LOCUS       NM_001419061            1678 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus DNA methyltransferase 1-associated protein 1 (Dmap1),
            transcript variant 2, mRNA.
ACCESSION   NM_001419061 XM_006503268
VERSION     NM_001419061.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1678)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1678)
  AUTHORS   Lee,Y.J., Son,S.H., Lim,C.S., Kim,M.Y., Lee,S.W., Lee,S., Jeon,J.,
            Ha,D.H., Jung,N.R., Han,S.Y., Do,B.R., Na,I., Uversky,V.N. and
            Kim,C.G.
  TITLE     MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic
            Stem Cells by Crosstalk with PcG Proteins
  JOURNAL   Cells 9 (5), 1190 (2020)
   PUBMED   32403252
  REMARK    GeneRIF: MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of
            Embryonic Stem Cells by Crosstalk with PcG Proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1678)
  AUTHORS   Yu,J.S.L., Palano,G., Lim,C., Moggio,A., Drowley,L.,
            Plowright,A.T., Bohlooly-Y,M., Rosen,B.S., Hansson,E.M., Wang,Q.D.
            and Yusa,K.
  TITLE     CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of
            Chemically Induced Reprogramming and Differentiation of Cardiac
            Progenitors
  JOURNAL   Stem Cells 37 (7), 958-972 (2019)
   PUBMED   30932271
  REMARK    GeneRIF: The results establish Dmap1 as a modulator of cardiac
            reprogramming and myocytic induction.
REFERENCE   4  (bases 1 to 1678)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1678)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   6  (bases 1 to 1678)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   7  (bases 1 to 1678)
  AUTHORS   Muromoto,R., Sugiyama,K., Takachi,A., Imoto,S., Sato,N.,
            Yamamoto,T., Oritani,K., Shimoda,K. and Matsuda,T.
  TITLE     Physical and functional interactions between Daxx and DNA
            methyltransferase 1-associated protein, DMAP1
  JOURNAL   J Immunol 172 (5), 2985-2993 (2004)
   PUBMED   14978102
  REMARK    GeneRIF: In this study, two-hybrid screening leads to the
            identification of DNMT1 associated protein, DMAP1, as a
            Daax-interacting protein.
REFERENCE   8  (bases 1 to 1678)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   9  (bases 1 to 1678)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 1678)
  AUTHORS   Rountree,M.R., Bachman,K.E. and Baylin,S.B.
  TITLE     DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex
            at replication foci
  JOURNAL   Nat Genet 25 (3), 269-277 (2000)
   PUBMED   10888872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671520.6.
            
            On Mar 27, 2023 this sequence version replaced XM_006503268.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.857704.1,
                                           SRR17784650.1382957.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AL671520.6         132217-132388       c
            173-322             AL671520.6         131968-132117       c
            323-414             AL671520.6         131409-131500       c
            415-610             AL671520.6         130978-131173       c
            611-769             AL671520.6         126744-126902       c
            770-937             AL671520.6         126485-126652       c
            938-1123            AL671520.6         126085-126270       c
            1124-1195           AL671520.6         125867-125938       c
            1196-1268           AL671520.6         125562-125634       c
            1269-1564           AL671520.6         125156-125451       c
            1565-1678           AL671520.6         124816-124929       c
FEATURES             Location/Qualifiers
     source          1..1678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.46 cM"
     gene            1..1678
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="DNA methyltransferase 1-associated protein 1"
                     /db_xref="GeneID:66233"
                     /db_xref="MGI:MGI:1913483"
     exon            1..172
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            173..322
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1624
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="DNMT1 associated protein-1; MAT1-mediated
                     transcriptional repressor"
                     /codon_start=1
                     /product="DNA methyltransferase 1-associated protein 1"
                     /protein_id="NP_001405990.1"
                     /db_xref="GeneID:66233"
                     /db_xref="MGI:MGI:1913483"
                     /translation="MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSET
                     LTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTN
                     PARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHL
                     FDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVF
                     DAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAAD
                     TTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVG
                     QKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLR
                     HRHEALARAGVLGAPAAAAVGPTPASAEPTVSESGLGLDPTKDTIIDVVGAPLTPNSR
                     KRRESASSSSSVKKAKKP"
     exon            323..414
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            415..610
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            611..769
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            770..937
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1123
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1195
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1268
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1564
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1678
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="hexamer: AAGAAA"
     polyA_site      1678
                     /gene="Dmap1"
                     /gene_synonym="1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1;
                     mKIAA1425"
                     /note="major polyA site"
ORIGIN      
        1 gcacagccgg aagttcctat ccgtgggtct tcagagagag gtaatttgag gagtgggcta
       61 cagctggggg gactcaggtg tggctccccg gggatggcga ggcagggagg acagtgtgac
      121 cgtaagggac acctgcgcgg ggaggcggag aacgaggcag cacccaaacc tggtaccgac
      181 ccttgacgtc ggggtactac ctcatccctc gggcgtgatg gctacgggcg cagatgtacg
      241 agacattcta gaactcgggg gtccagaggg agatgccgcc tctgggacca tcagcaaaaa
      301 ggatattatc aacccggaca agaaaaagtc caagaagtcc tcagagacgc tgaccttcaa
      361 gaggcctgag ggcatgcatc gggaggtcta tgctttgctt tactctgaca aaaaggatgc
      421 acccccactg ctgcccagtg acactggtca ggggtatcgg acagtgaagg cgaaactggg
      481 gtccaagaag gttcgccctt ggaaatggat gccttttact aacccagctc gaaaggacgg
      541 cgctatgttt ttccactggc gacgagcggc ggaggagggc aaggactacc cttttgccag
      601 gttcaataag acggtgcagg tgcccgtgta ctcagagcag gagtaccaac tctaccttca
      661 tgatgacgca tggactaagg cagagactga ccacctattt gacctcagcc gccgatttga
      721 tctgcgcttc gtagttattc acgatcggta tgaccaccag cagttcaaga agcgttctgt
      781 ggaggacctg aaagagaggt actaccacat ttgtgccaag cttgccaacg tgagggctgt
      841 gccaggcaca gatctcaaga taccagtgtt tgatgctggg catgagagac ggcggaagga
      901 acagctagag cggctttaca accgaacccc agagcaggtg gcagaggagg agtacctcct
      961 acaggagctg cgtaagattg aggcccggaa aaaagagcgg gagaagcgca gccaagacct
     1021 gcagaagctg attacagcag cagacaccac tgcagagcag cggcgcacgg aacgcaaggc
     1081 tcccaagaag aagctacccc aaaagaagga ggctgagaag ccggctgtcc ctgagactgc
     1141 aggcatcaag tttccagatt ttaagtcggc aggtgtcacg ctacggagcc agcggatgaa
     1201 gctacccagc tctgtgggtc agaagaagat caaggcgctg gaacagatgc tgctggaact
     1261 tggtgtggag ctgagcccta cccccacaga ggagctggtg catatgttca atgagttgcg
     1321 gagcgacctg gtgttactct acgagctcaa gcaggcctgt gccaactgtg aatatgagct
     1381 acagatgctg cggcaccggc acgaggccct ggctcgggca ggagtgctgg gggcccctgc
     1441 cgcagcagca gtgggaccaa ccccggcttc tgctgagcca acagtgtctg aatctggact
     1501 tggtctggac cccaccaagg ataccatcat tgatgtcgtg ggtgcacccc tcacacccaa
     1561 ttcgcggaaa cgacgggaat cagcctccag ctcatcttct gtgaagaaag ccaagaaacc
     1621 ataaggggcc atctgagttg gtggtatggt gtaaatagag ctgttacatt ggactggg
//
