LOCUS       NM_027732               1619 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus doublesex and mab-3 related transcription factor like
            family C2 (Dmrtc2), mRNA.
ACCESSION   NM_027732
VERSION     NM_027732.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Ono,K., Hata,K., Nakamura,E., Ishihara,S., Kobayashi,S.,
            Nakanishi,M., Yoshida,M., Takahata,Y., Murakami,T., Takenoshita,S.,
            Komori,T., Nishimura,R. and Yoneda,T.
  TITLE     Dmrt2 promotes transition of endochondral bone formation by linking
            Sox9 and Runx2
  JOURNAL   Commun Biol 4 (1), 326 (2021)
   PUBMED   33707608
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Poulain,M., Frydman,N., Tourpin,S., Muczynski,V., Souquet,B.,
            Benachi,A., Habert,R., Rouiller-Fabre,V. and Livera,G.
  TITLE     Involvement of doublesex and mab-3-related transcription factors in
            human female germ cell development demonstrated by xenograft and
            interference RNA strategies
  JOURNAL   Mol Hum Reprod 20 (10), 960-971 (2014)
   PUBMED   25082981
  REMARK    Erratum:[Mol Hum Reprod. 2015 Jul;21(7):615. doi:
            10.1093/molehr/gav029.. Mucsynski, Vincent [Corrected to Muczynski,
            Vincent]. PMID: 26134375]
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Shimizu,H., Kubo,A., Uchibe,K., Hashimoto,M., Yokoyama,S.,
            Takada,S., Mitsuoka,K. and Asahara,H.
  TITLE     The AERO system: a 3D-like approach for recording gene expression
            patterns in the whole mouse embryo
  JOURNAL   PLoS One 8 (10), e75754 (2013)
   PUBMED   24146773
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1619)
  AUTHORS   Date,S., Nozawa,O., Inoue,H., Hidema,S. and Nishimori,K.
  TITLE     Impairment of pachytene spermatogenesis in Dmrt7 deficient mice,
            possibly causing meiotic arrest
  JOURNAL   Biosci Biotechnol Biochem 76 (9), 1621-1626 (2012)
   PUBMED   22972322
  REMARK    GeneRIF: Dmrt7 is critical for the normal pachytene spermatogenesis
            and complete meiotic recombination.
REFERENCE   6  (bases 1 to 1619)
  AUTHORS   Hong,C.S., Park,B.Y. and Saint-Jeannet,J.P.
  TITLE     The function of Dmrt genes in vertebrate development: it is not
            just about sex
  JOURNAL   Dev Biol 310 (1), 1-9 (2007)
   PUBMED   17720152
  REMARK    Review article
REFERENCE   7  (bases 1 to 1619)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1619)
  AUTHORS   Kim,S., Namekawa,S.H., Niswander,L.M., Ward,J.O., Lee,J.T.,
            Bardwell,V.J. and Zarkower,D.
  TITLE     A mammal-specific Doublesex homolog associates with male sex
            chromatin and is required for male meiosis
  JOURNAL   PLoS Genet 3 (4), e62 (2007)
   PUBMED   17447844
  REMARK    GeneRIF: DMRT7 may help control the transition from meiotic sex
            chromosome inactivation to postmeiotic sex chromatin in males.
REFERENCE   9  (bases 1 to 1619)
  AUTHORS   Kawamata,M. and Nishimori,K.
  TITLE     Mice deficient in Dmrt7 show infertility with spermatogenic arrest
            at pachytene stage
  JOURNAL   FEBS Lett 580 (27), 6442-6446 (2006)
   PUBMED   17098235
  REMARK    GeneRIF: decreased expression of Ccna1 mRNA and the accumulation of
            SCP3-positive spermatocytes showed the arrest of spermatogenesis at
            the pachytene stage in the Dmrt7-knockout mice.
REFERENCE   10 (bases 1 to 1619)
  AUTHORS   Kim,S., Kettlewell,J.R., Anderson,R.C., Bardwell,V.J. and
            Zarkower,D.
  TITLE     Sexually dimorphic expression of multiple doublesex-related genes
            in the embryonic mouse gonad
  JOURNAL   Gene Expr Patterns 3 (1), 77-82 (2003)
   PUBMED   12609607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161441.21 and AF542046.1.
            
            On Jun 15, 2010 this sequence version replaced NM_027732.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100434.1, AF542046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC161441.21        83392-83394         c
            4-983               AF542046.1         1-980
            984-984             AC161441.21        77464-77464         c
            985-1615            AF542046.1         982-1612
            1616-1619           AC161441.21        75800-75803         c
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.33 cM"
     gene            1..1619
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /note="doublesex and mab-3 related transcription factor
                     like family C2"
                     /db_xref="GeneID:71241"
                     /db_xref="MGI:MGI:1918491"
     exon            1..116
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     exon            117..344
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1233
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /note="doublesex and mab-3 related transcription factor 7"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor C2"
                     /protein_id="NP_082008.1"
                     /db_xref="CCDS:CCDS20965.1"
                     /db_xref="GeneID:71241"
                     /db_xref="MGI:MGI:1918491"
                     /translation="MDPSETAALHHCSADSSPADEARVPQSTELIPRRPVSRSPTCAR
                     CRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLAQG
                     LMKGATPLKAPLRVKKGAIRPGIPSGKENIAPQPQSPHGAVPLVLTPPGKENYGPLLL
                     SRPPEALPLPWTPVPPGPWGPGHWLPPGLSMPPPVVCRLLCQEPAVPLHPFPGFDPGT
                     SLRLPTHGTLPTCPGSRSVLTAPLSGEPQGPPNLPHTCSTLILQSCGTPDSLLLQPQA
                     PGASCLAWTSGPSERQLQREAAEALVGLKDSSQAPRLTPSVPPNPAWISLLHPCGPPA
                     PPGGRGFQPVGPPLRPSPGSSVSLHIGRLGSISLLS"
     exon            345..499
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     exon            500..576
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     exon            577..757
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     exon            758..884
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     exon            885..945
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1120
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1619
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1448..1453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /note="hexamer: AATAAA"
     polyA_site      1488
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /note="hexamer: AATAAA"
     polyA_site      1619
                     /gene="Dmrtc2"
                     /gene_synonym="4933432E21Rik; Dmrt7"
                     /note="major polyA site"
ORIGIN      
        1 cttgtgtgaa ggagcgagcg ggaaaagccg ctcgagccgg ccgttcctct tcgccactgt
       61 gtcgcccttt tctctgggcc ttctcctggc tgactgtgat tcggctcgag gctgtgatcc
      121 atggacccca gtgaaacggc tgctctccac cactgttctg ctgactcttc cccagccgac
      181 gaggccagag tgccccagag tacagagctt attcccagga gaccagtcag tcgctctcca
      241 acctgtgccc gctgtcgcaa ccatggggtc acagcccatc tcaagggaca caagcgcctc
      301 tgcctctttc aggcttgcga gtgtcacaaa tgtgtcctca tcctggaacg tcggagggtc
      361 atggctgccc aagtggcctt gcgcaggcag caggaggcac agctgaaaag gcacctggct
      421 cagggactga tgaaaggggc aacccctctg aaagctcccc tccgtgtcaa gaagggagcc
      481 attcggccag ggatcccttc tggaaaagag aacatagcac cccagcctca gagtccccat
      541 ggagcagtcc cactggtact gacaccccct gggaaggaga actatgggcc actgctgctc
      601 agccgccccc cggaagcctt gcctttgccc tggactccag tgcctcctgg gccttggggc
      661 cctggacact ggctgccccc aggcctctca atgccacctc cagtggtatg ccgcttgctg
      721 tgccaagaac ctgctgtccc tctacatcct tttcctggct ttgaccctgg cacctctctc
      781 cggctgccca ctcatgggac cctcccgacc tgcccaggat ctcgctcagt actgacggct
      841 ccactttctg gggagcccca aggaccccct aacctgcctc acacatgttc aactctgata
      901 ctccagtcct gtggcacccc agactctctt ctgctacagc cacaggcccc tggagcctcc
      961 tgcctggcct ggacatctgg cccctcggag cggcagctgc agcgggaggc agctgaggcc
     1021 cttgtaggtc tgaaagactc atcccaggct ccccgcctga ccccatctgt cccccctaac
     1081 cctgcctgga tctctctgct ccacccctgt ggcccaccag ctcctcctgg gggaagagga
     1141 ttccagcctg ttggcccacc tctccgaccc agtccaggtt cctctgtctc tctgcacatt
     1201 gggcgtctgg gatctatctc cctcctcagc tagacagcag aggtggaggc tacctcactg
     1261 ggacaaagag acgacaaact gcaggcactg catatttggt attttattta tggttttgca
     1321 tgggatttaa tgtaatgcaa gcttcagctt ttttttttat ataagctttc aggttccttt
     1381 tttagtgtgg gtattttctt gactgagggt ggctattctt gtagcccgtt taaatactaa
     1441 gtcccccaat aaaggcagtt gggcagttta agatgaccca tatctaaata cattttttca
     1501 tgagtttatg ctctctatat gcctatgttc ttatgtctgt ctctgaatgt gaaaatacaa
     1561 gaatatgttc actttgtatg taggtttctg taagcaagaa ataaaccttt gccatctaa
//
