LOCUS       NM_019457               2084 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dynein axonemal assembly factor 11 (Dnaaf11), mRNA.
ACCESSION   NM_019457
VERSION     NM_019457.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2084)
  AUTHORS   Kim,D.Y., Sub,Y.J., Kim,H.Y., Cho,K.J., Choi,W.I., Choi,Y.J.,
            Lee,M.G., Hildebrandt,F. and Gee,H.Y.
  TITLE     LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1
            translocation into the nucleus
  JOURNAL   Cell Commun Signal 21 (1), 142 (2023)
   PUBMED   37328841
  REMARK    GeneRIF: LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1
            translocation into the nucleus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2084)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2084)
  AUTHORS   Mahuzier,A., Shihavuddin,A., Fournier,C., Lansade,P., Faucourt,M.,
            Menezes,N., Meunier,A., Garfa-Traore,M., Carlier,M.F.,
            Voituriez,R., Genovesio,A., Spassky,N. and Delgehyr,N.
  TITLE     Ependymal cilia beating induces an actin network to protect
            centrioles against shear stress
  JOURNAL   Nat Commun 9 (1), 2279 (2018)
   PUBMED   29891944
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2084)
  AUTHORS   Inaba,Y., Shinohara,K., Botilde,Y., Nabeshima,R., Takaoka,K.,
            Ajima,R., Lamri,L., Takeda,H., Saga,Y., Nakamura,T. and Hamada,H.
  TITLE     Transport of the outer dynein arm complex to cilia requires a
            cytoplasmic protein Lrrc6
  JOURNAL   Genes Cells 21 (7), 728-739 (2016)
   PUBMED   27353389
  REMARK    GeneRIF: Our results suggest that outer dynein arms proteins may be
            transported from the cytoplasm to the cilia by an Lrrc6-dependent
            mechanism.
REFERENCE   5  (bases 1 to 2084)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 2084)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Lrrc6 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   7  (bases 1 to 2084)
  AUTHORS   Xue,J.C. and Goldberg,E.
  TITLE     Identification of a novel testis-specific leucine-rich protein in
            humans and mice
  JOURNAL   Biol Reprod 62 (5), 1278-1284 (2000)
   PUBMED   10775177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ046721.1 and BC046277.1.
            
            On Feb 22, 2008 this sequence version replaced NM_019457.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046277.1, AF092208.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CJ046721.1         2-50
            50-2084             BC046277.1         1-2035
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.22 cM"
     gene            1..2084
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /note="dynein axonemal assembly factor 11"
                     /db_xref="GeneID:54562"
                     /db_xref="MGI:MGI:1859553"
     exon            1..136
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1548
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /note="leucine-rich testis-specific protein; leucine-rich
                     repeat-containing protein 6; testis-specific leucine-rich
                     repeat protein; protein TILB homolog; leucine rich repeat
                     containing 6 (testis)"
                     /codon_start=1
                     /product="dynein axonemal assembly factor 11"
                     /protein_id="NP_062330.1"
                     /db_xref="CCDS:CCDS49620.1"
                     /db_xref="GeneID:54562"
                     /db_xref="MGI:MGI:1859553"
                     /translation="MGRITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCR
                     DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIERIENLEGCEWLTKLDLTVNFIGE
                     LSSVKTLTHNIHLKELFLMGNPCADFDGYRQFVVVTLQQLKWLDGKEIERSERIQALQ
                     NYTSVEQQIREQEKAYCLRRAKEKEEAQRKLEEENESEDKKKSSTGFDGHWYTDIHTA
                     CPSATENQDYPQVPETQEEQHNTKESDDIEDDLAFWNKPSLFTPESRLETLRHMEKQR
                     KAQDKLSEKKKKAKPPRTLITEDGKVLNVNEAKLDFSLKDDEKHNQIILDLAVYRYMD
                     TSLIEVDVQPTYVRVMVKGKPFQLALSTEVQPDRSSAKRSQTTGHLLICMPKVGEMIT
                     GGQRTPTSVKTTSTSSREQTNPRKKQIERLEVDPSKHSCPDVSTIVQEKRHRPKRMES
                     QPRDEPSEEDPDFEDNPEVPPLI"
     exon            137..304
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            305..382
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            383..555
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            556..782
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            783..974
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1052
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1118
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1188
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1284
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1370
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..2084
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /note="hexamer: AATAAA"
     polyA_site      2084
                     /gene="Dnaaf11"
                     /gene_synonym="Lrrc6; LRTP"
                     /note="major polyA site"
ORIGIN      
        1 atagaatccc tgttgccatg actcccggat tgcgtcccac actctgagag gcgcagctgc
       61 tagggctgag ggaaatcctg cctgccggtc tccctgtttc cctgaccaga gatccagaaa
      121 agcaccatgg gccgaatcac agaagatctt attagacgga atgctgagca caatgactgt
      181 gtaatttttt ccctggagga actctccttg catcagcaag aaatagaaag gctagaacat
      241 attgacaaat ggtgccggga cttaaaaatt ctctatcttc aaaataacct cattggaaaa
      301 attgaaaatg ttagcaaact gaagaaactt gaatatttga acttagcatt gaacaacatt
      361 gaaagaattg aaaacttgga aggatgtgag tggctgacaa aacttgactt gactgtaaat
      421 ttcattggag aactgagcag cgttaaaacc ctgacacaca atattcatct gaaggagttg
      481 ttcctcatgg gtaacccatg tgctgacttt gatggctaca ggcagtttgt ggtggtgacc
      541 ttacaacagt taaagtggtt ggatggcaaa gaaatagagc gttctgaaag gatccaggca
      601 ttgcagaact acacatcagt tgagcagcaa atcagagagc aggagaaagc ttactgcctt
      661 agacgagcca aagagaaaga ggaagctcag aggaaactcg aggaagaaaa tgaaagtgaa
      721 gacaagaaga agagcagcac aggctttgat gggcattggt acacagacat ccacactgct
      781 tgcccatctg ccacagaaaa ccaagactac ccccaggtac cagaaactca agaagagcaa
      841 cacaacacaa aggaatcaga tgacattgaa gatgatctgg cattctggaa caaaccgtct
      901 ttgttcaccc ctgaatctag actggaaact ctcagacaca tggaaaaaca gcgaaaagcc
      961 caagataagt taagtgaaaa gaaaaagaaa gcgaaaccac cccgcacttt gattacagaa
     1021 gatgggaaag tcctgaatgt caacgaagcc aaacttgatt tctctttgaa agatgatgag
     1081 aaacacaatc agatcatcct ggacctggct gtctataggt acatggatac ctctttgatt
     1141 gaggttgatg tgcagccaac ttacgttcga gtaatggtca aaggaaagcc atttcaactt
     1201 gccctttcta cagaggtcca gcctgaccgc agctctgcta aaaggtccca gacaacagga
     1261 catttgctga tctgcatgcc caaggtagga gaaatgatca caggaggtca acgaacaccc
     1321 acgtctgtga aaaccacctc aactagtagc agggaacaaa caaaccccag aaaaaagcag
     1381 atagaaagat tggaagttga ccccagcaag cattcttgcc ctgatgtgtc taccatagta
     1441 caagagaaaa gacacagacc caaaagaatg gaatctcaac cccgagatga acccagtgag
     1501 gaagatccag actttgagga taacccagaa gtgcctccac taatttgaaa taggaggctg
     1561 tgttgtcatt gaccctgacc cacagactca tgttgcttgg tgttgacagt ggctatgtgt
     1621 cattcatgga gtaaacatag ttcattatca tttttacctg atgctataat gctttccatg
     1681 cattgtaata tatttgagtt tacaattaaa ttgcatacct taaatatgct ataacttatc
     1741 actcatctat aattgaactt cgagcttgaa aatgtgaagt aatttaatag aactacgaca
     1801 ttcaacatta agaataagtc atttagtctt cacttatgca atagattgtg ttatatggaa
     1861 aaggtcttta gcaaattgtt caaactcaga agttaaaact gtactctcag gtcgaacgaa
     1921 aatgccctga catgatttta aatagtattt ttttattttt cttctcacgt ttctgctttc
     1981 tctagtggca tgatgtaatg gcaagaataa gaactttgac attagatttc ctgtatttag
     2041 attcctgctg agtcactgaa taaagacttt cagctggtcc ttga
//
