LOCUS       NM_001252664            4086 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus dematin actin binding protein (Dmtn), transcript
            variant 4, mRNA.
ACCESSION   NM_001252664
VERSION     NM_001252664.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4086)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4086)
  AUTHORS   Fritz,D.I., Ding,Y., Merrill-Skoloff,G., Flaumenhaft,R., Hanada,T.
            and Chishti,A.H.
  TITLE     Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt
            Activation in Platelets
  JOURNAL   Mol Cell Biol 43 (6), 283-299 (2023)
   PUBMED   37216480
  REMARK    GeneRIF: Dematin Regulates Calcium Mobilization, Thrombosis, and
            Early Akt Activation in Platelets.
REFERENCE   3  (bases 1 to 4086)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4086)
  AUTHORS   Huang,Y.S., Delgadillo,L.F., Cyr,K.H., Kingsley,P.D., An,X.,
            McGrath,K.E., Mohandas,N., Conboy,J.G., Waugh,R.E., Wan,J. and
            Palis,J.
  TITLE     Circulating primitive erythroblasts establish a functional, protein
            4.1R-dependent cytoskeletal network prior to enucleating
  JOURNAL   Sci Rep 7 (1), 5164 (2017)
   PUBMED   28701737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4086)
  AUTHORS   Lu,Y., Hanada,T., Fujiwara,Y., Nwankwo,J.O., Wieschhaus,A.J.,
            Hartwig,J., Huang,S., Han,J. and Chishti,A.H.
  TITLE     Gene disruption of dematin causes precipitous loss of erythrocyte
            membrane stability and severe hemolytic anemia
  JOURNAL   Blood 128 (1), 93-103 (2016)
   PUBMED   27073223
  REMARK    GeneRIF: results demonstrate that dematin plays a critical role in
            maintaining the fundamental properties of the membrane cytoskeleton
            complex.
REFERENCE   6  (bases 1 to 4086)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
REFERENCE   7  (bases 1 to 4086)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   8  (bases 1 to 4086)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
REFERENCE   9  (bases 1 to 4086)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   10 (bases 1 to 4086)
  AUTHORS   Peters,L.L., Eicher,E.M., Azim,A.C. and Chishti,A.H.
  TITLE     The gene encoding the erythrocyte membrane skeleton protein dematin
            (Epb4.9) maps to mouse chromosome 14
  JOURNAL   Genomics 26 (3), 634-635 (1995)
   PUBMED   7607697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY282941.1, AK158744.1, AK165204.1, BY601680.1 and AI413696.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            lacks an in-frame coding exon in the 5' region, compared to variant
            1. The resulting isoform (3) lacks an internal segment, compared to
            isoform 1. Variants 4, 11 and 12 encode the same isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158744.1, AK149301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BY282941.1         1-70
            71-945              AK158744.1         2-876
            946-2671            AK165204.1         1112-2837
            2672-2674           BY601680.1         296-298
            2675-3725           AK165204.1         2840-3890
            3726-4086           AI413696.1         1-361               c
FEATURES             Location/Qualifiers
     source          1..4086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..4086
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="dematin actin binding protein"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
     exon            1..229
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            230..399
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1524
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="isoform 3 is encoded by transcript variant 4;
                     erythrocyte membrane protein band 4.9; erythrocyte protein
                     band 4.9"
                     /codon_start=1
                     /product="dematin isoform 3"
                     /protein_id="NP_001239593.1"
                     /db_xref="CCDS:CCDS88707.1"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
                     /translation="MERLQKAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFT
                     YSLLEHVELPRSRECSLSPKSTSPPPSPEVWAESRTLGIISQASTPRTTGTPRTSLPH
                     FHHPETTRPDSNIYKKPPIYKQRESVGGSPQSKHLIEDLIIESSKFPAAQPPDPNQPA
                     KIETDYWPCPPSLAVVETEWRKRKASRKGAEEEEEEEDDDSEEEIKAIRERQKEELSK
                     VTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHSGTSKSSSLPSYGRTTLSRL
                     QSTEFSPSGSEAGSPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNKGRTKLP
                     PGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF"
     exon            400..555
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            556..600
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            601..700
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            701..757
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            758..910
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1035
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1141
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1206
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1255
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1263
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1329
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1410
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..4081
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2595
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="major polyA site"
     polyA_site      2646
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2812
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      4039..4044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AATGAA"
     regulatory      4056..4061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AGTAAA"
     polyA_site      4061
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     polyA_site      4081
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
ORIGIN      
        1 ggggggatgg cggcccctcc ctccgcgggc tccgatgtcc aggctcacgc gacgcgtctc
       61 tgctacctgt aggagagaag aaaacccaac ccctaggcgc ggccctgagc ggccgctggc
      121 agggacgggc gtcctgtggg gcccaggccc gggggaggag gggggtggca ggatcacagc
      181 ctggggacgc cagaagtcac ctcgcaggga gcaagattgc ttttttccgc cacccgcggt
      241 cagcagccca gagaggccca agggatgagg acaccacaga gcgctgtgac gccctcgctg
      301 caggagccgg gccgagcctg acgtctgtcc tctccaagtg cgcaccggcc cccgagggag
      361 cggccggcca gtggctgccg catggaacgt ctgcagaagg ccaagatgga caaccaggtg
      421 ttgggctaca aggatctggc tgccatcccc aaggacaagg ccatcctgga cattgagcga
      481 cctgacctca tgatctatga gccccacttt acctattccc tcctggaaca tgtagagctg
      541 cccagaagcc gggagtgctc actgtcaccc aaatccacat cccccccacc gtctccagag
      601 gtgtgggcgg agagccggac tcttggaatc atctctcagg cttcaacccc aaggaccaca
      661 gggaccccca ggaccagcct gccccacttc caccaccctg agactacccg cccggattcc
      721 aacatctaca agaagccacc catctacaaa cagagagaat ccgtgggagg cagccctcag
      781 agcaagcacc tcatcgagga cctcatcatc gaatcctcca agtttcctgc agcgcagccc
      841 cctgacccca accagccagc caagatagag actgactact ggccatgtcc cccgtcgctg
      901 gccgttgtgg agacagaatg gaggaaacgg aaggcatctc gaaagggggc agaggaagag
      961 gaggaagagg aagacgatga ctctgaagag gagattaagg ccatcaggga acggcagaaa
     1021 gaggagctca gtaaggttac ttccaacttg ggaaagatga tcttgaaaga agagatggaa
     1081 aagtcattgc ccatccggag gaaaacacgc tctctgcctg accggacacc cttccatacc
     1141 tccttgcatt cgggaacatc taaatcctct tcgcttcctt cctatggcag gaccaccctg
     1201 agccggctac agtccacaga attcagccca tcgggaagtg aggctgggag cccaggcctg
     1261 cagaacggag agggccagag ggggaggatg gatcggggga actccctgcc ctgtgtgctg
     1321 gagcagaaga tctatcccta tgagatgctg gtggtgacca ataaggggag aactaagctg
     1381 cctccgggtg tggaccgcat gaggcttgag aggcatttgt cagcagagga cttctctagg
     1441 gtcttcgcca tgtctcccga ggagtttggc aagctggccc tgtggaagcg gaacgaactt
     1501 aagaagaaag cttccctctt ctgacatccc tgccggctcg gctcgattcg gctcgccctg
     1561 tccgtgacag taccttcctt ctgctgcttc gaggccctga agctggggct gtgagaccct
     1621 tccctacagt gtcctcttcc tctgctggct gggagcagcg ggaggcaggg cagaaacgtt
     1681 gggctccatt cctcacggag agagccaaga agtgcacagt cccagagtca cgaggcgtgg
     1741 acttccttcc ccacgatggg ccagggggcc ttaccatttc cctgggctct actgcctaga
     1801 caaacccagc ccggactcca gcacacaatg tttgcacccg ttccctgtct gtcaccccac
     1861 atgagagtcc ccagaagaca gtgaggagaa acgaaggggg cttagcgggg aggtcggtct
     1921 gctgtcctgt acagggggag gcggcagctc tgggaccctg tgcctgtcca cccaaaggct
     1981 ccagccagct gcactcctgg cagtttcctg cacttgggcc tgatgcttct ctaactggca
     2041 gaagcaggct ctacctggac ctccagctgg gaggtcatcc tccctctagc ttgtatgtcc
     2101 tgtactttgc aacccctaag cttcaaacct cttgctcaag acccaagact tattcaaagc
     2161 tgtggctaag agcagagacg ctgttcacac aacgcctcac caccaccagc ctccaggcaa
     2221 aaccagatag gatgcaccgt tctagcacct gtccagggac caccgagccc aggcctcagc
     2281 ctccctaaga tgggatggag agtcccagct cccaggtccc tccattgcca tgcatctcct
     2341 actgtgctct ctacagaatg taatttattg gggcaccctc tgctgcttcc ctgactccct
     2401 gccctaccta attgcacttc cagtcctgtc tgtccacata tgtacgtgta tataattata
     2461 catatatata tatctatttt gcccaggtct gggtttcgtt tttacccaga ccctggcact
     2521 ccctgtccac tgtgtgtgtg atcatgctgg gaggggtaac tgcttggaat taaaaggttg
     2581 cactgggtcc ctaaatctat tgtttctatc catgcctgtg catatcagac aagcactgta
     2641 ccacaaccag ttgtcttacc tctttttttt ttcttttttt ctttttcaag acagggtttc
     2701 tctgtatagc cctggcggtc ctggaactca ctctgtagac caggctggcc tagaactcag
     2761 aaatcctcct gcctctgcct cccaagtgct gggattaaag catgtaccac tactgctggg
     2821 ctagtcttac ctctttagtt gcccaggcta gacctgacct ctcactctgt agcccaggaa
     2881 gttttggcct tcttggttca gtatcaagta gctggacgca taggcttagg ccagcagcct
     2941 gaactatcta ttcatttatt ctgttttgtt gttttgtttg aaataaggtg tcccatagca
     3001 aaggctggtc ttgaacccct gatccagcat ttgcctttcc gagtgctggg atcacaggca
     3061 tatatcgcat atttgtggat cttatttgtc tcacatagct cacactggcc tcaaacttac
     3121 ttgtatctga ggttgaactt cccatccgcc ttgcctctgc ctcacaagtg ctggaataca
     3181 ctgacagcca tggtttattc cgtgctgggg atggaaccca gggtctcttg cttgctaggt
     3241 gtgtgctcta ccaactgagc cacattgata acccacgttt gtttctttat aagccactag
     3301 ccctgagaca tagggacagg tgacatcagg tttcatgtga gccagagtgg gcttagagac
     3361 aataccatag tcccgttcct ctctaggacg caggagcaag ggctggccta gagagactgc
     3421 tacttgccac ctttccaggg gctctatgag acagaaagct atcttttgta gctagagaga
     3481 gcttgacaga gcctcagaag atgacctcaa acacaccggc ctccctagga cccaaggtgc
     3541 ctctgcatca gggaagccca gcagaaaacg ttaccaggag gttaccacct ggctgccaag
     3601 cactgagcag aggaagcagg aacggagacc tggtaactga gggacaaatg gtgccttggt
     3661 gccttgatgg cctctgactg ccttggtgaa gccttctgcc tgcaaccact atggagctgc
     3721 gtgcccaagg tggggctgag tgtgcagttt gattggaaga tcaaaaagaa gacgggatgg
     3781 gcttgcacag gggaagagga ccagctggcc ccaaagcaaa tagatgagaa ccattcaaaa
     3841 caatgatttt cttaccattg gaatggagtt tacagctgaa gactgccttg aatcgcctcc
     3901 ctctgcttct acctcctgcg tgttgagatg acaggtggac accattacgc ctgcttcatt
     3961 tggggctagg gagccaaccc aggctttgtg tgtgctaagt agacactctg cctgaaagac
     4021 ctacattctc agctcccgaa tgaacaatga ttttaagtaa agtcggctta tgtttacagc
     4081 aaaaaa
//
