LOCUS       NM_001360027            3994 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus dematin actin binding protein (Dmtn), transcript
            variant 10, mRNA.
ACCESSION   NM_001360027 XM_017315839
VERSION     NM_001360027.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3994)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3994)
  AUTHORS   Fritz,D.I., Ding,Y., Merrill-Skoloff,G., Flaumenhaft,R., Hanada,T.
            and Chishti,A.H.
  TITLE     Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt
            Activation in Platelets
  JOURNAL   Mol Cell Biol 43 (6), 283-299 (2023)
   PUBMED   37216480
  REMARK    GeneRIF: Dematin Regulates Calcium Mobilization, Thrombosis, and
            Early Akt Activation in Platelets.
REFERENCE   3  (bases 1 to 3994)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3994)
  AUTHORS   Huang,Y.S., Delgadillo,L.F., Cyr,K.H., Kingsley,P.D., An,X.,
            McGrath,K.E., Mohandas,N., Conboy,J.G., Waugh,R.E., Wan,J. and
            Palis,J.
  TITLE     Circulating primitive erythroblasts establish a functional, protein
            4.1R-dependent cytoskeletal network prior to enucleating
  JOURNAL   Sci Rep 7 (1), 5164 (2017)
   PUBMED   28701737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3994)
  AUTHORS   Lu,Y., Hanada,T., Fujiwara,Y., Nwankwo,J.O., Wieschhaus,A.J.,
            Hartwig,J., Huang,S., Han,J. and Chishti,A.H.
  TITLE     Gene disruption of dematin causes precipitous loss of erythrocyte
            membrane stability and severe hemolytic anemia
  JOURNAL   Blood 128 (1), 93-103 (2016)
   PUBMED   27073223
  REMARK    GeneRIF: results demonstrate that dematin plays a critical role in
            maintaining the fundamental properties of the membrane cytoskeleton
            complex.
REFERENCE   6  (bases 1 to 3994)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
REFERENCE   7  (bases 1 to 3994)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   8  (bases 1 to 3994)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
REFERENCE   9  (bases 1 to 3994)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   10 (bases 1 to 3994)
  AUTHORS   Peters,L.L., Eicher,E.M., Azim,A.C. and Chishti,A.H.
  TITLE     The gene encoding the erythrocyte membrane skeleton protein dematin
            (Epb4.9) maps to mouse chromosome 14
  JOURNAL   Genomics 26 (3), 634-635 (1995)
   PUBMED   7607697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270342.1, CJ070069.1, AA510592.1, CB527108.1, AK162866.1,
            AK165204.1, BY601680.1 and AI413696.1.
            
            On Jan 25, 2018 this sequence version replaced XM_017315839.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.11278.1,
                                           SRR1660817.133681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY270342.1         2-28
            28-590              CJ070069.1         2-564
            591-968             AA510592.1         1-378
            969-1364            CB527108.1         233-628
            1365-2500           AK162866.1         1242-2377
            2501-2579           AK165204.1         2759-2837
            2580-2582           BY601680.1         296-298
            2583-3633           AK165204.1         2840-3890
            3634-3994           AI413696.1         1-361               c
FEATURES             Location/Qualifiers
     source          1..3994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..3994
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="dematin actin binding protein"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
     exon            1..128
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            129..298
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1432
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="isoform 2 is encoded by transcript variant 10;
                     erythrocyte membrane protein band 4.9; erythrocyte protein
                     band 4.9"
                     /codon_start=1
                     /product="dematin isoform 2"
                     /protein_id="NP_001346956.1"
                     /db_xref="CCDS:CCDS27259.1"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
                     /translation="MERLQKQPLTSPGSVSSSRDSSVPGSPSSIVAKMDNQVLGYKDL
                     AAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEVWAE
                     SRTLGIISQASTPRTTGTPRTSLPHFHHPETTRPDSNIYKKPPIYKQRESVGGSPQSK
                     HLIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRKGAEEE
                     EEEEDDDSEEEIKAIRERQKEELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPF
                     HTSLHSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSEAGSPGLQIYPYEMLVVTNKGRT
                     KLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF"
     exon            299..373
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            374..529
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            530..574
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            575..674
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            675..731
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            732..884
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1009
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1115
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1180
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1229
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1237
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1318
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..3989
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2503
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="major polyA site"
     polyA_site      2554
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2720
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AATGAA"
     regulatory      3964..3969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AGTAAA"
     polyA_site      3969
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     polyA_site      3989
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
ORIGIN      
        1 gagctgggcc tgggctgcca ggaggttgtc ttggcaacgg gaggcggaga ggagatgcgc
       61 tgagggatgg aggtgtatgt caccgcagag gctgctgtgt tcctgcccca cgccccgggc
      121 ccttgaagcc acccgcggtc agcagcccag agaggcccaa gggatgagga caccacagag
      181 cgctgtgacg ccctcgctgc aggagccggg ccgagcctga cgtctgtcct ctccaagtgc
      241 gcaccggccc ccgagggagc ggccggccag tggctgccgc atggaacgtc tgcagaagca
      301 acctcttacc tccccgggga gcgtcagctc ctccagagac tccagtgtgc ccggctctcc
      361 ctccagcatc gtggccaaga tggacaacca ggtgttgggc tacaaggatc tggctgccat
      421 ccccaaggac aaggccatcc tggacattga gcgacctgac ctcatgatct atgagcccca
      481 ctttacctat tccctcctgg aacatgtaga gctgcccaga agccgggagt gctcactgtc
      541 acccaaatcc acatcccccc caccgtctcc agaggtgtgg gcggagagcc ggactcttgg
      601 aatcatctct caggcttcaa ccccaaggac cacagggacc cccaggacca gcctgcccca
      661 cttccaccac cctgagacta cccgcccgga ttccaacatc tacaagaagc cacccatcta
      721 caaacagaga gaatccgtgg gaggcagccc tcagagcaag cacctcatcg aggacctcat
      781 catcgaatcc tccaagtttc ctgcagcgca gccccctgac cccaaccagc cagccaagat
      841 agagactgac tactggccat gtcccccgtc gctggccgtt gtggagacag aatggaggaa
      901 acggaaggca tctcgaaagg gggcagagga agaggaggaa gaggaagacg atgactctga
      961 agaggagatt aaggccatca gggaacggca gaaagaggag ctcagtaagg ttacttccaa
     1021 cttgggaaag atgatcttga aagaagagat ggaaaagtca ttgcccatcc ggaggaaaac
     1081 acgctctctg cctgaccgga cacccttcca tacctccttg cattcgggaa catctaaatc
     1141 ctcttcgctt ccttcctatg gcaggaccac cctgagccgg ctacagtcca cagaattcag
     1201 cccatcggga agtgaggctg ggagcccagg cctgcagatc tatccctatg agatgctggt
     1261 ggtgaccaat aaggggagaa ctaagctgcc tccgggtgtg gaccgcatga ggcttgagag
     1321 gcatttgtca gcagaggact tctctagggt cttcgccatg tctcccgagg agtttggcaa
     1381 gctggccctg tggaagcgga acgaacttaa gaagaaagct tccctcttct gacatccctg
     1441 ccggctcggc tcgattcggc tcgccctgtc cgtgacagta ccttccttct gctgcttcga
     1501 ggccctgaag ctggggctgt gagacccttc cctacagtgt cctcttcctc tgctggctgg
     1561 gagcagcggg aggcagggca gaaacgttgg gctccattcc tcacggagag agccaagaag
     1621 tgcacagtcc cagagtcacg aggcgtggac ttccttcccc acgatgggcc agggggcctt
     1681 accatttccc tgggctctac tgcctagaca aacccagccc ggactccagc acacaatgtt
     1741 tgcacccgtt ccctgtctgt caccccacat gagagtcccc agaagacagt gaggagaaac
     1801 gaagggggct tagcggggag gtcggtctgc tgtcctgtac agggggaggc ggcagctctg
     1861 ggaccctgtg cctgtccacc caaaggctcc agccagctgc actcctggca gtttcctgca
     1921 cttgggcctg atgcttctct aactggcaga agcaggctct acctggacct ccagctggga
     1981 ggtcatcctc cctctagctt gtatgtcctg tactttgcaa cccctaagct tcaaacctct
     2041 tgctcaagac ccaagactta ttcaaagctg tggctaagag cagagacgct gttcacacaa
     2101 cgcctcacca ccaccagcct ccaggcaaaa ccagatagga tgcaccgttc tagcacctgt
     2161 ccagggacca ccgagcccag gcctcagcct ccctaagatg ggatggagag tcccagctcc
     2221 caggtccctc cattgccatg catctcctac tgtgctctct acagaatgta atttattggg
     2281 gcaccctctg ctgcttccct gactccctgc cctacctaat tgcacttcca gtcctgtctg
     2341 tccacatatg tacgtgtata taattataca tatatatata tctattttgc ccaggtctgg
     2401 gtttcgtttt tacccagacc ctggcactcc ctgtccactg tgtgtgtgat catgctggga
     2461 ggggtaactg cttggaatta aaaggttgca ctgggtccct aaatctattg tttctatcca
     2521 tgcctgtgca tatcagacaa gcactgtacc acaaccagtt gtcttacctc tttttttttt
     2581 ctttttttct ttttcaagac agggtttctc tgtatagccc tggcggtcct ggaactcact
     2641 ctgtagacca ggctggccta gaactcagaa atcctcctgc ctctgcctcc caagtgctgg
     2701 gattaaagca tgtaccacta ctgctgggct agtcttacct ctttagttgc ccaggctaga
     2761 cctgacctct cactctgtag cccaggaagt tttggccttc ttggttcagt atcaagtagc
     2821 tggacgcata ggcttaggcc agcagcctga actatctatt catttattct gttttgttgt
     2881 tttgtttgaa ataaggtgtc ccatagcaaa ggctggtctt gaacccctga tccagcattt
     2941 gcctttccga gtgctgggat cacaggcata tatcgcatat ttgtggatct tatttgtctc
     3001 acatagctca cactggcctc aaacttactt gtatctgagg ttgaacttcc catccgcctt
     3061 gcctctgcct cacaagtgct ggaatacact gacagccatg gtttattccg tgctggggat
     3121 ggaacccagg gtctcttgct tgctaggtgt gtgctctacc aactgagcca cattgataac
     3181 ccacgtttgt ttctttataa gccactagcc ctgagacata gggacaggtg acatcaggtt
     3241 tcatgtgagc cagagtgggc ttagagacaa taccatagtc ccgttcctct ctaggacgca
     3301 ggagcaaggg ctggcctaga gagactgcta cttgccacct ttccaggggc tctatgagac
     3361 agaaagctat cttttgtagc tagagagagc ttgacagagc ctcagaagat gacctcaaac
     3421 acaccggcct ccctaggacc caaggtgcct ctgcatcagg gaagcccagc agaaaacgtt
     3481 accaggaggt taccacctgg ctgccaagca ctgagcagag gaagcaggaa cggagacctg
     3541 gtaactgagg gacaaatggt gccttggtgc cttgatggcc tctgactgcc ttggtgaagc
     3601 cttctgcctg caaccactat ggagctgcgt gcccaaggtg gggctgagtg tgcagtttga
     3661 ttggaagatc aaaaagaaga cgggatgggc ttgcacaggg gaagaggacc agctggcccc
     3721 aaagcaaata gatgagaacc attcaaaaca atgattttct taccattgga atggagttta
     3781 cagctgaaga ctgccttgaa tcgcctccct ctgcttctac ctcctgcgtg ttgagatgac
     3841 aggtggacac cattacgcct gcttcatttg gggctaggga gccaacccag gctttgtgtg
     3901 tgctaagtag acactctgcc tgaaagacct acattctcag ctcccgaatg aacaatgatt
     3961 ttaagtaaag tcggcttatg tttacagcaa aaaa
//
