LOCUS       NM_010056               1410 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus distal-less homeobox 5 (Dlx5), transcript variant 1,
            mRNA.
ACCESSION   NM_010056
VERSION     NM_010056.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Nevorankova,P., Sulcova,M., Kavkova,M., Zimcik,D., Balkova,S.M.,
            Peleskova,K., Kristekova,D., Jakesova,V., Zikmund,T., Kaiser,J.,
            Hola,L.I., Kolar,M. and Buchtova,M.
  TITLE     Region-specific gene expression profiling of early mouse mandible
            uncovered SATB2 as a key molecule for teeth patterning
  JOURNAL   Sci Rep 14 (1), 18212 (2024)
   PUBMED   39107332
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Sivori,M., Dempsey,B., Chettouh,Z., Boismoreau,F., Ayerdi,M.,
            Eymael,A., Baulande,S., Lameiras,S., Coulpier,F., Delattre,O.,
            Rohrer,H., Mirabeau,O. and Brunet,J.F.
  TITLE     The pelvic organs receive no parasympathetic innervation
  JOURNAL   Elife 12, 91576 (2024)
   PUBMED   38488657
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Sheng,H.Z., Bertuzzi,S., Chiang,C., Shawlot,W., Taira,M., Dawid,I.
            and Westphal,H.
  TITLE     Expression of murine Lhx5 suggests a role in specifying the
            forebrain
  JOURNAL   Dev Dyn 208 (2), 266-277 (1997)
   PUBMED   9022063
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Stock,D.W., Ellies,D.L., Zhao,Z., Ekker,M., Ruddle,F.H. and
            Weiss,K.M.
  TITLE     The evolution of the vertebrate Dlx gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10858-10863 (1996)
   PUBMED   8855272
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Chen,X., Li,X., Wang,W. and Lufkin,T.
  TITLE     Dlx5 and Dlx6: an evolutionary conserved pair of murine homeobox
            genes expressed in the embryonic skeleton
  JOURNAL   Ann N Y Acad Sci 785, 38-47 (1996)
   PUBMED   8702182
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Qiu,M., Bulfone,A., Martinez,S., Meneses,J.J., Shimamura,K.,
            Pedersen,R.A. and Rubenstein,J.L.
  TITLE     Null mutation of Dlx-2 results in abnormal morphogenesis of
            proximal first and second branchial arch derivatives and abnormal
            differentiation in the forebrain
  JOURNAL   Genes Dev 9 (20), 2523-2538 (1995)
   PUBMED   7590232
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Simeone,A., Acampora,D., Pannese,M., D'Esposito,M., Stornaiuolo,A.,
            Gulisano,M., Mallamaci,A., Kastury,K., Druck,T., Huebner,K. et al.
  TITLE     Cloning and characterization of two members of the vertebrate Dlx
            gene family
  JOURNAL   Proc Natl Acad Sci U S A 91 (6), 2250-2254 (1994)
   PUBMED   7907794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF072452.1, AF033011.1 and U67840.1.
            
            On Nov 7, 2013 this sequence version replaced NM_010056.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF072452.1, AK158772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AF072452.1         1-160
            161-1406            AF033011.1         1-1246
            1407-1410           U67840.1           1383-1386
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 2.83 cM"
     gene            1..1410
                     /gene="Dlx5"
                     /note="distal-less homeobox 5"
                     /db_xref="GeneID:13395"
                     /db_xref="MGI:MGI:101926"
     exon            1..537
                     /gene="Dlx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1052
                     /gene="Dlx5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein DLX-5"
                     /codon_start=1
                     /product="homeobox protein DLX-5 isoform 1"
                     /protein_id="NP_034186.2"
                     /db_xref="CCDS:CCDS19905.1"
                     /db_xref="GeneID:13395"
                     /db_xref="MGI:MGI:101926"
                     /translation="MTGVFDRRVPSIRSGDFQAPFPTSAAMHHPSQESPTLPESSATD
                     SDYYSPAGAAPHGYCSPTSASYGKALNPYQYQYHGVNGSAAGYPAKAYADYGYASPYH
                     QYGGAYNRVPSATSQPEKEVAEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQ
                     YLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSP
                     QSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYPSAASSINSHLPPPGS
                     LQHPLALASGTLY"
     exon            538..722
                     /gene="Dlx5"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1410
                     /gene="Dlx5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1114..1119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dlx5"
                     /note="hexamer: AAGAAA"
     polyA_site      1161
                     /gene="Dlx5"
     regulatory      1364..1369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dlx5"
                     /note="hexamer: ATTAAA"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dlx5"
                     /note="hexamer: AATAAA"
     polyA_site      1392
                     /gene="Dlx5"
     polyA_site      1410
                     /gene="Dlx5"
                     /note="major polyA site"
ORIGIN      
        1 agacagagcc tccacgactc ccagcctcct cctcctcctc ctccccgccg ccgccgccgc
       61 ctcctcctct tcctcctcct ccctcgctcc cacagccatg tctgcttaga ccagagcagc
      121 tccacagcca attcaggcag cagcggccgc cgcagtagaa gaacagccac cgcccgggag
      181 ctatgacagg agtgtttgac agaagagtcc caagcatccg atccggcgac ttccaagctc
      241 cgttcccgac gtccgccgcc atgcaccacc cgtctcagga atcgccaact ttgcccgagt
      301 cctcggccac cgattctgac tactacagtc ccgcgggggc cgccccgcac ggctactgct
      361 ctcctacctc tgcttcttat ggcaaagcgc tcaaccccta ccagtaccag taccacggcg
      421 tgaacggctc cgcagccggc tacccggcca aggcttatgc cgactacggc tacgccagcc
      481 cctaccacca gtacggcggc gcctacaacc gcgtcccgag tgccaccagc cagccagaga
      541 aagaagtggc ggagccagag gtgaggatgg tgaatggtaa accaaagaaa gttcgtaaac
      601 ccaggactat ttattccagc tttcagctgg ccgctttaca gagaaggttt cagaagactc
      661 agtacctcgc cctgccagaa cgcgcggagt tggccgcctc tctaggactg acgcaaacac
      721 aggtgaaaat ctggtttcag aacaaaagat ccaagatcaa gaagatcatg aaaaacgggg
      781 agatgccccc ggagcacagt cccagctcca gcgaccctat ggcgtgtaac tcgccacagt
      841 caccagcggt gtgggagccc cagggctcat cccgctctct cagccaccac cctcatgccc
      901 accctccgac ctccaaccag tcccccgcgt ccagctacct ggagaactcg gcttcctggt
      961 acccaagcgc agccagctca atcaattccc acctgccacc gccgggctcc ttgcagcacc
     1021 cgctggcact ggcctccggg acgctttatt agatgggcta ctttctcttg ctcagttttg
     1081 ggactacagt gttgtgctgg tttagaaatc agaaagaaag gaattcatac ggggatgttt
     1141 gaacaatgga aacaaaaaag attcatgtgt aaactttttt tttgcatgta agttattgca
     1201 tttcagagag ccccgccccc ttttttacga aaagaaccct tttttttttt ttttttgcgc
     1261 aactgtggac actatcaatg gtgccttgaa atctatgacc tcaacttttc aaaagacttt
     1321 tttcaatgtt attttaaccg tgtaaataag tgtagataga ggaattaaac tgtatattct
     1381 ggataaataa aattatttcg accatggaaa
//
