 ggagaactgt caggtgctgg aatcagctca ttctgctgca ttaatcctcg ctgccctgaa
      241 tattcttcaa gctccaggac ctcctcagcc tccaagcacc ttgccttctg cacttctcca
      301 ccaggccctg acccgggctg tgacccggag tgggcgggac ctctttctgg ctttcagccg
      361 cggtcacggt cgccgccatg gagatcgtct acgtgtacct gaagaagcgc agcgaatttg
      421 ggaagcaatg caacttctca gatcgccagg ctgagctgaa catcgacatc ttacccaacc
      481 ccgagctggc cgcactgtat gtggagcgga atccagtaga cacaggcatc cagtgctccg
      541 ccagtatgtc ggaacacgag gccaacaccg agcggttcga gatggagagc tgtggcgtta
      601 atcatgtcga ggggggctgg cccaaggatg tgaaccccca ggagctggag cagaccatcc
      661 gtttccggaa gaaagtggag aaggatgaga actacatcaa cgccgtcatg cagctgggct
      721 cgatcatgga gcactgcatc aagcagaaca acgccatcga catctacgag gaatactttg
      781 atgacgagga ggccgtggag gtgactgaag aagccccttc ggccaagacc atcaatgtct
      841 tcagggaccc tcaggagatc aagcggacag ctacacacct ctcctggcac cctgatggca
      901 acaggaagct ggcagtagcc tattcctgct tgaagttcca gcgcgcaccc atgagcatga
      961 actacgactc ctacatctgg gacctggaaa accccaaccg acctgagatt gccctgaagc
     1021 cgttgtctcc tctcgtcacc ctggagtaca accccaagga ttcccacgtg ctcctagggg
     1081 gctgctacaa tgggcagata gcctgctggg atacccggaa gggcagcctg gtggcagagc
     1141 tgtccaccat cgagttcagc caccgagacc cagtgtatgg caccatctgg ctgcagtcaa
     1201 agacaggcac tgagtgcttc tcagcatcca ctgatgggca ggtcatgtgg tgggacatcc
     1261 gcaagatcag cgagcccatc gaagttgtca ttatggacat ttccagaaag gagcagctgg
     1321 agaacgccct gggcgccatc tccttggagt tcgagtctac cttgccaacc aagttcatgg
     1381 tgggcaccga acagggcatc gtcatctcct gcaaccgcaa ggccaagacg caagcagaga
     1441 agattgtttg caccttttat ggccaccacg gccccatcta tgccctccag agaaacccct
     1501 tctacccaaa gaactttctg actgttggag actggacagc ccgcatctgg tctgaggaca
     1561 gtcgggagtc atcgatcatg tggaccaagt accacatggc ttacctctcc gatggagcct
     1621 ggagtcctgt gagaccagcc gttttcttca ccaccaagat ggatgggacc ctggacatct
     1681 gggacttggt gttcaagcag tgtgaccctg ccctcagcct aaaggtgtgt gatgacccac
     1741 tcttctgcct ccgggttcag gacaacgggt gtctcatcgc gtgtggctcc gagctcggga
     1801 cgaccactct gctggaggtc tccagcagtc tctccactct gcagaggaat gagaagaaca
     1861 tagcttcttc catatttgaa cgtgaaaccc ggcgggaaaa gatcctggag gccaggcacc
     1921 gtgagatgcg actgaaggag aaaggcaagg tggagggcaa agaggatgac cagaaggagg
     1981 aggaggcagc cctggacctt gatgagctag ttggcaaagc agaggaggag ttctttgaag
     2041 tcatcttctc agagctgaag aggaaggagg cagaggcctt gaagaagaaa ccgaagccta
     2101 ggaaaaaatc aagtgtcaag gtggaagccg aagaggaagt ggaagaaaat gttggagagg
     2161 aggaagaagc aggtggcata ataggtatag atgcagttga agacatgagt gaagaagcag
     2221 gtgaagagca agaggatgtg cccacctagg gcagcctctg cccacggcac tgtcccttcg
     2281 tgctcacggc ttggacttcc acttgatacc gtctcatctg aaaagcgaaa agttgagttt
     2341 ccttcttcaa taattattgg tggggacaga tcagggacaa gtcactggcc cacactgggc
     2401 caagccccga atgcaccctt ctttagggtg ggaaggggta gggcttgtct ctctgctaac
     2461 tcccccggcc tcggcaaccc tgaggcgaac tcagattcag ggcacacaca cagccttaag
     2521 tcagacttta gatgggaccc tagattctgc ttattatggg ttatccaatg agtagttacc
     2581 aaggcctttt tccagaagct tccagagctc agctgagctc acctctgccc cacaggggcc
     2641 tctggagcgc ctgcacaggg gcaagcttct ctctctctct ttgtccatct gtaaaacctt
     2701 cccaagcaac cccccagggg gcatcttgac ctatggtcac acggtggggg gcggggcgcc
     2761 cccaagtgtg gagagtaggt aggtaggatg aactggactc tccctgtaca cacgtggttt
     2821 ttattgcttt gcttcttata acattaaatc agtgataaca cccatcaaaa aaaaaaaaaa
     2881 aaa
//
