LOCUS       NM_001252662            4254 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dematin actin binding protein (Dmtn), transcript
            variant 1, mRNA.
ACCESSION   NM_001252662
VERSION     NM_001252662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4254)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4254)
  AUTHORS   Fritz,D.I., Ding,Y., Merrill-Skoloff,G., Flaumenhaft,R., Hanada,T.
            and Chishti,A.H.
  TITLE     Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt
            Activation in Platelets
  JOURNAL   Mol Cell Biol 43 (6), 283-299 (2023)
   PUBMED   37216480
  REMARK    GeneRIF: Dematin Regulates Calcium Mobilization, Thrombosis, and
            Early Akt Activation in Platelets.
REFERENCE   3  (bases 1 to 4254)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4254)
  AUTHORS   Huang,Y.S., Delgadillo,L.F., Cyr,K.H., Kingsley,P.D., An,X.,
            McGrath,K.E., Mohandas,N., Conboy,J.G., Waugh,R.E., Wan,J. and
            Palis,J.
  TITLE     Circulating primitive erythroblasts establish a functional, protein
            4.1R-dependent cytoskeletal network prior to enucleating
  JOURNAL   Sci Rep 7 (1), 5164 (2017)
   PUBMED   28701737
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4254)
  AUTHORS   Lu,Y., Hanada,T., Fujiwara,Y., Nwankwo,J.O., Wieschhaus,A.J.,
            Hartwig,J., Huang,S., Han,J. and Chishti,A.H.
  TITLE     Gene disruption of dematin causes precipitous loss of erythrocyte
            membrane stability and severe hemolytic anemia
  JOURNAL   Blood 128 (1), 93-103 (2016)
   PUBMED   27073223
  REMARK    GeneRIF: results demonstrate that dematin plays a critical role in
            maintaining the fundamental properties of the membrane cytoskeleton
            complex.
REFERENCE   6  (bases 1 to 4254)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
REFERENCE   7  (bases 1 to 4254)
  AUTHORS   Cornwall,G.A. and Hsia,N.
  TITLE     ADAM7, a member of the ADAM (a disintegrin and metalloprotease)
            gene family is specifically expressed in the mouse anterior
            pituitary and epididymis
  JOURNAL   Endocrinology 138 (10), 4262-4272 (1997)
   PUBMED   9322939
REFERENCE   8  (bases 1 to 4254)
  AUTHORS   Malgaretti,N., Pozzoli,O., Bosetti,A., Corradi,A., Ciarmatori,S.,
            Panigada,M., Bianchi,M.E., Martinez,S. and Consalez,G.G.
  TITLE     Mmot1, a new helix-loop-helix transcription factor gene displaying
            a sharp expression boundary in the embryonic mouse brain
  JOURNAL   J Biol Chem 272 (28), 17632-17639 (1997)
   PUBMED   9211912
REFERENCE   9  (bases 1 to 4254)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
REFERENCE   10 (bases 1 to 4254)
  AUTHORS   Peters,L.L., Eicher,E.M., Azim,A.C. and Chishti,A.H.
  TITLE     The gene encoding the erythrocyte membrane skeleton protein dematin
            (Epb4.9) maps to mouse chromosome 14
  JOURNAL   Genomics 26 (3), 634-635 (1995)
   PUBMED   7607697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY789340.1, AK165204.1, AK162866.1 and BY601680.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 7, 8 and 9 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165204.1, AK143840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY789340.1         1-7
            8-622               AK165204.1         2-616
            623-1436            AK162866.1         301-1114
            1437-2844           AK165204.1         1430-2837
            2845-2847           BY601680.1         296-298
            2848-4254           AK165204.1         2840-4246
FEATURES             Location/Qualifiers
     source          1..4254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..4254
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="dematin actin binding protein"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
     exon            1..327
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            328..497
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..1697
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="isoform 1 is encoded by transcript variant 1;
                     erythrocyte membrane protein band 4.9; erythrocyte protein
                     band 4.9"
                     /codon_start=1
                     /product="dematin isoform 1"
                     /protein_id="NP_001239591.1"
                     /db_xref="CCDS:CCDS88708.1"
                     /db_xref="GeneID:13829"
                     /db_xref="MGI:MGI:99670"
                     /translation="MERLQKQPLTSPGSVSSSRDSSVPGSPSSIVAKMDNQVLGYKDL
                     AAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEVWAE
                     SRTLGIISQASTPRTTGTPRTSLPHFHHPETTRPDSNIYKKPPIYKQRESVGGSPQSK
                     HLIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRKGAEEE
                     EEEEDDDSEEEIKAIRERQKEELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPF
                     HTSLHSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSEAGSPGLQNGEGQRGRMDRGNSL
                     PCVLEQKIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLAL
                     WKRNELKKKASLF"
     exon            498..572
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            573..728
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            729..773
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            774..873
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            874..930
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1083
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1208
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1314
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1379
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1428
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1436
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1502
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1583
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..4254
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2768
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="major polyA site"
     polyA_site      2819
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      2967..2972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: ATTAAA"
     polyA_site      2985
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     regulatory      4212..4217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AATGAA"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
                     /note="hexamer: AGTAAA"
     polyA_site      4234
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
     polyA_site      4254
                     /gene="Dmtn"
                     /gene_synonym="dematin; Epb4.9; Epb49"
ORIGIN      
        1 agacaccaga ctcggactcc ccagctccgg gaacccaagc cggtggcttg cagagcagca
       61 ggggactggt gaagcgggtg ggggttcagg agggagatca gaccgctgag ctgagaccag
      121 ctcccctcct tcgccagctc ccaccccacc cacccaccct aagccggctt tcttcctgtt
      181 atttgtgctt cgtaaagcgc ggctgggttc ctggagaagc tgcctcttac ctagattcct
      241 gagaaaacgc ggccacccag tcgaccaggg cctagccttt tgcttcctgg ggcttcagag
      301 agcctgggcc ccactgtctg ggaggagcca cccgcggtca gcagcccaga gaggcccaag
      361 ggatgaggac accacagagc gctgtgacgc cctcgctgca ggagccgggc cgagcctgac
      421 gtctgtcctc tccaagtgcg caccggcccc cgagggagcg gccggccagt ggctgccgca
      481 tggaacgtct gcagaagcaa cctcttacct ccccggggag cgtcagctcc tccagagact
      541 ccagtgtgcc cggctctccc tccagcatcg tggccaagat ggacaaccag gtgttgggct
      601 acaaggatct ggctgccatc cccaaggaca aggccatcct ggacattgag cgacctgacc
      661 tcatgatcta tgagccccac tttacctatt ccctcctgga acatgtagag ctgcccagaa
      721 gccgggagtg ctcactgtca cccaaatcca catccccccc accgtctcca gaggtgtggg
      781 cggagagccg gactcttgga atcatctctc aggcttcaac cccaaggacc acagggaccc
      841 ccaggaccag cctgccccac ttccaccacc ctgagactac ccgcccggat tccaacatct
      901 acaagaagcc acccatctac aaacagagag aatccgtggg aggcagccct cagagcaagc
      961 acctcatcga ggacctcatc atcgaatcct ccaagtttcc tgcagcgcag ccccctgacc
     1021 ccaaccagcc agccaagata gagactgact actggccatg tcccccgtcg ctggccgttg
     1081 tggagacaga atggaggaaa cggaaggcat ctcgaaaggg ggcagaggaa gaggaggaag
     1141 aggaagacga tgactctgaa gaggagatta aggccatcag ggaacggcag aaagaggagc
     1201 tcagtaaggt tacttccaac ttgggaaaga tgatcttgaa agaagagatg gaaaagtcat
     1261 tgcccatccg gaggaaaaca cgctctctgc ctgaccggac acccttccat acctccttgc
     1321 attcgggaac atctaaatcc tcttcgcttc cttcctatgg caggaccacc ctgagccggc
     1381 tacagtccac agaattcagc ccatcgggaa gtgaggctgg gagcccaggc ctgcagaacg
     1441 gagagggcca gagggggagg atggatcggg ggaactccct gccctgtgtg ctggagcaga
     1501 agatctatcc ctatgagatg ctggtggtga ccaataaggg gagaactaag ctgcctccgg
     1561 gtgtggaccg catgaggctt gagaggcatt tgtcagcaga ggacttctct agggtcttcg
     1621 ccatgtctcc cgaggagttt ggcaagctgg ccctgtggaa gcggaacgaa cttaagaaga
     1681 aagcttccct cttctgacat ccctgccggc tcggctcgat tcggctcgcc ctgtccgtga
     1741 cagtaccttc cttctgctgc ttcgaggccc tgaagctggg gctgtgagac ccttccctac
     1801 agtgtcctct tcctctgctg gctgggagca gcgggaggca gggcagaaac gttgggctcc
     1861 attcctcacg gagagagcca agaagtgcac agtcccagag tcacgaggcg tggacttcct
     1921 tccccacgat gggccagggg gccttaccat ttccctgggc tctactgcct agacaaaccc
     1981 agcccggact ccagcacaca atgtttgcac ccgttccctg tctgtcaccc cacatgagag
     2041 tccccagaag acagtgagga gaaacgaagg gggcttagcg gggaggtcgg tctgctgtcc
     2101 tgtacagggg gaggcggcag ctctgggacc ctgtgcctgt ccacccaaag gctccagcca
     2161 gctgcactcc tggcagtttc ctgcacttgg gcctgatgct tctctaactg gcagaagcag
     2221 gctctacctg gacctccagc tgggaggtca tcctccctct agcttgtatg tcctgtactt
     2281 tgcaacccct aagcttcaaa cctcttgctc aagacccaag acttattcaa agctgtggct
     2341 aagagcagag acgctgttca cacaacgcct caccaccacc agcctccagg caaaaccaga
     2401 taggatgcac cgttctagca cctgtccagg gaccaccgag cccaggcctc agcctcccta
     2461 agatgggatg gagagtccca gctcccaggt ccctccattg ccatgcatct cctactgtgc
     2521 tctctacaga atgtaattta ttggggcacc ctctgctgct tccctgactc cctgccctac
     2581 ctaattgcac ttccagtcct gtctgtccac atatgtacgt gtatataatt atacatatat
     2641 atatatctat tttgcccagg tctgggtttc gtttttaccc agaccctggc actccctgtc
     2701 cactgtgtgt gtgatcatgc tgggaggggt aactgcttgg aattaaaagg ttgcactggg
     2761 tccctaaatc tattgtttct atccatgcct gtgcatatca gacaagcact gtaccacaac
     2821 cagttgtctt acctcttttt tttttctttt tttctttttc aagacagggt ttctctgtat
     2881 agccctggcg gtcctggaac tcactctgta gaccaggctg gcctagaact cagaaatcct
     2941 cctgcctctg cctcccaagt gctgggatta aagcatgtac cactactgct gggctagtct
     3001 tacctcttta gttgcccagg ctagacctga cctctcactc tgtagcccag gaagttttgg
     3061 ccttcttggt tcagtatcaa gtagctggac gcataggctt aggccagcag cctgaactat
     3121 ctattcattt attctgtttt gttgttttgt ttgaaataag gtgtcccata gcaaaggctg
     3181 gtcttgaacc cctgatccag catttgcctt tccgagtgct gggatcacag gcatatatcg
     3241 catatttgtg gatcttattt gtctcacata gctcacactg gcctcaaact tacttgtatc
     3301 tgaggttgaa cttcccatcc gccttgcctc tgcctcacaa gtgctggaat acactgacag
     3361 ccatggttta ttccgtgctg gggatggaac ccagggtctc ttgcttgcta ggtgtgtgct
     3421 ctaccaactg agccacattg ataacccacg tttgtttctt tataagccac tagccctgag
     3481 acatagggac aggtgacatc aggtttcatg tgagccagag tgggcttaga gacaatacca
     3541 tagtcccgtt cctctctagg acgcaggagc aagggctggc ctagagagac tgctacttgc
     3601 cacctttcca ggggctctat gagacagaaa gctatctttt gtagctagag agagcttgac
     3661 agagcctcag aagatgacct caaacacacc ggcctcccta ggacccaagg tgcctctgca
     3721 tcagggaagc ccagcagaaa acgttaccag gaggttacca cctggctgcc aagcactgag
     3781 cagaggaagc aggaacggag acctggtaac tgagggacaa atggtgcctt ggtgccttga
     3841 tggcctctga ctgccttggt gaagccttct gcctgcaacc actatggagc tgcgtgccca
     3901 aggtggggct gagtgtgcag tttgattgga agatcaaaaa gaagacggga tgggcttgca
     3961 caggggaaga ggaccagctg gccccaaagc aaatagatga gaaccattca aaacaatgat
     4021 tttcttacca ttggaatgga gtttacagct gaagactgcc ttgaatcgcc tccctctgct
     4081 tctacctcct gcgtgttgag atgacaggtg gacaccatta cgcctgcttc atttggggct
     4141 agggagccaa cccaggcttt gtgtgtgcta agtagacact ctgcctgaaa gacctacatt
     4201 ctcagctccc gaatgaacaa tgattttaag taaagtcggc ttatgtttac agca
//
