LOCUS       NM_175138               2508 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus dynein axonemal intermediate chain 1 (Dnai1), mRNA.
ACCESSION   NM_175138
VERSION     NM_175138.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Wildung,M., Herr,C., Riedel,D., Wiedwald,C., Moiseenko,A.,
            Ramirez,F., Tasena,H., Heimerl,M., Alevra,M., Movsisyan,N.,
            Schuldt,M., Volceanov-Hahn,L., Provoost,S., Nothe-Menchen,T.,
            Urrego,D., Freytag,B., Wallmeier,J., Beisswenger,C., Bals,R., van
            den Berge,M., Timens,W., Hiemstra,P.S., Brandsma,C.A., Maes,T.,
            Andreas,S., Heijink,I.H., Pardo,L.A. and Lize,M.
  TITLE     miR449 Protects Airway Regeneration by Controlling
            AURKA/HDAC6-Mediated Ciliary Disassembly
  JOURNAL   Int J Mol Sci 23 (14), 7749 (2022)
   PUBMED   35887096
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2508)
  AUTHORS   Wildung,M., Esser,T.U., Grausam,K.B., Wiedwald,C.,
            Volceanov-Hahn,L., Riedel,D., Beuermann,S., Li,L., Zylla,J.,
            Guenther,A.K., Wienken,M., Ercetin,E., Han,Z., Bremmer,F.,
            Shomroni,O., Andreas,S., Zhao,H. and Lize,M.
  TITLE     Transcription factor TAp73 and microRNA-449 complement each other
            to support multiciliogenesis
  JOURNAL   Cell Death Differ 26 (12), 2740-2757 (2019)
   PUBMED   31068677
REFERENCE   3  (bases 1 to 2508)
  AUTHORS   Yin,W., Livraghi-Butrico,A., Sears,P.R., Rogers,T.D., Burns,K.A.,
            Grubb,B.R. and Ostrowski,L.E.
  TITLE     Mice with a Deletion of Rsph1 Exhibit a Low Level of Mucociliary
            Clearance and Develop a Primary Ciliary Dyskinesia Phenotype
  JOURNAL   Am J Respir Cell Mol Biol 61 (3), 312-321 (2019)
   PUBMED   30896965
REFERENCE   4  (bases 1 to 2508)
  AUTHORS   Rojas,T., Cheng,W., Gao,Z., Liu,X., Wang,Y., Malla,A.P., Chin,A.C.,
            Romer,L.H., Snyder,S.H. and Fu,C.
  TITLE     Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover
            via interactions with dynein intermediate chain 2
  JOURNAL   Proc Natl Acad Sci U S A 116 (8), 3278-3287 (2019)
   PUBMED   30718399
REFERENCE   5  (bases 1 to 2508)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2508)
  AUTHORS   Ostrowski,L.E., Yin,W., Rogers,T.D., Busalacchi,K.B., Chua,M.,
            O'Neal,W.K. and Grubb,B.R.
  TITLE     Conditional deletion of dnaic1 in a murine model of primary ciliary
            dyskinesia causes chronic rhinosinusitis
  JOURNAL   Am J Respir Cell Mol Biol 43 (1), 55-63 (2010)
   PUBMED   19675306
  REMARK    GeneRIF: dnaic1 deletion in a murine model of primary ciliary
            dyskinesia causes chronic rhinosinusitis
REFERENCE   7  (bases 1 to 2508)
  AUTHORS   Jacquet,B.V., Salinas-Mondragon,R., Liang,H., Therit,B., Buie,J.D.,
            Dykstra,M., Campbell,K., Ostrowski,L.E., Brody,S.L. and
            Ghashghaei,H.T.
  TITLE     FoxJ1-dependent gene expression is required for differentiation of
            radial glia into ependymal cells and a subset of astrocytes in the
            postnatal brain
  JOURNAL   Development 136 (23), 4021-4031 (2009)
   PUBMED   19906869
REFERENCE   8  (bases 1 to 2508)
  AUTHORS   Zhang,X., Lei,K., Yuan,X., Wu,X., Zhuang,Y., Xu,T., Xu,R. and
            Han,M.
  TITLE     SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the
            nucleus during neurogenesis and neuronal migration in mice
  JOURNAL   Neuron 64 (2), 173-187 (2009)
   PUBMED   19874786
REFERENCE   9  (bases 1 to 2508)
  AUTHORS   Zariwala,M.A., Leigh,M.W., Ceppa,F., Kennedy,M.P., Noone,P.G.,
            Carson,J.L., Hazucha,M.J., Lori,A., Horvath,J., Olbrich,H.,
            Loges,N.T., Bridoux,A.M., Pennarun,G., Duriez,B., Escudier,E.,
            Mitchison,H.M., Chodhari,R., Chung,E.M., Morgan,L.C., de
            Iongh,R.U., Rutland,J., Pradal,U., Omran,H., Amselem,S. and
            Knowles,M.R.
  TITLE     Mutations of DNAI1 in primary ciliary dyskinesia: evidence of
            founder effect in a common mutation
  JOURNAL   Am J Respir Crit Care Med 174 (8), 858-866 (2006)
   PUBMED   16858015
REFERENCE   10 (bases 1 to 2508)
  AUTHORS   Kishi,M., Kummer,T.T., Eglen,S.J. and Sanes,J.R.
  TITLE     LL5beta: a regulator of postsynaptic differentiation identified in
            a screen for synaptically enriched transcripts at the neuromuscular
            junction
  JOURNAL   J Cell Biol 169 (2), 355-366 (2005)
   PUBMED   15851520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047808.1 and CD775688.1.
            
            On Apr 22, 2009 this sequence version replaced NM_175138.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047808.1, AK030213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2104              AK047808.1         2-2105
            2105-2508           CD775688.1         1-404               c
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.75 cM"
     gene            1..2508
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /note="dynein axonemal intermediate chain 1"
                     /db_xref="GeneID:68922"
                     /db_xref="MGI:MGI:1916172"
     exon            1..225
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2304
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /note="dynein intermediate chain 1, axonemal; axonemal
                     dynein intermediate chain 1"
                     /codon_start=1
                     /product="dynein axonemal intermediate chain 1"
                     /protein_id="NP_780347.2"
                     /db_xref="CCDS:CCDS18066.1"
                     /db_xref="GeneID:68922"
                     /db_xref="MGI:MGI:1916172"
                     /translation="MPSKQIRKQSISVTRGARRRDEDSGTDVGEGTDEWSQSKATVRP
                     PDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKLIGFVNQMAVHFSQVGN
                     LIPKDSDEGRRQHYRDEMVAGSQESIKVVTSEAENLEEEEEPKEGEGEAEAEAEAGSQ
                     TDIPAAAETTEKVIEEELMAPVQPKERKLTNQFNFSERASQTFNNPLRDRECQMEPPP
                     RTNFSATANQWEIYDAYVDELEKQEKTKEKEKAKTPVAKKTEKMAMRKLTSMESQSDD
                     ITKVTQAAKIVERMVNQNTYDDVAQDFKYYEDTADEYRDQEGTLLPLWKFQNDKAKRL
                     AVTALCWNPKYKDLFAVGHGSYDFMKQSRGMLLLYSMKNPSFPEYMFSSESGIMCLDV
                     HVDHPYLVVVGYYDGNVAIYNLKKPHSQPCFRSTSKSGKHTDPVWQVKWQKDDMDHNL
                     NFFSVSSDGRIVSWTLVKSELVHIDIIKLKTEGSTTEIPEGLQLHTVGCGTAFDFHKE
                     IDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMAVDAVLWNPYHTKVFMSCSSDWTV
                     KIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHVFDLAVNKYEAICNQ
                     PVVAKKKNKITHVQFNPIHPIIIVGDDRGHIICLKLSPNLRKMPKEKKGQEVQKGPAV
                     EIAKLDKLLNLVREVKTKT"
     exon            226..258
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..357
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..438
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..565
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..702
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..822
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..882
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1017
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1102
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1220
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1264
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1512
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1602
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1690
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1770
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1919
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2019
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2205
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2491
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="Dnai1"
                     /gene_synonym="1110066F04Rik; b2b1526Clo; Dnaic1"
                     /note="major polyA site"
ORIGIN      
        1 agggaggagc tgatgctgtt ctacaagggc gcgaggaccc acaacgtcag ctgtccccga
       61 agaaccctgg tgactgggaa ttgaagtgga agagagtctg cacttcctgt gtgtggtcaa
      121 gaaggagaaa ctactcccca ggagaggaag cgttttgtag gtttttcagg gtgtgaggtg
      181 ctttctattc ttgcggcaat gccctcgaaa cagattcgta agcagagcat cagtgtaacc
      241 agaggagcca ggagacgaga tgaagattca gggactgatg tgggagaagg aactgatgaa
      301 tggtcccaat ccaaagccac cgtgcgaccc cctgaccagc tggagctgac cgatgcggag
      361 ttaaaggagg agttcactcg gatcctgaca gccaacaacc cacatgcacc ccagaatatt
      421 gtcaggtaca gcttcaaaga gggcacatat aaacttattg gttttgtgaa ccaaatggcg
      481 gttcacttca gccaggtggg gaacctgata cccaaagact cagatgaagg ccgtcgccag
      541 cactaccgtg atgagatggt ggcaggttca caggagtcta tcaaggtggt gacttcagaa
      601 gcagaaaacc ttgaagaaga ggaagaaccc aaagaaggag aaggagaagc agaagcagaa
      661 gcagaagccg ggagccaaac ggacatccct gctgcagctg agacaactga aaaggtgatt
      721 gaagaagagc tgatggctcc tgtgcagccc aaggaacgga agctcacgaa ccagtttaac
      781 ttcagtgaga gagcatccca gaccttcaac aaccccctcc gggatcgaga gtgtcagatg
      841 gagcctccac cgaggacgaa cttttcagcc acagccaatc agtgggaaat ctatgatgcc
      901 tatgtagatg agctcgagaa acaggaaaag accaaagaga aggagaaggc aaagactcca
      961 gtggctaaga aaacagagaa gatggccatg aggaaactga catctatgga gtcccagagt
     1021 gatgatatca ccaaagtgac ccaagctgct aaaatcgtgg agcgaatggt caaccaaaat
     1081 acgtatgatg atgttgctca agattttaag tactatgagg atactgctga tgaatacagg
     1141 gaccaggagg gtacgctgct gcctctctgg aagtttcaaa atgacaaagc caagcgcctg
     1201 gcagtcaccg ccctctgctg gaatccaaag tacaaggatc tttttgcagt gggacacggc
     1261 tcctatgact tcatgaaaca gagccgtggc atgctgctgc tctacagcat gaagaaccct
     1321 agctttcccg agtacatgtt cagcagtgag agtggcatca tgtgtctgga cgtgcacgtg
     1381 gaccacccgt acctggtggt cgtgggctac tatgatggca acgtggccat ctacaacctc
     1441 aagaagcccc actcgcagcc ctgcttccgc agcacctcca agtctggcaa gcacacggac
     1501 cctgtatggc aggtcaagtg gcagaaggat gacatggacc acaacctcaa cttcttttct
     1561 gtgtcgtccg atggcaggat agtgtcatgg accctcgtca agagcgagct ggttcacatc
     1621 gacattatca agctgaagac tgaaggcagc actacagaaa tccccgaggg gctgcagttg
     1681 cacactgtag gctgtggcac tgcctttgac ttccacaaag agatcgacta catgttcctg
     1741 gtgggcacag aagagggaaa aatctacaag tgctccaaat cctactccag ccagttcttg
     1801 gacacctatg atgctcacaa catggcagta gacgctgtgc tatggaaccc ataccacacc
     1861 aaggtcttca tgtcctgcag ctctgactgg acagtgaaga tctgggacca caccatcaag
     1921 acccccatgt tcatttatga tctgaactca gccgtgggtg acgtggcctg ggcaccgtac
     1981 tcttccactg tgtttgcagc agtcaccacg gacgggaagg cccatgtgtt tgacttagcg
     2041 gtcaacaagt atgaagctat ctgcaaccag cctgtggtag ccaagaagaa gaacaagatc
     2101 acccacgtgc agttcaatcc catccacccc atcataatcg tgggcgacga ccgtggccac
     2161 atcatctgtc tcaagctctc tcccaacttg cgaaagatgc caaaggagaa gaaggggcag
     2221 gaagtgcaga aggggccagc tgtggagatc gcaaaattgg acaaactgct aaacctcgtg
     2281 agggaagtaa aaaccaaaac ctgagagtct ggcccagacc ctgctccgtg ttctgaaccc
     2341 aatacaagca aggacgtgcc tcaccctgac caatcccagt atttgctttt ctcattctgg
     2401 ctcttaaggg catgccacct ttctccatgg ccctcagcct ccattatacc ctctttgcac
     2461 aaataaaggc cagctggaca ctcacctcct aaaaaaaaaa aaaaaaaa
//
