LOCUS       NM_145831               2337 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus doublesex and mab-3 related transcription factor 2
            (Dmrt2), mRNA.
ACCESSION   NM_145831 XM_991997
VERSION     NM_145831.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Manzato,C., Larini,L., Oss Pegorar,C., Dello Stritto,M.R.,
            Jurikova,K., Jantsch,V. and Cusanelli,E.
  TITLE     TERRA expression is regulated by the telomere-binding proteins
            POT-1 and POT-2 in Caenorhabditis elegans
  JOURNAL   Nucleic Acids Res 51 (19), 10681-10699 (2023)
   PUBMED   37713629
  REMARK    GeneRIF: TERRA expression is regulated by the telomere-binding
            proteins POT-1 and POT-2 in Caenorhabditis elegans.
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Ono,K., Hata,K., Nakamura,E., Ishihara,S., Kobayashi,S.,
            Nakanishi,M., Yoshida,M., Takahata,Y., Murakami,T., Takenoshita,S.,
            Komori,T., Nishimura,R. and Yoneda,T.
  TITLE     Dmrt2 promotes transition of endochondral bone formation by linking
            Sox9 and Runx2
  JOURNAL   Commun Biol 4 (1), 326 (2021)
   PUBMED   33707608
  REMARK    GeneRIF: Dmrt2 promotes transition of endochondral bone formation
            by linking Sox9 and Runx2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Kordowitzki,P., Lopez de Silanes,I., Guio-Carrion,A. and
            Blasco,M.A.
  TITLE     Dynamics of telomeric repeat-containing RNA expression in early
            embryonic cleavage stages with regards to maternal age
  JOURNAL   Aging (Albany NY) 12 (16), 15906-15917 (2020)
   PUBMED   32860669
  REMARK    GeneRIF: Dynamics of telomeric repeat-containing RNA expression in
            early embryonic cleavage stages with regards to maternal age.
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Kikkawa,T., Sakayori,N., Yuuki,H., Katsuyama,Y., Matsuzaki,F.,
            Konno,D., Abe,T., Kiyonari,H. and Osumi,N.
  TITLE     Dmrt genes participate in the development of Cajal-Retzius cells
            derived from the cortical hem in the telencephalon
  JOURNAL   Dev Dyn 249 (6), 698-710 (2020)
   PUBMED   32012381
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Murphy,M.W., Zarkower,D. and Bardwell,V.J.
  TITLE     Vertebrate DM domain proteins bind similar DNA sequences and can
            heterodimerize on DNA
  JOURNAL   BMC Mol Biol 8, 58 (2007)
   PUBMED   17605809
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Seo,K.W., Wang,Y., Kokubo,H., Kettlewell,J.R., Zarkower,D.A. and
            Johnson,R.L.
  TITLE     Targeted disruption of the DM domain containing transcription
            factor Dmrt2 reveals an essential role in somite patterning
  JOURNAL   Dev Biol 290 (1), 200-210 (2006)
   PUBMED   16387292
  REMARK    GeneRIF: Dmrt2 is involved in somite development and provide
            evidence that DM domain genes have been co-opted into other
            critical developmental pathways distinct from that of sex
            determination or differentiation.
REFERENCE   8  (bases 1 to 2337)
  AUTHORS   Kim,S., Kettlewell,J.R., Anderson,R.C., Bardwell,V.J. and
            Zarkower,D.
  TITLE     Sexually dimorphic expression of multiple doublesex-related genes
            in the embryonic mouse gonad
  JOURNAL   Gene Expr Patterns 3 (1), 77-82 (2003)
   PUBMED   12609607
REFERENCE   9  (bases 1 to 2337)
  AUTHORS   Calvari,V., Bertini,V., De Grandi,A., Peverali,G., Zuffardi,O.,
            Ferguson-Smith,M., Knudtzon,J., Camerino,G., Borsani,G. and
            Guioli,S.
  TITLE     A new submicroscopic deletion that refines the 9p region for sex
            reversal
  JOURNAL   Genomics 65 (3), 203-212 (2000)
   PUBMED   10857744
REFERENCE   10 (bases 1 to 2337)
  AUTHORS   Meng,A., Moore,B., Tang,H., Yuan,B. and Lin,S.
  TITLE     A Drosophila doublesex-related gene, terra, is involved in
            somitogenesis in vertebrates
  JOURNAL   Development 126 (6), 1259-1268 (1999)
   PUBMED   10021344
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132140.3 and AC124540.4.
            
            On May 1, 2007 this sequence version replaced NM_145831.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF539811.1, AK044891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AC132140.3         1996-2343           c
            349-909             AC132140.3         778-1338            c
            910-1012            AC124540.4         51953-52055
            1013-2337           AC124540.4         54069-55393
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 20.53 cM"
     gene            1..2337
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /note="doublesex and mab-3 related transcription factor 2"
                     /db_xref="GeneID:226049"
                     /db_xref="MGI:MGI:1330307"
     exon            1..348
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /inference="alignment:Splign:2.1.0"
     exon            349..909
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..2070
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /note="terra homolog; doublesex-like 2 protein"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor 2"
                     /protein_id="NP_665830.1"
                     /db_xref="CCDS:CCDS29719.1"
                     /db_xref="GeneID:226049"
                     /db_xref="MGI:MGI:1330307"
                     /translation="MTEGQAVPGVGDWEIDVESLDLEEDSCGTPLRATPPQEPSPAAA
                     DGEEDEDEEEEDEDVEDEGDGEEPGVSSEVPGRPEQPGGLAPRPPPAAQALPAAAAAP
                     ERGATAGGGAEPRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQR
                     VMAAQVALRRQQATEDKKGLSGKQNNFDRKAVYQRQVRAPSLLAKSILEGYRPMTAET
                     YLGGTLPLPPPVSDRMRKRRAFADKELENIMLEREYKEREMLETSQAAALFLPNRMVP
                     GPEYSSYKGTYSPTAGELPSKDFCNFLPTCLDLTMQYSGSGNMELISSNVSVATTYRQ
                     YPLSSRFLVWPKCGPISDTLLYQQYLLNATTSVQALKPGTGWDLKGTRVQDGLSAEQD
                     MMPPKLEGSLVLPHLPEVPASRTDLQVHQVVPERSAFSPPGRNFSPIVDMDCLAAQGH
                     VLTKLSKENTRPSLPLKTNPFHSVFQQTLSDKSGPELNAPFVKEAFEETPKKHRECLV
                     KESQKYTFTIDRCAKDLFVAKQVGTKLSANEPLSFSVESILKRPSSAVTHVSQ"
     exon            910..1012
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..2337
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2312..2317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /note="hexamer: AATAAA"
     polyA_site      2336
                     /gene="Dmrt2"
                     /gene_synonym="Terra"
                     /note="major polyA site"
ORIGIN      
        1 gactgcagtg agtgtctctg cgccgaaagc aagcagggtg cgcctgaggc ggagtcctgg
       61 gtccgggccg gaccttttcc gtcctctttg gaccagaagt gggaagtgaa gtgaggcgat
      121 ccagggtgca gaggaccgaa cagaactttg cagaatttgg aatgtacggg gtgaggttgc
      181 tgaggccttg actcgcctcc ggcctctgtc ccccggtcgc catccagtgg gctcccgcct
      241 cctgctctca gacccaattc tgtttgctcc cactgcctgc agctccgggg gacagatcct
      301 gaagctggct ctcttttaac tgggttgcta gcctgagcct ggttcttgcg cgcgggcaac
      361 cgagccgaac gacagtctag tgtcatgacg gaagggcagg cagtcccggg agtcggggac
      421 tgggagatcg acgtggaaag cctagacctg gaggaagata gctgtgggac tccactgcgg
      481 gccacgccgc cgcaggaacc cagtccggcg gcggccgatg gggaggagga cgaggacgaa
      541 gaagaggagg atgaagatgt ggaggacgag ggtgacggcg aggagcccgg cgtgtcctcg
      601 gaggtgccag gccggccaga gcagcccggg ggactggcac ccaggccacc gcctgctgct
      661 caggcgctgc cagccgccgc cgccgcccct gagcgcggtg ccaccgccgg tggcggcgca
      721 gagccgcgca aactgagccg cacacccaag tgcgcacgct gccgcaacca cggcgtggta
      781 tcctgtctca agggccacaa gcgattctgt cgctggcggg actgccagtg cgccaactgc
      841 ctgctggtgg tggagcgcca gcgtgtcatg gccgcccagg tggcgctccg gaggcagcag
      901 gccacagagg acaagaaggg gctttctggg aaacagaaca atttcgatcg gaaagcagtg
      961 taccagaggc aagtcagggc gccgagtttg ctggccaaaa gcattttaga aggttatcgc
     1021 ccaatgacgg cagagactta cctaggaggg acccttcctc tacctccgcc tgtcagtgac
     1081 aggatgagga agagaagagc ctttgctgac aaggagttgg agaacattat gctggagaga
     1141 gaatataaag agagggagat gttagaaaca tctcaagctg ctgccttatt cctgcccaac
     1201 cgtatggtgc ctggacccga gtacagttcc tacaaaggta cctacagccc cactgcagga
     1261 gagctgccga gcaaggactt ctgtaacttt ttacctacct gccttgatct caccatgcag
     1321 tattcagggt ctgggaatat ggaacttatt tcttctaacg tcagtgtggc cacaacttac
     1381 agacaatatc ccctgtcctc acgattttta gtttggccca agtgcggtcc cattagtgac
     1441 acccttctct accagcaata tctgttaaat gctaccactt ctgtccaagc tctgaagccg
     1501 gggaccggct gggacttgaa aggaacccga gttcaggatg ggcttagcgc agagcaagac
     1561 atgatgccac ccaaactgga aggctctctg gtgctgcccc atctgccaga ggtcccagcc
     1621 tcgagaacag accttcaggt tcaccaggtg gttccagaga ggtctgcctt ctccccaccc
     1681 ggtcggaatt tctctcccat tgttgatatg gactgcctgg cagctcaagg gcacgtctta
     1741 accaagctca gcaaagaaaa cactagacct tctctgccac ttaaaactaa tccattccac
     1801 tcagtattcc agcagacgct cagcgacaaa tcaggccctg agttgaacgc accatttgtc
     1861 aaagaagcct ttgaagagac cccaaagaaa cacagagagt gtttggtcaa ggagagccag
     1921 aagtacacat ttacaataga cagatgcgca aaagacctct ttgtagccaa acaagttgga
     1981 acgaaacttt cggcgaatga gccactgtcg ttctctgtcg aatctattct taagaggcct
     2041 tcatctgccg tcactcacgt ctctcagtaa agggctgctt acaagggaag ctggattttc
     2101 tccagtctct gagggttctt ggcagttgcc tttttttttt ttaaagttaa gatgtatgta
     2161 taaagaaatt tctaatgtaa atgaccgatt cttaaaatcc tatgtatttc ctttgcatgt
     2221 atcttttcta tcacacgagt atatttaaag atagaaacta cttactgtgc aaattgtaag
     2281 ggtctgtgct ttacacagca ttccaaaaag caataaaaat aacaccgtct tctaaag
//
