LOCUS       NM_010054               2470 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus distal-less homeobox 2 (Dlx2), mRNA.
ACCESSION   NM_010054
VERSION     NM_010054.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2470)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2470)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   3  (bases 1 to 2470)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   4  (bases 1 to 2470)
  AUTHORS   Luzzio,A., Edie,S., Palmer,K., Caddle,L.B., Urban,R., Goodwin,L.O.,
            Welsh,I.C., Reinholdt,L.G., Bergstrom,D.E., Cox,T.C., Donahue,L.R.
            and Murray,S.A.
  TITLE     The spontaneous mouse mutant low set ears (Lse) is caused by tandem
            duplication of Fgf3 and Fgf4
  JOURNAL   Mamm Genome 34 (3), 453-463 (2023)
   PUBMED   37341808
REFERENCE   5  (bases 1 to 2470)
  AUTHORS   Troumpoukis,D., Vasileiou,A.R., Siskos,N., Stylianopoulou,E.,
            Ypsilantis,P., Skavdis,G. and Grigoriou,M.E.
  TITLE     Characterization of the Abracl-Expressing Cell Populations in the
            Embryonic Mammalian Telencephalon
  JOURNAL   Biomolecules 13 (9), 1337 (2023)
   PUBMED   37759737
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2470)
  AUTHORS   Ozcelik,T., Porteus,M.H., Rubenstein,J.L. and Francke,U.
  TITLE     DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to
            conserved regions on human and mouse chromosomes 2
  JOURNAL   Genomics 13 (4), 1157-1161 (1992)
   PUBMED   1354641
REFERENCE   7  (bases 1 to 2470)
  AUTHORS   Porteus,M.H., Bulfone,A., Ciaranello,R.D. and Rubenstein,J.L.
  TITLE     A partial cDNA sequence of the Dlx-2 cDNA
  JOURNAL   Neuron 9 (1), 187 (1992)
   PUBMED   1632970
  REMARK    Correction to:[Neuron. 1991 Aug;7(2):221-9. doi:
            10.1016/0896-6273(91)90260-7. PMID: 1678612]
REFERENCE   8  (bases 1 to 2470)
  AUTHORS   Porteus,M.H., Brice,A.E., Bulfone,A., Usdin,T.B., Ciaranello,R.D.
            and Rubenstein,J.L.
  TITLE     Isolation and characterization of a library of cDNA clones that are
            preferentially expressed in the embryonic telencephalon
  JOURNAL   Brain Res Mol Brain Res 12 (1-3), 7-22 (1992)
   PUBMED   1372074
REFERENCE   9  (bases 1 to 2470)
  AUTHORS   Robinson,G.W., Wray,S. and Mahon,K.A.
  TITLE     Spatially restricted expression of a member of a new family of
            murine Distal-less homeobox genes in the developing forebrain
  JOURNAL   New Biol 3 (12), 1183-1194 (1991)
   PUBMED   1687503
REFERENCE   10 (bases 1 to 2470)
  AUTHORS   Porteus,M.H., Bulfone,A., Ciaranello,R.D. and Rubenstein,J.L.
  TITLE     Isolation and characterization of a novel cDNA clone encoding a
            homeodomain that is developmentally regulated in the ventral
            forebrain
  JOURNAL   Neuron 7 (2), 221-229 (1991)
   PUBMED   1678612
  REMARK    Erratum:[Neuron. 1992 Jul;9(1):187. doi:
            10.1016/0896-6273(92)90233-4. PMID: 1632970]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928931.15.
            
            On Oct 27, 2022 this sequence version replaced NM_010054.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094317.1, AK144652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-768               AL928931.15        114230-114997       c
            769-953             AL928931.15        113630-113814       c
            954-2470            AL928931.15        111654-113170       c
FEATURES             Location/Qualifiers
     source          1..2470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 42.65 cM"
     gene            1..2470
                     /gene="Dlx2"
                     /gene_synonym="DII A; Dlx-2; Tes-1"
                     /note="distal-less homeobox 2"
                     /db_xref="GeneID:13392"
                     /db_xref="MGI:MGI:94902"
     exon            1..768
                     /gene="Dlx2"
                     /gene_synonym="DII A; Dlx-2; Tes-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..1358
                     /gene="Dlx2"
                     /gene_synonym="DII A; Dlx-2; Tes-1"
                     /note="homeobox protein TES-1"
                     /codon_start=1
                     /product="homeobox protein DLX-2"
                     /protein_id="NP_034184.1"
                     /db_xref="CCDS:CCDS16117.1"
                     /db_xref="GeneID:13392"
                     /db_xref="MGI:MGI:94902"
                     /translation="MTGVFDSLVADMHSTQITASSTYHQHQQPPSGAGAGPGGNSNSS
                     SSNSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGASPYAHMGSYQYHASGLNN
                     VSYSAKSSYDLGYTAAYTSYAPYGTSSSPVNNEPDKEDLEPEIRIVNGKPKKVRKPRT
                     IYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGE
                     IPTEQHPGASASPPCASPPVSAPASWDFGAPQRMAGGGPGSGGGGAGSSGSSPSSAAS
                     AFLGNYPWYHQASGSASHLQATAPLLHPSQTPQAHHHHHHHHHAGGGAPVSAGTIF"
     exon            769..953
                     /gene="Dlx2"
                     /gene_synonym="DII A; Dlx-2; Tes-1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2470
                     /gene="Dlx2"
                     /gene_synonym="DII A; Dlx-2; Tes-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dlx2"
                     /gene_synonym="DII A; Dlx-2; Tes-1"
                     /note="hexamer: AATAAA"
     polyA_site      2470
                     /gene="Dlx2"
                     /gene_synonym="DII A; Dlx-2; Tes-1"
                     /note="major polyA site"
ORIGIN      
        1 agacaatcgt aaagctgctc gggggtcgct cacctgctcc cgcctcctgg agcccctacc
       61 gggtctgacc gctcttgccc cctccattgc ccgccccccg cccgagccgg gccaggagcc
      121 gagaggtccg agaggcccgg gaaggatgcg gccagcagct gcggtcccga gccacgcacg
      181 gtgatcgcct cctccagggg aggaggcgcc tagaccgtag cctcatttct tgttttcctc
      241 tccctccccc tccccgtaat tacattggtt gctggaaggg acccggagag atagacagag
      301 gaggcgcctc gcatccccct ctcgcccgcc acccgtgctc tttcctgtcc cgggtcagga
      361 tgactggagt ctttgacagt ctggtggctg atatgcactc gacccagatc accgcctcca
      421 gcacgtacca ccagcaccag cagcccccga gcggtgcggg cgccggccct ggcggcaaca
      481 gcaacagcag cagcagcaac agcagcctgc acaagcccca ggagtcgcca accctcccgg
      541 tgtccacggc tacggacagc agctactaca ccaaccagca gcacccggcg ggcggcggcg
      601 gcgggggggc ctcgccctac gcgcacatgg gctcctacca gtaccacgcc agcggcctca
      661 acaatgtctc ctactccgcc aaaagcagct acgacctggg ctacaccgcc gcgtacacct
      721 cctacgcgcc ctacggcacc agttcgtctc cggtcaacaa cgagccggac aaggaagacc
      781 ttgagcctga aatccgaata gtgaacggga agccaaagaa agtccggaaa ccacgcacca
      841 tctactccag tttccagctg gcggcccttc aacgacgctt ccagaagacc cagtatctgg
      901 ccctgccaga gcgagccgag ctggcggcgt ccctgggcct cacccaaact caggtcaaaa
      961 tctggttcca gaaccgccga tccaagttca agaagatgtg gaaaagcggc gagataccca
     1021 ccgagcagca ccctggagcc agcgcttctc ctccttgtgc ctccccgccg gtctcggcgc
     1081 cagcatcctg ggacttcggc gcgccgcagc ggatggctgg cggcggcccg ggcagcggag
     1141 gcggcggtgc gggcagctct ggctccagcc cgagcagcgc cgcctcggcc tttctgggaa
     1201 actacccgtg gtaccaccag gcttcgggct ccgcttcaca cctgcaggcc acagcgccac
     1261 ttctgcatcc ttcgcagact ccgcaggcgc accatcacca ccatcaccac caccacgcag
     1321 gcgggggcgc cccggtgagc gcggggacga ttttctaacc tcgagtggac agcgtctgag
     1381 acttgagaac tgagacaccg tgttcttcag cacgcgtcct gtagctagag gctcgaacct
     1441 accagcccgc gaccgccacc cacccagcgg tattggaagt ggcgaccagg ggtgacccgt
     1501 cgtggagcca cttctcgcac tgccacggag cagccggaaa caaggaggcc tcgtgggatc
     1561 ctttagtgcc aagcctggcg tccctggcct caattccgac ctgagccccg gccactttta
     1621 ggccatcctc ggacttgtcg ccccttccca gccccctcag cgtgatcctc agggtccttg
     1681 gtctcttcag gccctgagcg gggtcaggca ctgggacgcc ttccccgccc tcgaggcttc
     1741 ccggctctca gaggctcctt ttttctctcc tgctccaggc ctcagctcca gtccgcttcg
     1801 gttattgacc tcctgggtcc tactccaccc tatcacctac ccccgtgacc cccgggatcc
     1861 cgccggtttt ttcccctcct gggggctcat gggggagaat tcccagctct cccaactctt
     1921 cccgcctccc actttcccca ggaacactcc cgtagctcct tcatccattg ccagtggagg
     1981 gtttttattt ttattttttt aaaagtttag gtgcctttgc ggatgacctc attttgatgt
     2041 taaaaaaaaa ctgatttttt taatatgtgg acgctgcaaa aaatgtgttt aaattatctt
     2101 ttttaagatg aattaaggac tattagctcg aacttcgatg cagagtttgt aaataagggt
     2161 gtctgtgcag atttccccac atttatttgt ataaaaattt ctcatctttt cagacttttt
     2221 tgtaaaccgc ccccgagttg tgaaagctgc gacgtagcag tgacctcagc agtccctatg
     2281 ttttccccct ttgaaaattt ttctcagtta aattaagcta ctgatttgaa tttgttttta
     2341 tcttgtccta aagtctttgt tcttgaaatg caaggtattt gggggttatt tattatgaaa
     2401 gcaacatact cttaatgttg attttacaat atgaagagat tatttaaaat aaattattgt
     2461 tttcattgga
//
