LOCUS       NM_015826               2251 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus doublesex and mab-3 related transcription factor 1
            (Dmrt1), mRNA.
ACCESSION   NM_015826
VERSION     NM_015826.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2251)
  AUTHORS   Ishikawa,N., Fujitani,K., Okano,N., Hayashi,S., Sakabe,N.,
            Inazumi,S., Okuyama,H., Seki,K., Suda,K., Tsukamoto,D., Matsuo,T.,
            Tamura,K. and Ito,M.
  TITLE     Diversity of transactivation regions of DMRT1 in vertebrates
  JOURNAL   Mol Biol Rep 51 (1), 1077 (2024)
   PUBMED   39432160
  REMARK    GeneRIF: Diversity of transactivation regions of DMRT1 in
            vertebrates.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2251)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (bases 1 to 2251)
  AUTHORS   Rajderkar,S., Barozzi,I., Zhu,Y., Hu,R., Zhang,Y., Li,B., Alcaina
            Caro,A., Fukuda-Yuzawa,Y., Kelman,G., Akeza,A., Blow,M.J., Pham,Q.,
            Harrington,A.N., Godoy,J., Meky,E.M., von Maydell,K., Hunter,R.D.,
            Akiyama,J.A., Novak,C.S., Plajzer-Frick,I., Afzal,V., Tran,S.,
            Lopez-Rios,J., Talkowski,M.E., Lloyd,K.C.K., Ren,B., Dickel,D.E.,
            Visel,A. and Pennacchio,L.A.
  TITLE     Topologically associating domain boundaries are required for normal
            genome function
  JOURNAL   Commun Biol 6 (1), 435 (2023)
   PUBMED   37081156
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2251)
  AUTHORS   Huang,S., Ye,L. and Chen,H.
  TITLE     Sex determination and maintenance: the role of DMRT1 and FOXL2
  JOURNAL   Asian J Androl 19 (6), 619-624 (2017)
   PUBMED   28091399
  REMARK    Review article
REFERENCE   5  (bases 1 to 2251)
  AUTHORS   Zarkower,D.
  TITLE     DMRT genes in vertebrate gametogenesis
  JOURNAL   Curr Top Dev Biol 102, 327-356 (2013)
   PUBMED   23287039
  REMARK    Review article
REFERENCE   6  (bases 1 to 2251)
  AUTHORS   Ferguson-Smith,M.
  TITLE     The evolution of sex chromosomes and sex determination in
            vertebrates and the key role of DMRT1
  JOURNAL   Sex Dev 1 (1), 2-11 (2007)
   PUBMED   18391511
  REMARK    Review article
REFERENCE   7  (bases 1 to 2251)
  AUTHORS   Brunner,B., Hornung,U., Shan,Z., Nanda,I., Kondo,M.,
            Zend-Ajusch,E., Haaf,T., Ropers,H.H., Shima,A., Schmid,M.,
            Kalscheuer,V.M. and Schartl,M.
  TITLE     Genomic organization and expression of the doublesex-related gene
            cluster in vertebrates and detection of putative regulatory regions
            for DMRT1
  JOURNAL   Genomics 77 (1-2), 8-17 (2001)
   PUBMED   11543627
REFERENCE   8  (bases 1 to 2251)
  AUTHORS   De Grandi,A., Calvari,V., Bertini,V., Bulfone,A., Peverali,G.,
            Camerino,G., Borsani,G. and Guioli,S.
  TITLE     The expression pattern of a mouse doublesex-related gene is
            consistent with a role in gonadal differentiation
  JOURNAL   Mech Dev 90 (2), 323-326 (2000)
   PUBMED   10640721
REFERENCE   9  (bases 1 to 2251)
  AUTHORS   Smith,C.A., McClive,P.J., Western,P.S., Reed,K.J. and Sinclair,A.H.
  TITLE     Conservation of a sex-determining gene
  JOURNAL   Nature 402 (6762), 601-602 (1999)
   PUBMED   10604464
REFERENCE   10 (bases 1 to 2251)
  AUTHORS   Raymond,C.S., Kettlewell,J.R., Hirsch,B., Bardwell,V.J. and
            Zarkower,D.
  TITLE     Expression of Dmrt1 in the genital ridge of mouse and chicken
            embryos suggests a role in vertebrate sexual development
  JOURNAL   Dev Biol 215 (2), 208-220 (1999)
   PUBMED   10545231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132140.3.
            
            On Oct 24, 2007 this sequence version replaced NM_015826.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL133300.1, AY169786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AC132140.3         168553-169048       c
            497-680             AC132140.3         164891-165074       c
            681-964             AC132140.3         128652-128935       c
            965-1109            AC132140.3         114743-114887       c
            1110-2251           AC132140.3         70426-71567         c
FEATURES             Location/Qualifiers
     source          1..2251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 20.45 cM"
     gene            1..2251
                     /gene="Dmrt1"
                     /note="doublesex and mab-3 related transcription factor 1"
                     /db_xref="GeneID:50796"
                     /db_xref="MGI:MGI:1354733"
     exon            1..496
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1273
                     /gene="Dmrt1"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor 1"
                     /protein_id="NP_056641.2"
                     /db_xref="CCDS:CCDS29717.1"
                     /db_xref="GeneID:50796"
                     /db_xref="MGI:MGI:1354733"
                     /translation="MPNDDTFGKPSTPTEVPHAPGAPPQGKAGGYSKAAGAMAGAAGG
                     SGAGGSGGASGSGPSGLGSGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKK
                     CSLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENNASNPCLMAEN
                     SSSAQPPPASTPTPAASEGRMVIQDIPAVTSRGHMENTSDLVSDPAYYSSFYQPSLFP
                     YYNNLYNYPQYSMALSAESSSGEVGNSLGGSPVKNSLRSLPAPYVPAQTGNQWQMKTS
                     ESRHPVSSQYRMHSYYGPPSYLGQSMSQIFTFEEGPSYSEAKASVFSPPSSQDSGLVS
                     LSSSSPMSNESSKGVLECESASSEPSSYAVNQVLEEDEDE"
     exon            497..680
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..964
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1109
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..2251
                     /gene="Dmrt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaaaaga aaaaagaaaa gaggtacaac cccccaccca ctccccgagc tcttcattta
       61 gactacaggt ccagctgcgg tgcacccgcc tcctgcgcgc cttctaggca gccggctggg
      121 tggatccggg agcgggagac gaagctccat gccgaacgac gacacattcg gcaagccctc
      181 taccccgacg gaggttcctc acgctcccgg ggccccgccg cagggcaaag ccggaggtta
      241 cagcaaagct gccggggcga tggctggagc ggctggaggc tcgggcgcgg ggggcagcgg
      301 aggtgcctcg ggctccgggc cgtcgggcct gggttctgga agcaagaagt ccccgaggct
      361 gcccaaatgc gctcgctgca ggaaccacgg ctacgcgtcg ccgctcaagg gccacaagcg
      421 cttctgcatg tggcgggatt gccagtgcaa gaagtgcagc ctgattgcgg agcgacagcg
      481 ggtgatggcc gcgcaggtgg ccctgagaag acagcaggcc caggaagaag aactgggtat
      541 cagccaccca attccgctgc ccagcgcagc cgagctcctg gtcaaaagag agaataatgc
      601 cagcaacccg tgcctgatgg ccgagaacag cagctctgcc cagcccccac cggccagcac
      661 cccaaccccc gctgcctcag agggacgcat ggtcatccag gatattcctg ctgtcaccag
      721 cagagggcat atggagaaca catctgacct ggtatcagac cccgcctact acagcagctt
      781 ttaccagcct tctctgtttc cttactacaa caatctgtac aactaccccc agtattccat
      841 ggccttgtct gctgagtcct cctcagggga ggtggggaat tccctcgggg gatcccccgt
      901 gaagaacagc ctgcggagtc tcccagcacc ttacgtgcct gctcagactg gaaaccagtg
      961 gcagatgaag acctcagaga gccgccaccc agtgagctcc cagtaccgga tgcactcata
     1021 ctacgggcct ccctcctacc tgggccagag catgtcccag atctttacct tcgaggaagg
     1081 cccctcctac tcagaagcca aagccagtgt gttctcgccc cccagcagtc aagattctgg
     1141 cttggtctcc ctctccagca gctctccgat gagcaacgag agctcgaagg gagttctgga
     1201 atgtgagtct gcgtcctcgg aacctagcag ctacgccgtc aaccaggtcc tggaagagga
     1261 tgaggacgag tgagccgccg ccggggctac tctggtcaca gggtgttagg cggcttgttt
     1321 tgttatcggc agggtttgtt gttatttgaa ttggcagtgc tggctgccca ttcagaagtt
     1381 tggttcatgt tagagttagg ttaaaacact tgtaacagtg taggatccca gactaccatc
     1441 tgcaagaagt aagtgcctgg ctcaccaagt ttaaacagta atgagactcg ctcccttgcc
     1501 cagagcctgt ccctttccct tccttctcca ctgtgttggt tttttttttt tggggggggg
     1561 ggggaggatc ttccagagaa aagaattgac tgtatgccca agttacaatt acatgctact
     1621 tttggggttc aaatgaaatt ttcggtgcct taggttgtaa ccaagttttc aggattttta
     1681 agaaaaccaa gaaaatataa atttagctct aagtacttga ccagtgagaa gagcgggcaa
     1741 acctcttttt agaattctgc agacagtaaa tggagacact gtttatgttt tggtgatgtg
     1801 ttggtggctg caccccacac cccaaatcca aatgtaacag gaatacagta agaagaaacc
     1861 acagcgagag gaaacaggga aaacctcccc aagccttact tctcagataa agggtaactt
     1921 agaaaacaat acaccgtgaa gtgaccccag gaggcatttc ctgggtgttg ttcctagaat
     1981 gagtttaact aacgcataca ttttctttac cacaggggga aaaatggagg caatctagac
     2041 gattttgtaa ccttaggttg taatctggct tgaaaattag tacatcttta aaagttacca
     2101 ctgatatttg agttcattat tttgttaaaa aaattgcttt taaagtactt atgttacagg
     2161 aagccatcct gaaatggaac cggtctaaaa aaaaataatt gtggtgtgtg gttgcagctg
     2221 tacctgaaat aaaaacgtta ttgatgactg c
//
