LOCUS       NM_011806               3755 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus cyclin D binding myb like transcription factor 1
            (Dmtf1), transcript variant 1, mRNA.
ACCESSION   NM_011806
VERSION     NM_011806.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3755)
  AUTHORS   Kendig RD, Kai F, Fry EA and Inoue K.
  TITLE     Stabilization of the p53-DNA Complex by the Nuclear Protein
            Dmp1alpha
  JOURNAL   Cancer Invest 35 (5), 301-312 (2017)
   PUBMED   28406729
  REMARK    GeneRIF: Dmp1 (Dmp1alpha) physically interacts with p53, stabilizes
            p53's binding to its target genes, and increases the
            transcriptional activity of p53.
REFERENCE   2  (bases 1 to 3755)
  AUTHORS   Fry EA, Taneja P and Inoue K.
  TITLE     Oncogenic and tumor-suppressive mouse models for breast cancer
            engaging HER2/neu
  JOURNAL   Int J Cancer 140 (3), 495-503 (2017)
   PUBMED   27553713
  REMARK    Review article
REFERENCE   3  (bases 1 to 3755)
  AUTHORS   Wei N, Cheng Y, Wang Z, Liu Y, Luo C, Liu L, Chen L, Xie Z, Lu Y
            and Feng Y.
  TITLE     SRSF10 Plays a Role in Myoblast Differentiation and Glucose
            Production via Regulation of Alternative Splicing
  JOURNAL   Cell Rep 13 (8), 1647-1657 (2015)
   PUBMED   26586428
REFERENCE   4  (bases 1 to 3755)
  AUTHORS   Zhu S, Mott RT, Fry EA, Taneja P, Kulik G, Sui G and Inoue K.
  TITLE     Cooperation between Dmp1 loss and cyclin D1 overexpression in
            breast cancer
  JOURNAL   Am J Pathol 183 (4), 1339-1350 (2013)
   PUBMED   23938323
  REMARK    GeneRIF: This study reveals a pivotal role of combined Dmp1 loss
            and cyclin D1 overexpression in breast cancer.
REFERENCE   5  (bases 1 to 3755)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3755)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 3755)
  AUTHORS   Inoue K, Wen R, Rehg JE, Adachi M, Cleveland JL, Roussel MF and
            Sherr CJ.
  TITLE     Disruption of the ARF transcriptional activator DMP1 facilitates
            cell immortalization, Ras transformation, and tumorigenesis
  JOURNAL   Genes Dev 14 (14), 1797-1809 (2000)
   PUBMED   10898794
REFERENCE   8  (bases 1 to 3755)
  AUTHORS   Bodner SM, Naeve CW, Rakestraw KM, Jones BG, Valentine VA,
            Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Downing JR,
            Roussel MF, Sherr CJ and Look AT.
  TITLE     Cloning and chromosomal localization of the gene encoding human
            cyclin D-binding Myb-like protein (hDMP1)
  JOURNAL   Gene 229 (1-2), 223-228 (1999)
   PUBMED   10095122
REFERENCE   9  (bases 1 to 3755)
  AUTHORS   Inoue K, Sherr CJ and Shapiro LH.
  TITLE     Regulation of the CD13/aminopeptidase N gene by DMP1, a
            transcription factor antagonized by D-type cyclins
  JOURNAL   J Biol Chem 273 (44), 29188-29194 (1998)
   PUBMED   9786929
REFERENCE   10 (bases 1 to 3755)
  AUTHORS   Hirai H and Sherr CJ.
  TITLE     Interaction of D-type cyclins with a novel myb-like transcription
            factor, DMP1
  JOURNAL   Mol Cell Biol 16 (11), 6457-6467 (1996)
   PUBMED   8887674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247901.1, AK029147.1, BC060109.1 and BF466048.1.
            
            [WARNING] On Nov 20, 2023 this sequence was replaced by
            NM_011806.4.
            
            On Nov 15, 2007 this sequence version replaced NM_011806.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.273135.1, AK029147.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY247901.1         1-60
            61-830              AK029147.1         3-772
            831-887             BC060109.1         753-809
            888-2976            AK029147.1         830-2918
            2977-3544           BC060109.1         2899-3466
            3545-3755           BF466048.1         1-211               c
FEATURES             Location/Qualifiers
     source          1..3755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.69 cM"
     gene            1..3755
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /note="cyclin D binding myb like transcription factor 1"
                     /db_xref="GeneID:23857"
                     /db_xref="MGI:MGI:1344415"
     exon            1..163
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..284
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..401
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2578
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin D binding myb-like transcription factor
                     1D-interacting myb-like protein; cyclin-D-binding Myb-like
                     transcription factor 1; mDmp1; cyclin-D-interacting
                     Myb-like protein 1; D-interacting myb-like protein"
                     /codon_start=1
                     /product="cyclin-D-binding Myb-like transcription factor 1
                     isoform 1"
                     /protein_id="NP_035936.3"
                     /db_xref="CCDS:CCDS19088.1"
                     /db_xref="GeneID:23857"
                     /db_xref="MGI:MGI:1344415"
                     /translation="MSTVEEDSDTVTVETVNSVTFTQDTDGNLILHCPQNDPDEVDSE
                     DSTEPPHKRLCLSSEDDQSIDDATPCISVVALPLSENDQSFEVTMTATTEVADDELSE
                     GTVTQIQILQNDQLDEISPLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEE
                     IDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMY
                     DDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKW
                     TEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQS
                     GGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIA
                     NHKDVSFPVLIKGLKQLHENQKNNPVLLENKSGSGVPNSNCNSSVQHVQIRVARLEDN
                     TAISPSPMAALQIPVQITHVSSTDSPAASVDSETITLNSGTLQTFEILPSFHLQPTGT
                     PGTYLLQTSSSQGLPLTLTTNPTVTLAAAAPASPEQIIVHALSPEHLLNTSDNVTVQC
                     HTPRVIIQTVATEDITSSLSQEELTVDSDLHSSDFPEPPDALEADTFPDEIPRPKMTI
                     QPSFNNAHVSKFSDQNSTELMNSVMVRTEEEIADTDLKQEEPPSDLASAYVTEDLESP
                     TIVHQVHQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPIFQHHQEASNIIG
                     SSLGSPVSEDSKDVEDLVNCH"
     exon            402..524
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..619
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..734
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..811
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..969
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1002
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1112
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1341
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1493
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1703
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1789
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1945
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2323
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2468
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..3739
                     /gene="Dmtf1"
                     /gene_synonym="Dimp; Dmp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggcgggg gcggggcgcg gcctcgcggc tccgtttccg gtggctggtt gcgctcgctc
       61 accccagctg cagccactct ctcccgcggc tgcttcctcc atcctggtat tttttggagc
      121 ctccatcctg gttcttccaa agtgcccgga cccaaaacag gaaaggatca cagatgcaca
      181 agcatggagg agaagcagtt tggttaacgt gagtgatgct gctggccgaa gcacagaggt
      241 gggattctat gggaaggcct gtagctaatc cacctgtggt ctagatttga gtatgagcac
      301 agttgaagag gattctgaca cagtaacagt agaaactgtg aactctgtga cgtttactca
      361 ggacacggac gggaatctca ttcttcattg ccctcagaat gaccctgatg aagtagactc
      421 agaagacagt actgaacctc cacataagag gctttgtttg tcctctgagg atgatcaaag
      481 cattgatgac gctacgccat gcatatcagt cgtggcactc ccactttcag aaaatgatca
      541 gagctttgag gtgaccatga cggcaactac agaggtggca gatgatgaac tttctgaggg
      601 aactgtgaca caaattcaga ttttacagaa tgatcaacta gatgaaatat ctccattggg
      661 tactgaggaa gtctcagcag ttagccaagc gtggtttaca actaaagaag ataaggattc
      721 tctcactaac aaaggacata aatggaagca ggggatgtgg tccaaggaag aaattgatat
      781 tttaatgaac aacatcgagc gctatctgaa ggctcgcgga ataaaagatg ctacagaaat
      841 catctttgag atgtcaaaag acgaaagaaa agatttctac aggactatag cgtgggggct
      901 gaaccggcct ttgtttgcag tttatagaag agtgctgcgc atgtatgatg acaggaacca
      961 tgtgggaaaa tacactcctg aagagatcga gaagctcaag gagctccgga taaaacacgg
     1021 caatgactgg gcaacaatag gggcggccct aggaagaagt gcctcttctg tcaaagaccg
     1081 ctgccggctg atgaaggata cctgcaacac agggaaatgg acagaagaag aagaaaagag
     1141 acttgcagag gtagttcatg aattaacaag cacggagcca ggtgacatcg tcacacaggg
     1201 tgtgtcttgg gcagctgtag ctgaaagagt gggtacccgc tcagaaaagc aatgccgttc
     1261 taaatggctc aactacctga actggaagca gagtgggggt actgaatgga ccaaggaaga
     1321 tgaaatcaat ctcatcctaa ggatagctga gcttgatgtg gccgatgaaa atgacataaa
     1381 ctgggatctt ttagctgaag gatggagcag tgtccgttca ccacagtggc ttcgaagtaa
     1441 atggtggacc atcaaaaggc aaattgcaaa ccataaggat gtttcatttc ctgtcctaat
     1501 aaaaggtctt aaacagttac atgagaacca aaaaaacaac ccagtgcttt tggagaataa
     1561 atcaggatct ggagttccaa acagtaattg caattccagt gtacagcatg ttcagatcag
     1621 agtcgcccgc ttggaagata atacagccat ctctccaagc cccatggcag cgttgcagat
     1681 tccagtccag atcacccacg tctcttcaac agactcccct gctgcttctg ttgactcaga
     1741 aacaatcaca ctaaacagtg gaacactaca aacatttgag attcttccat ctttccattt
     1801 acagcccact ggtactccag gcacctacct tcttcaaaca agctcaagtc aaggccttcc
     1861 cctaacactg accacaaatc ccacagtaac cctggcagct gctgctcctg cttctcctga
     1921 acagatcatt gttcatgctt tatccccaga acatttgttg aacacaagcg ataatgtcac
     1981 ggtacaatgt cacacaccaa gagtcatcat tcagacggta gctacagagg acatcacttc
     2041 ttcattatcc caagaggaac tgacagttga tagtgatctt cattcatctg atttccctga
     2101 gcctccagat gcactagaag cagacacttt cccagacgaa attcctcggc ctaagatgac
     2161 tatacaacca tcatttaata atgctcatgt atctaaattc agcgaccaaa atagcacaga
     2221 actgatgaac agtgtcatgg tcagaacaga ggaagaaatt gccgacactg accttaagca
     2281 ggaagaaccg ccgtctgact tagccagtgc ttatgttact gaggatttag agtctcccac
     2341 catagtgcac caagttcatc agacaattga tgatgaaaca atacttatcg ttccttcacc
     2401 tcatggcttt atccaggcat ctgatgttat agatactgaa tctgtcttgc ctttgacaac
     2461 actaacagat ccaatattcc agcatcatca ggaagcatca aatataattg gatcatcttt
     2521 gggcagtcct gtttctgaag actcaaagga tgttgaggac ttagtaaact gtcactagat
     2581 tattagaaac aggtacttca agaagccaca ttgtgactac attgtctcca aagaaaggag
     2641 ccatcccagg agttgtggtt tgccattcct ctggcttgta cttagctgcc atgcttaagc
     2701 catgcacatt gttgctgctg ttacttttac ctccttctca gtagatcatc tgaggtccaa
     2761 ttttataaca gttgttatga tggaggatag gaagtgtgaa ttgcccagac ttgttaggtt
     2821 ttatgtcaag agggagttgc agtcactgca gctacttata tcaccagagc ttaactactc
     2881 tggtttaaat ataagtagta atactcatct ctgcagttag acacagctct gtccagactc
     2941 aagctgggct ggttgtaatt cagcttatgt tagcagtgac tttcagaaag attaacttag
     3001 gagttgatga catgaccatg accagcatcc agataccaca ttatgggggg tggttgtgct
     3061 ggttaaccca ttgctggcag tgggagctga ctgaggcagg gtaaagaagc aaagcattac
     3121 agagttaaga aaattcacta caggtctttg atttttaact tttaaaggga acgtggttaa
     3181 agtggtaaca aaacagttat caactctcat cagaaaccag tcattagttt acagctagca
     3241 ctttgaagtg aaattaaatg aggggagagg tcatattgcc tgtgtctgat aaccatgact
     3301 ttttttatga catgttttac atataaattg cccagaagat agtgaggggt attaattaga
     3361 gtatgctgtt cacttcgtgc attacctgct gggggtacac tatagcttct ccctcaggca
     3421 cttttaaaaa acaaaatttg cttctgtatc aaaagaaaac aaatcaagag tcattcctaa
     3481 ggtaaagcca aaactagcct gtagggcttt aatgatatga tccttataga aaagtccaaa
     3541 aaaaggagga aaaaaaaagg aaacttgtat aaattatttt atttattatt gtaattagat
     3601 cttcacaatc aaagctgtct tttcaccatc tgtttattaa tgtaaaactg tagtaataag
     3661 caaaagttgg ttgcctaggg gaacaataat tgtatattca gtttaacaga aataaaagag
     3721 tatttgtctt aaaatgcaaa aaaaaaaaaa aaaaa
//
