LOCUS       NM_001025567            4039 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus diencephalon/mesencephalon homeobox 1 (Dmbx1),
            transcript variant 2, mRNA.
ACCESSION   NM_001025567
VERSION     NM_001025567.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4039)
  AUTHORS   Amadei,G., Handford,C.E., Qiu,C., De Jonghe,J., Greenfeld,H.,
            Tran,M., Martin,B.K., Chen,D.Y., Aguilera-Castrejon,A., Hanna,J.H.,
            Elowitz,M.B., Hollfelder,F., Shendure,J., Glover,D.M. and
            Zernicka-Goetz,M.
  TITLE     Embryo model completes gastrulation to neurulation and
            organogenesis
  JOURNAL   Nature 610 (7930), 143-153 (2022)
   PUBMED   36007540
REFERENCE   2  (bases 1 to 4039)
  AUTHORS   Ninou,I., Sevastou,I., Magkrioti,C., Kaffe,E., Stamatakis,G.,
            Thivaios,S., Panayotou,G., Aoki,J., Kollias,G. and Aidinis,V.
  TITLE     Genetic deletion of Autotaxin from CD11b+ cells decreases the
            severity of experimental autoimmune encephalomyelitis
  JOURNAL   PLoS One 15 (4), e0226050 (2020)
   PUBMED   32240164
  REMARK    GeneRIF: ATX genetic deletion from CD11b+ cells attenuated the
            severity of experimental autoimmune encephalomyelitis (EAE), thus
            proposing a pathogenic role for the ATX/LPA axis in
            neuroinflammatory disorders.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4039)
  AUTHORS   Switon,K., Kotulska,K., Janusz-Kaminska,A., Zmorzynska,J. and
            Jaworski,J.
  TITLE     Molecular neurobiology of mTOR
  JOURNAL   Neuroscience 341, 112-153 (2017)
   PUBMED   27889578
  REMARK    Review article
REFERENCE   4  (bases 1 to 4039)
  AUTHORS   Kato,K., Ikeda,H., Miyakawa,S., Futakawa,S., Nonaka,Y.,
            Fujiwara,M., Okudaira,S., Kano,K., Aoki,J., Morita,J., Ishitani,R.,
            Nishimasu,H., Nakamura,Y. and Nureki,O.
  TITLE     Structural basis for specific inhibition of Autotaxin by a DNA
            aptamer
  JOURNAL   Nat Struct Mol Biol 23 (5), 395-401 (2016)
   PUBMED   27043297
  REMARK    GeneRIF: The crystal structure of mouse ATX in complex with an
            anti-ATX aptamer.
REFERENCE   5  (bases 1 to 4039)
  AUTHORS   Hirono,S., Lee,E.Y., Kuribayashi,S., Fukuda,T., Saeki,N.,
            Minokoshi,Y., Iwanaga,T. and Miki,T.
  TITLE     Importance of Adult Dmbx1 in Long-Lasting Orexigenic Effect of
            Agouti-Related Peptide
  JOURNAL   Endocrinology 157 (1), 245-257 (2016)
   PUBMED   26505115
  REMARK    GeneRIF: Data (including data from studies in transgenic/knockout
            mice) suggest that expression in adult brain neurons (especially in
            parabrachial nucleus) of both Dmbx1 and AgRP (agouti-related
            peptide) is important in appetite regulation leading to leanness.
REFERENCE   6  (bases 1 to 4039)
  AUTHORS   Zhang,Y., Miki,T., Iwanaga,T., Koseki,Y., Okuno,M., Sunaga,Y.,
            Ozaki,N., Yano,H., Koseki,H. and Seino,S.
  TITLE     Identification, tissue expression, and functional characterization
            of Otx3, a novel member of the Otx family
  JOURNAL   J Biol Chem 277 (31), 28065-28069 (2002)
   PUBMED   12055180
  REMARK    GeneRIF: results suggest that Otx3 is a novel member of the Otx
            family and may be involved in the development of the central
            nervous system
REFERENCE   7  (bases 1 to 4039)
  AUTHORS   Soo,K., O'Rourke,M.P., Khoo,P.L., Steiner,K.A., Wong,N.,
            Behringer,R.R. and Tam,P.P.
  TITLE     Twist function is required for the morphogenesis of the cephalic
            neural tube and the differentiation of the cranial neural crest
            cells in the mouse embryo
  JOURNAL   Dev Biol 247 (2), 251-270 (2002)
   PUBMED   12086465
REFERENCE   8  (bases 1 to 4039)
  AUTHORS   Miyamoto,T., Kawahara,A., Teufel,A., Mukhopadhyay,M., Zhao,Y.,
            Dawid,I.B. and Westphal,H.
  TITLE     Mbx, a novel mouse homeobox gene
  JOURNAL   Dev Genes Evol 212 (2), 104-106 (2002)
   PUBMED   11914943
  REMARK    GeneRIF: provides a useful molecular marker for early mouse
            midbrain development and may play a critical role in brain
            development
REFERENCE   9  (bases 1 to 4039)
  AUTHORS   Ohtoshi,A., Nishijima,I., Justice,M.J. and Behringer,R.R.
  TITLE     Dmbx1, a novel evolutionarily conserved paired-like homeobox gene
            expressed in the brain of mouse embryos
  JOURNAL   Mech Dev 110 (1-2), 241-244 (2002)
   PUBMED   11744391
  REMARK    GeneRIF: Dmbx1, a novel evolutionarily conserved paired-like
            homeobox gene is expressed in the brain of mouse embryos. Linkage
            analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4.
REFERENCE   10 (bases 1 to 4039)
  AUTHORS   Martinez-Barbera,J.P., Signore,M., Boyl,P.P., Puelles,E.,
            Acampora,D., Gogoi,R., Schubert,F., Lumsden,A. and Simeone,A.
  TITLE     Regionalisation of anterior neuroectoderm and its competence in
            responding to forebrain and midbrain inducing activities depend on
            mutual antagonism between OTX2 and GBX2
  JOURNAL   Development 128 (23), 4789-4800 (2001)
   PUBMED   11731459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY732319.1 and BC050912.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' coding region, compared to variant 1. It encodes isoform
            b, which is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050912.1, AB037698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-664               BY732319.1         1-664
            665-4039            BC050912.1         642-4016
FEATURES             Location/Qualifiers
     source          1..4039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.07 cM"
     gene            1..4039
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="diencephalon/mesencephalon homeobox 1"
                     /db_xref="GeneID:140477"
                     /db_xref="MGI:MGI:2153518"
     exon            1..42
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            43..208
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1185
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="isoform b is encoded by transcript variant 2;
                     homeobox gene Atx; diencephalon/mesencephalon homeobox
                     protein 1; paired-type homeobox Atx; paired-like homeobox
                     protein DMBX1; diencephalon/mesencephalon-expressed brain
                     homeobox gene 1 protein; orthodenticle homolog 3"
                     /codon_start=1
                     /product="diencephalon/mesencephalon homeobox protein 1
                     isoform b"
                     /protein_id="NP_001020738.1"
                     /db_xref="CCDS:CCDS18500.1"
                     /db_xref="GeneID:140477"
                     /db_xref="MGI:MGI:2153518"
                     /translation="MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHAL
                     TLAERLADIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMC
                     TNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKVEAPASDTQLETE
                     QPPGLPSGDPPAELQLSLSEQSASESAPEDQLDREEDSRAEEPKAEKSPGSESKVPGC
                     KRGSPKADSPGSLAITPAAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLMHY
                     SSFEVGGPAPAAAAAAAAAVPYLGVNMAPLSSLHCQSYYQSLSAAAAAHQGVWGSPLL
                     PAPPTGLAPASAALNSKTTSIENLRLRAKQHAASLGLDTLPN"
     exon            209..387
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..730
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..4017
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3994..3999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="hexamer: AATAAA"
     polyA_site      4017
                     /gene="Dmbx1"
                     /gene_synonym="Atx; Cdmx; Mbx; Otx3"
                     /note="major polyA site"
ORIGIN      
        1 gtagatggca gcggcagcgg cggcgcgggc caaggagacc aggcggatgc cgccatgcag
       61 cactatgggg tgaatggcta ctccctgcac gctatgaact cactcagcgc catgtacaac
      121 ctgcaccagc aggcagccca gcaggcccag cacgcccccg actaccggcc atcagtgcat
      181 gcgcttacgt tggctgagcg cctagctgac atcatcttgg aggcccgcta tggctcccag
      241 caccgtaaac aacgtcggag tcgcacggcg ttcacggccc agcagcttga ggccctggag
      301 aagaccttcc aaaagactca ttacccagat gtggtgatgc gcgagaggct ggccatgtgt
      361 accaatcttc ctgaggcccg tgtacaggtg tggtttaaga accgcagggc caagttccga
      421 aagaagcagc gcagcctgca gaaagagcag ctccagaaac agaaggaggc cgagggttcc
      481 cacggagaag gcaaggtgga ggccccagcc tcagacacgc agctggaaac agaacagcct
      541 cctggtttgc ccagtggtga tcctcctgct gaacttcaac tgagcctgtc ggagcagtca
      601 gccagcgagt ctgccccaga agatcagctg gaccgtgaag aggactcccg tgccgaggag
      661 cccaaagctg aaaagagccc tggatctgag agcaaggtgc cgggctgcaa gaggggcagc
      721 cctaaggcag attccccagg cagcctggcc ataacgcccg cagccccagg gggcggcctc
      781 cttggtcctt cccactccta ctcctcatcc ccactcagcc tcttccgtct gcaggagcag
      841 ttccgccagc atatggcggc caccaacaac ctgatgcact actcgtcttt tgaagtgggc
      901 ggtcccgcac ctgcggcggc tgcagctgcg gcggctgccg tgccctacct aggggtcaac
      961 atggccccat tgagctccct acactgccag tcctattacc aatccctgtc agcagctgct
     1021 gctgcccacc agggtgtgtg ggggtcccca ttgctgccgg cgccccccac aggcctggca
     1081 cctgcctccg ctgccctgaa cagtaaaacc acgagcattg aaaaccttcg cctccgggcc
     1141 aagcagcacg ccgcatccct gggactcgat acactcccca attgactgtc tggcttctaa
     1201 cccaaccatg gtcttgggtg tacccctgtc tcggtcccat ggttattctc agaaggctct
     1261 ccaagttctc ctagaactaa ctttgagagc ccagggatgc tggggcctgg agtcctttca
     1321 ccttgtctcc cttattcaaa gtcccaatcc caagtgaaac ccacacaccc tctgcatggc
     1381 cctgcttgga ccccatggag gtcaaatggg gaggagggga gcaactggct acaccccctc
     1441 ttcagtattg cctcctccct cctgctcccc ccccccccgt tagtaagttg aagtgtggaa
     1501 tgtgagatat aaatataaat atataaaact atattttcag gcactgcctg ccccaggccc
     1561 cctttccctg ttctcacatc gccactaccc ttgcccctga gattcactcc agcagattct
     1621 ctctctctct ctctctctct ctctctctct ctctctctct catcctcctt tttctcctga
     1681 tcccccctcc cctgcagccc cactgcctct gtcttgatcc ctgtccctct acctaccctt
     1741 ggcctttggt gctggcttta ttattgtcca gtattctcaa acagtgtttc ttttgggggt
     1801 tgtaggtttt ttttttgttt ttgtttttgt tgttgttttt tgttttggtt ttagtcattt
     1861 tgtttcttcc tgtttctctt ctgctccgct tggctatctc ctcccttaac ctgaactctc
     1921 tctaggcaac tcttccattc catgccccaa gattcatcaa agtcctactt ggagacccag
     1981 gagcaacagg caggaggtag ctctaacccc acagcatctc cagatattag gaggggctca
     2041 cagtcacctt ttcttctctt tctttgcttg gaagtacccg ctcccagatt gcagaggggc
     2101 agccgcagta gaacagagac ctcattgcag ggttctagaa tcccttctca gtgagtgaac
     2161 ccttatggct acatacggtc tcaggacttg gcttcctgtt gcagaggccg gtgtgggagt
     2221 aggcgcttct gtctcgttag tcactggcat ggcagggtgt gttcttctat gtctaggcaa
     2281 ccctgctctg tggacgccct ttcaagcttg ctaggactgt cttgtctgga taagatgatt
     2341 tagaagattc tgtccatttc caaccaccca gtgttctatg ccacaacctt gtatggcaga
     2401 ggctttaatt aagtttaata ataataactg cagcataagc acttagagaa gcccagtttg
     2461 taagttagaa cattactgtt gttttgctga ggaacagtga gtcctgcata cctgaagatc
     2521 tctgtggata ctgcctctgt ttcccagtaa atgtaaatgg ctccttttta ggttagacaa
     2581 tctggatttg atcctatttt tcttggattc cagtgtgagc cttggggggg ggggctactc
     2641 cattcccctg cccatggtga ggggtgggca agattacttg aatagattcg tggttatgat
     2701 tccgcaaccc tttggctcgc cacagaaccc tcaaccccac gcccacacag tggtggcctg
     2761 gcacgactgg cctacagagc caatagtgct caccttagta atgtcagtct ggactggggt
     2821 aggagaaggt tttagccagt aaaaagtgag acaggaaagc atgaaagaaa gaaacaggag
     2881 aagtgagcca cggaacacaa ggtgactggc ctcgtgagag gtgaggcaga gagcctagga
     2941 cgcagtctca cattcccact ttcacgcagc agcaccaaag tcagttgagg gtttcttaag
     3001 aaggggtatc ttcctgggtt ctagaatctg cgaacatcag aggaggagag acttggacgg
     3061 ggagatgaga ggttagcaaa tccttaggga gatgaggggg ttctgggtta gggagggatc
     3121 agtgatcgat ccatggttac cctattgtgg tcagcttcaa gaaattatgt ttctgtattg
     3181 tctcatctgg aaccaggcgc agggctgaaa ctgtctttct attcctgggt gcaaatgact
     3241 gattgtcact gggacttggg atctaacact tctgggtatt accatttcca gaagccttcc
     3301 caacctccta aagagcaagg ccacctgagg tcatatctgg tcatgacatg agcctggtct
     3361 atcccaggct tttctaaact ctcttagatc tttgtcatgt gttctctcat gtgctgaccc
     3421 aaatccccaa ggccagagaa gggagggaag acacacgtgg gttttatctt catgaccatg
     3481 tcttcttagg aggattagag ggcacgattc tttgaagaaa ttgtgggtga gcccaccttc
     3541 ctgacactgc tgatggaatc tctctcaggc ctgctggtca cttagggcag agagcccaag
     3601 gattaaaccc ttacaagccc ttctaggaag agtcctgtat gtctctgctc tgtttgaggt
     3661 ctcctttgcc ctgcttcctc atttccctag agcatggttc aggggcctgg gtccccattt
     3721 ctatgcagag gctgactggc tgtatagact gcttttcaaa ccagctgttt tgtgaccact
     3781 tgtgcttaga ggttgtacaa agccttggca aaaaacaaaa caccgtgtat tgtatttatt
     3841 tattctgtta gttgatgaag caaaactcaa acctctcact ttccctcgtc ctgtcccctg
     3901 cgtagcacag catgaatctc tgtcctgtat atctgtcagt cttttggcct tacttcctgt
     3961 gactttgtga cctgttcgtt gtcttaattg gctaataaaa gagaacctgg cagcacaaaa
     4021 aaaaaaaaaa aaaaaaaaa
//
