LOCUS       NM_026314               1978 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynein axonemal assembly factor 4 (Dnaaf4), transcript
            variant 1, mRNA.
ACCESSION   NM_026314
VERSION     NM_026314.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Cheong,A., Degani,R., Tremblay,K.D. and Mager,J.
  TITLE     A null allele of Dnaaf2 displays embryonic lethality and mimics
            human ciliary dyskinesia
  JOURNAL   Hum Mol Genet 28 (16), 2775-2784 (2019)
   PUBMED   31107948
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Soulez,M., Saba-El-Leil,M.K., Turgeon,B., Mathien,S., Coulombe,P.,
            Klinger,S., Rousseau,J., Levesque,K. and Meloche,S.
  TITLE     Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3
            in Perinatal Survival and Postnatal Growth Using New Genetically
            Engineered Mouse Models
  JOURNAL   Mol Cell Biol 39 (6), e00527-18 (2019)
   PUBMED   30642949
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Muller,B., Schaadt,G., Boltze,J., Emmrich,F., Skeide,M.A.,
            Neef,N.E., Kraft,I., Brauer,J., Friederici,A.D., Kirsten,H. and
            Wilcke,A.
  CONSRTM   LEGASCREEN Consortium
  TITLE     ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR
  JOURNAL   Brain Behav 7 (11), e00851 (2017)
   PUBMED   29201552
  REMARK    GeneRIF: In total, four independent SNPs within DYX1C1 and ATP2C2
            were found to be associated with MMR stronger than expected from
            multiple testing. To explore potential pathomechanisms, we
            annotated these variants with functional data including
            tissue-specific expression analysis and eQTLs.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Rendall,A.R., Tarkar,A., Contreras-Mora,H.M., LoTurco,J.J. and
            Fitch,R.H.
  TITLE     Deficits in learning and memory in mice with a mutation of the
            candidate dyslexia susceptibility gene Dyx1c1
  JOURNAL   Brain Lang 172, 30-38 (2017)
   PUBMED   25989970
  REMARK    GeneRIF: findings in mice affirm existing evidence that DYX1C1 may
            play an underlying role in the development of neural systems
            important to learning and memory, and disruption of this function
            could contribute to the learning deficits seen in individuals with
            dyslexia
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
  REMARK    GeneRIF: DYX1C1 is required for axonemal dynein assembly and
            ciliary motility.
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Taipale,M., Kaminen,N., Nopola-Hemmi,J., Haltia,T., Myllyluoma,B.,
            Lyytinen,H., Muller,K., Kaaranen,M., Lindsberg,P.J.,
            Hannula-Jouppi,K. and Kere,J.
  TITLE     A candidate gene for developmental dyslexia encodes a nuclear
            tetratricopeptide repeat domain protein dynamically regulated in
            brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (20), 11553-11558 (2003)
   PUBMED   12954984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158997.2, AK161368.1 and AK005832.1.
            
            On Aug 8, 2009 this sequence version replaced NM_026314.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY428507.1, BC026462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC158997.2         100893-100928
            37-513              AK161368.1         2-478
            514-553             AC158997.2         104041-104080
            554-1405            AK005832.1         4-855
            1406-1978           AC158997.2         114603-115175
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     gene            1..1978
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /note="dynein axonemal assembly factor 4"
                     /db_xref="GeneID:67685"
                     /db_xref="MGI:MGI:1914935"
     exon            1..213
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1353
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dyslexia susceptibility 1 candidate gene 1 protein
                     homolog; dyslexia susceptibility 1 candidate 1 homolog;
                     dynein assembly factor 4, axonemal"
                     /codon_start=1
                     /product="dynein axonemal assembly factor 4 isoform 1"
                     /protein_id="NP_080590.3"
                     /db_xref="CCDS:CCDS23333.1"
                     /db_xref="GeneID:67685"
                     /db_xref="MGI:MGI:1914935"
                     /translation="MPVRVSEFSWQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNF
                     PPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLSVPGVDKEMMQRIREK
                     SILQAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELE
                     AWKECQKKADGQKRVQRKEKPLEGKQAEETKALKPRGLPRKAPPTRLPTRGRNWENIF
                     PEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLP
                     EFFDLKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLK
                     LKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALK
                     IDPANTVVQNDAEKIRNIIQGTALKSRD"
     exon            214..361
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..495
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..721
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..867
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..977
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1131
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1237
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1978
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1723..1728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /note="hexamer: AATATA"
     polyA_site      1743
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /note="major polyA site"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
                     /note="hexamer: AATAAA"
     polyA_site      1975
                     /gene="Dnaaf4"
                     /gene_synonym="1700010I24Rik; b2b811.1Clo; b2b811Clo;
                     Dyx1c1; EKN1"
ORIGIN      
        1 aagtgatggc aaccccgcaa tccccgcttc cctagcaacc cgatcggctt cctagcgacg
       61 taaagtggct gtgcagtccc tggtcccgcc atgccagtgc gagtgagcga gttcagctgg
      121 cagcagacgc cggccacgat cttcctgtcg ctgcctttgc ggggcgtctg cgtgcgcgat
      181 gctgacgtat tctgtgggga aagttacctg aaggttaact ttcctccatt tttatttgag
      241 ctgtttctct atgctcctat agatgatggg aagagcaaag ccaagattgg aaatgacacg
      301 attcttttca cattgtataa aaaggagcca gttctgtggg atagcctttc tgtgccgggt
      361 gttgataaag agatgatgca gagaataaga gaaaaatcta tcttgcaagc acaggagaaa
      421 gcaaaagagg ccacagaagc aaaagctgtt gccaagcgag aagaccagag atacgcacta
      481 ggcgagatga tgaagattga agaagaagag aggaaaaaaa tagaagatat gaaagaaaat
      541 gaacggaaaa aggcaactag cgaattagaa gcgtggaaag aatgtcaaaa gaaagctgac
      601 ggacaaaaaa gagtccagag gaaggagaaa ccgctcgagg gaaagcaagc tgaagagacc
      661 aaagctctaa aacctcgggg tttgccccgg aaggccccac ccactcgcct ccccacaaga
      721 gggaggaatt gggaaaacat atttcctgag aagttaaagg aagacagagt ccctgcgcct
      781 cgctccgctg gcagtattca aatcagcttt acccctcgag tgttcccaac agcacttcgg
      841 gaatcccaag tcgcagaaga ggaggagtgg ctgcataaac aagcagaagc acggagagcc
      901 atgagcactg accttcctga gttctttgac ttaaaagaag aagagaggaa tccagactgg
      961 ttgaaagaca agggaaacaa attgtttgca acagaaaact atttggcagc ggttgatgca
     1021 tataatttag ccatacgact gaactgtaag atcccattat tgtatttgaa tcgggctgct
     1081 tgccacctca aattaaaaaa cctacacaag gccatcgagg actcttctaa ggcactagag
     1141 ttattgacac cacctgttgc tgacaatgcc aatgcaagaa tgaaggcaca cgtccgacga
     1201 gggacagcgt tctgtcaact agaattgtat gttgaaggct tgcaagatta tgaagctgca
     1261 cttaagattg acccagccaa cacagttgta cagaacgatg cagagaagat tcggaatata
     1321 attcaaggga cggcactgaa gtctcgtgac tagaggcagc taggcacagg agtctctgca
     1381 agtactgtag ctctgtacag taccgcgcta gtgagccttt ggaatggcag tgcctgacga
     1441 atcatctcca aggggaaaat ggcctagctc tcactgcctt tgatcccagt accgggaagg
     1501 cagaggtagg caagtctcta tgagcttgag gccagccaga gctcgacagc atgcaaaaca
     1561 caaaagaaag ccagagaaca ggctgtttga gtcctcaatc ttggcacagg gattggctgg
     1621 gctctgatgt tgctgttgaa attgccagga tactactgag gaatctacag aatagaattt
     1681 ccacataaaa gattgtgcat ataaaatatt cttattatat taaatatagt atttcattct
     1741 aaatgattgg ctttggtata atatgtaaac aaattttagt cacttataga tacacataac
     1801 cacatagttt tctttgtatc atttgtcgtt tgaggctaga ccagttagag tataatatac
     1861 attgcatacc aaccctgggt ctgctgggta aaaggatata gaattccagg ctagcctggg
     1921 ctacatagtg aaactgtttc aagaaaaagt gaagaaataa acaacagaaa aaccagtt
//
