LOCUS       NM_172296               2947 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus doublesex and mab-3 related transcription factor like
            family A2 (Dmrta2), mRNA.
ACCESSION   NM_172296
VERSION     NM_172296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2947)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2947)
  AUTHORS   Di Bella,D.J., Habibi,E., Stickels,R.R., Scalia,G., Brown,J.,
            Yadollahpour,P., Yang,S.M., Abbate,C., Biancalani,T., Macosko,E.Z.,
            Chen,F., Regev,A. and Arlotta,P.
  TITLE     Molecular logic of cellular diversification in the mouse cerebral
            cortex
  JOURNAL   Nature 595 (7868), 554-559 (2021)
   PUBMED   34163074
  REMARK    Erratum:[Nature. 2021 Aug;596(7873):E11. doi:
            10.1038/s41586-021-03797-5.. PMID: 34341543]
REFERENCE   3  (bases 1 to 2947)
  AUTHORS   Ono,K., Hata,K., Nakamura,E., Ishihara,S., Kobayashi,S.,
            Nakanishi,M., Yoshida,M., Takahata,Y., Murakami,T., Takenoshita,S.,
            Komori,T., Nishimura,R. and Yoneda,T.
  TITLE     Dmrt2 promotes transition of endochondral bone formation by linking
            Sox9 and Runx2
  JOURNAL   Commun Biol 4 (1), 326 (2021)
   PUBMED   33707608
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2947)
  AUTHORS   Ratie,L., Desmaris,E., Garcia-Moreno,F., Hoerder-Suabedissen,A.,
            Kelman,A., Theil,T., Bellefroid,E.J. and Molnar,Z.
  TITLE     Loss of Dmrt5 Affects the Formation of the Subplate and Early
            Corticogenesis
  JOURNAL   Cereb Cortex 30 (5), 3296-3312 (2020)
   PUBMED   31845734
  REMARK    GeneRIF: Loss of Dmrt5 Affects the Formation of the Subplate and
            Early Corticogenesis.
REFERENCE   5  (bases 1 to 2947)
  AUTHORS   Konno,D., Kishida,C., Maehara,K., Ohkawa,Y., Kiyonari,H., Okada,S.
            and Matsuzaki,F.
  TITLE     Dmrt factors determine the positional information of cerebral
            cortical progenitors via differential suppression of homeobox genes
  JOURNAL   Development 146 (15) (2019)
   PUBMED   31371378
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2947)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   7  (bases 1 to 2947)
  AUTHORS   Gennet,N., Gale,E., Nan,X., Farley,E., Takacs,K., Oberwallner,B.,
            Chambers,D. and Li,M.
  TITLE     Doublesex and mab-3-related transcription factor 5 promotes
            midbrain dopaminergic identity in pluripotent stem cells by
            enforcing a ventral-medial progenitor fate
  JOURNAL   Proc Natl Acad Sci U S A 108 (22), 9131-9136 (2011)
   PUBMED   21576465
  REMARK    GeneRIF: Dmrt5 is an important player in ventral mesencephalic
            neural fate specification
REFERENCE   8  (bases 1 to 2947)
  AUTHORS   Hong,C.S., Park,B.Y. and Saint-Jeannet,J.P.
  TITLE     The function of Dmrt genes in vertebrate development: it is not
            just about sex
  JOURNAL   Dev Biol 310 (1), 1-9 (2007)
   PUBMED   17720152
  REMARK    Review article
REFERENCE   9  (bases 1 to 2947)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2947)
  AUTHORS   Kim,S., Kettlewell,J.R., Anderson,R.C., Bardwell,V.J. and
            Zarkower,D.
  TITLE     Sexually dimorphic expression of multiple doublesex-related genes
            in the embryonic mouse gonad
  JOURNAL   Gene Expr Patterns 3 (1), 77-82 (2003)
   PUBMED   12609607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ172393.1, AY145837.1, AL627188.18 and AI465212.1.
            
            On Aug 22, 2006 this sequence version replaced NM_172296.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY145837.1, AK080774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               CJ172393.1         2-408
            408-1485            AY145837.1         380-1457
            1486-2771           AL627188.18        141253-142538
            2772-2947           AI465212.1         1-176               c
FEATURES             Location/Qualifiers
     source          1..2947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.37 cM"
     gene            1..2947
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /note="doublesex and mab-3 related transcription factor
                     like family A2"
                     /db_xref="GeneID:242620"
                     /db_xref="MGI:MGI:2653629"
     exon            1..312
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /inference="alignment:Splign:2.1.0"
     exon            313..867
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1916
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /note="doublesex- and mab-3-related transcription factor
                     5"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor A2"
                     /protein_id="NP_758500.2"
                     /db_xref="CCDS:CCDS18469.1"
                     /db_xref="GeneID:242620"
                     /db_xref="MGI:MGI:2653629"
                     /translation="MELRSELPSVPGAATAAATATGPPVASVASVAAAAAAAASLPVS
                     VAGGLLRAPPLLLRAAEKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCLCAKCTLIA
                     ERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAAANGIIPPRPAYEVFGSVC
                     ATDGGGPGAGAPAGSAGGAGGAEAKLQKFDLFPKTLLQAGRPDSPQPPPGKPLSPDGA
                     DSGPRTSSPEVRPGSGSENGDGESFSGSPLARASKEAGGSCPGSAGAGGGGEEDSPGS
                     SSPLGSESGSEADKEEAEAAPTPGLGGGPGPRQRTPLDILTRVFPGHRRGVLELVLQG
                     CGGDVVQAIEQVLNHHRGGLAAGLGPAAPLEKAAVSAAVEDAWPGRVEAAAAGGAGLP
                     APLQTGPTAPPHHRPLLAGAMTPGALGSLSSRSAFSPLQPNASHFGADAGAYPLGAPL
                     GLSPLRLAYSAAAAHSRGLAFMAPYSTAGLVPTLGFRPPMDYAFSDLMRDRSAAAAAA
                     VHKEPGYGGGLYGPMVNGTPEKQ"
     exon            868..2947
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /note="hexamer: TATAAA"
     polyA_site      2353
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /note="major polyA site"
ORIGIN      
        1 gagcggctca ttgagagctg gcagcgccgg actacccggc ccggggcgag cgcagcgtcc
       61 ggagcgcacc gaggggacgc cggttgcaac cagcccgccc tcggccaggc ccccggcccc
      121 gaggcccctc cggggtgttg gactgctgtg ttcctagagg ggtccggaag ttcggacatg
      181 gtggctgaag gagggtgacg tggtcagaga aggggccggg ggcagaggga cgaggccaag
      241 agagccgagg cgcgagccga gctgggcgac gcgtgctgcg ccaacagagg aggagcccgg
      301 agctcgaggc aggtccagcc atggagctgc gctcggagct gcccagcgtg cccggtgcgg
      361 cgacagcagc agcgacagcg acgggaccac ccgtggcatc ggtggcgtcg gtggctgcgg
      421 cggcagctgc cgcagcatcg ctaccagtga gcgtggccgg aggcttgctg cgggcgccgc
      481 cgctgctgtt gagggcagcg gagaagtacc cgcggacccc caagtgcgcg cgctgccgca
      541 accacggagt ggtgtccgcg ctcaagggcc acaagcgcta ctgccgctgg aaggactgcc
      601 tgtgcgccaa gtgtacgctc atcgccgagc gccagcgcgt catggcggct caggtggcct
      661 tgcgcaggca gcaggcgcag gaggagaacg aggcgcgcga gttgcaattg ctgtacggca
      721 ctgccgaggg cctggcgctg gccgccgcca acggcatcat ccccccgcgg cctgcctacg
      781 aagtctttgg ctcggtttgc gccaccgacg gcgggggtcc tggagctgga gcgcccgcgg
      841 ggagtgcagg gggcgcaggg ggcgcagagg ccaaattgca gaagtttgat ctgtttccca
      901 agacgctgct tcaggccggc cgccccgaca gtccgcagcc gccgccaggg aagcccttgt
      961 cgcccgacgg cgcggactca ggtccccgga cctcgtcccc ggaggtgcgg cccggctcag
     1021 gctcggagaa cggagacggc gagtcctttt ccgggtcgcc tctggcccgg gcctccaagg
     1081 aggcgggtgg cagctgtcct gggagcgcgg gcgccggcgg tggcggcgag gaggacagcc
     1141 ccggctcctc cagccccctg ggttccgaat cgggttcgga ggctgacaaa gaagaagccg
     1201 aggccgcacc gactccgggg ctgggcggcg ggccggggcc gcggcagcgg acgccgctgg
     1261 acatcttgac gcgcgtcttc ccgggccacc ggagaggcgt cctggagctg gtgctgcagg
     1321 gctgtggcgg cgacgtggtg caggccatcg agcaggtgct caaccaccac cgcggaggcc
     1381 tggcggctgg cctgggcccc gccgcaccgc tggagaaggc cgcggtgagc gcggcggtgg
     1441 aggacgcgtg gcccgggcgc gtggaggccg cagccgccgg gggagccggg ttgcccgctc
     1501 cgctgcagac cgggcccacc gcgcccccgc accacagacc cttgctggcc ggggccatga
     1561 cgcccggcgc gctgggctcg ctcagcagcc gctccgcctt ctcgccactg cagcccaatg
     1621 ccagccactt cggcgccgac gcgggcgcct accctctggg tgcgccgctc ggcctgagcc
     1681 ccctgcgcct ggcctactcg gcggcggcgg cccacagccg cggcctggcc ttcatggcgc
     1741 cctactccac ggccggcctg gtgcccacac tcggttttcg gccgcccatg gactacgcct
     1801 tcagcgacct catgcgcgac cgctcggccg ctgccgccgc tgcggtgcac aaggagcccg
     1861 gctacggggg cgggctgtac gggcccatgg tcaacggcac ccctgagaag cagtagggta
     1921 tggggccagg cagcccggcc accccgaaac agcgacctag cctgctcccc cagctgcagg
     1981 cccctcctcg ccctgccctg cgccctccgc tcacagttgg ctttagggac ttgcttgggt
     2041 gggtgggtgg gagcacctcg gctgaccgcg caggtgtccc cagaggagcc ctgtggtctg
     2101 ggtgctcgcc ccgcttcggg tcaccttccc ccgggcctgc ccgccttgtt gtcaagaggc
     2161 tggggatccc taagaacccc gagggcgact gcggcctcgc ccacccctgc tgctccctct
     2221 gctccgctcg cctcctcaac acgcgctcag gtggatggca ggatggacca gcctcttgtg
     2281 tgtcctccaa tacccgttcc cctttcgttt ttaaaaaatc cgctctaaca aatataaatt
     2341 taggatgtat acatctcttg gcactgactc gagtctttgg gacacatata tatcagtatc
     2401 aactgtaaaa aaaaaaaaaa aaaagagacg tcctaaggtg cactttcctc gttgcggtat
     2461 ttgtcgctct ctttgttgct tatgccgata agcatgggtt tccttggtgc agtgtgagtt
     2521 tttatatatg tataaatcta tatataatct atacatatat atacaagcca gtgtataatg
     2581 ttataaaatg gaattctaag ttattaattg taatctgtag gtgacctcgg tattaacgtg
     2641 gaaaacattc aaaaatcaaa gcaaaaaaag gacaaaatgg aaaaaaatta gactattcgc
     2701 acattgtacg tatcgggttt tatagctgaa atctactgta ttctggggag gtaccctgcc
     2761 gacccctggt cccccggcct gcggctgttc tccaaagcgg tccaggctgc gctgaagcac
     2821 gaatagagcg tcgggtgagt gagccagaag ctcccggact cgccagcgag cgacgctgcg
     2881 cacagctgct cactttgtgc tttcctttgc ataggtatga gctagaaata aatgttattt
     2941 tctaaat
//
