LOCUS       NM_001360026            4190 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus dematin actin binding protein (Dmtn), transcript
            variant 9, mRNA.
ACCESSION   NM_001360026 XM_017315838
VERSION     NM_001360026.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4190)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4190)
  AUTHORS   Fritz,D.I., Ding,Y., Merrill-Skoloff,G., Flaumenhaft,R., Hanada,T.
            and Chishti,A.H.
  TITLE     Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt
            Activation in Platelets
  JOURNAL   Mol Cell Biol 43 (6), 283-299 (2023)
   PUBMED   37216480
  REMARK    GeneRIF: Dematin Regulates Calcium Mobilization, Thrombosis, and
            Early Akt Activation in Platelets.
REFERENCE   3  (bases 1 to 4190)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4190)
  AUTHORS   Huang,Y.S., Delgadillo,L.F., Cyr,K.H., Kingsley,P.D., An,X.,
            McGrath,K.E., Mohandas,N., Conboy,J.G., Waugh,R.E., Wan,J. and
            Palis,J.
  TITLE     Circulating primitive erythroblasts establish a functional, protein
            4.1R-dependent cytoskeletal network prior to enucleating
  JOURNAL   Sci Rep 7 (1), 5164 (2017)
   PUBMED   28701737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4190)
  AUTHORS   Lu,Y., Hanada,T., Fujiwara,Y., Nwankwo,J.O., Wieschhaus,A.J.,
            Hartwig,J., Huang,S., Han,J. and Chishti,A.H.
  TITLE     Gene disruption of dematin causes precipitous loss of erythrocyte
            membrane stability and severe hemolytic anemia
  JOURNAL   Blood 128 (1), 93-103 (2016)
   PUBMED   27073223
  REMARK    GeneRIF: results demonstrate that dematin plays a critical role in
            maintaining the fundamental properties of the membrane cytoskeleton
            complex.
REFERENCE   6  (bases 1 to 4190)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
REFERENCE   7  (bases 1 to 4190)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   8  (bases 1 to 4190)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
REFERENCE   9  (bases 1 to 4190)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   10 (bases 1 to 4190)
  AUTHORS   Peters,L.L., Eicher,E.M., Azim,A.C. and Chishti,A.H.
  TITLE     The gene encoding the erythrocyte membrane skeleton protein dematin
            (Epb4.9) maps to mouse chromosome 14
  JOURNAL   Genomics 26 (3), 634-635 (1995)
   PUBMED   7607697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270342.1, BB873101.1, BY278973.1, CJ070069.1, AK162866.1,
            AK165204.1, BY601680.1 and AI413696.1.
            
            On Jan 25, 2018 this sequence version replaced XM_017315838.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.208289.1,
                                           SRR1660821.189315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY270342.1         2-28
            28-244              BB873101.1         2-218
            245-392             BY278973.1         172-319
            393-720             CJ070069.1         237-564
            721-1367            AK162866.1         468-1114
            1368-2775           AK165204.1         1430-2837
            2776-2778           BY601680.1         296-298
            2779-3829           AK165204.1         2840-3890
            3830-4190           AI413696.1         1-361               c
FEATURES             Location/Qualifiers
     source          1..4190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..4190
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="dematin actin binding protein"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
     exon            1..128
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            129..258
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            259..428
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..1628
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="isoform 1 is encoded by transcript variant 9;
                     erythrocyte membrane protein band 4.9; erythrocyte protein
                     band 4.9"
                     /codon_start=1
                     /product="dematin isoform 1"
                     /protein_id="NP_001346955.1"
                     /db_xref="CCDS:CCDS88708.1"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
                     /translation="MERLQKQPLTSPGSVSSSRDSSVPGSPSSIVAKMDNQVLGYKDL
                     AAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEVWAE
                     SRTLGIISQASTPRTTGTPRTSLPHFHHPETTRPDSNIYKKPPIYKQRESVGGSPQSK
                     HLIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRKGAEEE
                     EEEEDDDSEEEIKAIRERQKEELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPF
                     HTSLHSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSEAGSPGLQNGEGQRGRMDRGNSL
                     PCVLEQKIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLAL
                     WKRNELKKKASLF"
     exon            429..503
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            504..659
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            660..704
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            705..804
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            805..861
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1014
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1139
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1245
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1310
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1359
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1367
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1433
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1514
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..4185
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2673..2678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2699
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="major polyA site"
     polyA_site      2750
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2916
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      4143..4148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AATGAA"
     regulatory      4160..4165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AGTAAA"
     polyA_site      4165
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     polyA_site      4185
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
ORIGIN      
        1 gagctgggcc tgggctgcca ggaggttgtc ttggcaacgg gaggcggaga ggagatgcgc
       61 tgagggatgg aggtgtatgt caccgcagag gctgctgtgt tcctgcccca cgccccgggc
      121 ccttgaagcg cggctgggtt cctggagaag ctgcctctta cctagattcc tgagaaaacg
      181 cggccaccca gtcgaccagg gcctagcctt ttgcttcctg gggcttcaga gagcctgggc
      241 cccactgtct gggaggagcc acccgcggtc agcagcccag agaggcccaa gggatgagga
      301 caccacagag cgctgtgacg ccctcgctgc aggagccggg ccgagcctga cgtctgtcct
      361 ctccaagtgc gcaccggccc ccgagggagc ggccggccag tggctgccgc atggaacgtc
      421 tgcagaagca acctcttacc tccccgggga gcgtcagctc ctccagagac tccagtgtgc
      481 ccggctctcc ctccagcatc gtggccaaga tggacaacca ggtgttgggc tacaaggatc
      541 tggctgccat ccccaaggac aaggccatcc tggacattga gcgacctgac ctcatgatct
      601 atgagcccca ctttacctat tccctcctgg aacatgtaga gctgcccaga agccgggagt
      661 gctcactgtc acccaaatcc acatcccccc caccgtctcc agaggtgtgg gcggagagcc
      721 ggactcttgg aatcatctct caggcttcaa ccccaaggac cacagggacc cccaggacca
      781 gcctgcccca cttccaccac cctgagacta cccgcccgga ttccaacatc tacaagaagc
      841 cacccatcta caaacagaga gaatccgtgg gaggcagccc tcagagcaag cacctcatcg
      901 aggacctcat catcgaatcc tccaagtttc ctgcagcgca gccccctgac cccaaccagc
      961 cagccaagat agagactgac tactggccat gtcccccgtc gctggccgtt gtggagacag
     1021 aatggaggaa acggaaggca tctcgaaagg gggcagagga agaggaggaa gaggaagacg
     1081 atgactctga agaggagatt aaggccatca gggaacggca gaaagaggag ctcagtaagg
     1141 ttacttccaa cttgggaaag atgatcttga aagaagagat ggaaaagtca ttgcccatcc
     1201 ggaggaaaac acgctctctg cctgaccgga cacccttcca tacctccttg cattcgggaa
     1261 catctaaatc ctcttcgctt ccttcctatg gcaggaccac cctgagccgg ctacagtcca
     1321 cagaattcag cccatcggga agtgaggctg ggagcccagg cctgcagaac ggagagggcc
     1381 agagggggag gatggatcgg gggaactccc tgccctgtgt gctggagcag aagatctatc
     1441 cctatgagat gctggtggtg accaataagg ggagaactaa gctgcctccg ggtgtggacc
     1501 gcatgaggct tgagaggcat ttgtcagcag aggacttctc tagggtcttc gccatgtctc
     1561 ccgaggagtt tggcaagctg gccctgtgga agcggaacga acttaagaag aaagcttccc
     1621 tcttctgaca tccctgccgg ctcggctcga ttcggctcgc cctgtccgtg acagtacctt
     1681 ccttctgctg cttcgaggcc ctgaagctgg ggctgtgaga cccttcccta cagtgtcctc
     1741 ttcctctgct ggctgggagc agcgggaggc agggcagaaa cgttgggctc cattcctcac
     1801 ggagagagcc aagaagtgca cagtcccaga gtcacgaggc gtggacttcc ttccccacga
     1861 tgggccaggg ggccttacca tttccctggg ctctactgcc tagacaaacc cagcccggac
     1921 tccagcacac aatgtttgca cccgttccct gtctgtcacc ccacatgaga gtccccagaa
     1981 gacagtgagg agaaacgaag ggggcttagc ggggaggtcg gtctgctgtc ctgtacaggg
     2041 ggaggcggca gctctgggac cctgtgcctg tccacccaaa ggctccagcc agctgcactc
     2101 ctggcagttt cctgcacttg ggcctgatgc ttctctaact ggcagaagca ggctctacct
     2161 ggacctccag ctgggaggtc atcctccctc tagcttgtat gtcctgtact ttgcaacccc
     2221 taagcttcaa acctcttgct caagacccaa gacttattca aagctgtggc taagagcaga
     2281 gacgctgttc acacaacgcc tcaccaccac cagcctccag gcaaaaccag ataggatgca
     2341 ccgttctagc acctgtccag ggaccaccga gcccaggcct cagcctccct aagatgggat
     2401 ggagagtccc agctcccagg tccctccatt gccatgcatc tcctactgtg ctctctacag
     2461 aatgtaattt attggggcac cctctgctgc ttccctgact ccctgcccta cctaattgca
     2521 cttccagtcc tgtctgtcca catatgtacg tgtatataat tatacatata tatatatcta
     2581 ttttgcccag gtctgggttt cgtttttacc cagaccctgg cactccctgt ccactgtgtg
     2641 tgtgatcatg ctgggagggg taactgcttg gaattaaaag gttgcactgg gtccctaaat
     2701 ctattgtttc tatccatgcc tgtgcatatc agacaagcac tgtaccacaa ccagttgtct
     2761 tacctctttt ttttttcttt ttttcttttt caagacaggg tttctctgta tagccctggc
     2821 ggtcctggaa ctcactctgt agaccaggct ggcctagaac tcagaaatcc tcctgcctct
     2881 gcctcccaag tgctgggatt aaagcatgta ccactactgc tgggctagtc ttacctcttt
     2941 agttgcccag gctagacctg acctctcact ctgtagccca ggaagttttg gccttcttgg
     3001 ttcagtatca agtagctgga cgcataggct taggccagca gcctgaacta tctattcatt
     3061 tattctgttt tgttgttttg tttgaaataa ggtgtcccat agcaaaggct ggtcttgaac
     3121 ccctgatcca gcatttgcct ttccgagtgc tgggatcaca ggcatatatc gcatatttgt
     3181 ggatcttatt tgtctcacat agctcacact ggcctcaaac ttacttgtat ctgaggttga
     3241 acttcccatc cgccttgcct ctgcctcaca agtgctggaa tacactgaca gccatggttt
     3301 attccgtgct ggggatggaa cccagggtct cttgcttgct aggtgtgtgc tctaccaact
     3361 gagccacatt gataacccac gtttgtttct ttataagcca ctagccctga gacataggga
     3421 caggtgacat caggtttcat gtgagccaga gtgggcttag agacaatacc atagtcccgt
     3481 tcctctctag gacgcaggag caagggctgg cctagagaga ctgctacttg ccacctttcc
     3541 aggggctcta tgagacagaa agctatcttt tgtagctaga gagagcttga cagagcctca
     3601 gaagatgacc tcaaacacac cggcctccct aggacccaag gtgcctctgc atcagggaag
     3661 cccagcagaa aacgttacca ggaggttacc acctggctgc caagcactga gcagaggaag
     3721 caggaacgga gacctggtaa ctgagggaca aatggtgcct tggtgccttg atggcctctg
     3781 actgccttgg tgaagccttc tgcctgcaac cactatggag ctgcgtgccc aaggtggggc
     3841 tgagtgtgca gtttgattgg aagatcaaaa agaagacggg atgggcttgc acaggggaag
     3901 aggaccagct ggccccaaag caaatagatg agaaccattc aaaacaatga ttttcttacc
     3961 attggaatgg agtttacagc tgaagactgc cttgaatcgc ctccctctgc ttctacctcc
     4021 tgcgtgttga gatgacaggt ggacaccatt acgcctgctt catttggggc tagggagcca
     4081 acccaggctt tgtgtgtgct aagtagacac tctgcctgaa agacctacat tctcagctcc
     4141 cgaatgaaca atgattttaa gtaaagtcgg cttatgttta cagcaaaaaa
//
