LOCUS       NM_010059               2227 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus DNA meiotic recombinase 1 (Dmc1), transcript variant
            1, mRNA.
ACCESSION   NM_010059
VERSION     NM_010059.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2227)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2227)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2227)
  AUTHORS   Ito,M., Furukohri,A., Matsuzaki,K., Fujita,Y., Toyoda,A. and
            Shinohara,A.
  TITLE     FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic
            DNA replication and meiotic recombination
  JOURNAL   Nat Commun 14 (1), 6857 (2023)
   PUBMED   37891173
  REMARK    GeneRIF: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in
            pre-meiotic DNA replication and meiotic recombination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2227)
  AUTHORS   Yoshida,K., Kondoh,G., Matsuda,Y., Habu,T., Nishimune,Y. and
            Morita,T.
  TITLE     The mouse RecA-like gene Dmc1 is required for homologous chromosome
            synapsis during meiosis
  JOURNAL   Mol Cell 1 (5), 707-718 (1998)
   PUBMED   9660954
REFERENCE   5  (bases 1 to 2227)
  AUTHORS   Pittman,D.L., Cobb,J., Schimenti,K.J., Wilson,L.A., Cooper,D.M.,
            Brignull,E., Handel,M.A. and Schimenti,J.C.
  TITLE     Meiotic prophase arrest with failure of chromosome synapsis in mice
            deficient for Dmc1, a germline-specific RecA homolog
  JOURNAL   Mol Cell 1 (5), 697-705 (1998)
   PUBMED   9660953
REFERENCE   6  (bases 1 to 2227)
  AUTHORS   Koike,M., Matsuda,Y., Mimori,T., Harada,Y.N., Shiomi,N. and
            Shiomi,T.
  TITLE     Chromosomal localization of the mouse and rat DNA double-strand
            break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA
            expression in various mouse tissues
  JOURNAL   Genomics 38 (1), 38-44 (1996)
   PUBMED   8954777
REFERENCE   7  (bases 1 to 2227)
  AUTHORS   Matsuda,Y., Habu,T., Hori,T. and Morita,T.
  TITLE     Chromosome mapping of the mouse homologue of DMC1, the yeast
            meiosis-specific homologous recombination gene
  JOURNAL   Chromosome Res 4 (3), 249-250 (1996)
   PUBMED   8793211
REFERENCE   8  (bases 1 to 2227)
  AUTHORS   Habu,T., Taki,T., West,A., Nishimune,Y. and Morita,T.
  TITLE     The mouse and human homologs of DMC1, the yeast meiosis-specific
            homologous recombination gene, have a common unique form of
            exon-skipped transcript in meiosis
  JOURNAL   Nucleic Acids Res 24 (3), 470-477 (1996)
   PUBMED   8602360
REFERENCE   9  (bases 1 to 2227)
  AUTHORS   Sato,S., Seki,N., Hotta,Y. and Tabata,S.
  TITLE     Expression profiles of a human gene identified as a structural
            homologue of meiosis-specific recA-like genes
  JOURNAL   DNA Res 2 (4), 183-186 (1995)
   PUBMED   8590282
REFERENCE   10 (bases 1 to 2227)
  AUTHORS   Sato,S., Kobayashi,T., Hotta,Y. and Tabata,S.
  TITLE     Characterization of a mouse recA-like gene specifically expressed
            in testis
  JOURNAL   DNA Res 2 (3), 147-150 (1995)
   PUBMED   8581742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK169570.1, BC116767.1 and
            AV451479.1.
            
            On May 21, 2013 this sequence version replaced NM_010059.2.
            
            Summary: This gene encodes a member of the superfamily of
            recombinases (also called DNA strand-exchange proteins).
            Recombinases are important for repairing double-strand DNA breaks
            during mitosis and meiosis. This protein, which is evolutionarily
            conserved, is reported to be essential for meiotic homologous
            recombination and may thus play an important role in generating
            diversity of genetic information. In mouse, deficiency of this gene
            causes infertility. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D64107.1, BC116767.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AK169570.1         1-115
            116-1516            BC116767.1         1-1401
            1517-2147           AK169570.1         1142-1772
            2148-2227           AV451479.1         219-298
FEATURES             Location/Qualifiers
     source          1..2227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.79 cM"
     gene            1..2227
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /note="DNA meiotic recombinase 1"
                     /db_xref="GeneID:13404"
                     /db_xref="MGI:MGI:105393"
     exon            1..148
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            149..232
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            233..277
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            278..424
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            425..507
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            508..560
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            561..602
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            603..675
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            676..767
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            768..841
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            842..956
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1017
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1134
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..2220
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /note="hexamer: ATTAAA"
     polyA_site      1335
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /note="major polyA site"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /note="hexamer: AGTAAA"
     polyA_site      2220
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /note="major polyA site"
ORIGIN      
        1 atttggcgcc aagcccggag ctgttcgacg acagggcggg ctgccggcct ccgcgttctg
       61 ggtcggcgtt agaattctgg accggacggg aaagccggag cgggtgtcgc cttgaaaatt
      121 ctcggggagg ctgtgggttc gagtcgggaa ttgattattt tactgccgct ctcctttcaa
      181 catgaaggag gatcaagttg tgcaggaaga atcgggattc caagatgatg aggaatctct
      241 gtttcaagac attgacctgt tgcagaagca tgggattaac atggctgata ttaagaaact
      301 gaagtctgta ggaatctgta ccattaaagg gatacaaatg acaacaagaa gagccctctg
      361 caatgtcaaa ggcctctcag aagccaaagt ggaaaagatt aaagaggcag ccaacaagct
      421 tattgaacca ggattcctaa ctgcatttca gtacagtgaa aggaggaaga tggtattcca
      481 tatcactact gggagccagg aatttgataa attactagga ggtggcattg aaagtatggc
      541 aattacagaa gcttttggag aatttcgtac tggaaaaact cagctgtctc ataccctctg
      601 tgtgacagct caacttccag gaacaggcgg ctactcaggt ggaaagatta tcttcatcga
      661 tacagaaaat actttccgtc cagatcgcct tcgggacatt gctgaccgct tcaacgtaga
      721 ccatgaagca gtactggaca acgtgctcta tgcacgtgcc tatactagtg agcatcagat
      781 ggagctactt gattatgtcg cagccaagtt tcatgaggaa gctggcattt tcaaactatt
      841 gatcattgac tcaataatgg cactttttcg agtggatttc agtggccgtg gggaattggc
      901 tgaacgccag caaaaattgg cccagatgtt gtcacgactc caaaaaatct cagaagaata
      961 taatgttgct gtttttgtga ccaatcaaat gactgcagat ccaggagcaa ctatgacctt
     1021 tcaggctgat cccaaaaaac ccattggtgg acacattctg gctcacgctt ccacaacaag
     1081 aataagcttg cgcaagggaa gaggagaact gaggatcgcc aagatttatg acagccccga
     1141 gatgcctgaa aatgaagcca ccttcgcaat aaccgctgga gggatcgggg atgccaagga
     1201 gtaggtgggg aattggtaca gactgcttct tgctgcttat taggggctgg agaagtggga
     1261 agcagccttg aatttacatc ttgaaataag agtttgtttt tttccccaag tgttattaaa
     1321 agaaagtcag caaaagcgat gtgaagctta tatttatctt aaaagttcct tcctgatatg
     1381 caaccaacta tatatatata ctgcatgttg attcagaaat atgcatacat attcttgaat
     1441 tacttgatag acacatatgc ataaatgtgc ctgtcaggta ttggggaagg ggtacccagt
     1501 gcccttcctt ctgcctacta aagtaagcca ttgagcacac agaaattcaa aggagctcag
     1561 atatgtatca tcttccccac aaccccccaa ccccagactt ctcatccagc atttcttggg
     1621 gcatagcacc aatgactatg gtgctgggac tgagaactgg gtgctgttcc ccaagagagc
     1681 tcatgtgagg tgaaagcttg gagtatacat gagctgtttg taatcaccct ggtggccttc
     1741 acatgcatct ttacaataag aggagagaaa cattaagcca acttttcaat catctgatat
     1801 gtcaagttga aatgactttt aaaaaatgtg ttatgataat tgggcatggt ggtgcacact
     1861 tgtaatctca atatttggga ggcctaggta gctttagcta ccatgcccaa ttatcaaaac
     1921 tggcctgggc gatatgacac tatccaaaaa tggtatgttt ttatgttttg agtggagaat
     1981 tcaaagttgt tgttttttta attttagagc taatataaat gtaaaatcta tagctgagac
     2041 atcaaagaat ttgtgaaaga acattgtttt tgagtgtgtg tgattgtcaa aaataaaatc
     2101 tagttttcaa aatataagac tatttaaaaa ttaaaatact aatatataat tgctacaggt
     2161 gatcttttat attgtgttaa ctaaaatgaa aatccaaaaa gtaaagtatt tactactaaa
     2221 aaaaaaa
//
