LOCUS       NM_001419062            1583 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus DNA methyltransferase 1-associated protein 1 (Dmap1),
            transcript variant 3, mRNA.
ACCESSION   NM_001419062 XM_006503267
VERSION     NM_001419062.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Lee,Y.J., Son,S.H., Lim,C.S., Kim,M.Y., Lee,S.W., Lee,S., Jeon,J.,
            Ha,D.H., Jung,N.R., Han,S.Y., Do,B.R., Na,I., Uversky,V.N. and
            Kim,C.G.
  TITLE     MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic
            Stem Cells by Crosstalk with PcG Proteins
  JOURNAL   Cells 9 (5), 1190 (2020)
   PUBMED   32403252
  REMARK    GeneRIF: MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of
            Embryonic Stem Cells by Crosstalk with PcG Proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Yu,J.S.L., Palano,G., Lim,C., Moggio,A., Drowley,L.,
            Plowright,A.T., Bohlooly-Y,M., Rosen,B.S., Hansson,E.M., Wang,Q.D.
            and Yusa,K.
  TITLE     CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of
            Chemically Induced Reprogramming and Differentiation of Cardiac
            Progenitors
  JOURNAL   Stem Cells 37 (7), 958-972 (2019)
   PUBMED   30932271
  REMARK    GeneRIF: The results establish Dmap1 as a modulator of cardiac
            reprogramming and myocytic induction.
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Muromoto,R., Sugiyama,K., Takachi,A., Imoto,S., Sato,N.,
            Yamamoto,T., Oritani,K., Shimoda,K. and Matsuda,T.
  TITLE     Physical and functional interactions between Daxx and DNA
            methyltransferase 1-associated protein, DMAP1
  JOURNAL   J Immunol 172 (5), 2985-2993 (2004)
   PUBMED   14978102
  REMARK    GeneRIF: In this study, two-hybrid screening leads to the
            identification of DNMT1 associated protein, DMAP1, as a
            Daax-interacting protein.
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Rountree,M.R., Bachman,K.E. and Baylin,S.B.
  TITLE     DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex
            at replication foci
  JOURNAL   Nat Genet 25 (3), 269-277 (2000)
   PUBMED   10888872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671520.6.
            
            On Mar 27, 2023 this sequence version replaced XM_006503267.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.7182795.1,
                                           SRR7345562.3522402.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL671520.6         132312-132388       c
            78-227              AL671520.6         131968-132117       c
            228-319             AL671520.6         131409-131500       c
            320-515             AL671520.6         130978-131173       c
            516-674             AL671520.6         126744-126902       c
            675-842             AL671520.6         126485-126652       c
            843-1028            AL671520.6         126085-126270       c
            1029-1100           AL671520.6         125867-125938       c
            1101-1173           AL671520.6         125562-125634       c
            1174-1469           AL671520.6         125156-125451       c
            1470-1583           AL671520.6         124816-124929       c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.46 cM"
     gene            1..1583
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="DNA methyltransferase 1-associated protein 1"
                     /db_xref="GeneID:66233"
                     /db_xref="MGI:MGI:1913483"
     exon            1..77
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            78..227
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1529
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="DNMT1 associated protein-1; MAT1-mediated
                     transcriptional repressor"
                     /codon_start=1
                     /product="DNA methyltransferase 1-associated protein 1"
                     /protein_id="NP_001405991.1"
                     /db_xref="GeneID:66233"
                     /db_xref="MGI:MGI:1913483"
                     /translation="MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSET
                     LTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTN
                     PARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHL
                     FDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVF
                     DAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAAD
                     TTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVG
                     QKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLR
                     HRHEALARAGVLGAPAAAAVGPTPASAEPTVSESGLGLDPTKDTIIDVVGAPLTPNSR
                     KRRESASSSSSVKKAKKP"
     exon            228..319
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            320..515
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            516..674
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            675..842
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1028
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1100
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1173
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1469
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1583
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1518..1523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="hexamer: AAGAAA"
     polyA_site      1583
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="major polyA site"
ORIGIN      
        1 gcacagccgg aagttcctat ccgtgggtct tcagagagag gtaatttgag gagtgggcta
       61 cagctggggg gactcaggta ccgacccttg acgtcggggt actacctcat ccctcgggcg
      121 tgatggctac gggcgcagat gtacgagaca ttctagaact cgggggtcca gagggagatg
      181 ccgcctctgg gaccatcagc aaaaaggata ttatcaaccc ggacaagaaa aagtccaaga
      241 agtcctcaga gacgctgacc ttcaagaggc ctgagggcat gcatcgggag gtctatgctt
      301 tgctttactc tgacaaaaag gatgcacccc cactgctgcc cagtgacact ggtcaggggt
      361 atcggacagt gaaggcgaaa ctggggtcca agaaggttcg cccttggaaa tggatgcctt
      421 ttactaaccc agctcgaaag gacggcgcta tgtttttcca ctggcgacga gcggcggagg
      481 agggcaagga ctaccctttt gccaggttca ataagacggt gcaggtgccc gtgtactcag
      541 agcaggagta ccaactctac cttcatgatg acgcatggac taaggcagag actgaccacc
      601 tatttgacct cagccgccga tttgatctgc gcttcgtagt tattcacgat cggtatgacc
      661 accagcagtt caagaagcgt tctgtggagg acctgaaaga gaggtactac cacatttgtg
      721 ccaagcttgc caacgtgagg gctgtgccag gcacagatct caagatacca gtgtttgatg
      781 ctgggcatga gagacggcgg aaggaacagc tagagcggct ttacaaccga accccagagc
      841 aggtggcaga ggaggagtac ctcctacagg agctgcgtaa gattgaggcc cggaaaaaag
      901 agcgggagaa gcgcagccaa gacctgcaga agctgattac agcagcagac accactgcag
      961 agcagcggcg cacggaacgc aaggctccca agaagaagct accccaaaag aaggaggctg
     1021 agaagccggc tgtccctgag actgcaggca tcaagtttcc agattttaag tcggcaggtg
     1081 tcacgctacg gagccagcgg atgaagctac ccagctctgt gggtcagaag aagatcaagg
     1141 cgctggaaca gatgctgctg gaacttggtg tggagctgag ccctaccccc acagaggagc
     1201 tggtgcatat gttcaatgag ttgcggagcg acctggtgtt actctacgag ctcaagcagg
     1261 cctgtgccaa ctgtgaatat gagctacaga tgctgcggca ccggcacgag gccctggctc
     1321 gggcaggagt gctgggggcc cctgccgcag cagcagtggg accaaccccg gcttctgctg
     1381 agccaacagt gtctgaatct ggacttggtc tggaccccac caaggatacc atcattgatg
     1441 tcgtgggtgc acccctcaca cccaattcgc ggaaacgacg ggaatcagcc tccagctcat
     1501 cttctgtgaa gaaagccaag aaaccataag gggccatctg agttggtggt atggtgtaaa
     1561 tagagctgtt acattggact ggg
//
