LOCUS       NM_010058               2520 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dystrophia myotonica-containing WD repeat motif
            (Dmwd), transcript variant 1, mRNA.
ACCESSION   NM_010058 XM_986190
VERSION     NM_010058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Westerlaken,J.H., Van der Zee,C.E., Peters,W. and Wieringa,B.
  TITLE     The DMWD protein from the myotonic dystrophy (DM1) gene region is
            developmentally regulated and is present most prominently in
            synapse-dense brain areas
  JOURNAL   Brain Res 971 (1), 116-127 (2003)
   PUBMED   12691844
  REMARK    GeneRIF: The DMWD protein level gradually increased, was expressed
            specifically in the neuropil of areas with a high density of
            synaptic connections and was dispersed in a punctuate fashion
            throughout the neural cell body, but excluded from axons
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Wansink,D.G. and Wieringa,B.
  TITLE     Transgenic mouse models for myotonic dystrophy type 1 (DM1)
  JOURNAL   Cytogenet Genome Res 100 (1-4), 230-242 (2003)
   PUBMED   14526185
  REMARK    Review article
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Ivandic,B.T., Utz,H.F., Kaczmarek,P.M., Aherrahrou,Z., Axtner,S.B.,
            Klepsch,C., Lusis,A.J. and Katus,H.A.
  TITLE     New Dyscalc loci for myocardial cell necrosis and calcification
            (dystrophic cardiac calcinosis) in mice
  JOURNAL   Physiol Genomics 6 (3), 137-144 (2001)
   PUBMED   11526197
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2520)
  AUTHORS   Popova,N.K. and Kulikov,A.V.
  TITLE     On the role of brain serotonin in expression of genetic
            predisposition to catalepsy in animal models
  JOURNAL   Am J Med Genet 60 (3), 214-220 (1995)
   PUBMED   7573174
REFERENCE   7  (bases 1 to 2520)
  AUTHORS   Jansen,G., Bachner,D., Coerwinkel,M., Wormskamp,N., Hameister,H.
            and Wieringa,B.
  TITLE     Structural organization and developmental expression pattern of the
            mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic
            dystrophy locus
  JOURNAL   Hum Mol Genet 4 (5), 843-852 (1995)
   PUBMED   7633444
REFERENCE   8  (bases 1 to 2520)
  AUTHORS   Jansen,G., Bartolomei,M., Kalscheuer,V., Merkx,G., Wormskamp,N.,
            Mariman,E., Smeets,D., Ropers,H.H. and Wieringa,B.
  TITLE     No imprinting involved in the expression of DM-kinase mRNAs in
            mouse and human tissues
  JOURNAL   Hum Mol Genet 2 (8), 1221-1227 (1993)
   PUBMED   8401505
REFERENCE   9  (bases 1 to 2520)
  AUTHORS   Mahadevan,M.S., Amemiya,C., Jansen,G., Sabourin,L., Baird,S.,
            Neville,C.E., Wormskamp,N., Segers,B., Batzer,M., Lamerdin,J. et
            al.
  TITLE     Structure and genomic sequence of the myotonic dystrophy (DM
            kinase) gene
  JOURNAL   Hum Mol Genet 2 (3), 299-304 (1993)
   PUBMED   8499920
REFERENCE   10 (bases 1 to 2520)
  AUTHORS   Jansen,G., Mahadevan,M., Amemiya,C., Wormskamp,N., Segers,B.,
            Hendriks,W., O'Hoy,K., Baird,S., Sabourin,L., Lennon,G. et al.
  TITLE     Characterization of the myotonic dystrophy region predicts multiple
            protein isoform-encoding mRNAs
  JOURNAL   Nat Genet 1 (4), 261-266 (1992)
   PUBMED   1302022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170864.2, CF169673.1, BC089027.1 and AK086899.1.
            
            On Mar 25, 2009 this sequence version replaced NM_010058.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.74014.1,
                                           SRR11927931.299745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AC170864.2         10426-10762         c
            338-991             CF169673.1         1-654
            992-1494            BC089027.1         1224-1726
            1495-2520           AK086899.1         1057-2082
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.46 cM"
     gene            1..2520
                     /gene="Dmwd"
                     /gene_synonym="Dm9; DMR-N9"
                     /note="dystrophia myotonica-containing WD repeat motif"
                     /db_xref="GeneID:13401"
                     /db_xref="MGI:MGI:94907"
     exon            1..502
                     /gene="Dmwd"
                     /gene_synonym="Dm9; DMR-N9"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2068
                     /gene="Dmwd"
                     /gene_synonym="Dm9; DMR-N9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dystrophia myotonica WD repeat-containing protein;
                     dystrophia myotonica-containing WD repeat motif protein;
                     dystrophia myotonica linked gene, N9"
                     /codon_start=1
                     /product="dystrophia myotonica WD repeat-containing
                     protein isoform 1"
                     /protein_id="NP_034188.2"
                     /db_xref="CCDS:CCDS20888.2"
                     /db_xref="GeneID:13401"
                     /db_xref="MGI:MGI:94907"
                     /translation="MAAGGAEGGPGPSAAMGDCAEIKSQFRTREGFYKLLPGDATRRS
                     GPTSAQTPAPPQPTQPPPGPAAASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGD
                     PDGAGEPPSTPSGLGAGGDRVCFNLGRELYFYPGCCRSGSQRSIDLNKPIDKRIYKGT
                     QPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKW
                     LPESESLFLASHASGHLYLYNVSHPCTSTPPQYSLLKQGEGFAVYAAKSKAPRNPLAK
                     WAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPD
                     GRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAASASADGDP
                     SGEEEEPEVTSSDTGAPVSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLSPHPSLAR
                     TRTLPGTPGATPPASGSSRAGETGAGPLPRSLSRSNSLPHPAGGGKAGGPSASMEPGI
                     PFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGNSSNDKLSGPAPRSRLDP
                     AKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFLEDCIITACQEGLICTWARPGK
                     AFTDEETEAQAGQASWPRSPSKSVVEGISSQPGSSPSGTVV"
     exon            503..685
                     /gene="Dmwd"
                     /gene_synonym="Dm9; DMR-N9"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1945
                     /gene="Dmwd"
                     /gene_synonym="Dm9; DMR-N9"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2020
                     /gene="Dmwd"
                     /gene_synonym="Dm9; DMR-N9"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2520
                     /gene="Dmwd"
                     /gene_synonym="Dm9; DMR-N9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcaactt ccggctgggg ggtctggcgg tgggcggtcg ggctgcggtg cggcccgggg
       61 ggcggccaag atggcggcgg gcggcgcgga gggcggcccg ggccccagcg ccgccatggg
      121 cgactgcgcg gagatcaagt cgcagtttcg cacccgcgag ggcttctaca agctgctccc
      181 cggcgacgcg acgcgcaggt cgggcccgac ctccgctcag accccggcgc cgcctcagcc
      241 cactcagccc ccgcccgggc ccgccgcagc ctccgggccc ggcgccgcgg gtcccgcgtc
      301 gtccccgccg cccgccggcc ccgggcccgg gcccgcgctg cccgccgtcc gcctcagcct
      361 ggtgcgccta ggcgacccgg atggcgctgg ggagccgccc tccacgccct ccggactggg
      421 cgcgggagga gaccgcgtct gcttcaacct gggccgggag ctttatttct accccggctg
      481 ctgccgcagc gggagccagc ggtccatcga tctcaacaag cccatcgaca agcggatcta
      541 caaggggacc cagcccacct gccacgactt caaccagttc acagctgcca cagagaccat
      601 ttccctgctg gtgggcttct ctgccggcca ggtgcagtat ctggacctca tcaagaaaga
      661 caccagcaag ctattcaatg aagagcggct gattgacaag accaaggtga catatttgaa
      721 gtggctgcct gagtcagaga gtctgttcct tgcttctcac gccagtggcc acctgtacct
      781 ctacaacgtc agtcacccct gcacctccac cccaccccag tatagtctgc tgaaacaggg
      841 tgagggcttt gctgtctatg cagccaaaag caaggcaccc cgcaatccac tagccaagtg
      901 ggcagtgggt gaggggcccc tcaatgagtt tgcattctca cctgatggcc gacacttagc
      961 ctgtgtcagc caggatggct gcctgcgtgt cttccacttt gacagcatgc ttctgcgtgg
     1021 gctcatgaag agctactttg ggggtctgct gtgtgtgtgc tggagccctg atggccgcta
     1081 cgtggtgaca ggaggggaag atgacttagt cactgtgtgg tccttcacgg agggtcgtgt
     1141 ggtggctcga ggccatggcc acaagtcctg ggtcaacgct gtagcctttg atccctacac
     1201 cactcgcgca gaggaggcgg cgtcagccag tgctgatgga gatcccagtg gtgaagagga
     1261 ggagcctgaa gtcaccagct cagacacagg agccccagtg tccccactgc ccaaggctgg
     1321 ctccatcacg taccgctttg gctcagctgg ccaggacaca cagttctgcc tgtgggacct
     1381 cacagaagat gtgctctccc ctcatccgtc tctggcccgt acccgcaccc ttccgggcac
     1441 acctggtgcc accccaccag cttctggtag ttctcgggcc ggagagacag gtgcaggccc
     1501 cctgccccgc tccctgtctc gttccaacag tctcccacac ccagctggtg gtggcaaggc
     1561 tggtgggcct agtgcatcga tggagcctgg cataccattc agcattggcc gctttgccac
     1621 actgaccctg caggagcggc gggaccgggg agctgagaag gaacacaaac gctaccatag
     1681 cctgggaaac atcagccgcg gtggcagtgg gggcaatagc agcaatgaca agctcagtgg
     1741 tcctgccccc cgaagccgat tggacccagc taaggtgctg ggcacggcac tgtgccctcg
     1801 gatccatgag gtgccactgc tggagcctct cgtgtgcaag aagattgctc aggaacgcct
     1861 gaccgtgcta ctgttcctgg aggattgtat catcactgcc tgccaagagg gcctcatctg
     1921 cacctgggcc cggccaggca aggcgttcac agacgaggag accgaggccc aggcagggca
     1981 agcaagttgg cccaggtcac ccagcaagtc agttgtagag ggcatctcct cccaaccagg
     2041 cagctccccc agtggcactg tggtgtgaaa tgtggatgtc ccatgttccc ggcctcctag
     2101 ccataaccct ccccgctgac ctcaagaatc actgtattaa caagactaat catgatggaa
     2161 ggactgctcc aagccccacg ctgcacacat actgggggtc ccctaggttg gcccagccat
     2221 ggggatgtag tgtcctgtgt ggccttggcc ctgtcctcca cccactgcca agtacaatga
     2281 cctgttctct gaaacatcag tgttaaccat atccctgtcc cagcatgtga ctgttcactc
     2341 ctgggagaga cttagcccac agtacccctg ggtgagaggg cagggcaggg gccatcccca
     2401 ctcctgccca aactccaccc cttgctatgg tctgtgattt tgaaagtgtt aaattatgga
     2461 agccctgagg gccctccttg ttcccctgga cctcttattt atactaaagt ccttgtttgc
//
