LOCUS       NP_056641                374 aa            linear   ROD 27-APR-2025
DEFINITION  doublesex- and mab-3-related transcription factor 1 [Mus musculus].
ACCESSION   NP_056641
VERSION     NP_056641.2
DBSOURCE    REFSEQ: accession NM_015826.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 374)
  AUTHORS   Ishikawa,N., Fujitani,K., Okano,N., Hayashi,S., Sakabe,N.,
            Inazumi,S., Okuyama,H., Seki,K., Suda,K., Tsukamoto,D., Matsuo,T.,
            Tamura,K. and Ito,M.
  TITLE     Diversity of transactivation regions of DMRT1 in vertebrates
  JOURNAL   Mol Biol Rep 51 (1), 1077 (2024)
   PUBMED   39432160
  REMARK    GeneRIF: Diversity of transactivation regions of DMRT1 in
            vertebrates.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 374)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (residues 1 to 374)
  AUTHORS   Rajderkar,S., Barozzi,I., Zhu,Y., Hu,R., Zhang,Y., Li,B., Alcaina
            Caro,A., Fukuda-Yuzawa,Y., Kelman,G., Akeza,A., Blow,M.J., Pham,Q.,
            Harrington,A.N., Godoy,J., Meky,E.M., von Maydell,K., Hunter,R.D.,
            Akiyama,J.A., Novak,C.S., Plajzer-Frick,I., Afzal,V., Tran,S.,
            Lopez-Rios,J., Talkowski,M.E., Lloyd,K.C.K., Ren,B., Dickel,D.E.,
            Visel,A. and Pennacchio,L.A.
  TITLE     Topologically associating domain boundaries are required for normal
            genome function
  JOURNAL   Commun Biol 6 (1), 435 (2023)
   PUBMED   37081156
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 374)
  AUTHORS   Huang,S., Ye,L. and Chen,H.
  TITLE     Sex determination and maintenance: the role of DMRT1 and FOXL2
  JOURNAL   Asian J Androl 19 (6), 619-624 (2017)
   PUBMED   28091399
  REMARK    Review article
REFERENCE   5  (residues 1 to 374)
  AUTHORS   Zarkower,D.
  TITLE     DMRT genes in vertebrate gametogenesis
  JOURNAL   Curr Top Dev Biol 102, 327-356 (2013)
   PUBMED   23287039
  REMARK    Review article
REFERENCE   6  (residues 1 to 374)
  AUTHORS   Ferguson-Smith,M.
  TITLE     The evolution of sex chromosomes and sex determination in
            vertebrates and the key role of DMRT1
  JOURNAL   Sex Dev 1 (1), 2-11 (2007)
   PUBMED   18391511
  REMARK    Review article
REFERENCE   7  (residues 1 to 374)
  AUTHORS   Brunner,B., Hornung,U., Shan,Z., Nanda,I., Kondo,M.,
            Zend-Ajusch,E., Haaf,T., Ropers,H.H., Shima,A., Schmid,M.,
            Kalscheuer,V.M. and Schartl,M.
  TITLE     Genomic organization and expression of the doublesex-related gene
            cluster in vertebrates and detection of putative regulatory regions
            for DMRT1
  JOURNAL   Genomics 77 (1-2), 8-17 (2001)
   PUBMED   11543627
REFERENCE   8  (residues 1 to 374)
  AUTHORS   De Grandi,A., Calvari,V., Bertini,V., Bulfone,A., Peverali,G.,
            Camerino,G., Borsani,G. and Guioli,S.
  TITLE     The expression pattern of a mouse doublesex-related gene is
            consistent with a role in gonadal differentiation
  JOURNAL   Mech Dev 90 (2), 323-326 (2000)
   PUBMED   10640721
REFERENCE   9  (residues 1 to 374)
  AUTHORS   Smith,C.A., McClive,P.J., Western,P.S., Reed,K.J. and Sinclair,A.H.
  TITLE     Conservation of a sex-determining gene
  JOURNAL   Nature 402 (6762), 601-602 (1999)
   PUBMED   10604464
REFERENCE   10 (residues 1 to 374)
  AUTHORS   Raymond,C.S., Kettlewell,J.R., Hirsch,B., Bardwell,V.J. and
            Zarkower,D.
  TITLE     Expression of Dmrt1 in the genital ridge of mouse and chicken
            embryos suggests a role in vertebrate sexual development
  JOURNAL   Dev Biol 215 (2), 208-220 (1999)
   PUBMED   10545231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132140.3.
            
            On Dec 20, 2003 this sequence version replaced NP_056641.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL133300.1, AY169786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 20.45 cM"
     Protein         1..374
                     /product="doublesex- and mab-3-related transcription
                     factor 1"
                     /calculated_mol_wt=39313
     Region          1..73
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZ59.2)"
     Region          70..116
                     /region_name="DM"
                     /note="DM DNA binding domain; pfam00751"
                     /db_xref="CDD:459924"
     Region          128..200
                     /region_name="Dmrt1"
                     /note="Double-sex mab3 related transcription factor 1;
                     pfam12374"
                     /db_xref="CDD:463555"
     Region          154..176
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZ59.2)"
     Region          317..374
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZ59.2)"
     Site            337
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QZ59.2)"
     CDS             1..374
                     /gene="Dmrt1"
                     /coded_by="NM_015826.5:149..1273"
                     /db_xref="CCDS:CCDS29717.1"
                     /db_xref="GeneID:50796"
                     /db_xref="MGI:MGI:1354733"
ORIGIN      
        1 mpnddtfgkp stptevphap gappqgkagg yskaagamag aaggsgaggs ggasgsgpsg
       61 lgsgskkspr lpkcarcrnh gyasplkghk rfcmwrdcqc kkcsliaerq rvmaaqvalr
      121 rqqaqeeelg ishpiplpsa aellvkrenn asnpclmaen sssaqpppas tptpaasegr
      181 mviqdipavt srghmentsd lvsdpayyss fyqpslfpyy nnlynypqys malsaesssg
      241 evgnslggsp vknslrslpa pyvpaqtgnq wqmktsesrh pvssqyrmhs yygppsylgq
      301 smsqiftfee gpsyseakas vfsppssqds glvslssssp msnesskgvl ecesasseps
      361 syavnqvlee dede
//
