LOCUS       NM_010057               1071 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus distal-less homeobox 6 (Dlx6), mRNA.
ACCESSION   NM_010057
VERSION     NM_010057.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1071)
  AUTHORS   Cheffer A, Garcia-Miralles M, Maier E, Akol I, Franz H, Srinivasan
            VSV and Vogel T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   2  (bases 1 to 1071)
  AUTHORS   Kurihara Y, Ekimoto T, Gordon CT, Uchijima Y, Sugiyama R, Kitazawa
            T, Iwase A, Kotani R, Asai R, Pingault V, Ikeguchi M, Amiel J and
            Kurihara H.
  TITLE     Mandibulofacial dysostosis with alopecia results from ETAR
            gain-of-function mutations via allosteric effects on ligand binding
  JOURNAL   J Clin Invest 133 (4), e151536 (2023)
   PUBMED   36637912
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1071)
  AUTHORS   Mullen RD, Bellessort B, Levi G and Behringer RR.
  TITLE     Distal-less homeobox genes Dlx5/6 regulate Mullerian duct
            regression
  JOURNAL   Front Endocrinol (Lausanne) 13, 916173 (2022)
   PUBMED   35909540
  REMARK    GeneRIF: Distal-less homeobox genes Dlx5/6 regulate Mullerian duct
            regression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1071)
  AUTHORS   Gu R, Zhang S, Saha SK, Ji Y, Reynolds K, McMahon M, Sun B, Islam
            M, Trainor PA, Chen Y, Xu Y, Chai Y, Burkart-Waco D and Zhou CJ.
  TITLE     Single-cell transcriptomic signatures and gene regulatory networks
            modulated by Wls in mammalian midline facial formation and clefts
  JOURNAL   Development 149 (14) (2022)
   PUBMED   35781558
REFERENCE   5  (bases 1 to 1071)
  AUTHORS   Aouci R, El Soudany M, Maakoul Z, Fontaine A, Kurihara H, Levi G
            and Narboux-Neme N.
  TITLE     Dlx5/6 Expression Levels in Mouse GABAergic Neurons Regulate Adult
            Parvalbumin Neuronal Density and Anxiety/Compulsive Behaviours
  JOURNAL   Cells 11 (11), 1739 (2022)
   PUBMED   35681437
  REMARK    GeneRIF: Dlx5/6 Expression Levels in Mouse GABAergic Neurons
            Regulate Adult Parvalbumin Neuronal Density and Anxiety/Compulsive
            Behaviours.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1071)
  AUTHORS   Anderson SA, Qiu M, Bulfone A, Eisenstat DD, Meneses J, Pedersen R
            and Rubenstein JL.
  TITLE     Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the
            striatal subventricular zone and differentiation of late born
            striatal neurons
  JOURNAL   Neuron 19 (1), 27-37 (1997)
   PUBMED   9247261
REFERENCE   7  (bases 1 to 1071)
  AUTHORS   Qiu M, Bulfone A, Ghattas I, Meneses JJ, Christensen L, Sharpe PT,
            Presley R, Pedersen RA and Rubenstein JL.
  TITLE     Role of the Dlx homeobox genes in proximodistal patterning of the
            branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter
            morphogenesis of proximal skeletal and soft tissue structures
            derived from the first and second arches
  JOURNAL   Dev Biol 185 (2), 165-184 (1997)
   PUBMED   9187081
REFERENCE   8  (bases 1 to 1071)
  AUTHORS   Stock DW, Ellies DL, Zhao Z, Ekker M, Ruddle FH and Weiss KM.
  TITLE     The evolution of the vertebrate Dlx gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10858-10863 (1996)
   PUBMED   8855272
REFERENCE   9  (bases 1 to 1071)
  AUTHORS   Chen X, Li X, Wang W and Lufkin T.
  TITLE     Dlx5 and Dlx6: an evolutionary conserved pair of murine homeobox
            genes expressed in the embryonic skeleton
  JOURNAL   Ann N Y Acad Sci 785, 38-47 (1996)
   PUBMED   8702182
REFERENCE   10 (bases 1 to 1071)
  AUTHORS   Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A,
            Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K et al.
  TITLE     Cloning and characterization of two members of the vertebrate Dlx
            gene family
  JOURNAL   Proc Natl Acad Sci U S A 91 (6), 2250-2254 (1994)
   PUBMED   7907794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EF535989.1 and AC122240.4.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_010057.3.
            
            On Aug 4, 2009 this sequence version replaced NM_010057.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF022078.1, SRR1660815.392232.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-977               EF535989.1         1-977
            978-1071            AC122240.4         111112-111205
FEATURES             Location/Qualifiers
     source          1..1071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 2.83 cM"
     gene            1..1071
                     /gene="Dlx6"
                     /note="distal-less homeobox 6"
                     /db_xref="GeneID:13396"
                     /db_xref="MGI:MGI:101927"
     exon            1..494
                     /gene="Dlx6"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..940
                     /gene="Dlx6"
                     /codon_start=1
                     /product="homeobox protein DLX-6"
                     /protein_id="NP_034187.1"
                     /db_xref="CCDS:CCDS51719.1"
                     /db_xref="GeneID:13396"
                     /db_xref="MGI:MGI:101927"
                     /translation="MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQQQQ
                     QQQPPPPPPPPPPQPHSQQTSPAMAGAHYPLHCLHSAAAAAAAAGSHHHHHQHHHHGS
                     PYASSGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENG
                     EIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIW
                     FQNKRSKFKKLLKQGSNPHESDPLPGSAALSPRSPALPPVWDVSASAKGVSMPPNSYM
                     PGYSHWYSSPHQDTMQRPQMM"
     exon            495..688
                     /gene="Dlx6"
                     /inference="alignment:Splign:2.1.0"
     exon            689..977
                     /gene="Dlx6"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1071
                     /gene="Dlx6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaagaaa cccgggagaa ggctttctcc agcccccaaa gttttgatga tgaccatgac
       61 tacgatggct gacggcttgg aaggccagga ctcgtccaaa tccgccttca tggagttcgg
      121 gcagcagcaa cagcagcagc agcaacaaca gcagcagcaa cagcagcagc agcagcagca
      181 acagcagccg ccgccgccgc caccgccgcc gccgccgcag ccgcactcgc agcagacctc
      241 cccggccatg gcaggcgcac attaccctct gcactgcttg cactcggccg cggcggcggc
      301 ggcggcggcc ggctcccacc atcaccacca ccagcaccac caccacggct cgccctacgc
      361 gtcgagcgga ggcaactcct acaaccaccg atcgctcgcc gcctacccct acatgagcca
      421 ctcgcagcac agcccttacc tccagtccta ccacaacagc agcgcggccg cccagacgcg
      481 cggggacgac acagatcaac aaaaaacgac agtgatcgaa aacggggaaa tcaggttcaa
      541 cggaaagggg aaaaagattc ggaagcctcg gaccatttat tccagcctgc agctccaggc
      601 tttaaaccat cgctttcagc agactcaata cctggccctt cccgagagag ccgaactggc
      661 tgcttcctta ggactgacac aaacacaggt gaagatatgg tttcagaata agcgctctaa
      721 gtttaagaaa ttgctgaagc agggtagtaa cccacacgag agtgaccccc tcccgggttc
      781 agcagccctg tcaccacgat caccagccct gcctccagtg tgggacgttt ctgcctctgc
      841 caagggcgtc agtatgcctc ccaacagcta catgccgggg tattcacact ggtattcctc
      901 accacaccag gacaccatgc agagaccaca gatgatgtga cttctctgag tgaacgccta
      961 cggagcttct gaaggagaca ttctccaccg gcagaagaat ctgcacaaac atggcagcat
     1021 ttttacttgt ttaatgagtt taagacatta catgataaaa aacaaagatt t
//
