LOCUS       NM_001166173            2070 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus dermokine (Dmkn), transcript variant 3, mRNA.
ACCESSION   NM_001166173
VERSION     NM_001166173.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Zhang,Y., Zhang,H.W., Zhu,X.D., Wang,Y.Q., Wang,X.W., Zheng,B.S.,
            Chen,B.C. and Chen,Z.J.
  TITLE     Overexpression of Dermokine-alpha enhances the proliferation and
            epithelial-mesenchymal transition of pancreatic tumor cells
  JOURNAL   Cell Signal 99, 110439 (2022)
   PUBMED   35981655
  REMARK    GeneRIF: Overexpression of Dermokine-alpha enhances the
            proliferation and epithelial-mesenchymal transition of pancreatic
            tumor cells.
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Utsunomiya,A., Chino,T., Utsunomiya,N., Luong,V.H., Tokuriki,A.,
            Naganuma,T., Arita,M., Higashi,K., Saito,K., Suzuki,N., Ohara,A.,
            Sugai,M., Sugawara,K., Tsuruta,D., Oyama,N. and Hasegawa,M.
  TITLE     Homeostatic Function of Dermokine in the Skin Barrier and
            Inflammation
  JOURNAL   J Invest Dermatol 140 (4), 838-849 (2020)
   PUBMED   31669414
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Leclerc,E.A., Huchenq,A., Kezic,S., Serre,G. and Jonca,N.
  TITLE     Mice deficient for the epidermal dermokine beta and gamma isoforms
            display transient cornification defects
  JOURNAL   J Cell Sci 127 (Pt 13), 2862-2872 (2014)
   PUBMED   24794495
  REMARK    GeneRIF: Authors improved the knowledge of Dmkn expression in mouse
            and highlighted a role for Dmkn beta and gamma in cornification.
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Hasegawa,M., Higashi,K., Matsushita,T., Hamaguchi,Y., Saito,K.,
            Fujimoto,M. and Takehara,K.
  TITLE     Dermokine inhibits ELR(+)CXC chemokine expression and delays early
            skin wound healing
  JOURNAL   J Dermatol Sci 70 (1), 34-41 (2013)
   PUBMED   23428944
  REMARK    GeneRIF: These results suggest that dermokine-beta delays early
            cutaneous wound healing in part by inhibiting expression of CXC
            chemokines containing the ERL-sequence motif.
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Jheon,A.H., Mostowfi,P., Snead,M.L., Ihrie,R.A., Sone,E.,
            Pramparo,T., Attardi,L.D. and Klein,O.D.
  TITLE     PERP regulates enamel formation via effects on cell-cell adhesion
            and gene expression
  JOURNAL   J Cell Sci 124 (Pt 5), 745-754 (2011)
   PUBMED   21285247
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Naso,M.F., Liang,B., Huang,C.C., Song,X.Y., Shahied-Arruda,L.,
            Belkowski,S.M., D'Andrea,M.R., Polkovitch,D.A., Lawrence,D.R.,
            Griswold,D.E., Sweet,R.W. and Amegadzie,B.Y.
  TITLE     Dermokine: an extensively differentially spliced gene expressed in
            epithelial cells
  JOURNAL   J Invest Dermatol 127 (7), 1622-1631 (2007)
   PUBMED   17380110
  REMARK    GeneRIF: Dermokine gene is expressed in epithelial tissues other
            than the skin and this expression is transcriptionally and
            posttranscriptionally complex.
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Bazzi,H., Fantauzzo,K.A., Richardson,G.D., Jahoda,C.A. and
            Christiano,A.M.
  TITLE     Transcriptional profiling of developing mouse epidermis reveals
            novel patterns of coordinated gene expression
  JOURNAL   Dev Dyn 236 (4), 961-970 (2007)
   PUBMED   17330888
  REMARK    GeneRIF: Drmkn and Krtdap are the highest differentially expressed
            genes in epidermis embryonic development in mice.
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Matsui,T., Hayashi-Kisumi,F., Kinoshita,Y., Katahira,S., Morita,K.,
            Miyachi,Y., Ono,Y., Imai,T., Tanigawa,Y., Komiya,T. and Tsukita,S.
  TITLE     Identification of novel keratinocyte-secreted peptides
            dermokine-alpha/-beta and a new stratified epithelium-secreted
            protein gene complex on human chromosome 19q13.1
  JOURNAL   Genomics 84 (2), 384-397 (2004)
   PUBMED   15234001
  REMARK    GeneRIF: identification of a novel gene (dermokine)giving rise to
            two splicing variants, both of which are expressed in the spinous
            layer of epidermis
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Moffatt,P., Salois,P., St-Amant,N., Gaumond,M.H. and Lanctot,C.
  TITLE     Identification of a conserved cluster of skin-specific genes
            encoding secreted proteins
  JOURNAL   Gene 334, 123-131 (2004)
   PUBMED   15256262
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK081753.1 and AC165340.3.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081753.1, SRR5189676.105686.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-743               AK081753.1         2-744
            744-2063            AK081753.1         746-2065
            2064-2070           AC165340.3         104415-104421
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.24 cM"
     gene            1..2070
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /note="dermokine"
                     /db_xref="GeneID:73712"
                     /db_xref="MGI:MGI:1920962"
     exon            1..546
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1743
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; epidermis-specific secreted protein SK30/SK89"
                     /codon_start=1
                     /product="dermokine isoform c precursor"
                     /protein_id="NP_001159645.1"
                     /db_xref="CCDS:CCDS52183.1"
                     /db_xref="GeneID:73712"
                     /db_xref="MGI:MGI:1920962"
                     /translation="MKLQGSLACLLLALCLGGGAANPLHSGGEGTGASAAHGAGDAIS
                     HGIGEAVGQGAKEAASSGIQNALGQGHGEEGGSTLMGSRGDVFEHRLGEAARSLGNAG
                     NEIGRQAEDIIRQGVDAVHNAGSWGTSGGHGAYGSQGGAGVQGNPGPQGTPWASGGNY
                     GTNSLGGSVGQGGNGGPLNYETNAQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFS
                     NSGGSSNDGSRGSQGSHGSNGQGSSGRGGGQGNSDNNGSSSSSSGSNSGNSNSGNSGN
                     SNSGNSGNSGSGSRDIETSNFDEGYSVSRGTGSRGGSGGSGGSGGGNKPECNNPGNDV
                     RMAGGSGSQESKESSHLLGGSHDYQGHGSNGGNIQKEAVNGLNTMNSDASTLPFNIDN
                     FWENLKSKTRFINWDAINKGHAPSPSTRALLYFRKLWENFKRSTPFFNWKQIEGSDLS
                     SLQKRAGGADQFSKPEARQDLSADSSKNYYNNQQVNPTYNWQYYTKTTAKAGVTPSSS
                     SASRAQPGLLKWLKFW"
     exon            547..723
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            724..780
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            781..831
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1038
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1083
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1146
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1197
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1245
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1305
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1353
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1401
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1458
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1503
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1551
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1599
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1668
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1695
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1743
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..2070
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2041..2046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /note="hexamer: AATAAA"
     polyA_site      2068
                     /gene="Dmkn"
                     /gene_synonym="1110014F24Rik; C130074A08; cI-36; SK30;
                     SK89"
                     /note="major polyA site"
ORIGIN      
        1 ctggaaagca gggaagtctg ggaacagaga gagaaggctg tgggtcctgg ggaaggagaa
       61 taaggaagca aggaaggaaa ggaaaaggtc tcagcccaga ggaagaaaga agggaacaaa
      121 tagactgggc tgcagacatc ctcagaggag agagggagct gggcagagat gaagctacag
      181 ggctctctgg cctgcctcct gctggcccta tgtctgggtg gtggggcagc taacccgctg
      241 cacagtggag gggagggcac aggggcaagt gctgcccatg gagcaggaga tgccattagc
      301 catggaattg gagaggctgt gggccaaggg gctaaagaag cagccagctc tggaatccag
      361 aatgccctag gccaggggca cggagaggaa ggtggctcca cattgatggg gagcagaggc
      421 gatgtttttg agcaccggct tggggaagca gcaagatctc tggggaacgc tgggaatgag
      481 attggcagac aggctgagga tatcattcgc caaggggtag atgctgtcca caacgctggg
      541 tcctggggga catctggagg tcatggcgca tatggctctc aaggtggtgc tggagtccag
      601 ggcaatcctg gtcctcaagg gacaccctgg gcctcaggag gcaactatgg gactaactct
      661 ctgggtggct ctgtgggtca gggtggcaat ggcggaccac tcaactatga aaccaatgcc
      721 cagggagctg tggctcagcc tggctacggg acagtgagag gcaacaacca gaactcaggg
      781 tgtaccaacc ccccaccttc tggctcccat gaaagcttca gtaactctgg gggaagcagc
      841 aatgatggca gtcgtggtag ccaaggcagt catggcagta atggtcaggg cagcagcggt
      901 agaggcggtg gccaaggcaa cagcgacaac aatggcagca gtagcagtag cagcggcagc
      961 aacagtggca acagcaacag tggcaacagc ggcaacagca acagtggcaa cagcggcaac
     1021 agcggttctg ggtcccggga catagaaaca tctaattttg atgaaggcta ttcggtctcc
     1081 aggggaaccg gcagcagggg tggaagtggt ggaagtggtg gaagtggtgg tggaaacaaa
     1141 cccgagtgta acaacccagg gaatgatgtg cgcatggccg gaggatctgg gagtcaggaa
     1201 agtaaagaaa gcagtcatct ccttggaggc tcccatgact accaggggca tgggtccaat
     1261 ggtggcaata tacaaaaaga agctgtcaat ggactcaaca ctatgaactc ggatgcatct
     1321 accttgccct tcaacattga caatttctgg gagaatctta agtccaagac gcgcttcatt
     1381 aactgggatg ccataaacaa gggtcatgcc ccatctccca gcactcgggc tttactctac
     1441 ttccgcaaac tgtgggagaa tttcaaacgc agcactcctt tcttcaactg gaaacagatt
     1501 gagggttcag atctgtcatc tctgcagaag agggcaggtg gagctgacca gttttctaag
     1561 cctgaagcaa gacaagatct ttcagctgac tcatccaaga actactacaa taaccagcag
     1621 gtgaatccta cttacaactg gcaatactat accaagacca ctgccaaggc gggagtcaca
     1681 ccttcatctt cctcggcttc ccgggcacaa cctggcctgc tgaagtggct gaagttttgg
     1741 tagaacattc cttctagtca ctgcggactc ctcacgaatg cacacaggtc ttcagggagt
     1801 ttgactgtcc ttacccagag tcctctctga tgcagctgac ctacctgggc atgacaagcc
     1861 tgtcatctcg cctggggacc tggtttatct gtcctcattc tccccattcg attgtggtgt
     1921 cttggcgact aatcagtttc attgtataac cagccagatc ttcacctctt cttccgtacg
     1981 tgaccgcaag tccctggaac gaggcatctg gagcttccta ctctccagtt tctctgtgga
     2041 aataaaacat gactctttgt ttccctgaga
//
