LOCUS       NM_001252665            3919 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus dematin actin binding protein (Dmtn), transcript
            variant 5, mRNA.
ACCESSION   NM_001252665
VERSION     NM_001252665.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3919)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3919)
  AUTHORS   Fritz,D.I., Ding,Y., Merrill-Skoloff,G., Flaumenhaft,R., Hanada,T.
            and Chishti,A.H.
  TITLE     Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt
            Activation in Platelets
  JOURNAL   Mol Cell Biol 43 (6), 283-299 (2023)
   PUBMED   37216480
  REMARK    GeneRIF: Dematin Regulates Calcium Mobilization, Thrombosis, and
            Early Akt Activation in Platelets.
REFERENCE   3  (bases 1 to 3919)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3919)
  AUTHORS   Huang,Y.S., Delgadillo,L.F., Cyr,K.H., Kingsley,P.D., An,X.,
            McGrath,K.E., Mohandas,N., Conboy,J.G., Waugh,R.E., Wan,J. and
            Palis,J.
  TITLE     Circulating primitive erythroblasts establish a functional, protein
            4.1R-dependent cytoskeletal network prior to enucleating
  JOURNAL   Sci Rep 7 (1), 5164 (2017)
   PUBMED   28701737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3919)
  AUTHORS   Lu,Y., Hanada,T., Fujiwara,Y., Nwankwo,J.O., Wieschhaus,A.J.,
            Hartwig,J., Huang,S., Han,J. and Chishti,A.H.
  TITLE     Gene disruption of dematin causes precipitous loss of erythrocyte
            membrane stability and severe hemolytic anemia
  JOURNAL   Blood 128 (1), 93-103 (2016)
   PUBMED   27073223
  REMARK    GeneRIF: results demonstrate that dematin plays a critical role in
            maintaining the fundamental properties of the membrane cytoskeleton
            complex.
REFERENCE   6  (bases 1 to 3919)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
REFERENCE   7  (bases 1 to 3919)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   8  (bases 1 to 3919)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
REFERENCE   9  (bases 1 to 3919)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   10 (bases 1 to 3919)
  AUTHORS   Peters,L.L., Eicher,E.M., Azim,A.C. and Chishti,A.H.
  TITLE     The gene encoding the erythrocyte membrane skeleton protein dematin
            (Epb4.9) maps to mouse chromosome 14
  JOURNAL   Genomics 26 (3), 634-635 (1995)
   PUBMED   7607697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270342.1, AK162866.1, AK165204.1, BY601680.1 and AI413696.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR and
            lacks an in-frame coding exon in the 5' region and an in-frame exon
            in the 3' coding region, compared to variant 1. The resulting
            isoform (4) lacks two internal segments, compared to isoform 1.
            Variants 5, 6 and 13 encode the same isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162866.1, SRR1660815.160094.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY270342.1         2-49
            49-2425             AK162866.1         1-2377
            2426-2504           AK165204.1         2759-2837
            2505-2507           BY601680.1         296-298
            2508-3558           AK165204.1         2840-3890
            3559-3919           AI413696.1         1-361               c
FEATURES             Location/Qualifiers
     source          1..3919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..3919
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="dematin actin binding protein"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
     exon            1..128
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            129..298
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1357
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="isoform 4 is encoded by transcript variant 5;
                     erythrocyte membrane protein band 4.9; erythrocyte protein
                     band 4.9"
                     /codon_start=1
                     /product="dematin isoform 4"
                     /protein_id="NP_001239594.1"
                     /db_xref="CCDS:CCDS88706.1"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
                     /translation="MERLQKAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFT
                     YSLLEHVELPRSRECSLSPKSTSPPPSPEVWAESRTLGIISQASTPRTTGTPRTSLPH
                     FHHPETTRPDSNIYKKPPIYKQRESVGGSPQSKHLIEDLIIESSKFPAAQPPDPNQPA
                     KIETDYWPCPPSLAVVETEWRKRKASRKGAEEEEEEEDDDSEEEIKAIRERQKEELSK
                     VTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHSGTSKSSSLPSYGRTTLSRL
                     QSTEFSPSGSEAGSPGLQIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFA
                     MSPEEFGKLALWKRNELKKKASLF"
     exon            299..454
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            455..499
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            500..599
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            600..656
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            657..809
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            810..934
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1040
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1105
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1154
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1162
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1243
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..3914
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2402..2407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2428
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="major polyA site"
     polyA_site      2479
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      2627..2632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2645
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      3872..3877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AATGAA"
     regulatory      3889..3894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AGTAAA"
     polyA_site      3894
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     polyA_site      3914
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
ORIGIN      
        1 gagctgggcc tgggctgcca ggaggttgtc ttggcaacgg gaggcggaga ggagatgcgc
       61 tgagggatgg aggtgtatgt caccgcagag gctgctgtgt tcctgcccca cgccccgggc
      121 ccttgaagcc acccgcggtc agcagcccag agaggcccaa gggatgagga caccacagag
      181 cgctgtgacg ccctcgctgc aggagccggg ccgagcctga cgtctgtcct ctccaagtgc
      241 gcaccggccc ccgagggagc ggccggccag tggctgccgc atggaacgtc tgcagaaggc
      301 caagatggac aaccaggtgt tgggctacaa ggatctggct gccatcccca aggacaaggc
      361 catcctggac attgagcgac ctgacctcat gatctatgag ccccacttta cctattccct
      421 cctggaacat gtagagctgc ccagaagccg ggagtgctca ctgtcaccca aatccacatc
      481 ccccccaccg tctccagagg tgtgggcgga gagccggact cttggaatca tctctcaggc
      541 ttcaacccca aggaccacag ggacccccag gaccagcctg ccccacttcc accaccctga
      601 gactacccgc ccggattcca acatctacaa gaagccaccc atctacaaac agagagaatc
      661 cgtgggaggc agccctcaga gcaagcacct catcgaggac ctcatcatcg aatcctccaa
      721 gtttcctgca gcgcagcccc ctgaccccaa ccagccagcc aagatagaga ctgactactg
      781 gccatgtccc ccgtcgctgg ccgttgtgga gacagaatgg aggaaacgga aggcatctcg
      841 aaagggggca gaggaagagg aggaagagga agacgatgac tctgaagagg agattaaggc
      901 catcagggaa cggcagaaag aggagctcag taaggttact tccaacttgg gaaagatgat
      961 cttgaaagaa gagatggaaa agtcattgcc catccggagg aaaacacgct ctctgcctga
     1021 ccggacaccc ttccatacct ccttgcattc gggaacatct aaatcctctt cgcttccttc
     1081 ctatggcagg accaccctga gccggctaca gtccacagaa ttcagcccat cgggaagtga
     1141 ggctgggagc ccaggcctgc agatctatcc ctatgagatg ctggtggtga ccaataaggg
     1201 gagaactaag ctgcctccgg gtgtggaccg catgaggctt gagaggcatt tgtcagcaga
     1261 ggacttctct agggtcttcg ccatgtctcc cgaggagttt ggcaagctgg ccctgtggaa
     1321 gcggaacgaa cttaagaaga aagcttccct cttctgacat ccctgccggc tcggctcgat
     1381 tcggctcgcc ctgtccgtga cagtaccttc cttctgctgc ttcgaggccc tgaagctggg
     1441 gctgtgagac ccttccctac agtgtcctct tcctctgctg gctgggagca gcgggaggca
     1501 gggcagaaac gttgggctcc attcctcacg gagagagcca agaagtgcac agtcccagag
     1561 tcacgaggcg tggacttcct tccccacgat gggccagggg gccttaccat ttccctgggc
     1621 tctactgcct agacaaaccc agcccggact ccagcacaca atgtttgcac ccgttccctg
     1681 tctgtcaccc cacatgagag tccccagaag acagtgagga gaaacgaagg gggcttagcg
     1741 gggaggtcgg tctgctgtcc tgtacagggg gaggcggcag ctctgggacc ctgtgcctgt
     1801 ccacccaaag gctccagcca gctgcactcc tggcagtttc ctgcacttgg gcctgatgct
     1861 tctctaactg gcagaagcag gctctacctg gacctccagc tgggaggtca tcctccctct
     1921 agcttgtatg tcctgtactt tgcaacccct aagcttcaaa cctcttgctc aagacccaag
     1981 acttattcaa agctgtggct aagagcagag acgctgttca cacaacgcct caccaccacc
     2041 agcctccagg caaaaccaga taggatgcac cgttctagca cctgtccagg gaccaccgag
     2101 cccaggcctc agcctcccta agatgggatg gagagtccca gctcccaggt ccctccattg
     2161 ccatgcatct cctactgtgc tctctacaga atgtaattta ttggggcacc ctctgctgct
     2221 tccctgactc cctgccctac ctaattgcac ttccagtcct gtctgtccac atatgtacgt
     2281 gtatataatt atacatatat atatatctat tttgcccagg tctgggtttc gtttttaccc
     2341 agaccctggc actccctgtc cactgtgtgt gtgatcatgc tgggaggggt aactgcttgg
     2401 aattaaaagg ttgcactggg tccctaaatc tattgtttct atccatgcct gtgcatatca
     2461 gacaagcact gtaccacaac cagttgtctt acctcttttt tttttctttt tttctttttc
     2521 aagacagggt ttctctgtat agccctggcg gtcctggaac tcactctgta gaccaggctg
     2581 gcctagaact cagaaatcct cctgcctctg cctcccaagt gctgggatta aagcatgtac
     2641 cactactgct gggctagtct tacctcttta gttgcccagg ctagacctga cctctcactc
     2701 tgtagcccag gaagttttgg ccttcttggt tcagtatcaa gtagctggac gcataggctt
     2761 aggccagcag cctgaactat ctattcattt attctgtttt gttgttttgt ttgaaataag
     2821 gtgtcccata gcaaaggctg gtcttgaacc cctgatccag catttgcctt tccgagtgct
     2881 gggatcacag gcatatatcg catatttgtg gatcttattt gtctcacata gctcacactg
     2941 gcctcaaact tacttgtatc tgaggttgaa cttcccatcc gccttgcctc tgcctcacaa
     3001 gtgctggaat acactgacag ccatggttta ttccgtgctg gggatggaac ccagggtctc
     3061 ttgcttgcta ggtgtgtgct ctaccaactg agccacattg ataacccacg tttgtttctt
     3121 tataagccac tagccctgag acatagggac aggtgacatc aggtttcatg tgagccagag
     3181 tgggcttaga gacaatacca tagtcccgtt cctctctagg acgcaggagc aagggctggc
     3241 ctagagagac tgctacttgc cacctttcca ggggctctat gagacagaaa gctatctttt
     3301 gtagctagag agagcttgac agagcctcag aagatgacct caaacacacc ggcctcccta
     3361 ggacccaagg tgcctctgca tcagggaagc ccagcagaaa acgttaccag gaggttacca
     3421 cctggctgcc aagcactgag cagaggaagc aggaacggag acctggtaac tgagggacaa
     3481 atggtgcctt ggtgccttga tggcctctga ctgccttggt gaagccttct gcctgcaacc
     3541 actatggagc tgcgtgccca aggtggggct gagtgtgcag tttgattgga agatcaaaaa
     3601 gaagacggga tgggcttgca caggggaaga ggaccagctg gccccaaagc aaatagatga
     3661 gaaccattca aaacaatgat tttcttacca ttggaatgga gtttacagct gaagactgcc
     3721 ttgaatcgcc tccctctgct tctacctcct gcgtgttgag atgacaggtg gacaccatta
     3781 cgcctgcttc atttggggct agggagccaa cccaggcttt gtgtgtgcta agtagacact
     3841 ctgcctgaaa gacctacatt ctcagctccc gaatgaacaa tgattttaag taaagtcggc
     3901 ttatgtttac agcaaaaaa
//
