LOCUS       NM_007868              13852 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus dystrophin, muscular dystrophy (Dmd), transcript
            variant 1, mRNA.
ACCESSION   NM_007868
VERSION     NM_007868.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13852)
  AUTHORS   Hiramuki,Y., Hosokawa,M., Osawa,K., Shirakawa,T., Watanabe,Y.,
            Hanajima,R., Kugoh,H., Awano,H., Matsuo,M. and Kazuki,Y.
  TITLE     Titin fragment is a sensitive biomarker in Duchenne muscular
            dystrophy model mice carrying full-length human dystrophin gene on
            human artificial chromosome
  JOURNAL   Sci Rep 15 (1), 1778 (2025)
   PUBMED   39805937
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13852)
  AUTHORS   Yang,J., Cao,C., Liu,J., Liu,Y., Lu,J., Yu,H., Li,X., Wu,J., Yu,Z.,
            Li,H. and Chen,G.
  TITLE     Dystrophin 71 deficiency causes impaired aquaporin-4 polarization
            contributing to glymphatic dysfunction and brain edema in cerebral
            ischemia
  JOURNAL   Neurobiol Dis 199, 106586 (2024)
   PUBMED   38950712
  REMARK    GeneRIF: Dystrophin 71 deficiency causes impaired aquaporin-4
            polarization contributing to glymphatic dysfunction and brain edema
            in cerebral ischemia.
REFERENCE   3  (bases 1 to 13852)
  AUTHORS   Miranda,R., Ceschi,L., Le Verger,D., Nagapin,F., Edeline,J.M.,
            Chaussenot,R. and Vaillend,C.
  TITLE     Social and emotional alterations in mice lacking the short
            dystrophin-gene product, Dp71
  JOURNAL   Behav Brain Funct 20 (1), 21 (2024)
   PUBMED   39182120
  REMARK    GeneRIF: Social and emotional alterations in mice lacking the short
            dystrophin-gene product, Dp71.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13852)
  AUTHORS   Kitajima,Y., Yoshioka,K., Mikumo,Y., Ohki,S., Maehara,K., Ohkawa,Y.
            and Ono,Y.
  TITLE     Loss of Tob1 promotes muscle regeneration through muscle stem cell
            expansion
  JOURNAL   J Cell Sci 137 (15) (2024)
   PUBMED   39037211
REFERENCE   5  (bases 1 to 13852)
  AUTHORS   Trundle,J., Lu-Nguyen,N., Malerba,A. and Popplewell,L.
  TITLE     Targeted Antisense Oligonucleotide-Mediated Skipping of Murine
            Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice
  JOURNAL   Int J Mol Sci 25 (11), 6113 (2024)
   PUBMED   38892298
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13852)
  AUTHORS   Dickson,G., Azad,A., Morris,G.E., Simon,H., Noursadeghi,M. and
            Walsh,F.S.
  TITLE     Co-localization and molecular association of dystrophin with
            laminin at the surface of mouse and human myotubes
  JOURNAL   J Cell Sci 103 (Pt 4), 1223-1233 (1992)
   PUBMED   1283164
REFERENCE   7  (bases 1 to 13852)
  AUTHORS   Head,S.I., Williams,D.A. and Stephenson,D.G.
  TITLE     Abnormalities in structure and function of limb skeletal muscle
            fibres of dystrophic mdx mice
  JOURNAL   Proc Biol Sci 248 (1322), 163-169 (1992)
   PUBMED   1352891
REFERENCE   8  (bases 1 to 13852)
  AUTHORS   McArdle,A., Edwards,R.H. and Jackson,M.J.
  TITLE     Accumulation of calcium by normal and dystrophin-deficient mouse
            muscle during contractile activity in vitro
  JOURNAL   Clin Sci (Lond) 82 (4), 455-459 (1992)
   PUBMED   1315657
REFERENCE   9  (bases 1 to 13852)
  AUTHORS   Wells,D.J., Wells,K.E., Walsh,F.S., Davies,K.E., Goldspink,G.,
            Love,D.R., Chan-Thomas,P., Dunckley,M.G., Piper,T. and Dickson,G.
  TITLE     Human dystrophin expression corrects the myopathic phenotype in
            transgenic mdx mice
  JOURNAL   Hum Mol Genet 1 (1), 35-40 (1992)
   PUBMED   1301134
REFERENCE   10 (bases 1 to 13852)
  AUTHORS   Chen,M., Li,H.J., Fang,Q., Goodwin,T.G., Florendo,J.A. and Law,P.K.
  TITLE     Dystrophin cytochemistry in mdx mouse muscles injected with labeled
            normal myoblasts
  JOURNAL   Cell Transplant 1 (1), 17-22 (1992)
   PUBMED   1344288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731776.7, AL808024.4,
            CR382328.14, CR352330.14, AL833800.6, AL732449.5, AL672146.9,
            BX000479.11, BX294443.5, AL806516.4, AL844151.3, AL645857.11,
            AL645848.15 and AL645477.8.
            
            On Sep 26, 2015 this sequence version replaced NM_007868.5.
            
            Summary: This gene encodes a large, rod-like cytoskeletal protein
            which is found at the inner surface of muscle fibers in skeletal
            and cardiac muscles. The encoded protein, dystrophin, is part of
            the dystrophin-glycoprotein complex, which bridges the inner
            cytoskeleton (F-actin) and the extra-cellular matrix. This protein
            is required for proper development and organization of myofibers as
            contractile units in striated muscles. Mutations in the human gene
            cause Duchenne and Becker Muscular Dystrophies and a form of heart
            disease called DMD-associated dilated cardiomyopathy. Several
            alternatively spliced transcript variants of this gene have been
            described, but the full-length nature of some of these variants has
            not been determined. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1), which is the major
            muscle isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M68859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AL731776.7         4576-4853
            279-340             AL731776.7         192334-192395
            341-433             AL808024.4         166647-166739
            434-511             AL808024.4         171811-171888
            512-604             CR382328.14        10916-11008
            605-777             CR382328.14        17042-17214
            778-896             CR382328.14        125684-125802
            897-1081            CR352330.14        49738-49922
            1082-1213           CR352330.14        51043-51174
            1214-1402           AL833800.6         5798-5986
            1403-1584           AL833800.6         6798-6979
            1585-1735           AL833800.6         20029-20179
            1736-1855           AL833800.6         33518-33637
            1856-1957           AL833800.6         55853-55954
            1958-2065           AL833800.6         56050-56157
            2066-2245           AL833800.6         63618-63797
            2246-2421           AL833800.6         71071-71246
            2422-2545           AL833800.6         97127-97250
            2546-2633           AL833800.6         114285-114372
            2634-2875           AL833800.6         123279-123520
            2876-3056           AL833800.6         127885-128065
            3057-3202           AL833800.6         143997-144142
            3203-3415           AL833800.6         145056-145268
            3416-3529           AL833800.6         147876-147989
            3530-3685           AL833800.6         149086-149241
            3686-3856           AL833800.6         155225-155395
            3857-4039           AL833800.6         159882-160064
            4040-4174           AL833800.6         169705-169839
            4175-4324           AL833800.6         172170-172319
            4325-4486           AL833800.6         197456-197617
            4487-4597           AL732449.5         22255-22365
            4598-4771           AL732449.5         22684-22857
            4772-4927           AL732449.5         25487-25642
            4928-5098           AL732449.5         31271-31441
            5099-5278           AL732449.5         49156-49335
            5279-5407           AL732449.5         50197-50325
            5408-5578           AL732449.5         52589-52759
            5579-5701           AL732449.5         66675-66797
            5702-5839           AL732449.5         69060-69197
            5840-5992           AL732449.5         72053-72205
            5993-6175           AL732449.5         73011-73193
            6176-6370           AL732449.5         99171-99365
            6371-6543           AL732449.5         108877-109049
            6544-6691           AL672146.9         7694-7841
            6692-6867           BX000479.11        80908-81083
            6868-7009           BX000479.11        118755-118896
            7010-7159           BX000479.11        121433-121582
            7160-7324           BX294443.5         39255-39419
            7325-7426           BX294443.5         91580-91681
            7427-7535           BX294443.5         97756-97864
            7536-7768           AL806516.4         5265-5497
            7769-7886           AL806516.4         63005-63122
            7887-8098           AL806516.4         106691-106902
            8099-8253           AL806516.4         130227-130381
            8254-8443           AL806516.4         178168-178357
            8444-8616           AL844151.3         127179-127351
            8617-8773           AL645857.11        3003-3159
            8774-8894           AL645857.11        38382-38502
            8895-9163           AL645857.11        39111-39379
            9164-9310           AL645857.11        69732-69878
            9311-9389           AL645848.15        29325-29403
            9390-9450           AL645848.15        59885-59945
            9451-9512           AL645848.15        139151-139212
            9513-9587           AL645848.15        174997-175071
            9588-9789           AL645477.8         16635-16836
            9790-9875           AL645477.8         19071-19156
            9876-10033          AL645477.8         21434-21591
            10034-10200         AL645477.8         50819-50985
            10201-10312         AL645477.8         53217-53328
            10313-10449         AL645477.8         55520-55656
            10450-10488         AL645477.8         56402-56440
            10489-10554         AL645477.8         60621-60686
            10555-10620         AL645477.8         61704-61769
            10621-10779         AL645477.8         64518-64676
            10780-11023         AL645477.8         89195-89438
            11024-11147         AL645477.8         90190-90313
            11148-11240         AL645477.8         102101-102193
            11241-11272         AL645477.8         108995-109026
            11273-13852         AL645477.8         113962-116541
FEATURES             Location/Qualifiers
     source          1..13852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.38 cM"
     gene            1..13852
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /note="dystrophin, muscular dystrophy"
                     /db_xref="GeneID:13405"
                     /db_xref="MGI:MGI:94909"
     exon            1..278
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..11284
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /note="isoform 1 is encoded by transcript variant 1;
                     X-linked muscular dystrophy; dystrophin
                     Dp71d(delta71,73-74); dystrophin delta-E40e; dystrophin
                     E40e; dystrophin E51b; dystrophin Dp427-E40e; dystrophin
                     Dp71f-delta71,74"
                     /codon_start=1
                     /product="dystrophin isoform 1"
                     /protein_id="NP_031894.1"
                     /db_xref="CCDS:CCDS41047.1"
                     /db_xref="GeneID:13405"
                     /db_xref="MGI:MGI:94909"
                     /translation="MLWWEEVEDCYEREDVQKKTFTKWINAQFSKFGKQHIDNLFSDL
                     QDGKRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQKNNVDLVNIGSTDIVDG
                     NHKLTLGLIWNIILHWQVKNVMKTIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFT
                     SSWSDGLALNALIHSHRPDLFDWNSVVSQHSATQRLEHAFNIAKCQLGIEKLLDPEDV
                     ATTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRTSSKVTREEHFQLHHQMHYS
                     QQITVSLAQGYEQTSSSPKPRFKSYAFTQAAYVATSDSTQSPYPSQHLEAPRDKSLDS
                     SLMETEVNLDSYQTALEEVLSWLLSAEDTLRAQGEISNDVEEVKEQFHAHEGFMMDLT
                     SHQGLVGNVLQLGSQLVGKGKLSEDEEAEVQEQMNLLNSRWECLRVASMEKQSKLHKV
                     LMDLQNQKLKELDDWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQVR
                     VNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWIVLQDILLKWQHF
                     TEEQCLFSTWLSEKEDAMKNIQTSGFKDQNEMMSSLHKISTLKIDLEKKKPTMEKLSS
                     LNQDLLSALKNKSVTQKMEIWMENFAQRWDNLTQKLEKSSAQISQAVTTTQPSLTQTT
                     VMETVTMVTTREQIMVKHAQEELPPPPPQKKRQITVDSELRKRLDVDITELHSWITRS
                     EAVLQSSEFAVYRKEGNISDLQEKVNAIAREKAEKFRKLQDASRSAQALVEQMANEGV
                     NAESIRQASEQLNSRWTEFCQLLSERVNWLEYQTNIITFYNQLQQLEQMTTTAENLLK
                     TQSTTLSEPTAIKSQLKICKDEVNRLSALQPQIEQLKIQSLQLKEKGQGPMFLDADFV
                     AFTNHFNHIFDGVRAKEKELQTIFDTLPPMRYQETMSSIRTWIQQSESKLSVPYLSVT
                     EYEIMEERLGKLQALQSSLKEQQNGFNYLSDTVKEMAKKAPSEICQKYLSEFEEIEGH
                     WKKLSSQLVESCQKLEEHMNKLRKFQNHIKTLQKWMAEVDVFLKEEWPALGDAEILKK
                     QLKQCRLLVGDIQTIQPSLNSVNEGGQKIKSEAELEFASRLETELRELNTQWDHICRQ
                     VYTRKEALKAGLDKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQTAVEEMKR
                     AKEEALQKETKVKLLTETVNSVIAHAPPSAQEALKKELETLTTNYQWLCTRLNGKCKT
                     LEEVWACWHELLSYLEKANKWLNEVELKLKTMENVPAGPEEITEVLESLENLMHHSEE
                     NPNQIRLLAQTLTDGGVMDELINEELETFNSRWRELHEEAVRKQKLLEQSIQSAQEIE
                     KSLHLIQESLEFIDKQLAAYITDKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK
                     DANQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLEESKMILDEVKMHLPALETKS
                     VEQEVIQSQLSHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL
                     HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDTELTKRSAVEGMPSNLD
                     SEVAWGKATQKEIEKQKAHLKSVTELGESLKMVLGKKETLVEDKLSLLNSNWIAVTSR
                     VEEWLNLLLEYQKHMETFDQNIEQITKWIIHADELLDESEKKKPQQKEDILKRLKAEM
                     NDMRPKVDSTRDQAAKLMANRGDHCRKVVEPQISELNRRFAAISHRIKTGKASIPLKE
                     LEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMSEDNEGTVNELLQRGDNLQQRITD
                     ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDEIEK
                     KLASLPEPRDERKLKEIDRELQKKKEELNAVRRQAEGLSENGAAMAVEPTQIQLSKRW
                     RQIESNFAQFRRLNFAQIHTLHEETMVVTTEDMPLDVSYVPSTYLTEISHILQALSEV
                     DHLLNTPELCAKDFEDLFKQEESLKNIKDNLQQISGRIDIIHKKKTAALQSATSMEKV
                     KVQEAVAQMDFQGEKLHRMYKERQGRFDRSVEKWRHFHYDMKVFNQWLNEVEQFFKKT
                     QNPENWEHAKYKWYLKELQDGIGQRQAVVRTLNATGEEIIQQSSKTDVNILQEKLGSL
                     SLRWHDICKELAERRKRIEEQKNVLSEFQRDLNEFVLWLEEADNIAITPLGDEQQLKE
                     QLEQVKLLAEELPLRQGILKQLNETGGAVLVSAPIRPEEQDKLEKKLKQTNLQWIKVS
                     RALPEKQGELEVHLKDFRQLEEQLDHLLLWLSPIRNQLEIYNQPSQAGPFDIKEIEVT
                     VHGKQADVERLLSKGQHLYKEKPSTQPVKRKLEDLRSEWEAVNHLLRELRTKQPDRAP
                     GLSTTGASASQTVTLVTQSVVTKETVISKLEMPSSLLLEVPALADFNRAWTELTDWLS
                     LLDRVIKSQRVMVGDLEDINEMIIKQKATLQDLEQRRPQLEELITAAQNLKNKTSNQE
                     ARTIITDRIERIQIQWDEVQEQLQNRRQQLNEMLKDSTQWLEAKEEAEQVIGQVRGKL
                     DSWKEGPHTVDAIQKKITETKQLAKDLRQRQISVDVANDLALKLLRDYSADDTRKVHM
                     ITENINTSWGNIHKRVSEQEAALEETHRLLQQFPLDLEKFLSWITEAETTANVLQDAS
                     RKEKLLEDSRGVRELMKPWQDLQGEIETHTDIYHNLDENGQKILRSLEGSDEAPLLQR
                     RLDNMNFKWSELQKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIG
                     GDFPAVQKQNDIHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP
                     EERAQNVTRLLRKQAEEVNAEWDKLNLRSADWQRKIDEALERLQELQEAADELDLKLR
                     QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVNRVNDLAHQLTTLGIQL
                     SPYNLSTLEDLNTRWRLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP
                     NKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLS
                     LSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
                     NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDS
                     IQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLH
                     RVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMV
                     EYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINF
                     WPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQ
                     HYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH
                     EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
                     LHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSESMGEEDLLS
                     PPQDTSTGLEEVMEQLNNSFPSSRGRNAPGKPMREDTM"
     exon            279..340
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            341..433
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            434..511
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            512..604
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            605..777
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            778..896
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1081
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1213
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1402
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1584
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1735
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1855
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1957
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2065
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2245
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2421
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2545
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2633
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2875
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3056
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3202
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3415
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3529
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3685
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3856
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..4039
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4174
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4324
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4486
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..4597
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4771
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            4772..4927
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            4928..5098
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            5099..5278
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            5279..5407
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5578
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            5579..5701
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            5702..5839
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            5840..5992
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            5993..6175
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            6176..6370
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            6371..6543
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            6544..6691
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            6692..6867
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            6868..7009
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            7010..7159
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            7160..7324
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            7325..7426
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            7427..7535
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            7536..7768
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            7769..7886
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            7887..8098
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            8099..8253
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            8254..8443
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            8444..8616
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            8617..8773
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            8774..8894
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            8895..9163
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9164..9310
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9311..9389
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9390..9450
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9451..9512
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9513..9587
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9588..9789
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9790..9875
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            9876..10033
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10034..10200
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10201..10312
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10313..10449
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10450..10488
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10489..10554
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10555..10620
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10621..10779
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            10780..11023
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            11024..11147
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            11148..11240
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            11241..11272
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     exon            11273..13852
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11366..11371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /note="hexamer: AATAAA"
     polyA_site      11388
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
     regulatory      13821..13826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /note="hexamer: AATAAA"
     polyA_site      13852
                     /gene="Dmd"
                     /gene_synonym="Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke"
                     /note="major polyA site"
ORIGIN      
        1 atcagttact atgttgactc actcagtgtt gggctcactc acttgcccct tacaggactc
       61 agctcttgaa ggcaatagcc tttatagaaa aaacgaatag gaagacttga agtgctattt
      121 ttttttttgt caaggctgct gaagtttatt ggcttctcat cgtacctaag cctcctggag
      181 caataaaact gggagaaact tttaccaaga tttttatccc tgccttgata tatacttttt
      241 cttccaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag atgttcaaaa
      301 gaaaacattc acaaaatgga taaatgcaca attttctaag tttggaaagc aacacataga
      361 caacctcttc agtgacctgc aggatggaaa acgcctccta gacctcttgg aaggccttac
      421 agggcaaaaa ctgccaaaag aaaagggatc tacaagagtt catgccctga acaatgtcaa
      481 caaggcactg cgggtcttac agaaaaataa tgttgattta gtgaatatag gaagcactga
      541 catagtggat ggaaatcata aactcactct tggtttgatt tggaatataa tcctccactg
      601 gcaggtcaaa aatgtgatga aaactatcat ggctggattg cagcaaacca acagtgaaaa
      661 gattcttctg agctgggttc gacagtcaac acgtaattat ccacaggtta acgtcatcaa
      721 cttcacctct agctggtccg acgggttggc tttgaatgct cttatccata gtcacaggcc
      781 cgacctgttt gattggaata gtgtggtttc acagcactca gccacccaaa gactggaaca
      841 tgccttcaac attgcaaaat gccagttagg catagaaaaa cttcttgatc ctgaagatgt
      901 tgctaccact tatccagaca agaagtccat cttaatgtac atcacatcac tctttcaagt
      961 tttgccacaa caagtgagca ttgaagccat tcaagaagtg gaaatgttgc ccaggacatc
     1021 ttcaaaagta actagagaag aacattttca attacatcac cagatgcatt actctcaaca
     1081 gatcacagtc agtctagcac agggctatga acaaacttct tcatctccta agcctcgatt
     1141 caagagttat gccttcacac aggctgctta tgttgccacc tctgattcca cacagagccc
     1201 ctatccttca cagcatttgg aagctcccag agacaagtca cttgacagtt cattgatgga
     1261 gacggaagta aatctggata gttaccaaac tgctttagaa gaagtacttt catggcttct
     1321 ttctgccgag gatacattgc gagcacaagg agagatttca aatgatgttg aagaagtgaa
     1381 agaacagttt catgctcatg agggattcat gatggatctg acatctcatc aaggacttgt
     1441 tggtaatgtt ctacagttag gaagtcaact agttggaaaa gggaaattat cagaagatga
     1501 agaagctgaa gtgcaagaac aaatgaatct cctaaattca agatgggaat gtctcagggt
     1561 agctagcatg gaaaaacaaa gcaaattaca caaagttcta atggatctcc agaatcagaa
     1621 attaaaagaa ctagatgact ggttaacaaa aactgaagag agaactaaga aaatggagga
     1681 agagcccttt ggacctgatc ttgaagatct aaaatgccaa gtacaacaac ataaggtgct
     1741 tcaagaagat ctagaacagg agcaggtcag ggtcaactcg ctcactcaca tggtagtagt
     1801 ggttgatgaa tccagcggtg atcatgcaac agctgctttg gaagaacaac ttaaggtact
     1861 gggagatcga tgggcaaata tctgcagatg gactgaagac cgctggattg ttttacaaga
     1921 tattcttcta aaatggcagc attttactga agaacagtgc ctttttagta catggctttc
     1981 agaaaaagaa gatgcaatga agaacattca gacaagtggc tttaaagatc aaaatgaaat
     2041 gatgtcaagt cttcacaaaa tatctacttt aaaaatagat ctagaaaaga aaaagccaac
     2101 catggaaaaa ctaagttcac tcaatcaaga tctactttcg gcactgaaaa ataagtcagt
     2161 gactcaaaag atggaaatct ggatggaaaa ctttgcacaa cgttgggaca atttaaccca
     2221 aaaacttgaa aagagttcag cacaaatttc acaggctgtc accaccactc aaccatccct
     2281 aacacagaca actgtaatgg aaacggtaac tatggtgacc acaagggaac aaatcatggt
     2341 aaaacatgcc caagaggaac ttccaccacc acctcctcaa aagaagaggc agataactgt
     2401 ggattctgaa ctcaggaaaa ggttggatgt cgatataact gaacttcaca gttggattac
     2461 tcgttcagaa gctgtattac agagttctga atttgcagtc tatcgaaaag aaggcaacat
     2521 ctcagacttg caagaaaaag tcaatgccat agcacgagaa aaagcagaga agttcagaaa
     2581 actgcaagat gccagcagat cagctcaggc cctggtggaa cagatggcaa atgagggtgt
     2641 taatgctgaa agtatcagac aagcttcaga acaactgaac agccggtgga cagaattctg
     2701 ccaattgctg agtgagagag ttaactggct agagtatcaa accaacatca ttacctttta
     2761 taatcagcta caacaattgg aacagatgac aactactgcc gaaaacttgt tgaaaaccca
     2821 gtctaccacc ctatcagagc caacagcaat taaaagccag ttaaaaattt gtaaggatga
     2881 agtcaacaga ttgtcagctc ttcagcctca aattgagcaa ttaaaaattc agagtctaca
     2941 actgaaagaa aagggacagg ggccaatgtt tctggatgca gactttgtgg cctttactaa
     3001 tcattttaac cacatctttg atggtgtgag ggccaaagag aaagagctac agacaatttt
     3061 tgacacttta ccaccaatgc gctatcagga gacaatgagt agcatcagga cgtggatcca
     3121 gcagtcagaa agcaaactct ctgtacctta tcttagtgtt actgaatatg aaataatgga
     3181 ggagagactc gggaaattac aggctctgca aagttctttg aaagagcaac aaaatggctt
     3241 caactatctg agtgacactg tgaaggagat ggccaagaaa gcaccttcag aaatatgcca
     3301 gaaatatctg tcagaatttg aagagattga ggggcactgg aagaaacttt cctcccagtt
     3361 ggtggaaagc tgccaaaagc tagaagaaca tatgaataaa cttcgaaaat ttcagaatca
     3421 cataaaaacc ttacagaaat ggatggctga agttgatgtt ttcctgaaag aggaatggcc
     3481 tgccctgggg gatgctgaaa tcctgaaaaa acagctcaaa caatgcagac ttttagttgg
     3541 tgatattcaa acaattcagc ccagtttaaa tagtgttaat gaaggtgggc agaagataaa
     3601 gagtgaagct gaacttgagt ttgcatccag actggagaca gaacttagag agcttaacac
     3661 tcagtgggat cacatatgcc gccaggtcta caccagaaag gaagccttaa aggcaggttt
     3721 ggataaaacc gtaagcctcc aaaaagatct atcagagatg catgagtgga tgacacaagc
     3781 tgaagaagaa tatctagaga gagattttga atataaaact ccagatgaat tacagactgc
     3841 tgttgaagaa atgaagagag ctaaagaaga ggcactacaa aaagaaacta aagtgaaact
     3901 ccttactgag actgtaaata gtgtaatagc tcacgctcca ccctcagcac aagaggcctt
     3961 aaaaaaggaa cttgaaactc tgaccaccaa ctaccaatgg ctgtgcacca ggctgaatgg
     4021 aaaatgcaaa actttggaag aagtttgggc atgttggcat gagttattgt catatttaga
     4081 gaaagcaaac aagtggctca atgaagtaga attgaaactt aaaaccatgg aaaatgttcc
     4141 tgcaggacct gaggaaatca ctgaagtgct agaatctctt gaaaatctga tgcatcattc
     4201 agaggagaac ccaaatcaga ttcgtctatt ggcacagact cttacagatg gaggagtcat
     4261 ggatgaactg atcaatgagg agcttgagac gtttaattct cgttggaggg aactacatga
     4321 agaggctgtg aggaaacaaa agttgcttga acagagtatc cagtctgccc aggaaattga
     4381 aaagtccttg cacttaattc aggagtcgct tgaattcatt gacaagcagt tggcagctta
     4441 tatcactgac aaggtggatg cagctcaaat gcctcaggaa gcccagaaaa tccaatcaga
     4501 tttgacaagt catgagataa gtttagaaga aatgaagaaa cataaccagg ggaaggatgc
     4561 caaccaaagg gttctttcac aaattgatgt tgcacagaaa aaattacaag atgtctccat
     4621 gaaatttcga ttattccaaa aaccagccaa ttttgaacaa cgtctagagg aaagtaagat
     4681 gattttagat gaagtcaaga tgcatttgcc tgcattggaa accaagagtg ttgaacagga
     4741 agtaattcag tcacaactaa gtcattgtgt gaacttgtat aaaagcctga gtgaagtcaa
     4801 gtctgaagtg gaaatggtga ttaaaaccgg acgtcaaatt gtacagaaaa agcagacaga
     4861 aaatcccaaa gagcttgatg aacgagtaac agctttgaaa ttgcattaca atgagttggg
     4921 tgcgaaggta acagagagaa agcaacagtt ggagaaatgc ttgaagttgt cccgtaagat
     4981 gagaaaggaa atgaatgtct taacagaatg gctggcagca acagatacag aattgacgaa
     5041 gagatcagca gttgaaggaa tgccaagtaa tttggattct gaagttgcct ggggaaaggc
     5101 tactcaaaaa gagattgaga aacagaaggc tcacttgaag agtgttacag aattaggaga
     5161 gtctttgaaa atggtgttgg gcaagaaaga aaccttggta gaagataaac tgagtcttct
     5221 gaacagtaac tggatagctg tcacctccag agtagaagaa tggctaaatc ttttgttgga
     5281 ataccagaaa cacatggaaa cctttgatca gaacatagaa caaatcacaa agtggatcat
     5341 tcatgcagat gaacttttag atgagtctga aaagaagaaa ccacaacaaa aggaagacat
     5401 tcttaagcgt ttaaaggctg aaatgaatga catgcgccca aaggtggact ccacacgtga
     5461 ccaagcagca aaattgatgg caaaccgcgg tgaccactgc aggaaagtag tagagcccca
     5521 aatctctgag ctcaaccgtc gatttgcagc tatttctcac agaattaaga ctggaaaggc
     5581 ctccattcct ttgaaggaat tggagcagtt taactcagat atacaaaaat tgcttgaacc
     5641 actggaggct gaaattcagc agggggtgaa tctgaaagag gaagacttca ataaagatat
     5701 gagtgaagac aatgagggta ctgtaaatga attgttgcaa agaggagaca acttacaaca
     5761 aagaatcaca gatgagagaa agcgagagga aataaagata aaacagcagc tgttacagac
     5821 aaaacataat gctctcaagg atttgaggtc tcaaagaaga aaaaaggccc tagaaatttc
     5881 tcaccagtgg tatcagtaca agaggcaggc tgatgatctc ctgaaatgct tggatgaaat
     5941 tgaaaaaaaa ttagccagcc tacctgaacc cagagatgaa agaaaattaa aggaaattga
     6001 tcgtgaattg cagaagaaga aagaggagct gaatgcagtg cgcaggcaag ctgagggctt
     6061 gtctgagaat ggggccgcaa tggcagtgga gccaactcag atccagctca gcaagcgctg
     6121 gcggcaaatt gagagcaatt ttgctcagtt tcgaagactc aactttgcac aaattcacac
     6181 tctccatgaa gaaactatgg tagtgacgac tgaagatatg cctttggatg tttcttatgt
     6241 gccttctact tatttgaccg agatcagtca tatcttacaa gctctttcag aagttgatca
     6301 tcttctaaat actcctgaac tctgtgctaa agattttgaa gatcttttta agcaagagga
     6361 gtctcttaag aatataaaag acaatttgca acaaatctca ggtcggattg atattattca
     6421 caagaagaag acagcagcct tgcaaagtgc cacctccatg gaaaaggtga aagtacagga
     6481 agccgtggca cagatggatt tccaggggga aaaacttcat agaatgtaca aggaacgaca
     6541 agggcgattc gacagatcag ttgaaaaatg gcgacacttt cattatgata tgaaggtatt
     6601 taatcaatgg ctgaatgaag ttgaacagtt tttcaaaaag acacaaaatc ctgaaaactg
     6661 ggaacatgct aaatacaaat ggtatcttaa ggaactccag gatggcattg ggcagcgtca
     6721 agctgttgtc agaacactga atgcaactgg ggaagaaata attcaacagt cttcaaaaac
     6781 agatgtcaat attctacaag aaaaattagg aagcttgagt ctgcggtggc acgacatctg
     6841 caaagagctg gcagaaagga gaaagaggat tgaagaacaa aagaatgtct tgtcagaatt
     6901 tcaaagagat ttaaatgaat ttgttttgtg gctggaagaa gcagataaca ttgctattac
     6961 tccacttgga gatgagcagc agctaaaaga acaacttgaa caagtcaagt tactggcaga
     7021 agagttgccc ctgcgccagg gaattctaaa acaattaaat gaaacaggag gagcagtact
     7081 tgtaagtgct cccataaggc cagaagagca agataaactt gaaaagaagc tcaaacagac
     7141 aaatctccag tggataaagg tctccagagc tttacctgag aaacaaggag agcttgaggt
     7201 tcacttaaaa gattttaggc agcttgaaga gcagctggat cacctgcttc tgtggctctc
     7261 tcctattaga aaccagttgg aaatttataa ccaaccaagt caggcaggac cgtttgacat
     7321 aaaggagatt gaagtaacag ttcacggtaa acaagcggat gtggaaaggc ttttgtcgaa
     7381 agggcagcat ttgtataagg aaaaaccaag cactcagcca gtgaagagga agttagaaga
     7441 tctgaggtct gagtgggagg ctgtaaacca tttacttcgg gagctgagga caaagcagcc
     7501 tgaccgtgcc cctggactga gcactactgg agcctctgcc agtcagactg ttactctagt
     7561 gacacaatct gtggttacta aggaaactgt catctccaaa ctagaaatgc catcttcttt
     7621 gctgttggag gtacctgcac tggcagactt caaccgagct tggacagaac ttacagactg
     7681 gctgtctctg cttgatcgag ttataaaatc acagagagtg atggtgggtg atctggaaga
     7741 catcaatgaa atgatcatca aacagaaggc aacactgcaa gatttggaac agagacgccc
     7801 ccaattggaa gaactcatta ctgctgccca gaatttgaaa aacaaaacca gcaatcaaga
     7861 agctagaaca atcattactg atcgaattga aagaattcag attcagtggg atgaggttca
     7921 agaacagctg cagaacagga gacaacagtt gaatgaaatg ttaaaggatt caacacaatg
     7981 gctggaagct aaggaagaag ccgaacaggt cataggacag gtcagaggca agcttgactc
     8041 atggaaagaa ggtcctcaca cagtagatgc aatccaaaag aagatcacag aaaccaagca
     8101 gttggccaaa gacctccgtc aacggcagat aagtgtagac gtggcaaatg atttggcact
     8161 gaaacttctt cgggactatt ctgctgatga taccagaaaa gtacacatga taacagagaa
     8221 tatcaatact tcttggggaa acattcataa aagagtaagt gagcaagagg ctgctttgga
     8281 agaaactcat agattactgc agcagttccc tctggacctg gagaagtttc tttcctggat
     8341 tacggaagca gaaacaactg ccaatgtcct acaggacgct tcccgtaagg agaagctcct
     8401 agaagactcc aggggagtca gagagctgat gaaaccatgg caagatctcc aaggagaaat
     8461 tgaaactcac acagatatct atcacaatct tgatgaaaat ggccaaaaaa tcctgagatc
     8521 cctggaaggt tcggatgaag cacccctgtt acaaagacgt ttggataaca tgaatttcaa
     8581 gtggagtgaa cttcagaaaa agtctctcaa cattaggtcc catttggaag caagttctga
     8641 ccagtggaag cgtttgcatc tttctcttca ggaacttctt gtttggctac agctgaaaga
     8701 tgatgaactg agccgtcagg cacccatcgg tggtgatttc ccagcagttc agaagcagaa
     8761 tgatatacat agggccttca agagggaatt gaaaactaaa gaacctgtaa tcatgagtac
     8821 tctggagact gtgagaatat ttctgacaga gcagcctttg gaaggactag agaaactcta
     8881 ccaggagccc agagaactgc ctcctgaaga aagagctcag aatgtcactc ggctcctacg
     8941 aaagcaggct gaagaggtca acgctgaatg ggacaaattg aacctgcgct cagctgattg
     9001 gcagagaaaa atagatgaag ctcttgaaag actccaggaa cttcaggaag ctgccgatga
     9061 actggacctc aagttgcgcc aagctgaggt gatcaaggga tcctggcagc cagtggggga
     9121 tctcctcatt gactctctgc aagatcacct tgaaaaagtc aaggcacttc ggggagaaat
     9181 tgcacctctt aaagagaatg tcaatcgtgt caatgacctt gcacatcagc tgaccacact
     9241 gggcattcag ctctcacctt ataacctcag cactttggaa gatctgaata ccagatggag
     9301 gcttctacag gtggctgtgg aggaccgtgt cagacagctg catgaagccc acagggactt
     9361 tggtcctgca tcccagcact tcctttccac ttcagttcag ggtccctggg agagagccat
     9421 ctcaccaaac aaagtgccct actatatcaa ccacgagacc caaaccactt gttgggacca
     9481 ccccaaaatg acagagctct accagtcttt agctgacctg aataatgtca ggttctccgc
     9541 gtataggact gccatgaagc tcagaaggct ccagaaggcc ctttgcttgg atctcttgag
     9601 cctgtcagct gcatgtgatg ccctggacca gcacaacctc aagcaaaatg accagcccat
     9661 ggatatcctg cagataatta actgtttgac tacaatttat gatcgtctgg agcaagagca
     9721 caacaatctg gtcaatgtcc ctctctgtgt ggatatgtgt ctcaactggc ttctcaatgt
     9781 ttatgatacg ggacgaacag ggaggatccg tgtcctgtct tttaaaactg gcatcatttc
     9841 tctgtgtaaa gcacacttgg aagacaagta cagatacctt ttcaagcaag tggcaagttc
     9901 aactggcttt tgtgaccagc gtaggctggg tcttcttctg catgattcta ttcaaatccc
     9961 aagacagttg ggtgaagttg cttcctttgg gggcagtaac attgagccga gtgtcaggag
    10021 ctgcttccaa tttgccaata ataaacctga gattgaagct gctctcttcc ttgactggat
    10081 gcgcctggaa ccccagtcta tggtgtggct gcccgtcttg cacagagtgg ctgctgctga
    10141 aactgccaag catcaagcca agtgtaacat ctgtaaggag tgtccaatca ttggattcag
    10201 gtacagaagc ctaaagcatt ttaattatga catctgccaa agttgctttt tttctggccg
    10261 agttgcaaag ggccataaaa tgcactaccc catggtagag tattgcactc cgactacatc
    10321 cggagaagat gttcgcgact tcgccaaggt actaaaaaac aaatttcgaa ccaaaaggta
    10381 ttttgcgaag catccccgaa tgggctacct gccagtgcag actgtgttag agggggacaa
    10441 catggaaact cccgttactc tgatcaactt ctggccagta gattctgcgc ctgcctcgtc
    10501 cccccagctt tcacacgatg atactcattc acgcattgaa cattatgcta gcaggctagc
    10561 agaaatggaa aacagcaatg gatcttatct aaatgatagc atctctccta atgagagcat
    10621 agatgatgaa catttgttaa tccagcatta ctgccaaagt ttgaaccagg actcccccct
    10681 gagccagcct cgtagtcctg cccagatctt gatttcctta gagagtgagg aaagagggga
    10741 gctagagaga atcctagcag atcttgagga agaaaacagg aatctgcaag cagaatatga
    10801 tcgcctgaag cagcagcatg agcataaagg cctgtctcca ctgccatctc ctcctgagat
    10861 gatgcccacc tctcctcaga gtcccaggga tgctgagctc attgctgagg ctaagctact
    10921 gcgccaacac aaaggacgcc tggaagccag gatgcaaatc ctggaagacc acaataaaca
    10981 gctggagtct cagttacata gactgagaca gctcctggag cagccccagg ctgaagctaa
    11041 ggtgaatggc accacggtgt cctctccttc cacctctctg cagaggtcag atagcagtca
    11101 gcctatgctg ctccgagtgg ttggcagtca aacttcagaa tctatgggtg aggaagatct
    11161 tctgagtcct ccccaggaca caagcacagg gttagaagaa gtgatggagc aactcaacaa
    11221 ctccttccct agttcaagag gaagaaatgc ccccggaaag ccaatgagag aggacacaat
    11281 gtaggaagcc ttttccacat ggcagatgat ttgggcagag cgatggagtc cttagtttca
    11341 gtcatgacag atgaagaagg agcagaataa atgttttaca actcctgatt cccgcatggt
    11401 ttttataata ttcgtacaac aaagaggatt agacagtaag agtttacaag aaataaaatc
    11461 tatatttttg tgaagggtag tggtactata ctgtagattt cagtagtttc taagtctgtt
    11521 attgttttgt taacaatggc aggttttaca cgtctatgca attgtacaaa aaagttaaaa
    11581 gaaaacatgt aaaatcttga tagctaaata acttgccatt tctttatatg gaacgcattt
    11641 tgggttgttt aaaaatttat aacagttata aagaaagatt gtaaactaaa gtgtgcttta
    11701 taaaaaaagt tgtttataaa aacccctaaa caaacacaca cgcacacaca cacacacaca
    11761 cacacacaca cacacacgca cacatacatg cacgaaccca ccacacacac acacacacac
    11821 acacacactg aggcagcaca ttgttttgca ttactttagc gtggtattca tatggaattc
    11881 atgacgtttt tttattttct tgcatacgaa ccccaccaaa tgactgcttc atattgctct
    11941 tttgagaatt gttgactgag tggggctggc tatgggcttt cattttatac atctatatgt
    12001 ctacaagtat ataaatacta taggtatata gataaataga tatgaagtta cttcttcaaa
    12061 tgttcttgcc acttcctaat ggaaattgct tctagtcatc tgggcttatc tgcttgggca
    12121 agagtgaatt ttccctggag cccaaagcca ggagactacc gccacactaa aatattgtct
    12181 agggctccag atgtttctag ttttaaactt tccactgaga gctagaggat tcattttttt
    12241 caaggaacat gcgaatgaat acacaggact tactatcata gtaatttgtt ggctgatata
    12301 ttcaacttcc tactgttggg ttatatttaa tgatgtttct gcaatagaac atcagatgac
    12361 atttttaact cccagacagt aggaggaaga tggtaggagc taaaggttgc ggctcctcag
    12421 tcaatttata tgaggggagc aacaactctg taaaagaatg gatgaatatt tacaactata
    12481 catataaaca tctctataat tacaactaaa ttgttctgcc ctcttcataa actcaacctg
    12541 aagtgggtgg ttttgttgtt gttgttgttg ttgttgttga tgatgatgat gaattttaga
    12601 ttttagattt tttgggtttt tttttcttca ttgtgatgat tttttttttt aatgctgcaa
    12661 gacttaggat tactgttaag aaagtaaccc aatcacattg tgaccctggt gaatatcagt
    12721 ccagaagccc atgaactgca tttgtctcct ttgcattggt ttccctgcaa gtaactccac
    12781 acaggattgt gggtgagaag gcacagtggt tggaaagttt tgagagcaaa agcgtctcca
    12841 aactctctgg tctagttgac gggctgaaat gtctaaacaa atgcaagtca ttgaaccagg
    12901 agaaaaagtg caacagaaag ctaaggactg ctaggaagag ctttactcct ctcatgccag
    12961 tttcttcttc ttagcattta aagagcattc tctcaataga aatcactgtc ctatcatttt
    13021 gcaaatctgt tacctctaac gtcaagtgta attaacttct agcgagtggg ttttgtccat
    13081 tattaattgt aattaacatc aaacacagct tctcatgcta tttctacctc actttggttt
    13141 tggggtgttt ctagtaattg tgcacaccta atttcacaac ttcaccactt gtctgttgtg
    13201 tggacaccag tttccttttt tcatttataa tttccaaaag aaaacccaaa gctctaagat
    13261 aacaaattga aatttggttc tggtcttgct ttctctctct ctctctcctt tatgtggcac
    13321 tgggcatttt ctttatccaa ggatttgttt tcaccaagat ttaaaacaag gggttccttt
    13381 cctactaaga agttttaagt ttcattctaa aatccaaggt agatagagtg catagttttg
    13441 ttttaatctt ttcgttttat cttttagata ttagttctgg agtgaatcta tcaaaatatt
    13501 tgaataaaaa ctgagagctt tattgctgat tttaagcata atttggacat catttcatgt
    13561 tctttataac catcaagtat taaagtgtaa atcataatca gtgtaactga agcataatca
    13621 tcacatggca tgtatcatca ttgtctccag gtactggact cttacttgag tatcataata
    13681 gattgtgttt taacaccaac actgtaacat ttactaatta tttttttaaa cttcagtttt
    13741 actgcatttt cacaacatat cagatttcac caaatatatg ccttactatt gtattatatt
    13801 actgctttac tgtgtatctc aataaagcac gcagttatgt tacaaaaaaa ta
//
