LOCUS       NM_016779               2760 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus dentin matrix protein 1 (Dmp1), transcript variant 2,
            mRNA.
ACCESSION   NM_016779
VERSION     NM_016779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2760)
  AUTHORS   Yoshida,Y., Inubushi,T., Yokoyama,M., Nag,P., Sasaki,J.I., Oka,A.,
            Murotani,T., Kani,R., Shiraishi,Y., Kurosaka,H., Takahata,Y.,
            Nishimura,R., Imazato,S., Papagerakis,P. and Yamashiro,T.
  TITLE     Slc26a2-mediated sulfate metabolism is important in tooth
            development
  JOURNAL   Dis Model Mech 17 (12) (2024)
   PUBMED   39508796
REFERENCE   2  (bases 1 to 2760)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Padilla,C.,
            Iben,J., Faucz,F.R., Cotney,J.L. and D'Souza,R.N.
  TITLE     Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in
            Palatogenesis'
  JOURNAL   J Dent Res 103 (13), 1412-1420 (2024)
   PUBMED   38910391
REFERENCE   3  (bases 1 to 2760)
  AUTHORS   Li,Y., Lin,Y., Guo,J., Huang,D., Zuo,H., Zhang,H., Yuan,G., Liu,H.
            and Chen,Z.
  TITLE     CREB3L1 deficiency impairs odontoblastic differentiation and molar
            dentin deposition partially through the TMEM30B
  JOURNAL   Int J Oral Sci 16 (1), 59 (2024)
   PUBMED   39384739
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2760)
  AUTHORS   Courbon,G., Kentrup,D., Thomas,J.J., Wang,X., Tsai,H.H.,
            Spindler,J., Von Drasek,J., Ndjonko,L.M., Martinez-Calle,M.,
            Lynch,S., Hivert,L., Wang,X., Chang,W., Feng,J.Q., David,V. and
            Martin,A.
  TITLE     FGF23 directly inhibits osteoprogenitor differentiation in
            Dmp1-knockout mice
  JOURNAL   JCI Insight 8 (24), e156850 (2023)
   PUBMED   37943605
  REMARK    GeneRIF: FGF23 directly inhibits osteoprogenitor differentiation in
            Dmp1-knockout mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2760)
  AUTHORS   Toyosawa,S., Sato,A., O'hUigin,C., Tichy,H. and Klein,J.
  TITLE     Expression of the dentin matrix protein 1 gene in birds
  JOURNAL   J Mol Evol 50 (1), 31-38 (2000)
   PUBMED   10654257
REFERENCE   7  (bases 1 to 2760)
  AUTHORS   MacDougall,M., Gu,T.T., Luan,X., Simmons,D. and Chen,J.
  TITLE     Identification of a novel isoform of mouse dentin matrix protein 1:
            spatial expression in mineralized tissues
  JOURNAL   J Bone Miner Res 13 (3), 422-431 (1998)
   PUBMED   9525343
REFERENCE   8  (bases 1 to 2760)
  AUTHORS   D'Souza,R.N., Cavender,A., Sunavala,G., Alvarez,J., Ohshima,T.,
            Kulkarni,A.B. and MacDougall,M.
  TITLE     Gene expression patterns of murine dentin matrix protein 1 (Dmp1)
            and dentin sialophosphoprotein (DSPP) suggest distinct
            developmental functions in vivo
  JOURNAL   J Bone Miner Res 12 (12), 2040-2049 (1997)
   PUBMED   9421236
REFERENCE   9  (bases 1 to 2760)
  AUTHORS   George,A., Bannon,L., Sabsay,B., Dillon,J.W., Malone,J., Veis,A.,
            Jenkins,N.A., Gilbert,D.J. and Copeland,N.G.
  TITLE     The carboxyl-terminal domain of phosphophoryn contains unique
            extended triplet amino acid repeat sequences forming ordered
            carboxyl-phosphate interaction ridges that may be essential in the
            biomineralization process
  JOURNAL   J Biol Chem 271 (51), 32869-32873 (1996)
   PUBMED   8955126
REFERENCE   10 (bases 1 to 2760)
  AUTHORS   George,A., Gui,J., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Veis,A.
  TITLE     In situ localization and chromosomal mapping of the AG1 (Dmp1) gene
  JOURNAL   J Histochem Cytochem 42 (12), 1527-1531 (1994)
   PUBMED   7983353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132177.1.
            
            On Feb 28, 2006 this sequence version replaced NM_016779.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This sequence has been modified as follows: removed
            17/38 bp suspected to be vector contamination from the 5'/3' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132177.1, AK157973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2760              AK132177.1         2-2761
FEATURES             Location/Qualifiers
     source          1..2760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.61 cM"
     gene            1..2760
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /note="dentin matrix protein 1"
                     /db_xref="GeneID:13406"
                     /db_xref="MGI:MGI:94910"
     exon            1..96
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /inference="alignment:Splign:2.1.0"
     exon            97..171
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1629
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /note="dentin matrix acidic phosphoprotein 1; serine rich
                     acidic phosphoprotein"
                     /codon_start=1
                     /product="dentin matrix acidic phosphoprotein 1 precursor"
                     /protein_id="NP_058059.2"
                     /db_xref="CCDS:CCDS19484.1"
                     /db_xref="GeneID:13406"
                     /db_xref="MGI:MGI:94910"
                     /translation="MKTVILLVFLWGLSCALPVARYHNTESESSEERTGDLAGSPPPP
                     TNSESSEESQASPEGQANSDHTDSSESGEELGYDRGQYRPAGGLSKSTGTGADKEDDE
                     DDSGDDTFGDEDNDLGPEEGQWGGPSKLDSDEDSTDTTQSSEDSTSQENSAQDTPSDS
                     KDHDSEDEADSRPEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPEST
                     RSDRGHARMSSAGIRSEESKGDHEPTSTQDSDDSQSVEFSSRKSFRRSHVSEEDYRGE
                     LTDSNSRETQSDSTEDTASKEESRSESQEDTAESQSQEDSPEGQDPSSESSEEAGEPS
                     QESSSESQEGVTSESRGDNPDNTSQAGDQEDSESSEEDSLNTFSSSESQSTEEQADSE
                     SNESLSLSEESQESAQDGDSSSQEGLQSQSASTESRSQESQSEQDSRSEEDSDSQDSS
                     RSKEESNSTGSASSSEEDIRPKNMEADSRKLIVDAYHNKPIGDQDDNDCQDGY"
     exon            172..219
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /inference="alignment:Splign:2.1.0"
     exon            220..252
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /inference="alignment:Splign:2.1.0"
     exon            253..297
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /inference="alignment:Splign:2.1.0"
     exon            298..2760
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmp1"
                     /gene_synonym="AG1; Dmp; DMP-1; PP"
                     /note="putative"
ORIGIN      
        1 gagcagcagc tggagagtgg cttctctgag atccctcttc gagaacttcg ctgaggtttt
       61 gaccttgtgg gaaaaagacc ttgggagcca gagagggtag aggaatcgca tcccaatatg
      121 aagactgtca ttctccttgt gttcctttgg gggctgtcct gtgctctccc agttgccaga
      181 taccacaata ctgaatctga aagctctgaa gagaggacgg gtgatttggc tgggtcacca
      241 ccaccaccca cgaacagtga gtcatcagaa gaaagtcaag ctagcccaga gggacaggca
      301 aatagtgacc acacggacag cagtgaatct ggagaggagc tgggctacga cagaggccag
      361 tacagaccgg ctggtggact ctctaagagt acggggaccg gcgccgataa ggaggatgat
      421 gaagacgaca gtggagatga tacctttggc gatgaggaca atgatctagg gcccgaagaa
      481 ggacagtggg gaggaccctc caaactggac agtgatgagg actccacaga caccacacag
      541 tccagtgaag acagcacctc tcaagaaaac agtgcccaag atacccccag cgacagcaaa
      601 gaccacgaca gtgaggatga ggcagacagc cggcctgagg caggcgactc cactcaggac
      661 agtgagagtg aggaacagcg ggtgggaggt ggcagcgagg gggagagtag ccacggggac
      721 ggttctgagt tcgatgatga agggatgcag agcgacgacc ccgagagtac caggagcgat
      781 cgaggccacg ccagaatgag cagcgctggt atcaggtcgg aagaatctaa aggggaccac
      841 gagcccacga gcactcagga ttcagatgac agccagtctg tggaattttc aagcaggaag
      901 tccttcagaa ggtcccacgt ctctgaggaa gactacagag gtgagcttac tgacagcaac
      961 agcagggaaa cccagagcga ctccacggag gatacggcct ccaaggagga aagcaggagc
     1021 gagtctcagg aggacacagc cgagagccag tcccaggaag atagcccaga ggggcaagac
     1081 cccagcagtg agtccagcga agaggctggt gagccatccc aggaaagcag cagcgaatct
     1141 caggaagggg tgaccagcga gtccaggggt gacaacccag ataacacaag tcaggcagga
     1201 gaccaagaag acagtgagtc cagtgaggag gacagcctga acacattctc cagctcagaa
     1261 agccagtcca ccgaggagca agctgacagc gagtccaacg agagcctcag cctctccgag
     1321 gagagtcagg agtcggccca ggatggtgac agctccagcc aggaaggcct gcagtcccag
     1381 agcgcatcca ctgagagcag gagccaggag agccagtctg agcaggacag ccgttctgag
     1441 gaagacagtg actctcagga cagtagccga tccaaagaag agagcaactc cacagggagc
     1501 gcttccagca gcgaggagga catccgtccc aagaacatgg aagctgacag taggaaacta
     1561 atagttgatg cttaccacaa caaacccatc ggggaccaag atgacaatga ctgtcaggac
     1621 ggctactagc attagcttgt ctaagaaatg gctctcacag gacggagtct tgggggctcc
     1681 agagtagaga gttcactata actataattt attaatgttt tggtcagaag gagaaccagg
     1741 ggcaggtttt tttgttttgt tttgtttttg tttgtttgtt tgttttcccc ctgtgaggaa
     1801 ctgttggaca cgacactgtt ttccagggtg tctcccactc cttagaggct taagtacgtg
     1861 ggatgatgtc agagcacaca tggtgagaga agaacacagg gatcacgtgc acagccgctt
     1921 cacagatgct ctggttcacc aacctgacag tgactgaggt tctggtacac accaggcaca
     1981 gccctgggcg ggggaggggg tggtggtgct tcaggctcag ttttgctccg gaggagcttg
     2041 ttccaaggag actctcaaaa gtaacacatt aaaggataca aagaaggagc ccctggagct
     2101 gggctacatt gctttggctc ctggagggtg agaacttact gcagcaagcc cctgccgcag
     2161 ctgaggcgag taccacaggg aatgggagca ggacaggaag tgaccagttt tgctttggag
     2221 aatcagaggt tccacagtag caaagcctgg agctggaggg ttacatagga tttctccatt
     2281 gaagacaata taactctatt tattcttgag ataagcagta tcaaatcgta tgcaattaaa
     2341 tatttagtac gtaaaggcat tctcaaatga taacccaatg ggatatcttg gataacatat
     2401 ttttcccaac gaatttacct tattgagtgc ttttgtgggc cttctgtaaa catggcctca
     2461 atgatgagga ggaggaagaa aatttggtgt ggagatggga gaaaaacata attaaaagaa
     2521 gatttatagc ttaatttttt tccagattat ttatgtgcag tgtaaatact atccctgagt
     2581 cctttctatg tgttgcacat agaaaaaatt ctgcacatag ggctcaagta ttttgttgtt
     2641 gtttctttat cttttcttgt ttttttgttt tttgtttttt tggggttttt tttgggtcaa
     2701 gtgccattga agcattacct catgaaaaat atttgttttg taataaagat aataattccc
//
