LOCUS       NM_177360               2401 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus doublesex and mab-3 related transcription factor 3
            (Dmrt3), mRNA.
ACCESSION   NM_177360
VERSION     NM_177360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2401)
  AUTHORS   Rajderkar,S., Barozzi,I., Zhu,Y., Hu,R., Zhang,Y., Li,B., Alcaina
            Caro,A., Fukuda-Yuzawa,Y., Kelman,G., Akeza,A., Blow,M.J., Pham,Q.,
            Harrington,A.N., Godoy,J., Meky,E.M., von Maydell,K., Hunter,R.D.,
            Akiyama,J.A., Novak,C.S., Plajzer-Frick,I., Afzal,V., Tran,S.,
            Lopez-Rios,J., Talkowski,M.E., Lloyd,K.C.K., Ren,B., Dickel,D.E.,
            Visel,A. and Pennacchio,L.A.
  TITLE     Topologically associating domain boundaries are required for normal
            genome function
  JOURNAL   Commun Biol 6 (1), 435 (2023)
   PUBMED   37081156
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2401)
  AUTHORS   Vieillard,J., Franck,M.C.M., Hartung,S., Jakobsson,J.E.T.,
            Ceder,M.M., Welsh,R.E., Lagerstrom,M.C. and Kullander,K.
  TITLE     Adult spinal Dmrt3 neurons receive direct somatosensory inputs from
            ipsi- and contralateral primary afferents and from brainstem motor
            nuclei
  JOURNAL   J Comp Neurol 531 (1), 5-24 (2023)
   PUBMED   36214727
REFERENCE   3  (bases 1 to 2401)
  AUTHORS   Bernhardt,N., Memic,F., Velica,A., Tran,M.A., Vieillard,J.,
            Sayyab,S., Chersa,T., Andersson,L., Whelan,P.J., Boije,H. and
            Kullander,K.
  TITLE     Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally
            Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26
  JOURNAL   eNeuro 9 (2) (2022)
   PUBMED   35210288
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2401)
  AUTHORS   Iglesias Gonzalez,A.B., Jakobsson,J.E.T., Vieillard,J.,
            Lagerstrom,M.C., Kullander,K. and Boije,H.
  TITLE     Single Cell Transcriptomic Analysis of Spinal Dmrt3 Neurons in
            Zebrafish and Mouse Identifies Distinct Subtypes and Reveal Novel
            Subpopulations Within the dI6 Domain
  JOURNAL   Front Cell Neurosci 15, 781197 (2021)
   PUBMED   35002627
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2401)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   6  (bases 1 to 2401)
  AUTHORS   Hong,C.S., Park,B.Y. and Saint-Jeannet,J.P.
  TITLE     The function of Dmrt genes in vertebrate development: it is not
            just about sex
  JOURNAL   Dev Biol 310 (1), 1-9 (2007)
   PUBMED   17720152
  REMARK    Review article
REFERENCE   7  (bases 1 to 2401)
  AUTHORS   Ahituv,N., Zhu,Y., Visel,A., Holt,A., Afzal,V., Pennacchio,L.A. and
            Rubin,E.M.
  TITLE     Deletion of ultraconserved elements yields viable mice
  JOURNAL   PLoS Biol 5 (9), e234 (2007)
   PUBMED   17803355
REFERENCE   8  (bases 1 to 2401)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2401)
  AUTHORS   Kim,S., Kettlewell,J.R., Anderson,R.C., Bardwell,V.J. and
            Zarkower,D.
  TITLE     Sexually dimorphic expression of multiple doublesex-related genes
            in the embryonic mouse gonad
  JOURNAL   Gene Expr Patterns 3 (1), 77-82 (2003)
   PUBMED   12609607
REFERENCE   10 (bases 1 to 2401)
  AUTHORS   Smith,C.A., Hurley,T.M., McClive,P.J. and Sinclair,A.H.
  TITLE     Restricted expression of DMRT3 in chicken and mouse embryos
  JOURNAL   Mech Dev 119 Suppl 1, S73-S76 (2002)
   PUBMED   14516663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF541936.1 and BC052041.1.
            
            On Aug 28, 2009 this sequence version replaced NM_177360.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052041.1, BU054807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AF541936.1         1-6
            7-2401              BC052041.1         1-2395
FEATURES             Location/Qualifiers
     source          1..2401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 20.5 cM"
     gene            1..2401
                     /gene="Dmrt3"
                     /note="doublesex and mab-3 related transcription factor 3"
                     /db_xref="GeneID:240590"
                     /db_xref="MGI:MGI:2449470"
     exon            1..731
                     /gene="Dmrt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1693
                     /gene="Dmrt3"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor 3"
                     /protein_id="NP_796334.2"
                     /db_xref="CCDS:CCDS29718.1"
                     /db_xref="GeneID:240590"
                     /db_xref="MGI:MGI:2449470"
                     /translation="MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGH
                     KRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGD
                     AAATAATASQSSPASQASQPPAPPRPTAELAAAAALRWVAEPQPGTLPAQLAKPDLTE
                     ERVGDSSSTDNTAEAFSDKDTDQRSSPDVVKSKNCFTPESPEIVSVDEGGYAVQKNGG
                     NPESCPDSPKYHAEQSHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELI
                     LKGCGGDLVSAVEVLLSSRSSAAGAERTAEESLVLPSSGHIFEHTLGSYPISSSKWSV
                     GSAFRVPDTLRFSADSSNVVPNPLAVPLQHPFPQPPRYPLMLRNTLARNQSSPFLPND
                     VTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLSSRTTEDPRISIPDDGCPIVT
                     KQSIYTEDDYDERSDSSDSRILNTSS"
     exon            732..2391
                     /gene="Dmrt3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2374..2379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmrt3"
                     /note="hexamer: AATAAA"
     polyA_site      2383
                     /gene="Dmrt3"
     polyA_site      2391
                     /gene="Dmrt3"
                     /note="major polyA site"
ORIGIN      
        1 tcagaccgta atcagagctc tccccggctc cttgcagctg ctggagagcc tcagcgtggg
       61 aggacctgcg ggtggagcct gcgccccgag agcggcgggc agagaggcgg cacgcgtggg
      121 taccggcggg ctgcgagcgc catcggagcc ggggagactg ctgccgtagc tccggccgcc
      181 gcggaccttc cggggcctcc cgagagcggg cctccgagct ctgtgctcca gctcccgccg
      241 ccggccgggg ggagccctgg gcatgaacgg ctacggctcc ccctacctgt acatgggcgg
      301 cccggtgtcg cagccgccgc gggcgccctt gcagcgcacg cccaagtgcg cgcgctgccg
      361 gaaccacggg gtgctgtcct ggctcaaggg ccacaagcgc tactgtcgct tcaaggactg
      421 cacctgcgag aagtgcatcc tgatcatcga gcggcagcgg gtgatggcgg cgcaggtggc
      481 gctgcgcagg cagcaggcca acgagagcct ggagagcctc atcccggact cgctgcgggc
      541 tctgccaggg cccccgccgc cgggggacgc tgcggccacc gccgctaccg cctcgcagtc
      601 gtcgccagcc tcccaagcgt cccagccgcc cgcgccgcct cgtcccaccg cggagttggc
      661 cgcggccgcc gcgctgcgct gggtcgcgga gccccagccc gggacgctgc cagcgcagct
      721 tgctaaacca gatctgacag aagagagagt tggggacagc agttccacgg acaacactgc
      781 ggaggccttc agtgacaaag acaccgatca gaggagctcc ccagatgttg tcaaaagcaa
      841 gaactgcttc actccggaga gccccgagat cgtgtccgtg gatgaaggtg ggtacgccgt
      901 gcagaaaaac gggggcaacc ccgagagctg ccccgacagc cccaagtacc acgctgagca
      961 gagccacctc ctgatcgagg gcccatcggg gaccgtctct ctgcccttca gcttgaaagc
     1021 caaccggcca cccctggaag tgttgaagaa aatctttccc aaccagaagc ccactgtcct
     1081 ggagctcatc ttgaaaggtt gcgggggcga cctggtcagt gccgtggagg tcctgctgtc
     1141 cagtcgctcc tccgcggctg gggcggagcg gacggccgaa gagagcctgg tgctgccctc
     1201 tagcggccat atctttgaac acacgctggg ctcctaccct atctcttcct ccaagtggtc
     1261 cgtgggctct gccttccgtg tccctgacac cttacgcttt tccgcagact ccagcaacgt
     1321 ggtccccaac cccttggccg tgcccctgca gcatcctttc ccccagccac ctcggtaccc
     1381 gctgatgctg aggaatactt tggccagaaa ccagtcgagc ccctttttac ccaatgacgt
     1441 caccctgtgg aacaccatga cgctgcagca gcagtaccag ctgaggtccc agtatgtcag
     1501 tccatttccc agtaactcca ctagcgtctt ccggagctcg cccgtgctct cctcccgcac
     1561 caccgaggac cctcggatct ccatccctga cgacggttgt ccaatcgtga caaagcagtc
     1621 catctacaca gaggatgact atgacgagag gtctgactcc tcggattcta gaatactcaa
     1681 cacgtcatcg taaaatgtac ctatgggtgt tgccaggtga cattttatgt gtgttggaac
     1741 cctggacgtc ccccctcccc tttcaggaga gtccactaat actgtatact cttgcctcct
     1801 gtttgacaaa gtgactgtgc ttgatagtct atacattagc aataaaaaca taacttattt
     1861 aattccctgc actccactgg aaaatgccaa atagctctgc tctgtggatt tagtgctgaa
     1921 tgctgtaaat gagtttaaag ctgaggacgc ccgggaaggc cgggccagtg tgtggggggg
     1981 tgctagttga ggggggtcag ctttactccc taaattcaac ccggaatgtt cagtggcata
     2041 gtacacttga atgccatttt gtaaaagaga attcctcagg acactggaaa ccttagggag
     2101 tggttcgatt gccaaccgac tatgagcagg gacgttatct gactgcactc agactagagc
     2161 ggactgagca ggcaggctct tgtttaagct cgggccgttt tcagagacaa acttcattaa
     2221 gaatcatcct tttcacatgg ctgaatggaa acacgtgtta tgtcaaccta aaaccaatcc
     2281 cagctgtgaa ctgcatgagg cgtatcgcga agcgaacaca agattaagct ttgtcaggtt
     2341 aatgtagcat gctaagtaag aactctagaa aaaaataaac taaggacgcg aaaaaaaaaa
     2401 a
//
