LOCUS       NP_001030050             623 aa            linear   ROD 27-APR-2025
DEFINITION  dynein axonemal intermediate chain 2 [Mus musculus].
ACCESSION   NP_001030050
VERSION     NP_001030050.2
DBSOURCE    REFSEQ: accession NM_001034878.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 623)
  AUTHORS   Serra,C.F.H., Liu,H., Qian,J., Mori,M., Lu,J. and Cardoso,W.V.
  TITLE     Prominin 1 and Notch regulate ciliary length and dynamics in
            multiciliated cells of the airway epithelium
  JOURNAL   iScience 25 (8), 104751 (2022)
   PUBMED   35942101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 623)
  AUTHORS   Rojas,T., Cheng,W., Gao,Z., Liu,X., Wang,Y., Malla,A.P., Chin,A.C.,
            Romer,L.H., Snyder,S.H. and Fu,C.
  TITLE     Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover
            via interactions with dynein intermediate chain 2
  JOURNAL   Proc Natl Acad Sci U S A 116 (8), 3278-3287 (2019)
   PUBMED   30718399
REFERENCE   3  (residues 1 to 623)
  AUTHORS   Yang,Z., Xu,B., Hu,X., Yao,X., Tang,Y., Qian,C., Wang,S., Chen,H.,
            Bai,X. and Wu,J.
  TITLE     Dynein axonemal intermediate chain 2 plays a role in gametogenesis
            by activation of Stat3
  JOURNAL   J Cell Mol Med 23 (1), 417-425 (2019)
   PUBMED   30387321
  REMARK    GeneRIF: Dnaic2 plays a role in oogenesis and spermatogenesis by
            activation of Stat3.
REFERENCE   4  (residues 1 to 623)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 623)
  AUTHORS   Shorter,S.L., Albaghdadi,A.J. and Kan,F.W.
  TITLE     Alterations in oviductal cilia morphology and reduced expression of
            axonemal dynein in diabetic NOD mice
  JOURNAL   Tissue Cell 48 (6), 588-595 (2016)
   PUBMED   27823762
  REMARK    GeneRIF: Results obtained with Western blot analysis revealed that
            the expression of DNAI2 protein was significantly less in oviducts
            of dNOD mice as compared to that of cNOD mice corroborating the
            results obtained with immunohistochemistry
REFERENCE   6  (residues 1 to 623)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   7  (residues 1 to 623)
  AUTHORS   Matsuo,M., Shimada,A., Koshida,S., Saga,Y. and Takeda,H.
  TITLE     The establishment of rotational polarity in the airway and
            ependymal cilia: analysis with a novel cilium motility mutant mouse
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 304 (11), L736-L745 (2013)
   PUBMED   23525783
REFERENCE   8  (residues 1 to 623)
  AUTHORS   Omran,H., Kobayashi,D., Olbrich,H., Tsukahara,T., Loges,N.T.,
            Hagiwara,H., Zhang,Q., Leblond,G., O'Toole,E., Hara,C., Mizuno,H.,
            Kawano,H., Fliegauf,M., Yagi,T., Koshida,S., Miyawaki,A.,
            Zentgraf,H., Seithe,H., Reinhardt,R., Watanabe,Y., Kamiya,R.,
            Mitchell,D.R. and Takeda,H.
  TITLE     Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal
            dyneins
  JOURNAL   Nature 456 (7222), 611-616 (2008)
   PUBMED   19052621
REFERENCE   9  (residues 1 to 623)
  AUTHORS   Yang,Z. and Wu,J.
  TITLE     Mouse dynein axonemal intermediate chain 2: cloning and expression
  JOURNAL   DNA Cell Biol 27 (9), 479-488 (2008)
   PUBMED   18547164
  REMARK    GeneRIF: These data suggest that Dnaic2 plays a role in ovarian
            follicular development.
REFERENCE   10 (residues 1 to 623)
  AUTHORS   Geremek,M. and Witt,M.
  TITLE     Primary ciliary dyskinesia: genes, candidate genes and chromosomal
            regions
  JOURNAL   J Appl Genet 45 (3), 347-361 (2004)
   PUBMED   15306728
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB867928.1, AK138639.1, BM950889.1, AK081229.1, CJ049712.1,
            AL663079.9 and BE946605.1.
            
            On Sep 7, 2006 this sequence version replaced NP_001030050.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.60716.1,
                                           SRR10662774.2750597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.19 cM"
     Protein         1..623
                     /product="dynein axonemal intermediate chain 2"
                     /note="dynein, axonemal, intermediate polypeptide 2;
                     dynein intermediate chain 2, axonemal"
                     /calculated_mol_wt=70837
     Region          165..212
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          166..472
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(180,201..202,215,234,238,244..245,261..262,281,286,
                     292..293,308,336,346,362..363,381,385,391..392,405..406,
                     424,429,435..436,448..449,469)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          214..254
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AC93.2)"
     Region          220..259
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          261..302
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AC93.2)"
     Region          266..361
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          318..351
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          362..401
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AC93.2)"
     Region          367..403
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          405..445
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AC93.2)"
     Region          410..435
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          450..489
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AC93.2)"
     Region          565..602
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AC93.2)"
     CDS             1..623
                     /gene="Dnai2"
                     /gene_synonym="b2b3405Clo; C030015H18Rik; Dnaic2; Gm728"
                     /coded_by="NM_001034878.3:378..2249"
                     /db_xref="CCDS:CCDS36366.1"
                     /db_xref="GeneID:432611"
                     /db_xref="MGI:MGI:2685574"
ORIGIN      
        1 meivyvylkk rsefgkqcnf sdrqaelnid ilpnpelaal yvernpvdtg iqcsasmseh
       61 eanterfeme scgvnhvegg wpkdvnpqel eqtirfrkkv ekdenyinav mqlgsimehc
      121 ikqnnaidiy eeyfddeeav evteeapsak tinvfrdpqe ikrtathlsw hpdgnrklav
      181 aysclkfqra pmsmnydsyi wdlenpnrpe ialkplsplv tleynpkdsh vllggcyngq
      241 iacwdtrkgs lvaelstief shrdpvygti wlqsktgtec fsastdgqvm wwdirkisep
      301 ievvimdisr keqlenalga islefestlp tkfmvgteqg iviscnrkak tqaekivctf
      361 yghhgpiyal qrnpfypknf ltvgdwtari wsedsressi mwtkyhmayl sdgawspvrp
      421 avffttkmdg tldiwdlvfk qcdpalslkv cddplfclrv qdngcliacg selgtttlle
      481 vssslstlqr nekniassif eretrrekil earhremrlk ekgkvegked dqkeeeaald
      541 ldelvgkaee effevifsel krkeaealkk kpkprkkssv kveaeeevee nvgeeeeagg
      601 iigidavedm seeageeqed vpt
//
