LOCUS       NM_001252666            3952 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus dematin actin binding protein (Dmtn), transcript
            variant 6, mRNA.
ACCESSION   NM_001252666
VERSION     NM_001252666.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3952)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3952)
  AUTHORS   Fritz,D.I., Ding,Y., Merrill-Skoloff,G., Flaumenhaft,R., Hanada,T.
            and Chishti,A.H.
  TITLE     Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt
            Activation in Platelets
  JOURNAL   Mol Cell Biol 43 (6), 283-299 (2023)
   PUBMED   37216480
  REMARK    GeneRIF: Dematin Regulates Calcium Mobilization, Thrombosis, and
            Early Akt Activation in Platelets.
REFERENCE   3  (bases 1 to 3952)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3952)
  AUTHORS   Huang,Y.S., Delgadillo,L.F., Cyr,K.H., Kingsley,P.D., An,X.,
            McGrath,K.E., Mohandas,N., Conboy,J.G., Waugh,R.E., Wan,J. and
            Palis,J.
  TITLE     Circulating primitive erythroblasts establish a functional, protein
            4.1R-dependent cytoskeletal network prior to enucleating
  JOURNAL   Sci Rep 7 (1), 5164 (2017)
   PUBMED   28701737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3952)
  AUTHORS   Lu,Y., Hanada,T., Fujiwara,Y., Nwankwo,J.O., Wieschhaus,A.J.,
            Hartwig,J., Huang,S., Han,J. and Chishti,A.H.
  TITLE     Gene disruption of dematin causes precipitous loss of erythrocyte
            membrane stability and severe hemolytic anemia
  JOURNAL   Blood 128 (1), 93-103 (2016)
   PUBMED   27073223
  REMARK    GeneRIF: results demonstrate that dematin plays a critical role in
            maintaining the fundamental properties of the membrane cytoskeleton
            complex.
REFERENCE   6  (bases 1 to 3952)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
REFERENCE   7  (bases 1 to 3952)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   8  (bases 1 to 3952)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
REFERENCE   9  (bases 1 to 3952)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   10 (bases 1 to 3952)
  AUTHORS   Peters,L.L., Eicher,E.M., Azim,A.C. and Chishti,A.H.
  TITLE     The gene encoding the erythrocyte membrane skeleton protein dematin
            (Epb4.9) maps to mouse chromosome 14
  JOURNAL   Genomics 26 (3), 634-635 (1995)
   PUBMED   7607697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY000876.1, BC037021.1, AK165204.1, BY601680.1 and AI413696.1.
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            lacks an in-frame coding exon in the 5' region and an in-frame exon
            in the 3' coding region, compared to variant 1. The resulting
            isoform (4) lacks two internal segments, compared to isoform 1.
            Variants 5, 6 and 13 encode the same isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.250463.1, BC037021.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BY000876.1         2-25
            25-2461             BC037021.1         12-2448
            2462-2537           AK165204.1         2762-2837
            2538-2540           BY601680.1         296-298
            2541-3591           AK165204.1         2840-3890
            3592-3952           AI413696.1         1-361               c
FEATURES             Location/Qualifiers
     source          1..3952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..3952
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="dematin actin binding protein"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
     exon            1..331
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1390
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="isoform 4 is encoded by transcript variant 6;
                     erythrocyte membrane protein band 4.9; erythrocyte protein
                     band 4.9"
                     /codon_start=1
                     /product="dematin isoform 4"
                     /protein_id="NP_001239595.1"
                     /db_xref="CCDS:CCDS88706.1"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
                     /translation="MERLQKAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFT
                     YSLLEHVELPRSRECSLSPKSTSPPPSPEVWAESRTLGIISQASTPRTTGTPRTSLPH
                     FHHPETTRPDSNIYKKPPIYKQRESVGGSPQSKHLIEDLIIESSKFPAAQPPDPNQPA
                     KIETDYWPCPPSLAVVETEWRKRKASRKGAEEEEEEEDDDSEEEIKAIRERQKEELSK
                     VTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHSGTSKSSSLPSYGRTTLSRL
                     QSTEFSPSGSEAGSPGLQIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFA
                     MSPEEFGKLALWKRNELKKKASLF"
     exon            332..487
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            488..532
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            533..632
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            633..689
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            690..842
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            843..967
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1073
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1138
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1187
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1195
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1276
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..3947
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2435..2440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2461
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="major polyA site"
     polyA_site      2512
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      2660..2665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2678
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      3905..3910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AATGAA"
     regulatory      3922..3927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AGTAAA"
     polyA_site      3927
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     polyA_site      3947
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
ORIGIN      
        1 gtcatttcct ctgaagccag agaacaatgg ctgaaaaaac aagtgcagcc gactcacgca
       61 gccaccgcct ggccacatgc acgcacaact ccctggggct gaactcagcg ccgcggaacc
      121 tgacagccta acgcccttac tggggctcac tgtccttcca gccacccgcg gtcagcagcc
      181 cagagaggcc caagggatga ggacaccaca gagcgctgtg acgccctcgc tgcaggagcc
      241 gggccgagcc tgacgtctgt cctctccaag tgcgcaccgg cccccgaggg agcggccggc
      301 cagtggctgc cgcatggaac gtctgcagaa ggccaagatg gacaaccagg tgttgggcta
      361 caaggatctg gctgccatcc ccaaggacaa ggccatcctg gacattgagc gacctgacct
      421 catgatctat gagccccact ttacctattc cctcctggaa catgtagagc tgcccagaag
      481 ccgggagtgc tcactgtcac ccaaatccac atccccccca ccgtctccag aggtgtgggc
      541 ggagagccgg actcttggaa tcatctctca ggcttcaacc ccaaggacca cagggacccc
      601 caggaccagc ctgccccact tccaccaccc tgagactacc cgcccggatt ccaacatcta
      661 caagaagcca cccatctaca aacagagaga atccgtggga ggcagccctc agagcaagca
      721 cctcatcgag gacctcatca tcgaatcctc caagtttcct gcagcgcagc cccctgaccc
      781 caaccagcca gccaagatag agactgacta ctggccatgt cccccgtcgc tggccgttgt
      841 ggagacagaa tggaggaaac ggaaggcatc tcgaaagggg gcagaggaag aggaggaaga
      901 ggaagacgat gactctgaag aggagattaa ggccatcagg gaacggcaga aagaggagct
      961 cagtaaggtt acttccaact tgggaaagat gatcttgaaa gaagagatgg aaaagtcatt
     1021 gcccatccgg aggaaaacac gctctctgcc tgaccggaca cccttccata cctccttgca
     1081 ttcgggaaca tctaaatcct cttcgcttcc ttcctatggc aggaccaccc tgagccggct
     1141 acagtccaca gaattcagcc catcgggaag tgaggctggg agcccaggcc tgcagatcta
     1201 tccctatgag atgctggtgg tgaccaataa ggggagaact aagctgcctc cgggtgtgga
     1261 ccgcatgagg cttgagaggc atttgtcagc agaggacttc tctagggtct tcgccatgtc
     1321 tcccgaggag tttggcaagc tggccctgtg gaagcggaac gaacttaaga agaaagcttc
     1381 cctcttctga catccctgcc ggctcggctc gattcggctc gccctgtccg tgacagtacc
     1441 ttccttctgc tgcttcgagg ccctgaagct ggggctgtga gacccttccc tacagtgtcc
     1501 tcttcctctg ctggctggga gcagcgggag gcagggcaga aacgttgggc tccattcctc
     1561 acggagagag ccaagaagtg cacagtccca gagtcacgag gcgtggactt ccttccccac
     1621 gatgggccag ggggccttac catttccctg ggctctactg cctagacaaa cccagcccgg
     1681 actccagcac acaatgtttg cacccgttcc ctgtctgtca ccccacatga gagtccccag
     1741 aagacagtga ggagaaacga agggggctta gcggggaggt cggtctgctg tcctgtacag
     1801 ggggaggcgg cagctctggg accctgtgcc tgtccaccca aaggctccag ccagctgcac
     1861 tcctggcagt ttcctgcact tgggcctgat gcttctctaa ctggcagaag caggctctac
     1921 ctggacctcc agctgggagg tcatcctccc tctagcttgt atgtcctgta ctttgcaacc
     1981 cctaagcttc aaacctcttg ctcaagaccc aagacttatt caaagctgtg gctaagagca
     2041 gagacgctgt tcacacaacg cctcaccacc accagcctcc aggcaaaacc agataggatg
     2101 caccgttcta gcacctgtcc agggaccacc gagcccaggc ctcagcctcc ctaagatggg
     2161 atggagagtc ccagctccca ggtccctcca ttgccatgca tctcctactg tgctctctac
     2221 agaatgtaat ttattggggc accctctgct gcttccctga ctccctgccc tacctaattg
     2281 cacttccagt cctgtctgtc cacatatgta cgtgtatata attatacata tatatatatc
     2341 tattttgccc aggtctgggt ttcgttttta cccagaccct ggcactccct gtccactgtg
     2401 tgtgtgatca tgctgggagg ggtaactgct tggaattaaa aggttgcact gggtccctaa
     2461 atctattgtt tctatccatg cctgtgcata tcagacaagc actgtaccac aaccagttgt
     2521 cttacctctt ttttttttct ttttttcttt ttcaagacag ggtttctctg tatagccctg
     2581 gcggtcctgg aactcactct gtagaccagg ctggcctaga actcagaaat cctcctgcct
     2641 ctgcctccca agtgctggga ttaaagcatg taccactact gctgggctag tcttacctct
     2701 ttagttgccc aggctagacc tgacctctca ctctgtagcc caggaagttt tggccttctt
     2761 ggttcagtat caagtagctg gacgcatagg cttaggccag cagcctgaac tatctattca
     2821 tttattctgt tttgttgttt tgtttgaaat aaggtgtccc atagcaaagg ctggtcttga
     2881 acccctgatc cagcatttgc ctttccgagt gctgggatca caggcatata tcgcatattt
     2941 gtggatctta tttgtctcac atagctcaca ctggcctcaa acttacttgt atctgaggtt
     3001 gaacttccca tccgccttgc ctctgcctca caagtgctgg aatacactga cagccatggt
     3061 ttattccgtg ctggggatgg aacccagggt ctcttgcttg ctaggtgtgt gctctaccaa
     3121 ctgagccaca ttgataaccc acgtttgttt ctttataagc cactagccct gagacatagg
     3181 gacaggtgac atcaggtttc atgtgagcca gagtgggctt agagacaata ccatagtccc
     3241 gttcctctct aggacgcagg agcaagggct ggcctagaga gactgctact tgccaccttt
     3301 ccaggggctc tatgagacag aaagctatct tttgtagcta gagagagctt gacagagcct
     3361 cagaagatga cctcaaacac accggcctcc ctaggaccca aggtgcctct gcatcaggga
     3421 agcccagcag aaaacgttac caggaggtta ccacctggct gccaagcact gagcagagga
     3481 agcaggaacg gagacctggt aactgaggga caaatggtgc cttggtgcct tgatggcctc
     3541 tgactgcctt ggtgaagcct tctgcctgca accactatgg agctgcgtgc ccaaggtggg
     3601 gctgagtgtg cagtttgatt ggaagatcaa aaagaagacg ggatgggctt gcacagggga
     3661 agaggaccag ctggccccaa agcaaataga tgagaaccat tcaaaacaat gattttctta
     3721 ccattggaat ggagtttaca gctgaagact gccttgaatc gcctccctct gcttctacct
     3781 cctgcgtgtt gagatgacag gtggacacca ttacgcctgc ttcatttggg gctagggagc
     3841 caacccaggc tttgtgtgtg ctaagtagac actctgcctg aaagacctac attctcagct
     3901 cccgaatgaa caatgatttt aagtaaagtc ggcttatgtt tacagcaaaa aa
//
