LOCUS       NP_758500                531 aa            linear   ROD 10-FEB-2025
DEFINITION  doublesex- and mab-3-related transcription factor A2 [Mus
            musculus].
ACCESSION   NP_758500
VERSION     NP_758500.2
DBSOURCE    REFSEQ: accession NM_172296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Di Bella,D.J., Habibi,E., Stickels,R.R., Scalia,G., Brown,J.,
            Yadollahpour,P., Yang,S.M., Abbate,C., Biancalani,T., Macosko,E.Z.,
            Chen,F., Regev,A. and Arlotta,P.
  TITLE     Molecular logic of cellular diversification in the mouse cerebral
            cortex
  JOURNAL   Nature 595 (7868), 554-559 (2021)
   PUBMED   34163074
  REMARK    Erratum:[Nature. 2021 Aug;596(7873):E11. doi:
            10.1038/s41586-021-03797-5.. PMID: 34341543]
REFERENCE   3  (residues 1 to 531)
  AUTHORS   Ono,K., Hata,K., Nakamura,E., Ishihara,S., Kobayashi,S.,
            Nakanishi,M., Yoshida,M., Takahata,Y., Murakami,T., Takenoshita,S.,
            Komori,T., Nishimura,R. and Yoneda,T.
  TITLE     Dmrt2 promotes transition of endochondral bone formation by linking
            Sox9 and Runx2
  JOURNAL   Commun Biol 4 (1), 326 (2021)
   PUBMED   33707608
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 531)
  AUTHORS   Ratie,L., Desmaris,E., Garcia-Moreno,F., Hoerder-Suabedissen,A.,
            Kelman,A., Theil,T., Bellefroid,E.J. and Molnar,Z.
  TITLE     Loss of Dmrt5 Affects the Formation of the Subplate and Early
            Corticogenesis
  JOURNAL   Cereb Cortex 30 (5), 3296-3312 (2020)
   PUBMED   31845734
  REMARK    GeneRIF: Loss of Dmrt5 Affects the Formation of the Subplate and
            Early Corticogenesis.
REFERENCE   5  (residues 1 to 531)
  AUTHORS   Konno,D., Kishida,C., Maehara,K., Ohkawa,Y., Kiyonari,H., Okada,S.
            and Matsuzaki,F.
  TITLE     Dmrt factors determine the positional information of cerebral
            cortical progenitors via differential suppression of homeobox genes
  JOURNAL   Development 146 (15) (2019)
   PUBMED   31371378
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 531)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   7  (residues 1 to 531)
  AUTHORS   Gennet,N., Gale,E., Nan,X., Farley,E., Takacs,K., Oberwallner,B.,
            Chambers,D. and Li,M.
  TITLE     Doublesex and mab-3-related transcription factor 5 promotes
            midbrain dopaminergic identity in pluripotent stem cells by
            enforcing a ventral-medial progenitor fate
  JOURNAL   Proc Natl Acad Sci U S A 108 (22), 9131-9136 (2011)
   PUBMED   21576465
  REMARK    GeneRIF: Dmrt5 is an important player in ventral mesencephalic
            neural fate specification
REFERENCE   8  (residues 1 to 531)
  AUTHORS   Hong,C.S., Park,B.Y. and Saint-Jeannet,J.P.
  TITLE     The function of Dmrt genes in vertebrate development: it is not
            just about sex
  JOURNAL   Dev Biol 310 (1), 1-9 (2007)
   PUBMED   17720152
  REMARK    Review article
REFERENCE   9  (residues 1 to 531)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 531)
  AUTHORS   Kim,S., Kettlewell,J.R., Anderson,R.C., Bardwell,V.J. and
            Zarkower,D.
  TITLE     Sexually dimorphic expression of multiple doublesex-related genes
            in the embryonic mouse gonad
  JOURNAL   Gene Expr Patterns 3 (1), 77-82 (2003)
   PUBMED   12609607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ172393.1, AY145837.1, AL627188.18 and AI465212.1.
            
            On Aug 22, 2006 this sequence version replaced NP_758500.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY145837.1, AK080774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.37 cM"
     Protein         1..531
                     /product="doublesex- and mab-3-related transcription
                     factor A2"
                     /note="doublesex- and mab-3-related transcription factor
                     5"
                     /calculated_mol_wt=52796
     Region          65..111
                     /region_name="DM"
                     /note="DM DNA binding domain; pfam00751"
                     /db_xref="CDD:459924"
     Region          197..312
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A9A2.1)"
     Region          308..349
                     /region_name="CUE_DMA_DMRTA2"
                     /note="CUE-like DMA domain found in doublesex- and
                     mab-3-related transcription factor A2 (DMRTA2); cd14418"
                     /db_xref="CDD:270601"
     Region          423..502
                     /region_name="DMRT5_DMB"
                     /note="DMRT5, DMB domain; pfam20624"
                     /db_xref="CDD:466773"
     CDS             1..531
                     /gene="Dmrta2"
                     /gene_synonym="Dmrt5"
                     /coded_by="NM_172296.2:321..1916"
                     /db_xref="CCDS:CCDS18469.1"
                     /db_xref="GeneID:242620"
                     /db_xref="MGI:MGI:2653629"
ORIGIN      
        1 melrselpsv pgaataaata tgppvasvas vaaaaaaaas lpvsvaggll rapplllraa
       61 ekyprtpkca rcrnhgvvsa lkghkrycrw kdclcakctl iaerqrvmaa qvalrrqqaq
      121 eenearelql lygtaeglal aaangiippr payevfgsvc atdgggpgag apagsaggag
      181 gaeaklqkfd lfpktllqag rpdspqpppg kplspdgads gprtsspevr pgsgsengdg
      241 esfsgsplar askeaggscp gsagagggge edspgssspl gsesgseadk eeaeaaptpg
      301 lgggpgprqr tpldiltrvf pghrrgvlel vlqgcggdvv qaieqvlnhh rgglaaglgp
      361 aaplekaavs aavedawpgr veaaaaggag lpaplqtgpt apphhrplla gamtpgalgs
      421 lssrsafspl qpnashfgad agayplgapl glsplrlays aaaahsrgla fmapystagl
      481 vptlgfrppm dyafsdlmrd rsaaaaaavh kepgygggly gpmvngtpek q
//
