LOCUS       NM_027591               1247 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DMRT-like family C1a (Dmrtc1a), transcript variant 1,
            mRNA.
ACCESSION   NM_027591
VERSION     NM_027591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Veith,A.M., Klattig,J., Dettai,A., Schmidt,C., Englert,C. and
            Volff,J.N.
  TITLE     Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes
            in the mouse
  JOURNAL   Genomics 88 (2), 185-195 (2006)
   PUBMED   16488114
  REMARK    GeneRIF: Dmrt8.1 mRNA was detected in Sertoli cells by in situ
            hybridization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773565.17 and AK014934.1.
            
            On Dec 1, 2009 this sequence version replaced NM_027591.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014934.1, DQ316772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL773565.17        130695-130707       c
            14-1247             AK014934.1         15-1248
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 45.79 cM"
     gene            1..1247
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /note="DMRT-like family C1a"
                     /db_xref="GeneID:70887"
                     /db_xref="MGI:MGI:1918137"
     exon            1..74
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..657
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /note="isoform a is encoded by transcript variant 1;
                     doublesex- and mab-3-related transcription factor C1;
                     doublesex and mab-3 related transcription factor 8.1;
                     likely ortologue to human doublesex-and mab-3-related
                     transcription factor C1 (Dmrtc1)"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor C1 isoform a"
                     /protein_id="NP_081867.1"
                     /db_xref="CCDS:CCDS30327.1"
                     /db_xref="GeneID:70887"
                     /db_xref="MGI:MGI:1918137"
                     /translation="MQRSSGSREPRKDFSPVTTSKKEEATPLKRRLVERHKRTMAAAH
                     PSHMHVKKLAVEEGVRTGKNTVQQIQAQVDTATQEESSQGPVLLNQHPETTSVPYTPE
                     TVGQQLMVSLPGEPHGTSAMPSMCPSLILQPCATTDPMLLQPQVMGPSASNQASVSAT
                     LEWQEMLEAAEALLALKNSSQTRHQPCGMPVKRELSGASRM"
     exon            75..232
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..288
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..425
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..492
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..622
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..1247
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /note="hexamer: AATAAA"
     polyA_site      1246
                     /gene="Dmrtc1a"
                     /gene_synonym="1700030H14Rik; 4921520P21Rik; Dmrt8.1;
                     DMRTC1"
                     /note="major polyA site"
ORIGIN      
        1 actctggaca gcccagcagc ctgaacacaa ggtcccctgg ctgaactgaa aatgcagcgg
       61 tcttcgggtt cccgggaacc tcgtaaggac ttttctcctg tgaccacctc caagaaggag
      121 gaggctaccc cattaaagag acgcctggtt gagagacata aaaggactat ggctgctgct
      181 catccatcac acatgcacgt caagaaattg gctgtagaag aaggagttcg cactggaaag
      241 aacactgtgc agcagatcca ggcccaggtt gacacagcaa cccaggagga gagctcccaa
      301 gggcctgtgc tgctgaacca gcacccagaa acaacatctg tgccatatac tccagagact
      361 gtggggcaac aactgatggt gtcccttcct ggggagcccc atgggacctc tgccatgcca
      421 agcatgtgtc caagcctgat tcttcagccc tgtgccacca ctgaccctat gctactgcaa
      481 ccacaggtca tgggccccag tgcctccaac caggcttcag tttctgctac cttagagtgg
      541 caggagatgc tggaggctgc tgaagctctg ctggctctga aaaattcgtc tcagacacgt
      601 caccagccct gtggcatgcc agtgaagaga gagctaagcg gagcatcacg tatgtgattt
      661 ggctctggac tttgttggct ctggactttg tctttctgtc tccaggtact gctggagaga
      721 ggggactgca gctggccaac ccctctatgc caccaaggcc taccagctct ggttctctgc
      781 cttctggaca tctggattgc atgtccctct tgacttaaga acccagacta tgaggcctca
      841 ctagagcact gcctgtttga ttactgtttc tgaacttgca aaatggctcc tgtccaaagt
      901 gcttaatgtg ttttttaagc cttcaggtat tttataagct ttaagatcct ttttatgatg
      961 tagagcaatt acttggcttt cctatgttct ttacccccat ccgtaatttc tttggaagct
     1021 ggggcttttt atgtgtctta taaaatgctt tgtgcaatct aatatgatca aacaatctat
     1081 caatggggtt ctgagtggta tcaaatgcca gtgttttcct ttgtgtgcac tcactcgcac
     1141 acatatctgc acactactgt acttaaaaca tgcatgtgga aacatgagga ttttcacatt
     1201 gcatctagat ttgtgtgtta ccaaaaataa ataattttgt aaggcat
//
