LOCUS       NM_001416985            2907 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus distal-less homeobox 1 (Dlx1), transcript variant 2,
            mRNA.
ACCESSION   NM_001416985
VERSION     NM_001416985.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2907)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2907)
  AUTHORS   Chen,L., Saito,R., Noda-Narita,S., Kassai,H. and Aiba,A.
  TITLE     Hyperactive mTORC1 in striatum dysregulates dopamine receptor
            expression and odor preference behavior
  JOURNAL   Front Neurosci 18, 1461178 (2024)
   PUBMED   39280263
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2907)
  AUTHORS   Ghuwalewala,S., Jiang,K., Ragi,S., Shalloway,D. and Tumbar,T.
  TITLE     A transit-amplifying progenitor with biphasic behavior contributes
            to epidermal renewal
  JOURNAL   Development 151 (12) (2024)
   PUBMED   38934416
REFERENCE   4  (bases 1 to 2907)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   5  (bases 1 to 2907)
  AUTHORS   Yuan,H., Xie,B., Yu,X., Lin,C., Li,M., Zhang,Y., Zou,X., Lu,M.,
            Zhao,M. and Wen,X.
  TITLE     A potential role of p75NTR in the regulation of circadian rhythm
            and incremental growth lines during tooth development
  JOURNAL   Front Physiol 13, 981311 (2022)
   PUBMED   36213234
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2907)
  AUTHORS   Weiss,K.M., Ruddle,F.H. and Bollekens,J.
  TITLE     Dlx and other homeobox genes in the morphological development of
            the dentition
  JOURNAL   Connect Tissue Res 32 (1-4), 35-40 (1995)
   PUBMED   7554933
REFERENCE   7  (bases 1 to 2907)
  AUTHORS   Salinas,P.C. and Nusse,R.
  TITLE     Regional expression of the Wnt-3 gene in the developing mouse
            forebrain in relationship to diencephalic neuromeres
  JOURNAL   Mech Dev 39 (3), 151-160 (1992)
   PUBMED   1363370
REFERENCE   8  (bases 1 to 2907)
  AUTHORS   Dolle,P., Price,M. and Duboule,D.
  TITLE     Expression of the murine Dlx-1 homeobox gene during facial, ocular
            and limb development
  JOURNAL   Differentiation 49 (2), 93-99 (1992)
   PUBMED   1350766
REFERENCE   9  (bases 1 to 2907)
  AUTHORS   Price,M., Lazzaro,D., Pohl,T., Mattei,M.G., Ruther,U., Olivo,J.C.,
            Duboule,D. and Di Lauro,R.
  TITLE     Regional expression of the homeobox gene Nkx-2.2 in the developing
            mammalian forebrain
  JOURNAL   Neuron 8 (2), 241-255 (1992)
   PUBMED   1346742
REFERENCE   10 (bases 1 to 2907)
  AUTHORS   Price,M., Lemaistre,M., Pischetola,M., Di Lauro,R. and Duboule,D.
  TITLE     A mouse gene related to Distal-less shows a restricted expression
            in the developing forebrain
  JOURNAL   Nature 351 (6329), 748-751 (1991)
   PUBMED   1676488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL928931.15.
            
            Summary: The protein encoded by this gene is a homeobox-containing
            transcription factor involved in development. The encoded protein
            plays a role in craniofacial patterning, as well as in bone,
            placenta, and sensory organ formation. [provided by RefSeq, Aug
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.4242073.1,
                                           SRR13948564.595502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AL928931.15        97351-97660
            311-989             AL928931.15        97874-98552
            990-1189            AL928931.15        99203-99402
            1190-2907           AL928931.15        100510-102227
FEATURES             Location/Qualifiers
     source          1..2907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 42.61 cM"
     gene            1..2907
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /note="distal-less homeobox 1"
                     /db_xref="GeneID:13390"
                     /db_xref="MGI:MGI:94901"
     exon            1..310
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..989
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             677..1444
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /codon_start=1
                     /product="homeobox protein DLX-1"
                     /protein_id="NP_001403914.1"
                     /db_xref="GeneID:13390"
                     /db_xref="MGI:MGI:94901"
                     /translation="MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHC
                     LHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLE
                     DPGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAE
                     LAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNP
                     NSSSGKGSGSSAGSYVPSYTSWYPSAHQEAMQQPQLM"
     exon            990..1189
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..2907
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2883..2888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /note="hexamer: AGTAAA"
     polyA_site      2907
                     /gene="Dlx1"
                     /gene_synonym="DII B; Dlx; Dlx-1"
                     /note="major polyA site"
ORIGIN      
        1 agacccgtgc agcctcgagc tggagtggcc agctgggcct ggagagatgc gagcaagccc
       61 ctgggaacgg tggcaacggc ggggcggcgg ccgagtgagt gagttgggcc agagggcccc
      121 caaacccaga tccccgggat gtggccgaga gaaccccaac ctgggaggcg cggcctggag
      181 cgcgctgagc taggcacaag acgctcagaa ggaccgctgg ctgcaggcta cctgggttgt
      241 cgcccagtgc gcgactccgc gatccagaga ccgcggccgg actctggagc ggcgctccgc
      301 accggactag aggagccccg gccgggacgt gtggaccgga ttctccccag gccgggccgc
      361 gtcgcccgct ctagtccagc cgagcccgag cttctcggac caatccccgg tgattatgca
      421 agagagccga ccaatcagct ccaccagctc atgaatattt atgaccttgg ctgagtcaaa
      481 gctttgaacc gagtttgggg agctcggcag catcatgctt agacttttca aagagacaaa
      541 ctccattttc ttatgaatgg aaagtgaaaa cccctgttcc gcttaaattg ggttccttcc
      601 tgtcctgaga aacatagaga cccccaaaag ggaagcagag gagagaaaga cccacaccca
      661 gaccccgcga gaagagatga ccatgaccac catgccagaa agtctcaaca gccccgtgtc
      721 gggcaaggct gtgtttatgg agtttgggcc gcccaaccag caaatgtctc cttctcccat
      781 gtcccacggg cactactcca tgcactgttt acactcggcg ggccattcgc agcccgacgg
      841 tgcctacagt tcggcctcat ccttctcccg accgctgggc tacccctacg tcaactcggt
      901 cagcagccac gcgtccagcc cctacatcag ttccgtgcag tcctaccccg gcagcgccag
      961 cctcgcccag agccgcctgg aggacccagg ggcggactcc gagaagagta cggtggtgga
     1021 aggcggcgag gtgcgcttta acggcaaagg gaaaaagatc cgtaaaccca ggacaattta
     1081 ttccagtttg cagttgcagg ctttgaaccg gaggttccaa caaactcagt acttagctct
     1141 gcctgagagg gcggagctgg cggcctcctt gggactcaca cagacgcagg tcaagatatg
     1201 gttccagaac aaacgctcca agttcaagaa gctgatgaag caaggcgggg cagctctgga
     1261 gggcagcgcg ctggcgaacg gcagagcctt gtctgccggc tccccaccgg taccacccgg
     1321 ctggaatccg aactcctcat ctgggaaggg ctccggcagc agcgctggct cctacgtccc
     1381 cagctataca tcatggtatc cctcagcgca ccaagaagct atgcagcagc ctcaactgat
     1441 gtgaggttat cagttcgcac tcacccgctt cctgcccgtc tcccttggcc cggcccctcc
     1501 cgcctccagg ttcatccacc ttttcgcacg ccctgggcca ggaggagaag agcccacgag
     1561 cgggagcagg ggtgggggtg gggagctaaa aataaaagaa aaaggaacag tgaaggcaga
     1621 gggcttgctg cttctcggag cccctaaaag tctgactcag cgacctttca gcccgaatct
     1681 ggtttgggcc acggtgaaca gcagagtggc ctcaaagcgc aggcacagcc actggagaca
     1741 gccagtgcca caagataacc cgctggaccg gaccagactc tcatctttgt gagactatca
     1801 ggaaaaacaa atacgtagga gggggaaata cgctcttttt tgattctgtc cgtctttgtc
     1861 tcctttttgc actgtctgtg cgccgaagtc aaggtcctcg tgtgtctgct gtcctcattc
     1921 tacgacctct ccaaaaagtc accaggtctg agccacaccg gtctgccggc agcccatcca
     1981 ccgagtcctg gaccactttt tcctgaatgg tcttcttccg ggccctgctt gaccatctat
     2041 gtagcttgtt tgggaaatgg gggaaatcag agggaggggg gttaatttat tgaaaaacag
     2101 acttcatctg acgctgagtg ttggccaatt ccaaattctc tgggacatgg agtgggcgct
     2161 gtccaaacat actatttacc ttaaacacac cagaagaggg aacaaggaca ggaaagtgac
     2221 ttttaaggtg cacagtaact tttgtacttg gctgaaatgc agaaagggaa aacaggatgc
     2281 cgtgcatttt acatgctcca aattattaaa aataacaaca aaagaaagac cgaagtaagg
     2341 aagtaagata tgtaaaacca ataggatgtt gtcaaaaacg tttggacaag aacacctggc
     2401 caagaagaaa aatcatactt tgggcagcaa gagagaggac caatgagcct tggagagaaa
     2461 ataatttgtc ctttatgtaa aagcacccca attccaggtc gctttaaagt aagacacaag
     2521 cagcggctcg accacagaac acaagtcatc accctgaatg cacgggctct ggtgcaagat
     2581 ctaattgctg tacatattat tgttgttatt attattaatt attattatta ttgttctgta
     2641 aacatgttgc acaagcttag cctctttccg ttctgttgtg tgtggctgta aacccgatgc
     2701 tttgtgaaat gagaatcttg acattttact tgtgaaattt ggaaaatgtg accgattgaa
     2761 atccaccgtg ttttgtgttc tctatgtcaa agtttagttt tatattgaga atgttaactt
     2821 attgctttgt atcttggggg gggggcgaac tttgtaaata agttataaag tttctttgag
     2881 acagtaaaat tatggtttca agaaaga
//
